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Background. The study of psoriasis biological therapy aspects in children has certain topicality due to the small number and disunity of individual observations and the lack of special registers for pediatric patients.Objective. Our aim was to study ustekinumab efficacy and safety in children with plaque (PP), erythrodermic (EP) and palmoplanar (PPP) forms of psoriasis.Methods. The analysis of ustekinumab efficacy and safety has been carrying out for 1 year. The evaluation of therapy efficacy was based on definition of improvement of PASI scores (PASI 75, PASI 90 and PASI 100) on the 16th, 28th, 40th and 52nd weeks of follow-up and children's dermatology life quality index (CDLQI). Ustekinumab therapy safety analysis was based on registration and evaluation of adverse effects. Results. The study included 67 children with PP, EP and PPP aged 12 to 18 years. PP group results: the PASI 75 response at the 52nd week of therapy was observed in 35 children (100%), PASI 90 — in 33 (94%), PASI 100 — in 30 (86%). EP group results: 10 patients (56%) have reached PASI 75 on the 16th week, while none of patients have improved to PASI 90 and PASI 100 scores. The PASI 75 response at the 52nd week of therapy was observed in 18 children (100%), PASI 90 — in 17 (94%), PASI 100 — in 7 (39%). Only 1 patient (7%) with PPP has showed the score decrease to PASI 75 on the 16th week. Adverse effects were reported in 2 patients.Conclusion. Ustekinumab is the effective and safe treatment for moderate and severe forms of PP and EP in children, and it can also be considered as one of the alternative methods for PPP treatment in pediatrics.

Research objective: Definition of psoriasis clinical-demographical peculiarities among people of Kazakh ethnicity. Research object: 2068 individuals of Kazakh ethnicity, including 668 patients with psoriasis of different clinical forms (index group) and 1400 healthy individuals (control group) identical to index group patients by gender and age. Research methods: sociological, clinical-diagnostic, laboratory (genetic). Research design: case-control. Results: During the reporting period, 2068 participants of Kazakh ethnicity were involved in the research. The index group consisted of 668 patients, including 405 (60.6%) males and 263 (39.4%) females, with psoriasis of different clinical form. The control group consisted of 1400 participants of Kazakh ethnicity, including 680 (48.6%) males and 720 (51.4%) females, without medical history of psoriasis. [ABSTRACT FROM AUTHOR]