1. Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles.
- Author
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Zhang, Jie, Guo, Dan, Zhang, Limeng, Li, Deping, and Deng, Baichuan
- Subjects
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AMINO acid analysis , *HAIR growth , *HAIR analysis , *DIETARY supplements , *FECAL analysis , *WEIGHT gain - Abstract
Simple Summary: Methylsulfonylmethane (MSM) has been used as a supplement for skin nourishment, hair growth promotion, and hair quality improvement. Myo-inositol (MI) plays a role in various physiological processes in animals. The aim of this study is to assess the effects of MSM and MI as feed additives on the hair quality of poodles. Compared to the control, supplementation with MSM and MI decreased scale thickness, increased the contents of hair sulfur, and regulated gut microbiota and fecal metabolites. In conclusion, MSM and MI enhanced hair smoothness, suggesting potential benefits to fecal microbiota and the metabolic profiles of poodles. In conclusion, MSM and MI supplementation enhanced hair smoothness and appeared to positively influence fecal microbiota composition and metabolic profiles in poodles. This study aimed to investigate the effects of dietary supplementation with methylsulfonylmethane (MSM) and myo-inositol (MI) on hair quality, fecal microbiota, and metabolome in poodles. Thirty-two adult poodles categorized based on initial body weight and sex were randomly assigned to four groups. These groups (designated the CON, MSM, MI, and MSM + MI groups) received a basal diet, the same diet supplemented with 0.2% MSM + 0% MI, the same diet supplemented with 0% MSM + 0.2% MI, or the same diet supplemented with 0.2% MSM + 0.2% MI, respectively. The study lasted for 65 days. During the entire study period, body weight, average daily weight gain, feed intake, energy intake, and fecal output were normal in all the animals and did not differ significantly among the treatment groups. Hair scale thickness was lower in the MI and MSM + MI groups than in the CON group on Day 65 (p < 0.05). An amino acid analysis of the hair revealed higher sulfur content in the MI and MSM + MI groups on Day 65 than on Day 0 (p < 0.05). Moreover, the poodles in the MSM, MI, and MSM + MI groups presented significantly lower levels of Proteobacteria_unclassified and Candidatus Phytoplasma than did those in the CON group. The relative abundance of Gammaproteobacteria_unclassified was greater in the MSM and MI groups than in the CON group (p < 0.05). The MSM group presented a greater abundance of Glucerabacter than the CON group (p < 0.05). Compared with those in the CON and MSM + MI groups, the abundances of Paramuribaculum and Hafnia in the MSM group were greater (p < 0.05). The abundances of Enterobacter and Kineothrix were greater (p < 0.05) in the MI group than in the CON and MSM + MI groups. The poodles in the MI group presented significantly greater abundances of Bacteroidales_unclassified, Halanaerobium, Mycobacterium, and Erysipelotrichaceae_unclassified than did poodles in the CON, MSM, and MSM + MI groups. Fecal metabolomics analysis revealed that MSM, MI, and MSM + MI treatment markedly affected carbohydrate metabolism. MSM + MI treatment also influenced lipid metabolism. These findings suggest that dietary supplementation with MSM and MI can improve the hair quality of poodles. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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