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9 results on '"prirojena imunost"'

1. MODULATION OF SYSTEMIC INNATE AND ADAPTIVE IMMUNE PARAMETERS IN WEANED PIGS BY SINGLE ORAL APPLICATION OF IMMUNOBIOTICS.

Author

Valpotić, Hrvoje, Barić-Rafaj, Renata, Žaja, Ivona Žura, Vince, Silvijo, Samardžija, Marko, Turk, Romana, Đuričić, Dražen, Dobranić, Tomislav, Sobiech, Przemyslaw, Cvetnić, Luka, and Valpotić, Ivica

Subjects
*ANIMAL weaning, *ORAL drug administration, *POLYETHYLENE glycol, *ANTIBIOTICS, *PHAGOCYTOSIS
Abstract

The aims of this study were to evaluate the effects of peroral treatment of 4-week old pigs at weaning (Day 0) with a single dose of levamisole (LEVA) or polyoxyethyle-polyoxypropylene (POE-POP), well known immunobiotics (IBC) and promising alternatives to dietary antibiotic growth promoters (AGP), on systemic innate and adaptive immunity by determining phagocytosis (PHC) and microbicidity (MBC) efficiency of their monocytes (MO) and granulocytes (GR), changes of serum C-reactive protein (CRP) and haptoglobin (HpG) profiles and kinetics of CD4+CD8+ T cells expression during 5 weeks following the treatments. Levels of CRP were decreased by either POE-POP or LEVA (P<0.05) at Day 7 and 21, respectively. LEVA-treated pigs had increased levels of HpG (P<0.05) at Day 14 and 21, whereas POE-POP-treated pigs had decreased and increased levels (P<0.05) at Day 7 and 21, respectively. Both IBC stimulated in vitro PHC of GR (from Day 7 to 35) and MBC of MO (at Day 35) from treated pigs (P<0.05). MO from POE-POP-treated pigs exhibited increased PHC (P<0.05) at Day 35, whereas GR from LEVA- or POE-POP-treated pigs showed increased MBC (P<0.05) at Day 7 and 35, respectively. The pigs treated by LEVA or POE-POP had higher proportions of CD4+CD8+ T cells (P<0.05) from Day 14 to 35 or Day 28 to 35, respectively. Tested IBC showed capability of stimulating particularly cellular components of nonspecific and specific immunity during early postweaning period before pigs reach adult immunocompetence values, and thus could be considered as potent immunostimulators in swine production. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Distinctive probiotic features share common TLR2-dependent signalling in intestinal epithelial cells

Author

Irena Rogelj, Roman Jerala, Mojca Benčina, Karolina Ivičak-Kocjan, Primož Treven, and Diana Paveljšek

Subjects
Immunology, mikrobiologija, bifidobakterije, Microbiology, probiotiki, law.invention, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Probiotic, udc:579, Immune system, law, Virology, postbiotiki, Humans, Intestinal Mucosa, innate immunity, Protein Kinase C, Research Articles, 030304 developmental biology, Bifidobacterium, postbiotics, TLR10, 0303 health sciences, Innate immune system, Host Microbial Interactions, biology, 030306 microbiology, Probiotics, NF-kappa B, Epithelial Cells, Actin cytoskeleton, biology.organism_classification, Intestinal epithelium, Toll-Like Receptor 2, Bifidobacterium animalis, Cell biology, Lactobacillus, TLR2, HEK293 Cells, Toll-Like Receptor 10, prirojena imunost, Caco-2 Cells, HT29 Cells, Signal Transduction, Research Article
Abstract

The underlying mechanisms of probiotics and postbiotics are not well understood, but it is known that both affect the adaptive and innate immune responses. In addition, there is a growing concept that some probiotic strains have common core mechanisms that provide certain health benefits. Here, we aimed to elucidate the signalization of the probiotic bacterial strains Lactobacillus paragasseri K7, Limosilactobacillus fermentum L930BB, Bifidobacterium animalis subsp. animalis IM386 and Lactiplantibacillus plantarum WCFS1. We showed in in vitro experiments that the tested probiotics exhibit common TLR2‐ and TLR10‐dependent downstream signalling cascades involving inhibition of NF‐κB signal transduction. Under inflammatory conditions, the probiotics activated phosphatidylinositol 3‐kinase (PI3K)/Akt anti‐apoptotic pathways and protein kinase C (PKC)‐dependent pathways, which led to regulation of the actin cytoskeleton and tight junctions. These pathways contribute to the regeneration of the intestinal epithelium and modulation of the mucosal immune system, which, together with the inhibition of canonical TLR signalling, promote general immune tolerance. With this study we identified shared probiotic mechanisms and were the first to pinpoint the role of anti‐inflammatory probiotic signalling through TLR10.

Published
2020

5. Izražanje delov človeškega perforina v bakteriji Escherichia coli

Author

Skočaj, Matej and Anderluh, Gregor

Subjects
citotoksični T limfociti, TolA, MACPF-CDC domena, human perforin, NK-cells, NK-celice, imunski sistem, udc:577.27+612.017:577.112, immune system, MACPF-CDC domain, cytotoxic T lymphocites, Escherichia coli, prirojena imunost, človeški perforin, innate immunity
Published
2020

7. Priprava in izolacija himernih flagelinov za aktivacijo imunskega odziva

Author

Mori, Jerneja and Žgur-Bertok, Darja

Subjects
receptor TLR5, udc:604.4:615.371:579.61:616-092, Helicobacter pylori, pridobljena imunost, flagelin, adaptive immunity, flagellin, immune response, cepiva proti Helicobacter pylori, bacterial proteins, himerni flagelin, chimeric flagellin, bakterijski proteini, Escherichia coli, imunski odziv, prirojena imunost, vaccines against Helicobacter pylori, innate immunity
Published
2020

9. Priprava in biološka aktivnost kompleksov imunostimulatornih nukleinskih kislin za stabilizacijo, tarčno dostavo in postopno sproščanje

Author

Smole, Anže and Horvat, Simon

Subjects
CpG ODN, receptor TLR3, udc:577.27:616-006:606(043.2), C) [poli(I], receptors, receptorji, immune response, immunology, vaccine, rak, imunostimulatorne nukleinske kisline, cepivo, immunostimulatory nucleic acids, cancer, imunologija, imunski odziv, prirojena imunost, C) [poly(I], innate immunity
Published
2014

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