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AIM:To observe the clinical effects of YAG laser ablation in patients with physiological vitreous floaters by A/B ultrasound combined with autofluorescence(AF)of angiography.METHODS: Screening of 30 patients(30 eyes)with physiological vitreous floaters from August 2018 to January 2019 in Hankou Aier Eye Hospital, we used A/B ultrasound to measure the distance from the wall of the ball and the back surface of the lens before operations. Check the patient's best corrected visual acuity, non-contact intraocular pressure, scanning laser fundus photography, A/B ultrasound and autofluorescence(AF)of angiography before treatment, laser ablation was performed by the same skilled doctor using ELLEX YAG laser ablation machine. After treatment, the patients were followed up at the point of 1d, 1wk, and 1mo. The same examination was performed after operation. The Image-J software was used to measure the vitreous opacity in the autofluorescence of angiography pictures before and after treatment.RESULTS:There was no significant difference in the best corrected visual acuity and non-contact intraocular pressure before and after treatment(P>0.05). Of the 30 eyes, 28 eyes underwent laser ablation treatment once, and 2 eyes underwent laser ablation treatment twice. The average number of treatments was 1.06. After treatment, the autofluorescence of angiography showed that the vitreous opacity was obviously reduced or disappeared, and the difference was statistically significant before and after treatment(PCONCLUSION: A/B ultrasound combined with autofluorescence confirmed that Nd:YAG laser is safe and effective in the treatment of physiological vitreous floaters.

AIM: To observe the structure changes of vitreous and retina after YAG laser ablation in patients with physiological vitreous floaters.METHODS: The selected 40 patients of physiological vitreous floaters, before YAG laser ablation, were checked for best corrected visual acuity, non-contact intraocular pressure, took their anterior segment photos, measured their foveola thickness(FT)and retinal nerve fiber layer(RNFL)by OCT. The YAG laser ablation was completed by one experienced surgeon. After the YAG laser ablation, all patients were checked for non-contact intraocular pressure and gave pranoprofen eye drops tid for 3d. At 2d, 1wk, 1 and 3mo after the surgery, they were reviewed for best corrected visual acuity, non-contact intraocular pressure. At 3mo later anterior segment photos were taken. At 1wk, 1 and 3mo after the surgery, FT and RNFL were measured again.RESULTS: The postoperative 2d, 1wk, 1 and 3mo, best corrected visual acuity, non-contact intraocular pressure of the patients had no significant difference with preoperative(P>0.05). The preoperative anterior segment photos showed obvious single or sheet opacity of vitreous, the postoperative 3mo photos showed that vitreous opacities decreased or disappeared, no other abnormal changes were found. The preoperative OCT data showed that FT was 214.60±9.35μm, the postoperative 1wk, 1 and 3mo FT were 213.75±9.07μm, 213.40±8.83μm, 213.85±9.22μm. The preoperative RNFL were upper 130.26±14.23μm, lower 133.15±14.46μm, nasal 82.48±13.50μm, temporal 75.40±11.89μm; The postoperative 1wk RNFL were upper 130.02±14.02μm, lower 132.99±14.05μm, nasal 82.35±13.07μm, temporal 75.42±11.66μm. The postoperative 1mo RNFL were upper 130.28±14.43μm, lower 133.08±13.99μm, nasal 82.31±13.72μm, temporal 75.45±12.03μm. The postoperative 3mo RNFL were upper 130.43±14.30μm, lower 133.22±14.20μm, nasal 82.27±13.11μm, temporal 75.46±11.91μm. The differences of preoperative and postoperative 1wk, 1 and 3mo FT and RNFL had no statistical significance(P>0.05). CONCLUSION: YAG laser ablation has no adverse effects to vitreous and retinal structure in patients with physiological vitreous floaters, it is effective and safe.