Search

The prevention and control of communicable diseases is a major concern for the livelihood of the people.General practitioners play an irreplaceable role in the community-based prevention and control of communicable diseases as one of the key providers of primary care. This study discusses the shortcomings of general practitioners and the role they should play in the community-based prevention and control of communicable diseases based on their current situation by reviewing relevant domestic and foreign literature, and proposes that the laws and regulation system for the prevention and control of communicable diseases should be improved, a hierarchical medical system should be implemented, a robust information platform of prevention and control system should be enhanced, an efficient incentive and development mechanism should be established, and the financial and material investment in primary care, continuing medical education and regular drills should be enhanced, aiming to enhance the job attraction of general practitioners and the capabilities of community-based comprehensive prevention and control of communicable diseases.

Pteropine orthoreovirus (PRV), potentially of bat origin, is reported to be a causative agent of emerging respiratory tract infections among humans in Southeast Asia. We evaluated the efficacy of serologic assays using the major outer capsid and cell attachment proteins (CAP) of PRV strains in the screening, confirmation and identification of three groups of human PRV infections; Indonesian/Japanese, Indonesian/Hong Kong and Malaysian strains. The different serologic assays were tested using rabbit polyclonal antisera raised against these proteins of selected PRV strains, and validation was carried out using sera from a Miyazaki-Bali/2007 PRV-infected patient and the patient’s contacts. The results of this study showed that rabbit polyclonal antisera raised against the CAP of the Miyazaki-Bali/2007 PRV strain showed the highest reactivity to the Miyazaki-Bali/2007 PRV and to a lesser extent, cross-reactivity with the HK23629/07 and Melaka PRVs, respectively. Neutralization activity against the Miyazaki-Bali/2007 PRV was observed using rabbit anti-Miyazaki-Bali/2007 PRV CAP (320) but not with rabbit anti-HK23629/07 (