1. Communication: High-Density Lipoprotein-Specific Phospholipid Efflux in Familial Hypercholesterolemia.
- Author
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Sato M, Hamasaki M, Neufeld EB, Remaley AT, and Kotani K
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Case-Control Studies, Cholesterol, HDL blood, Cholesterol, HDL metabolism, Cardiovascular Diseases metabolism, Cardiovascular Diseases blood, Hyperlipoproteinemia Type II blood, Hyperlipoproteinemia Type II metabolism, Lipoproteins, HDL metabolism, Lipoproteins, HDL blood, Phospholipids metabolism, Phospholipids blood
- Abstract
Objective: Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD). Although the role of LDL-C in FH has been studied, the contribution of high-density lipoproteins (HDL) to CVD in FH remains unknown. This study aimed at highlighting the role of HDL in FH., Methods: HDL-specific phospholipid efflux (HDL-SPE) assay was developed to predict CVD risk. HDL-SPE was examined in FH patients (n=30) and compared with age- and sex-matched non-FH controls (n=60)., Results: FH patients had significantly lower HDL-SPE levels (0.90±0.12) than controls (1.12±0.10; p <0.05), despite similar HDL-cholesterol levels in both groups (FH: 57.9±18.7 mg/dl; controls: 57.1±13.8 mg/dl). These differences remained significant after adjusting for confounders., Conclusions: These findings suggest there may be dysfunctionality of HDL in FH., (© 2024 by the Association of Clinical Scientists, Inc.)
- Published
- 2024