1. Systemic inflammation in pregnant women with HIV: relationship with HIV treatment regimen and preterm delivery
- Author
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Shivakoti, Rupak, Giganti, Mark J, Lederman, Michael M, Ketchum, Rachel, Brummel, Sean, Moisi, Daniela, Dadabhai, Sufia, Moodley, Dhayendre, Violari, Avy, Chinula, Lameck, Owor, Maxensia, Gupta, Amita, Currier, Judith S, Taha, Taha E, Fowler, Mary Glenn, and team, for the PROMISE study
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,HIV/AIDS ,Infectious Diseases ,Pediatric ,Women's Health ,Clinical Trials and Supportive Activities ,Clinical Research ,Sexually Transmitted Infections ,Pregnancy ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Infection ,Reproductive health and childbirth ,Good Health and Well Being ,Humans ,Female ,HIV Infections ,Premature Birth ,Adult ,Inflammation ,Case-Control Studies ,Pregnancy Complications ,Infectious ,Anti-HIV Agents ,Biomarkers ,Zidovudine ,Tenofovir ,Antiretroviral Therapy ,Highly Active ,Lopinavir ,Young Adult ,PROMISE study team ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveHIV treatment regimen during pregnancy was associated with preterm delivery (PTD) in the PROMISE 1077 BF trial. Systemic inflammation among pregnant women with HIV could help explain differences in PTD by treatment regimen. We assessed associations between inflammation, treatment regimen, and PTD.Design/methodsA nested 1 : 1 case-control study ( N = 362) was conducted within a multicountry randomized trial comparing three HIV regimens in pregnant women: zidovudine alone, or combination antiretroviral therapy (ART) with lopinavir/ritonavir and either zidovudine or tenofovir. Cases were women with PTD (
- Published
- 2024