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【Objective】 The Barkol Lake Basin is located in the east of Xinjiang of China, and groundwater plays a pivotal role in supporting agriculture, livestock and other sectors in the region. This study aims to analyze the chemical characteristics and health risks associated with groundwater in the plain areas in the basin. 【Method】 The analysis utilized groundwater quality data collected in August 2022. Factors influencing groundwater chemistry were evaluated using ion ratio and saturation index methods. Groundwater quality and the associated health risks were assessed with the entropy weight water quality index method and a health risk assessment model. 【Result】 The groundwater in the study area is weakly alkaline, with low salinity and moderate hardness. Its hydrochemical profile is primarily of the HCO₃·SO₄-Ca·Na type. The chemical properties are predominantly influenced by rock weathering and cation exchange. In the region, 75.0% of the groundwater is deemed drinkable without treatment, 8.3% is of moderate quality, and 16.7% is undrinkable without further treatment. The non-carcinogenic health risk index for Na⁺ is the highest, with children facing a greater potential non-carcinogenic risk compared to adults. 【Conclusion】 Overall, groundwater quality in the area is satisfactory, though there are potential risks in the northern part of Bolqiangji Town. This analysis provides a baseline for ensuring the safe use of groundwater in the region.