1. Postoperative cognitive dysfunction: toward the Alzheimer disease: Pathomechanism Hypothesis
- Author
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Fodale, Federico Bilotta, Luca Titi, Elisabetta Stazi, Giovanni Rosa, Andrea Doronzio, Di Nino G, F. Bilotta, A. Doronzio, E. Stazi, L. Titi, V. Fodale, G. Di Nino, and G. Rosa
- Subjects
Programmed cell death ,COGNITIVE DYSFUNCTION ,Disease ,Nervous System ,Postoperative Complications ,Alzheimer Disease ,medicine ,Aging brain ,Dementia ,Humans ,pathology/psychology ,Aged ,business.industry ,General Neuroscience ,Social impact ,Delirium ,Cognition ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Aged, Alzheimer Disease ,pathology/psychology, Anesthesia Recovery Period, Chronic Disease, Cognition Disorders ,pathology/psychology, Delirium ,pathology/psychology, Humans, Nervous System ,pathology, Postoperative Complications ,Clinical research ,ALZHEIMER'S DISEASE ,Anesthesia Recovery Period ,Chronic Disease ,pathology ,POSTOPERATIVE ,Geriatrics and Gerontology ,business ,Cognition Disorders ,Neuroscience ,Postoperative cognitive dysfunction - Abstract
Alzheimer's disease (AD), a chronic and progressive deterioration of memory and other cognitive domains, is the most common form of dementia. Because of related health and social impact, there is growing interest in assessing potential relationship between anesthesia and the onset and progression of chronic neurodegenerative disorders, including AD. Currently, preclinical and clinical research is addressed to identify underlying pathomechanisms, patient risk factors, and the use of the least provocative drugs and techniques, to minimize the incidence of chronic neurodegenerative disorders. Preclinical studies are providing an increasing body of evidences on some of the mechanisms that link anesthetics to neuronal programmed cell death (apoptosis) and accumulation of misfolded proteins in the aging brain. Therefore, risk factors and pathomechanisms of chronic neurodegenerative disorders, including AD, and persistent postoperative-postanesthesia cognitive dysfunction may overlap.
- Published
- 2010