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Background. Protein-calorie deficiency is common multifactorial medical condition in infants. Nutrition therapy of protein-calorie deficiency in premature infants with special medical food is not always quite effective. It can be associated with residual manifestations of overlapping perinatal pathology.Clinical case description. Extremely premature child with severe protein-calorie deficiency in the late period with combined perinatal pathology (perinatal central nervous system damage and bronchopulmonary dysplasia) was administrated with therapeutic highly nutritious (high-protein/high-energy) milk formula according to individual plan. The positive dynamics in clinical manifestations of the main and associated diseases was noted on nutrition therapy.Conclusion. High-calorie and protein-enriched therapeutic formula can effectively correct protein-calorie deficiency in premature infants with associated perinatal pathology in the recovery period (disfunction compensation).

Goal: to develop and evaluate the efficiency of the tactics for peri-operative nutritional-metabolic therapy as a component of Fast Track programme (FTP) in elderly patients suffering from colon cancer and having planned surgery. Methods. Treatment outcomes were analyzed for 400 elderly patients with colon cancer divided into two groups: main group (prospective n = 170), who were treated complying with optimized FTP and nutritional-metabolic therapy and control group (retrospective, n = 230), who were managed in the traditional way. Peri-operative nutritional-metabolic therapy in the main group included detection of those initially suffering from protein-calorie deficiency basing on changes in body mass loss and body weight index, and provision of integral nutritional support for them. During pre-operative preparation period lasting from 10 to 14 days they were prescribed with residue-free diet additionally to which, depending on the volume of food consumed by sipping, they received liquid nutritional mixture (Impact® Oral, Nestle) with high protein (7.6 g per 100 ml) and calories (1.4 kcal in ml) content. Post-operative nutritional support included early (from the 1st day after the surgery) enteral feeding with use of standard multisubstrate nutritional mixtures with protein content of 40g/l (Isosource® Standard, Nestle) in order to prevent paresis of gastro-intestinal tract combined with early activation of patients. Results. Patients in the main group confidently earlier restored the protein pool and immune status, nasogastric tube was removed faster, the duration of stay in the intensive care department and hospital after the surgery was less, the severity of complications as per Clavien – Dindo classification was lower, and life quality and late treatment outcomes were better. Conclusions. Use of the offered tactics of peri-operative nutritional-metabolic therapy as a component of FTP allowed speeding up rehabilitation and enhancing surgical and oncological outcomes in the burdened elderly patients having planned surgery due to colon cancer.

Background Although it is commonly accepted that the immune response is affected by malnutrition there are very few data about its effect in allergic diseases.Objective The aim of the present study was to investigate the effect of malnutrition in allergic lung inflammation.Methods An anaphylactic reaction was induced in rat lungs and the increased vascular permeability was measured in the trachea, internal and external bronchi and parenchyma by the Evans blue extravasation method. These studies were conducted in two dietary groups: one fed a normoproteic diet (18%) and the other a hypoproteic diet (4.5%). When the animals were 60 days old the group fed the hypoproteic diet presented a reduction of 77.86% in bodyweight, 63.3% in food intake and 36% in plasma protein concentration characterizing a severe protein-calorie malnutrition.Results The anaphylactic reaction in the lungs induced a significant increase in vascular permeability in the trachea and bronchi of both dietary groups. However, the intensity of this effect was significantly lower in the malnourished group. Analysis of immunoglobulin isotypes in the serum by ELISA showed that whereas IgG1 and IgG2a levels were similar in both groups, the levels of IgE were significantly lower in the malnourished animals. Moreover, the levels of antigen-specific IgG1, IgG2a and IgE were all significantly inhibited by the protein-calorie malnutrition. When antibodies were passively transfered to the malnourished rats, they developed a reaction as intense as the normoproteic group.Conclusion These results suggest that the capacity to release inflammatory mediators and the vascular response to these mediators is not affected by this type of malnutrition and, therefore, the diminished response of the airways reported here is probably due to the lower levels of anaphylactic antibodies produced by the malnourished rats. UNIV SAO PAULO,INST BIOMED SCI,DEPT IMMUNOL,BR-05508900 SAO PAULO,BRAZIL UNIV FED SAO PAULO,DEPT PAEDIAT,DIV CLIN IMMUNOL & ALLERGY,SAO PAULO,BRAZIL INST BUTANTAN,IMMUNOPATHOL LAB,SAO PAULO,BRAZIL UNIV FED SAO PAULO,DEPT PAEDIAT,DIV CLIN IMMUNOL & ALLERGY,SAO PAULO,BRAZIL Web of Science