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3 results on '"oral vitamin-b-12"'

1. Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly persons

Author

Pieter van 't Veer, Carla Dullemeijer, Lisette C P G M de Groot, Maria Plada, Janneke P van Wijngaarden, Hilko van der Voet, Esmée L Doets, Rosalie A M Dhonukshe-Rutten, Waldo J. de Boer, Olga W. Souverein, Adrienne E J M Cavelaars, and Paulette H. in 't Veld

Subjects
b-vitamins, Aging, Nutrition and Disease, Medicine (miscellaneous), Nutrition Policy, chemistry.chemical_compound, Blood serum, Voeding en Ziekte, Medicine, folic-acid, older-adults, Human Nutrition & Health, media_common, Evidence-Based Medicine, Nutrition and Dietetics, Humane Voeding & Gezondheid, multivitamin supplementation, Micronutrient, Vitamin B 12, Biometris, Meta-analysis, homocysteine concentration, Adult, Vitamin, medicine.medical_specialty, Internal medicine, Humans, media_common.cataloged_instance, European Union, Vitamin B12, European union, cognitive function, Aged, VLAG, Global Nutrition, oral vitamin-b-12, Transcobalamins, Wereldvoeding, methylmalonic acid, business.industry, Nutritional Requirements, Case-control study, Vitamin B 12 Deficiency, Surgery, B vitamins, chemistry, business, nutritional-status, plasma homocysteine, Biomarkers
Abstract

Background: Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. Objective: We systematically reviewed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12 status and estimated dose-response relations with the use of a meta-analysis. Design: This systematic review included all RCTs, prospective cohort studies, nested case-control studies, and cross-sectional studies in healthy adult populations published through January 2010 that supplied or measured dietary vitamin B-12 intake and measured vitamin B-12 status as serum or plasma vitamin B-12, methylmalonic acid (MMA), or holotranscobalamin. We calculated an intake-status regression coefficient () for each individual study and calculated the overall pooled and SE () by using random-effects meta-analysis on a double-log scale. Results: The meta-analysis of observational studies showed a weaker slope of dose-response relations than the meta-analysis of RCTs. The pooled dose-response relation of all studies between vitamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin B-12 concentrations by 11% (95% CI: 9.4%, 12.5%). This increase was larger for studies in elderly persons (13%) than in studies in adults (8%). The dose-response relation between vitamin B-12 intake and MMA concentrations indicated a decrease in MMA of 7% (95% CI: -10%, -4%) for every doubling of the vitamin B-12 intake. The assessment of risk of bias within individual studies and across studies indicated risk that was unlikely to seriously alter these results. Conclusion: The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of populations.

Published
2013

2. Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial

Author

Martijn B. Katan, Renate M. Winkels, Robert Clarke, Petra Verhoef, Ingeborg A. Brouwer, and Nutrition and Health

Subjects
Male, Aging, Erythrocytes, Homocysteine, homocysteine concentrations, food fortification, Methylmalonic acid, Medicine (miscellaneous), law.invention, chemistry.chemical_compound, Randomized controlled trial, law, Medicine, Food science, Neural Tube Defects, Nutrition and Dietetics, food and beverages, Bread, deficiency, Middle Aged, Vitamin B 12, Biochemistry, Food, Fortified, Female, double-blind, serum vitamin-b-12, neural-tube defects, Vitamin, Fortification, united-states, Nutritional Status, Folic Acid, Double-Blind Method, Humans, Vitamin B12, cognitive function, Aged, Global Nutrition, oral vitamin-b-12, Wereldvoeding, business.industry, Food fortification, Nutritional Requirements, Vitamin B 12 Deficiency, B vitamins, chemistry, supplementation, business, Methylmalonic Acid
Abstract

BACKGROUND: Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America. Concerns that high intakes of folic acid might mask vitamin B-12 deficiency in older persons have delayed the introduction of fortification in many European countries. Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status. OBJECTIVE: The objective was to estimate the effect of the consumption of bread fortified with modest amounts of folic acid and vitamin B-12 on folate and vitamin B-12 status in healthy older persons living in the Netherlands, where folic acid fortification is not taking place. DESIGN: Men and women aged 50-75 y were randomly assigned in this 12-wk double-blind, placebo-controlled trial to consume bread fortified with 138 mug folic acid and 9.6 mug vitamin B-12 daily (n = 72) or unfortified bread (n = 70). RESULTS: The consumption of fortified bread increased serum folate concentrations by 45% (mean: 6.3 nmol/L; 95% CI: 4.5, 8.1 nmol/L) and serum vitamin B-12 concentrations by 49% (mean: 102 pmol/L; 95% CI: 82, 122 pmol/L) relative to the placebo group. Fortified bread increased erythrocyte folate concentrations by 22% and holotranscobalamin concentrations by 35%; it decreased homocysteine concentrations by 13% and methylmalonic acid concentrations by 10%. Consumption of fortified bread decreased the proportion of individuals with marginal serum vitamin B-12 concentrations (

Published
2008

3. Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial

Author

Winkels, R.M., Brouwer, I.A., Clarke, R., Katan, M.B., Verhoef, P., Winkels, R.M., Brouwer, I.A., Clarke, R., Katan, M.B., and Verhoef, P.

Abstract

Background: Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America. Concerns that high intakes of folic acid might mask vitamin B-12 deficiency in older persons have delayed the introduction of fortification in many European countries. Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status. Objective: The objective was to estimate the effect of the consumption of bread fortified with modest amounts of folic acid and vitamin B-12 on folate and vitamin B-12 status in healthy older persons living in the Netherlands, where folic acid fortification is not taking place. Design: Men and women aged 50-75 y were randomly assigned in this 12-wk double-blind, placebo-controlled trial to consume bread fortified with 138 mu g folic acid and 9.6 mu g vitamin B-12 daily (n = 72) or unfortified bread (n = 70). Results: The consumption of fortified bread increased serum folate concentrations by 45% (mean: 6.3 nmol/L; 95% CI: 4.5, 8.1 nmol/L) and serum vitamin B-12 concentrations by 49% (mean: 102 pmol/L; 95% CI: 82, 122 pmol/L) relative to the placebo group. Fortified bread increased erythrocyte folate concentrations by 22% and holo-transcobalamin concentrations by 35%; it decreased homocysteine concentrations by 13% and methylmalonic acid concentrations by 10%. Consumption of fortified bread decreased the proportion of individuals with marginal serum vitamin B-12 concentrations (

Published
2008

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