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2 results on '"photodynamic therapy-macrophage vaccine"'

1. Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats

Author

Madsen, Steen J, Christie, Catherine, Huynh, Khoi, Peng, Qian, Uzal, Francisco A, Krasieva, Tatiana B, and Hirschberg, Henry

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Brain Cancer, Immunization, Orphan Drug, Rare Diseases, Brain Disorders, Cancer, Vaccine Related, Neurosciences, Animals, Brain Neoplasms, Cancer Vaccines, Cell Line, Tumor, Glioma, Histocytochemistry, Immunotherapy, Macrophages, Male, Photochemotherapy, Rats, glioma, immunogenic apoptotic cells, photodynamic therapy-macrophage vaccine, macrophages, photodynamic therapy, allogeneic cells, Optical Physics, Biomedical Engineering, Opthalmology and Optometry, Optics, Ophthalmology and optometry, Biomedical engineering, Atomic, molecular and optical physics
Abstract

Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage (MaF98) vaccines can be increased by: (1) photodynamic therapy (PDT) of the priming tumor cells and (2) intracranial injection of allogeneic glioma cells directly into the tumor site. Experiments were conducted in an in vivo brain tumor development model using Fischer rats and F98 (syngeneic) and BT4C (allogeneic) glioma cells. The results showed that immunization with Ma (acting as antigen-presenting cells), primed with PDT-treated tumor cells (MaF98), significantly slowed but did not prevent the growth of F98-induced tumors in the brain. Complete suppression of tumor development was obtained via MaF98 inoculation combined with direct intracranial injection of allogeneic glioma cells. No deleterious effects were noted in any of the animals during the 14-day observation period.

Published
2018

2. Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: An in vivo histological study in rats

Author

Francisco A. Uzal, Tatiana B. Krasieva, Khoi Huynh, Steen J. Madsen, Qian Peng, Henry Hirschberg, and Catherine Christie

Subjects
Male, medicine.medical_treatment, Priming (immunology), Stimulation, Optical Physics, 0302 clinical medicine, glioma, Medicine, Cancer, immunogenic apoptotic cells, Tumor, Brain Neoplasms, Histocytochemistry, Glioma, Atomic and Molecular Physics, and Optics, 3. Good health, Electronic, Optical and Magnetic Materials, photodynamic therapy, 030220 oncology & carcinogenesis, Immunotherapy, photodynamic therapy-macrophage vaccine, Brain tumor, Biomedical Engineering, Cancer Vaccines, Cell Line, Biomaterials, Vaccine Related, 03 medical and health sciences, Immune system, Rare Diseases, Antigen, In vivo, Opthalmology and Optometry, Cell Line, Tumor, Animals, business.industry, Prevention, Macrophages, allogeneic cells, Neurosciences, Optics, medicine.disease, Brain Disorders, Rats, Brain Cancer, Orphan Drug, Research Papers: Therapeutic, Photochemotherapy, Cancer research, Immunization, business, 030217 neurology & neurosurgery
Abstract

Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood–brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage ( MaF98 ) vaccines can be increased by: (1) photodynamic therapy (PDT) of the priming tumor cells and (2) intracranial injection of allogeneic glioma cells directly into the tumor site. Experiments were conducted in an in vivo brain tumor development model using Fischer rats and F98 (syngeneic) and BT4C (allogeneic) glioma cells. The results showed that immunization with Ma (acting as antigen-presenting cells), primed with PDT-treated tumor cells ( MaF98 ), significantly slowed but did not prevent the growth of F98-induced tumors in the brain. Complete suppression of tumor development was obtained via MaF98 inoculation combined with direct intracranial injection of allogeneic glioma cells. No deleterious effects were noted in any of the animals during the 14-day observation period. © 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)

Published
2018

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