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Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder that is characterized by snoring, apnea and hypopnea attacks as a result of airway obstruction during sleep, and can lead to hearing loss. Obstructive sleep apnea syndrome can cause complications in many organ systems associated with ischemia and intermittent hypoxia that develop with recurrent apnea attacks. Because the cochlea is highly dependent on the amount of oxygen, repeated apnea attacks can cause damage to cochlear cells. One study found that obstructive sleep apnea increases the likelihood of hearing loss by 21%. This study aims to determine the effect of OSAS on hearing and raise awareness on this issue by compiling studies in the literature examining the relationship between obstructive sleep apnea syndrome and hearing loss. In studies conducted with pure tone audiometry evaluation in individuals with OSAS, it has been reported that hearing thresholds are higher, especially at high frequencies. In studies where OSAS patients were evaluated with otoacoustic emission (OAE) measurement, the results varied, but lower repeatability, signal-to-noise ratio and amplitude were obtained, especially at high frequencies. In studies examining auditory brainstem responses (ABR) in OSAS patients, absolute latencies and interpeak latencies were often found to be prolonged compared to the control group. In the audiological evaluation of patients with OSAS symptoms and suspected hearing loss who apply to the audiology clinic, highfrequency pure tone audiometry, OAE and ABR measurements, as well as pure tone audiometry measurements, are thought to be important for early diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Objective: Excessive daytime sleepiness (EDS), a symptom of obstructive sleep apnea syndrome (OSAS), is an important cause of morbidity. It is frequently evaluated using the Epworth sleepiness scale (ESS) in clinical practice. This study was conducted to investigate the relationship between EDS and polysomnographic respiratory parameters in OSAS patients. Materials and Methods: The records of 274 adult patients who applied to our sleep and disorders unit between 2014 and 2016 and were polysomnographically diagnosed with OSAS were retrospectively reviewed. EDS was evaluated subjectively with ESS; OSAS patients were divided into two groups: those with EDS (ESS total score >10) and those without (ESS total score ≤10). Clinical and polysomnographic data were then compared between the study groups. Results: While there was no significant difference in terms of age, gender, and mean apnea durations (p>0.05) between the two groups with and without EDS, body mass index (BMI), apnea-hypopnea index (AHI), mean O2 desaturation was higher and minimum O2 saturation was lower (p<0.05) in the group with EDS. While there was no significant correlation between the ESS total score and age and mean apnea duration, there was a weak positive correlation between the ESS total score and BMI, AHI, mean O2 desaturation, hourly desaturation duration percentage, and desaturation depth; a very weak and negative significant correlation was found with minimum O2 saturation. Conclusion: EDS observed in OSAS is weakly related to standard polysomnographic respiratory parameters and composite respiratory indices, and it should be evaluated with other indicators of inflammation and oxidative stress caused by intermittent hypoxia. [ABSTRACT FROM AUTHOR]

Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: This study aimed to compare total bilirubin levels with monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients diagnosed with obstructive sleep apnea syndrome (OSAS) according to the apnea-hypopnea index (AHI) values. Patients and methods: The files of patients who underwent polysomnography and had total bilirubin and complete blood count values were retrospectively reviewed. Patients were divided into three groups: AHI <5, AHI =5-29.99, and AHI ≥30. All blood parameters and calculated ratios were compared between the groups, and the relationship between these parameters and OSAS severity was investigated. Results: The study included 240 patients (149 males, 91 females; mean age: 47.4±11.9 years; range, 21 to 82 years). High-density lipoprotein values were significantly lower and MHR was significantly higher in the group with AHI ≥30 compared to the other two groups (p<0.001 and p=0.001, respectively). Apnea-hypopnea index was correlated with MHR (r=0.270, p<0.001). The groups were similar in terms of MLR, NLR, PLR, and total bilirubin levels. Conclusion: Considering that these easily accessible blood parameters are affected by many factors, they can only be used as auxiliary parameters in assessing the severity and follow-up of diseases such as OSAS. [ABSTRACT FROM AUTHOR]

Objective: Multilevel surgery (MLS) has become one of the most preferred surgical methods for the treatment of obstructive sleep apnea syndrome (OSAS). In this study, we aimed to present our results for MLS together with modified expansion sphincter pharyngoplasty (MESP) for the treatment of OSAS. We also investigated whether performing anteriorpalatoplasty (AP) affected surgical results in these patients. Methods: Fifty patients diagnosed with moderate-to-severe OSAS after polysomnography (PSG) were prospectively included in the study. The patients underwent MLS comprising; nasal surgery, MESP, and ablation of the tongue base with radiofrequency. In addition, AP was performed in 30 patients. Surgical success was determined using PSG data and Epworth sleepiness scale (ESS) scoring performed before and after surgery. Results: There was a statistically significant improvement in ESS scores and postoperative PSG findings compared with preoperative means (p<0.001). Surgical success was achieved in 40 patients (80%) according to the Sher criteria. Surgical success ratio revealed exactly same (p=1.000) compared with the patients who were not performed AP. Preoperative apnea index, apnea/hypopnea index (AHI), and supine AHI were significantly higher in surgically unsuccessful cases (p<0.05). Conclusion: MLS, including MESP, performed together with nasal surgery and tongue base RF is an alternative procedure in the surgical treatment of OSAS with a postoperative success rate of 80%, according to our study results. In addition to MESP, AP may not affect the results of multilevel surgery. [ABSTRACT FROM AUTHOR]

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: This study aimed to determine the demographic characteristics of the patients who applied to the Cardiology Out-patient Clinic before laboratory-based polysomnography was performed. Material and Method: 123 adult patients undergoing laboratorybased polysomnography were included in this retrospective study. The demographic features of the patients were recorded. Routine laboratory tests, electrocardiography (ECG), transthoracic echocardiography (TTE), 24-hour ambulatory blood pressure monitoring, cardiovascular stress test, and laboratory-based polysomnography were performed in the same hospital. The apnea-hypopnea index (AHI) was used to diagnose obstructive sleep apnea syndrome (OSAS). Results: In this study, we found the following patient findings. The mean age of the patients was 49±1.61 years. The majority of the patients were in the middle age group. Forty-two (34.10%) patients were female and 81 (65.90%) were male. Normal AHI value was detected in 5 (4.2%) patients. Mild OSAS was detected in 30 (24.2%) of the patients, moderate OSAS in 24 (18.9%), and severe OSAS in 64 (51.6%). Continuous positive airway pressure (CPAP) device report was given to 67 (54.7%) of the patients. The most accompanying comorbidity of the patients was hypertension (HT). There was a weak positive correlation between AHI and HT; r=0.280, N=95, and the relationship was statistically significant (p=0.006). Nine (7.30%) of the patients were newly diagnosed with hypertension. Invasive coronary angiography was recommended for two (1.6%) patients with positive test results, and coronary computed tomographic angiography was recommended for four (3.2%) patients. Myocardial perfusion scintigraphy was recommended to nine (7.3%) patients who could not perform cardiovascular stress tests. Conclusion: Cardiac evaluation should be performed before laboratory-based polysomnography is performed. Electrocardiography and TTE recording should be performed on the patients, and 24-hour ABPM should be inserted. Additional tests should be performed to investigate ischemia in patients with myocardial ischemia findings. [ABSTRACT FROM AUTHOR]

Objective: Obstructive sleep apnea syndrome (OSAS) is a sleep disorder whose frequency is increasing daily due to modern lifestyle. Patients with atrial fibrillation (AF), which has the same predisposing factors, frequently visit the outpatient clinic with complaints of palpitation. Existing symptoms are often associated with the course of OSAS, and the development of AF, a disease with high morbidity and mortality, cannot be detected. In our study, we investigated the relationship between the visceral adiposity index (VAI) and AF development in these patients. Methods: We retrospectively analyzed 207 patients with OSAS who visited the cardiology outpatient clinic. The data of 44 patients with AF and 163 patients without AF were compared. Results: Demographic characteristics and clinical risk factors were similar between the groups (p>0.05). VAI, apnea-hypopnea index, and inflammatory markers were higher in the AF group, and these risk factors were significant in the multivariate analysis (p<0.05). Conclusions: Our study is important in terms of showing VAI as one of the most important predictors of AF, which has an impact on mortality and morbidity in patients with OSAS, whose frequency is increasing daily. Further prospective studies are required to confirm our observations and determine their clinical applicability. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Exercise Therapy & Rehabilitation is the property of Yavuz Yakut and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular disease. Autonomic dysfunction and inflammation are thought to play an important role in this increase. Heart rate variability (HRV) analysis provides noninvasive detection of autonomic dysfunction. The number and distribution of blood cells are also considered important markers of inflammation. In this study, HRV and hemogram parameters were examined in patients with OSAS, and the relationship between them was investigated. Materials and Methods: The data of all patients who had overnight polysomnography (PSG) recording and hemogram parameters between 2019 and 2021 were reviewed. HRV analysis was performed on all patients included in the study. Along with demographic and clinical characteristics, the relationship between PSG parameters, HRV, and hemogram parameters was statistically analyzed. The patients were divided into two groups as apnea hypopnea index (AHI) ≥15/hr and AHI<15/hr, and the parameters were compared. Results: A total of 321 patients (210 men, 111 women) were included in this study. The mean age was 54.8±16.1 years. The white blood cells count, hemoglobin level, hematocrit level, and neutrophil count, which are considered as indicators of inflammation, were significantly higher in the AHI ≥15/hr group (p=0.015; p=0.040; p=0.019 and p=0.012, respectively). Among the HRV parameters, the median low-frequency component power / high-frequency component power (LF/HF) ratio was 3.1 in patients with AHI>15/hr, while it was 2.1 in the AHI<15/hr group and was significantly higher in the moderate-severe OSAS group (p=0.012). A significant correlation was found between the LF/HF ratio and neutrophil count, leukocyte count, and neutrophil/lymphocyte ratio (r=0.201; p=0.005 and r=0.165; p=0.020 and r=0.189; p=0.008). Conclusion: In this study, the presence of increased inflammation and deterioration in sympathovagal balance in patients with OSAS has been demonstrated once again. The correlation of autonomic dysfunction with increased inflammation has been noted for the first time, suggesting that inflammation may play a primary role in sympathetic dysfunction, which is an important complication of OSAS. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Morning headaches have been associated with sleep-related breathing disorders and Sleep Bruxism (SB). The present study aims to investigate the relationship between SB, primary headaches and the severity of Obstructive Sleep Apnea Syndrome (OSAS) in patients presenting with morning headaches and a prediagnosis of OSAS. MATERIALS AND METHODS: The study included 480 patients who prediagnosis of OSAS and morning headache complaints, and were diagnosed with primary headache according to the International Classification of Headache Disorders (ICHD). Age, gender, Body Mass Index (BMI), headache type, presence of SB, OSAS stage according to Apnea-Hypopnea Index (AHI), and presence of hypoxia were recorded. Patients were then divided into 2 groups of SB (-) and SB (+), and both groups were compared in terms of headache. RESULTS. In the classification according to headache types, 31.5% of the patients were classified as migraine, 41.9% as tension-type headache (TTH), 2.1% as cluster, and 24.6% as other types of headache. While 76% of the patients had no SB, 24% had SB. The rate TTH was significantly (p

Objective: Obstructive sleep apnea syndrome (OSAS) is a common disorder among the public and it is associated with many cardio-cerebrovascular consequences. Aspirin is used as the first line of treatment regarding such complications; however, >20% of the patients have drug resistance which causes ongoing vulnerability to vascular accidents. The objective of this study is the evaluation of potential aspirin resistance in drug naïve severe OSAS patients. Materials and Methods: Thirty patients with a diagnosis of severe OSAS and 30 age-matched non-OSAS controls enrolled in the study. Urine samples of both patients and controls were analyzed for 11-dehydrothromboxane B2 (11-DHTBXB2) levels and compared afterward. Pairwise comparisons were performed and a two-tailed p-value of <0.05 was considered statistically significant. Results: Biochemical analysis of the urine samples revealed an 11-DHTBXB2 level of 26.7 pg/dL for the patient group, whereas the relative value was 12.7 pg/dL for the control group (p=0.005). The significant increase in urinary 11-DHTBXB2 levels among patients was independent of sex, age, and body mass index. Conclusion: Patients with OSAS had higher levels of urine 11-DHTBXB2 levels, hence higher aspirin resistance than controls. Identification of aspirin resistance and prediction of potential unresponsiveness to first-line antiplatelet therapy is essential in OSAS to guide the primary or secondary prophylaxis in this population who have a marked propensity to vascular insult. [ABSTRACT FROM AUTHOR]

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: We evaluated and compare sleep quality and disorders according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) A, B, C, D groups in patients with Chronic Obstructive Pulmonary Disease (COPD) and to determine sleep disorders. Materials and Methods: Our study included 94 patients who applied to Pamukkale University Medical Faculty Hospital Chest Diseases Polyclinic between January 2016 and January 2017, were diagnosed with COPD according to GOLD criteria, were not in a COPD attack at the time of admission and agreed to participate in the study. Results: In patients with COPD, as the severity of stages increased, a decrease in mean FEV1 values was detected and as the FEV1 values decreased, the mean oxygen values measured during the night decreased. According to the GOLD stage, there was no significant difference between total sleep periods, sleep activity, sleep latency, rapid eye movement (REM) sleep duration, and non-REM sleep duration. According to polysomnography results, apnea-hypopnea index (AHI) was found to be below 5 in 40% of the patients. There was no statistically significant difference between the AHI and COPD stages (p=0.581). Conclusion: No significant difference was found between the COPD stage and AHI severity. However, as COPD stages increased, a decrease in mean nocturnal oxygen saturation was detected. Nocturnal oxygen desaturation is the main cause of comorbidities observed in patients COPD. As a result, careful attention should be given to night desaturation in advanced patients with COPD, and the necessary procedures must be performed to prevent comorbidities. [ABSTRACT FROM AUTHOR]

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Sakarya Tıp Dergisi is the property of Sakarya Tip Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Present study's objective is to investigate the relationship between serum 25-hydroxyvitamin D and the severity of sleep apnea at altitude. Material and Method: Fifty obstructive sleep apnea syndrome patients and 18 persons without apnea participated in this study. Apnea Hypopnea Index scores were measured with polysomnography during the night and classified as AHI<15:control, 15=AHI<30 moderate, and AHI=30 severe obstructive sleep apnea. In addition, the serum 25-hydroxyvitamin D levels of the patients were also measured. Results: In the logistic regression analysis, it was found that there was an independent correlation between the apnea-hypopnea index and 25-hydroxyvitamin D (AUROC=0.658, p=0.028). We found a significant difference between the control and obstructive sleep apnea groups for 25-hydroxyvitamin D (p<0.05). A significant relationship has been found between moderate and severe obstructive sleep apnea groups for vitamin D deficiency and average vitamin D (p<0.0001). Conclusion: We found an independent association between 25-hydroxyvitamin D and obstructive sleep apnea severity at high altitudes. An interesting point of our study is that our study has been conducted at a high altitude region with an elevation of more than 1768 meters. Therefore, effective vitamin D management may help prevent obstructive sleep apnea syndrome development, and patients' medical status can be improved. [ABSTRACT FROM AUTHOR]

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Obstructive sleep apnea syndrome (OSAS) is a common disorder that results from the collapse of the upper airways during sleep and causes temporary hypoxia. OSAS and hypertension are common and multifactorial diseases. aim This study aimed to determine the clinical, demographic, polysomnographic and prognostic features of OSAS patients with hypertension. Materials and Methods: In this study, 364 patients diagnosed with OSAS in the sleep laboratory of the Department of Neurology, Bursa Uludağ University Faculty of Medicine between 2016 and 2021 were retrospectively scanned and included. The patients were analyzed by comparing them with and without hypertension. Results: When patients with and without hypertension were compared according to clinical, demographic and polysomnography data, age (p<0.001), sex (p=0.009), presence of diabetes mellitus (DM) (p<0.001), presence of coronary artery disease (p<0.001), presence of heart failure (p=0.020), presence of atrial fibrillation (p=0.004), ischemic stroke (p<0.001), minimum oxygen saturation (p=0.015), oxygen desaturation index (p=0.034) and body mass index (BMI) (p<0.001) were statistically significantly correlated. When the significant variables were analyzed with binary logistic regression, the most significant variables were age [p<0.001, odds ratio (OR): 1.07], DM (p<0.001, OR: 7.58), coronary artery disease (p=0.003, OR: 4.92), heart failure (p=0.041, OR: 5.53), ischemic stroke (p=0.042, OR: 3.38) and BMI (p<0.001, OR: 1.28). Conclusion: In this study, we found that cardiovascular diseases such as coronary artery disease, heart failure and ischemic stroke are more common in OSAS patients with hypertension, and this is independent of risk factors such as age, DM and BMI. OSAS and cardiovascular diseases may show ethnic and racial differences. For this reason, we suggest conducting multicenter prospective studies examining the effects on blood pressure regulation and cardiovascular diseases in our own population. [ABSTRACT FROM AUTHOR]

Objective: Coronavirus disease-2019 (COVID-19) pandemic mentioned some disease-specific problems related to obstructive sleep apnea syndrome (OSAS). This study determined problems faced by patients using positive airway pressure (PAP) devices due to OSAS during the COVID-19 pandemic. Materials and Methods: Patients with OSAS using PAP were retrospectively identified. The cases that were contacted by phone were invited to complete the survey. Patients who agreed to participate in the study were asked whether the pandemic process affected their daily lives, OSAS treatment and PAP device use, and their responses were recorded. Results: Fifty patients (37 men/13 women) included in this study. Eleven cases had a history of COVID-19 infection; however, the disease symptoms were not severe in any case. Half of the patients reported that daily living was moderately or severely affected during the pandemic. Eight patients experienced problems with their PAP devices, five patients started to use the PAP devices irregularly during the pandemic, and 10 cases completely stopped using them. Conclusion: A significant portion of the patients experienced serious problems with PAP devices and the daily living activities were affected in half of the them during the pandemic. However, the follow-up and treatment services for many chronic diseases, as for OSAS, have been interrupted in this period that obligate the patients to handle their condition on their own. To provide continuous and adequate health care for OSAS patients under similar conditions in the future, it may be beneficial to establish widespread remote telecommunication systems in advance. [ABSTRACT FROM AUTHOR]

Objective: Obstructive sleep apnea (OSA) and cardiovascular diseases have some common pathophysiologic characteristics and effects on the outcomes of each other. This study is conducted to determine the characteristics of obstructive sleep apnea patients with a history of a cardiovascular event. Materials and Methods: For this multicenter study, the patients with obstructive sleep apnea [apnea-hypopnea index (AHI) >5/hour] who had a history of coronary angioplasty, coronary bypass grafting, or cerebrovascular event after the onset of the symptoms related to OSA were recruited as the study group. The control group included patients without a history of a cardiovascular event. The weight, subjective sleep duration, smoking, and menopausal status, and the presence of comorbidities before and after the cardiovascular event were also questioned during the follow-up visits and by phone calls. This data was compared with the control group. Results: This multicenter study comprised 281 patients (100 study group and 181 control group), 83% of whom had moderate/severe obstructive sleep apnea. Age, family history for cardiovascular event and, Epworth sleepiness scale score were statistically higher in the study group (p<0.001). Polysomnographic data showed that the study group had higher central AHI (p=0.002), non-supine AHI (p=0.017) and lower NREM3% (p=0.001), mean and minimum oxygen saturation (p=0.002). A subgroup analysis proved that polysomnographic data, which had statistically significant differences, can vary according to gender. Conclusion: The results of this study guide for phenotyping obstructive sleep apnea patients with cardiovascular events. It has also been shown that cardiovascular events may have different effects on sleep parameters in women. [ABSTRACT FROM AUTHOR]

Amaç: Bu çalışma hafif dereceli obstrüktif uyku apne sendromu (OSAS) tanısı alan olgularda D vitamini suplemantasyonunun antropometik ölçümler ve vücut bileşimine etkisini incelemek amacıyla yapılmıştır. Gereç ve Yöntem: Polisomnografi ile hafif dereceli OSAS tanısı alan ve D vitamini düzeyi yetersiz olan 20 yetişkin erkek (19-64 yıl) çalışmaya dahil edilmiştir. Olgulara sekiz hafta süresince 50.000 IU/hafta D3 vitamini suplemantasyonu verilmiştir. Çalışma başında ve sonunda tüm olguların bazı antropometrik ölçümleri (vücut ağırlığı, boy uzunluğu, bel, kalça ve boyun çevresi) alınmış ve vücut bileşimi analizleri yapılmıştır. Enerji ve besin ögesi alımları çalışma başında ve sonunda alınan 3 günlük bireysel besin tüketim kayıtları ile hesaplanmıştır. Bulgular: Serum D vitamini düzeyi başlangıçta 19,1±5,16 ng/mL iken suplemantasyon sonrası 41,6±10,25 ng/mL’ye yükselmiş ve olguların %90’nın D vitamini düzeyi normal sınırlara ulaşmıştır. D vitamini suplemantasyonu sonunda olguların antropometrik ölçümleri ve vücut bileşimlerinde anlamlı fark olmamıştır. D vitamini suplemantasyonu sonunda diyet enerji, protein, yağ alımlarında ve apne hipopne indeksinde anlamlı azalma saptanmıştır. Sonuç: Hafif dereceli obstrüktif uyku apne sendromu tanısı alan olgularda D vitamini suplemantasyonun enerji ve besin ögesi alımını etkileyebileceği görülmüştür. Ayrıca yetişkin olgularda D vitamini suplemantasyonunun hastalık prognozuna olumlu etkisinin olabileceği düşünülmektedir. Ancak D vitamininin vücut bileşimi ve antropometrik ölçümler üzerine etkisini incelemek amacıyla daha büyük örneklem ile uzunlamasına yapılacak çalışmalara ihtiyaç vardır.

ÖZET: Amaç: Çalışmanın amacı horlama şikayeti ile başvuran hastalarda obstrüktif uyku apne sendromu (OUAS) varlığının değerlendirilmesi ve OUAS’lı hastaların demografik verilerini ve eşlik eden kronik hastalık birlikteliğini araştırmaktır. Gereç ve Yöntemler: Bu çalışmada Ocak 2017- Haziran 2018 tarihleri arasında, uykuda horlama ve apne şikayetleriyle İstanbul Eğitim ve Araştırma Hastanesi uyku laboratuvarına yönlendirilen hastalar incelendi. Hastaların anamnezleri alınarak horlama ve/veya apne şikayetlerinin yanı sıra kronik rahatsızlıklarının olup olmadığı sorgulanmış, alışkanlıkları ve demografik verileri kaydedilmiştir. Hastalarda OUAS varlığının tespiti için 1 gece süreyle polisomnografi testi yapılmış ve Apne Hipopne İndeksine (AHİ) göre hastalar gruplandırılmıştır. AHİ ≥ 5 olması OUAS olarak kabul edilmiş, AHİ 5.0-14.9 arası hafif, 15.0-29.9 arası orta, 30.0 ve üzeri ağır olarak gruplandırılmıştır. Hastaların ayrıca periyodik bacak hareket İndeksi (PBHİ) değerlendirilmiştir. Bulgular: Polisomnografi test sonuçlarına göre hastaların 100'ü basit horlama (%26), 103'ü (%26.7) hafif derecede OUAS, 84'ü (%21.8) orta derecede OUAS ve 98'i (%25.4) ağır derecede OUAS olarak değerlendirilmiştir. Yaş, Beden Kitle İndeksi (VKİ) ve hipertansiyon varlığı OUAS’lı grupta daha yüksek olarak saptanmıştır. Sonuç: OUAS hastalarında; erkek cinsiyetin hakim olduğu, bu hastaların daha yaşlı olduğu, hipertansiyonun eşlik ettiği ve vücut kitle indekslerinin (VKİ) daha yüksek olduğu bulunmuştur.

Copyright of Mersin Üniversitesi sağlık Bilimleri Dergisi is the property of Mersin University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Tissue hypoxia results in an increased erythrocyte distribution width (EDW) and secondary ocular complications in obstructive sleep apnea syndrome (OSAS). Thus, this study aimed to investigate the correlation between EDW and central corneal thickness (CCT) in patients with varying OSAS severities. Materials and Methods: This study included 70 patients with OSAS (23 mild, 22 moderate, and 25 severe cases) and 30 healthy participants. EDW was measured using an automated blood cell counter. CCTs were measured by spectral-domain optic coherence tomography. Results: The EDW values were significantly higher in patients with severe OSAS than with moderate (p=0.042) and mild (p=0.015) OSAS. Additionally, EDW values were significantly higher in the control group than in patients with mild (p=0.011) and moderate OSAS (p=0.038). The control group and the patient group did not significantly differ in the mean CCT values (p=0.45/p=0.14). No statistically significant correlation was found between EDW and CCT values in the control group (r=-0.22, p=0.25) or patient group (r=-0.1, p=0.63). The correlations between RDW and apnea-hypopnea index (r=0.334, p=0.001) and minimal oxygen saturation (r=-0.29, p=0.004) were statistically significant. Conclusion: Our study revealed that EDW was higher in patients with OSAS than control group. Therefore, EDW can be used as an important diagnostic tool for the early diagnosis of atherosclerosis risk in patients with OSAS. The required metabolic activity for the sustainability of corneal transparency is thought to be affected by hypoxia in OSAS. [ABSTRACT FROM AUTHOR]

Objective: To investigate the association between obstructive sleep apnea syndrome (OSAS), glutathione peroxidase-1 (GPX1) Pro198Leu, and manganese superoxide dismutase (MnSOD) Ala16Val gene polymorphisms. Materials and Methods: The study included 81 patients with OSAS and 75 healthy controls from the Turkish population. Genotypes of the MnSOD rs4880 T/C (Ala16Val) and GPX1 rs1050450 T/C (Pro198Leu) variants were determined via single-nucleotide polymorphisms genotyping analysis, which is based on simple probe melting curve analysis. Results: The frequencies of the MnSOD rs4880 T/T, T/C, and C/C were 35.8%, 50.6%, and 13.5% in patients with OSAS and 34.6%, 49.3%, and 16% in the controls, respectively. No statistically significant difference was determined between patients and controls in terms of MnSOD rs4880 variant genotype and allele distribution (odds ratio: 1.07; 95% confidence interval: 0.68-1.69; p>0.05). The frequencies of the GPX1 rs1050450T/T, T/C, and C/C were 12.0%, 38.5%, and 49.4% in patients with OSAS and 13.1%, 42.1%, and 44.7% in the controls, respectively. No statistically significant difference was determined in the genotype and allele frequencies of the GPX1 rs1050450 variant between the patients and controls (p>0.05). Additionally, the haplotype was examined on the basis of combined genotypes for the two variants in patients with OSAS and controls, which revealed no statistically significant correlation. Conclusion: Our study indicates that two polymorphisms in these antioxidant enzymes were not associated with Turkish patients with OSAS. Further studies may reveal an association between these two polymorphisms with some clinical parameters in patients with OSAS. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the coincidence of obstructive sleep apnea syndrome (OSAS) and systemic diseases in elderly patients presenting to our sleep disorders center. Patients and Methods: Ninety-seven patients with ages older than 65 years, who had at least one of snoring, witnessed apnea, and excessive daytime sleepiness symptoms, and whose systemic diseases were under evaluation, were included in the study. The patients were divided into 4 groups according to their apnea-hypopnea indexes (AHI) and body mass index (BMI) values. The association of BMI and the polysomnography parameters such as AHI, arousal index, lowest oxygen saturation and mean oxygen desaturation in patients with and without systemic illnesses ,were evaluated. Results: Seventy-one (73.2%) of the patients comprised the group with systemic illnesses, and 26 (26.80%) patients comprised the group without systemic illnesses. AHI value was found to be higher in patients with systemic diseases compared to patients without systemic illnesses, and this was statistically significant (p25) (p

Amaç; Bu çalışmanın amacı; Obstrüktif uyku apne sendromu (OUAS) olan hastalarda, 2-boyutlu ve pulse dalga doppler (PDD) ekokardiyografi teknikleri kullanılarak SV fonksiyonlarının değerlendirilmesidir. Yöntem; Çalışmaya polisomnografi ile OUAS tanısı konulan ve henüz tedavi uygulanmamış 40 hasta ve 28 sağlıklı birey kontrol grubu olarak alındı. Hastalara M-mod, 2- boyutlu ve PDD ekokardiyografi incelemeleri yapıldı. Bulgular; Gruplar arasında M-mode ölçümleri ile elde edilen SV sistolik ve diyastolik çapları, ejeksiyon fraksiyonları açısından fark saptanmadı. OUAS’ li grupta SV kitle ve kitle indeksi ve SV diyastolik duvar kalınlıkları, kontrol grubuna göre anlamlı olarak daha fazla tespit edildi. Transmitral diyastolik doluş parametrelerinin PDD ekokardiyografi ile yapılan incelemesinde; OUAS grupta erken diyastolik doluma ait E dalga hızında, E/A oranlarında anlamlı azalma izlendi. E dalga deselerasyon zamanı ve izovolümetrik gevşeme zamanının OUAS’ lı grupta anlamlı olarak daha uzun saptandı. Apne-hipopne indeksi ile SV diyastolik parametreler arasında ilişki saptanmadı. Sonuç; OUAS, altta yatan herhangi bir kalp hastalığı olmasa da SV kitlesini etkileyen ve hastalığın şiddetinden bağımsız olarak SV diyastolik fonksiyonlarını bozan bir durumdur. Bu nedenle OSAS hastaları kardiyak açıdan da mutlaka değerlendirilmelidir.

Abstract Objectives: This study aimed to examine factors (BMI, neck circumference, AHI etc.) affecting optimal CPAP levels in patients with obstructive sleep apnea syndrome (OSAS). Materials and Methods: A total of 120 patients with OSAS who underwent successful auto-titration for CPAP treatment were included in this study. Correlations between the optimal CPAP level and baseline data were analyzed. Results: The mean optimal pressure level in the 120 OSAS patients was 9.11 ± 2.81 cm H2O. The mean optimal pressure levels in the mild, moderate, and severe OSAS groups were 8.01 ± 2.60, 8.32 ± 2.22, and 9.71 ± 3.01 cm H2O, respectively. Apnea/hypopnea index (AHI) (r=0.297, p lt;0.001) and minimal SaO2 (r=-0.264, p lt;0.004) were significantly correlated with optimal pressure level. 22 patients in the titration failure group had severe AHI overall; 6 patients had REM-related and 2 had position-related OSAS. Patients in the titration failure group who did not have a specific diagnosis (rapid eye movement (REM) or positional OSAS) had very severe AHI levels (mean AHI of 67.90). Conclusion: According to the correlation tests, AHI and the lowest saturation were the two most important predictors of optimal CPAP level.

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Objective: Parasomnias are sleep disorders that are characterised by abnormal or unwanted movements, behaviours, emotions, perceptions, dreams and autonomic nervous system dysfunction. This study aimed to investigate the presence of childhood traumatic experiences and dissociative symptoms in patients with parasomnia. Materials and Methods: This study included 38 patients with parasomnias and 40 patients with obstructive sleep apnoea syndrome (OSAS), who were diagnosed according to International sleep disorders classification 3 in the sleep outpatient clinics of İstanbul Provincial Health Directorate İstanbul 2nd Division Public Hospitals Association Sleep Disorders Diagnosis and Treatment Centers, between March 2018 and July 2018. All participants were evaluated with the childhood trauma scale, dissociative experience scale (DES), Beck depression scale and Beck anxiety scale. Mediator analyses were applied to process data. Results: A significant difference was found between the parasomnia and OSAS groups in terms of the cut-off scores of the childhood trauma questionnaire (childhood trauma questionnaire; p=0.004) and depressive symptoms (p=0.005). No significant differences were found in terms of DES scores (p=0.456) and anxiety symptoms (p=0.934). A significant difference was noted in the scores of the sexual abuse (p=0.038) and emotional abuse (p=0.001) subscales of childhood trauma questionnaire. No significant difference was found in other subscales. Conclusion: The finding that childhood trauma is higher in patients in the parasomnia group than in those in the control group emphasises the importance of cooperation with psychiatrists in order to diagnose and treat these patients. [ABSTRACT FROM AUTHOR]

Objective: The prevalence of obstructive sleep apnea syndrome (OSAS) has increased in recent years. Despite these high prevalence rates, it is suggested that actual prevalence is even higher, because of the very low awareness about the disease and many cases of OSAS were not diagnosed. This study aimed to determine awareness about OSAS. Materials and Methods: A face-to-face survey was conducted to individuals who sought to primary health care services. Participants were asked to complete the STOP-BANG questionnaire, a screening test for diagnosis of OSAS. Results: A total of 293 participants completed the survey. Of these, 39.6% stated that they had heard about the disorder, but when asked to describe the disease, this rate dropped to 28.7%. Only 20.5% could respond adequately. The STOP-BANG questionnaire was administered to the study group. Of the 293 patients, 194 (66.2%) were diagnosed with low risk, 31 (10.6%) had moderate risk and 68 (23.2%) had high risk of OSAS. Based on the results of STOP-BANG questionnaire survey, 52 (24.9%) patients who stated that they had no information about the disorder had a high risk of OSAS and 23 (11%) had a moderate risk of OSAS. Conclusion: Patients at risk of developing OSAS should be monitored by polysomnography and receive appropriate treatment. However, owing to the lack of knowledge, these patients are deprived of necessary treatment and thus become more susceptible to complications such as impaired concentration, hypertension, cardiac diseases, cerebrovascular diseases and even death. [ABSTRACT FROM AUTHOR]

Objective: Polysomnography (PSG) is a standard test used in the diagnosis of sleep-related breathing disorders. However, carbon dioxide monitoring is not routinely implemented in adults. This study aimed to investigate the necessity of full-night carbon dioxide monitoring during PSG in patients with pulmonary disease. Materials and Methods: This retrospective cohort study enrolled adult patients with pulmonary disease and a control group who had PSG recordings and carbon dioxide monitoring for the last 3 years. Results: The study group included 36 individuals with asthma and 27 individuals with chronic obstructive pulmonary disease (COPD), whereas the control group included 52 individuals without any pulmonary diseases. The three groups were comparable in terms of age, gender and body mass index. Obstructive sleep apnoea syndrome was most commonly observed in patients in the COPD group (p=0.003). However, no difference was observed between patients in the asthma and control groups. Partial carbon dioxide pressure during wakefulness, non-rapid eye movement and rapid eye movement sleep were not significantly different among the three groups. In the control group, no patient had sleep-related hypoxemia and/or hypoventilation. Two patients with asthma (5.5%) and one patient with COPD (3.7%) had sleep-related hypoxemia, while one patient with COPD had sleeprelated hypoventilation (3.7%). Conclusion: In this study, sleep-related hypoventilation was not detected in any patient with asthma and in controls, while one patient with COPD was diagnosed with sleep-related hypoventilation upon routine carbon dioxide monitoring. Defining some criteria using additional correlations with respiratory parameters would help monitor carbon dioxide level in a selected subgroup of patients with COPD. [ABSTRACT FROM AUTHOR]

Objective: In this study, we aimed to compare the clinical and polysomnographic features of rapid eye movement sleep-dependent obstructive sleep apnoea syndrome (REM-OSAS) and positional OSAS (pos-OSAS). Materials and Methods: This study included all patients diagnosed with REM-OSAS and pos-OSAS who were examined at our sleep and disorders unit between January 2019 and November 2020. All patients underwent a full-night polysomnographic examination. Results: A total of 300 patients with OSAS were included in the study, of which 60 (20%) were diagnosed with REM-OSAS and 75 (25%) with pos-OSAS. REM-OSAS had a female predominance, whereas pos-OSAS demonstrated a male predominance (p<0.001). Body mass index was significantly higher in patients with REM-OSAS than in those with pos-OSAS (p=0.003). OSAS severity was found to be higher in patients with pos-OSAS than in those with REM-OSAS (apnoea-hypopnea index: 23/hour, p<0.001). The supine and REM sleep pulse rates were significantly higher and the minimum oxygen saturation level was significantly lower in patients with REM-OSAS than in those with pos-OSAS (p<0.001, p=0.010). Conclusion: The results of this study revealed that OSAS severity was higher in patients with pos-OSAS than in those with REM-OSAS. Body position plays a more significant role than sleep stage on OSAS severity. REM-OSAS was more common in female patients, whereas pos-OSAS had a male predominance. Patients diagnosed with REM-OSAS had a significant tendency to be overweight. Oxygen saturation was lower in patients with REM-OSAS than in those with pos-OSAS. [ABSTRACT FROM AUTHOR]

Amaç: Psoriazis toplumda sık görülen, genel nüfusun %2-3’ünü etkileyen, birçok komorbiditenin eşlik ettiği kronik sistemik enflamatuvar bir hastalıktır. Psoriazis’e eşlik eden nadir görülen komorbiditeler arasında obstrüktif uyku apne sendromu (OUAS) yer almaktadır. OUAS uyku sırasında tekrarlayan tam (apne) veya parsiyel (hipopne) üst solunum yolu obstrüksiyonu epizodları ve sıklıkla kan oksijen satürasyonunda azalma ile karakterize bir hastalıktır. Bu çalışmanın amacı psoriazis hastalarında OUAS semptomları sorgulanarak, OUAS risk faktörlerini değerlendirmektir.Gereç ve Yöntemler: Düzce Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıkları polikliniğinden takipli ve Psoriazis tanılı 16 yaşından büyük 82 hasta çalışmaya alındı. Hastalar OUAS semptomları açısından sorgulandı. Aşırı gündüz uykululuğu değerlendirmek için ise Epworth uykululuk skalası kullanıldı.Bulgular: Hastaların %51,2 (n=42)’sı erkek, %48,8 (n=40)’i kadındı. Hastaların yaş ortalaması 47,09±14,10 yıl idi. Hastaların ortalama psoriazis tanı süreleri 16,97±10,55 yıl, ortalama Psoriatik Alan Şiddet İndeksi (PAŞİ) 11,25±6,32 idi. PAŞİ sınıflamasına göre hastaların %54,9 (n=45)’ü şiddetliydi. Bu hastalarda horlama için %56,1, gündüz aşırı uyku hali için %25,6, tanıklı apne için %15,9’luk prevalans saptandı. En az bir semptomu olan olgu sayısı 47 (%57,3) idi. Minör semptomlar sorgulandığında en sık gözlenen %25,6 (n=21) ile uyuyamama ve %22,0 (n=18) ile yetersiz bölünmüş uyku şikayetiydi.Sonuç: Psoriazis hastalarında OUAS semptom sıklığı yüksek olarak bulunmuştur. OUAS semptomları olan psoriazis hastaları muhakkak polisomnografik değerlendirme için ilgili uzmanlara yönlendirilmelidir.

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Central or mixed apneas may accompany obstructive apneas in patients with Obstructive Sleep Apnea syndrome (OSAS). There is scant evidence about the potential impact of mixed apneas on the therapy modalities. Here, apneas/hypopnoeas' central and/or mixed effects on the positive airway pressure (PAP) modes chosen to be effective in patients with OSAS were evaluated. Materials and Methods: Patients who underwent a whole night polysomnography within last 2 years in our Sleep and Disorders Unit were consecutively examined. The patients included were those diagnosed with OSAS associated with central and/or mixed apneas. To determine the effective PAP modes, a second night polysomnography for titration was performed in these patients. Results: A total of 70 patients were included in the study, wherein 55 (78.6%) were males, with a mean age of 55.4±11.7 years. Continuous mode PAP (CPAP) therapy was effective in 60 patients (85.7%, group 1), whereas other modes (as BPAP-ST/ASV) were needed in 10 patients (14.3%, group 2). No statistically significant difference was found between the two groups in terms of gender, age or comorbid diseases (p=0.314, p=0.193 and p=0.081, respectively). Although BPAP-ST/ASV mode was needed in the presence of central apneas (p=0.039), CPAP mode was effective in OSAS patients with mixed apneas (p=0.055). Conclusion: The results showed that gender, age or comorbid conditions did not play a significant role in the determination of effective PAP mode. Mixed type abnormal respiratory events differed from central apneas/hypopnoeas as they did not require the use of BPAP-ST/ASV mode, and CPAP mode was effective enough in OSAS patients that manifested mixed type abnormal respiratory events. [ABSTRACT FROM AUTHOR]

Amaç: Obstrüktif uyku apne sendromu (OUAS), uykuda oksijen desatürasyonlarının sıklıkla eşlik ettiği tekrarlayan üst solunum yolu obstrüksiyonu olarak tanımlanır. OUAS’ın kardiyovasküler hastalıklar açısından bağımsız bir risk faktörü olduğu kabul edilmektedir. Bu çalışmada aort elastikiyetini gösteren parametrelerin OUAS’ın ağırlık derecesi ile olan ilişkisinin araştırılması amaçlanmıştır.Gereç ve Yöntemler: Uyku kliniğinde polisomnografi ile OUAS tanısı alan 65 hasta apne hipopne indekslerine göre hafif-orta ve ağır OUAS olmak üzere iki gruba ayrıldı. Hipertansiyon, koroner arter hastalığı, hiperlipidemi ve diyabetes mellitus komorbid hastalıklar olarak değerlendirildi. Bu kesitsel çalışmada iki grubun aortik strain ve aortik distensibilite açısından karşılaştırmaları yapıldı.Bulgular: Ortanca apne hipopne indeksi, hafif-orta OUAS’ta 15,2 (n=28) iken ağır OUAS’ta 56,5 (n=37) bulundu. Oksijen desatürasyon indeksi (p

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Archives of Lung is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: The aim of our study was to compare the right ventricular systolic and diastolic functions and pulmonary artery pressure (PAP) in obese and non-obese patients with obstructive sleep apnea syndrome (OSAS) by tissue Doppler imaging (TDI) echocardiography. Materials and Methods: This study was conducted with 69 patients, 34 obese and 35 non-obese, diagnosed moderate or severe OSAS by an overnight polysomnographic sleep study. In all patients, LV (left ventricle) and RV (right ventricle) size, left atial (LA) and RA (right atrial) dimensions, LV and RV systolic and diastolic functions and systolic PAPs were measured by Mmode, two-dimensional analysis, color flow Doppler and TDI. Results: RV diastolic dysfunction was detected in both groups; this impairment was significantly higher in the obese group (lateral tricuspid late diastolic myocardial annular zone velocity A'a: 0.13 ± 0.03 in non-obese patients a nd 0 .11 ± 0 .04 in obese patients). The mean systolic PAP was significantly higher in obese patients (31.2±5.6, 27.1±5.8, respectively). Conclusion: Obstructive Sleep Apnea Syndrome increases cardiovascular morbidity and mortality. In our study, left ventricul and right ventricul diastolic dysfunction was determined by tissue Doppler imaging in patients with moderate and severe Obstructive Sleep Apnea Syndrome. Obesity contributes to this impairment regardless of Obstructive Sleep Apnea Syndrome. [ABSTRACT FROM AUTHOR]

Objectives: Sleep respiratory disorders, which are more common in epilepsy patients, are treatable diseases. We have discussed the diagnosis of sleep apnea syndrome after PSG of epileptic patients with visible apnea and snoring, in light of the findings in the literature. Methods: For this study, from 1120 patients with epilepsy, 32 of them who were diagnosed with OSA in the PSG test were selected. Thirty- two patients with epilepsy that snoring and apnea who consulted sleep center. Patients with simple snoring and upper airway resistance were not selected. Epworth Sleep Scales was applied to all patients and all patients were taken. Results: In this study, the findings showed that the ratio of OUAS in patients with epilepsy was 2.9%. 21 of the 32 cases were male and 11 were female. The mean age was 53 (42-69) years. 72% had partial epilepsies and 28% generalized. The Apne-hypopnea index was 28 (14-48). PAP treatment was performed after the diagnosis of sleep apnea syndrome. Conclusion: Sleep respiratory disorders are more common in patients with epilepsy than the rest of the population and they are treatable diseases. The other study revealed that the frequency of OSAS among epilepsy was10,2%. In this study, the findings showed that the ratio of OSAS in patients with epilepsy was 2.9%.This a risk for OSAS and the medication used for the treatment should be selected appropriately. Clinical screening of OSAS in settings of epileptic patients may be needed to diagnose to find out it maybe a potential and modifiable risk factor for epilepsy. [ABSTRACT FROM AUTHOR]

Objective: Erectile dysfunction (ED) is quite common in men with severe Obstructive Sleep Apnea syndrome (OSAS). The aim of this study was to determine whether a hematological parameter can be used for predicting ED in male patients with OSAS. Materials and Methods: Patients who applied to neurology-sleep disorders outpatient clinic of our hospital between March of 2018 and 2020, who had Apnea-hypopnea index ≥30 in polysomnography test, and who met the inclusion criteria were enrolled in this study. The patients were divided into two groups as those without ED (group 1) and with ED (group 2) according to the score of International Erectile Function (IIEF) questionnaire. The recorded demographic and basic characteristics of the patients along with measured hemogram, fasting serum biochemistry, blood lipid profile, and serum sex hormone parameters were statistically analyzed. Results: Of the 85 patients enrolled in the study, 48 (56.5%) had ED. While average age of all patients was 47.43±10.73 years, it was 43.95±8.70 years in group 1 and 49.96±11.06 years in group 2 and differed significantly between the two groups (p=0.006). Mean hemoglobin and hematocrit values in group 1 were higher than those in group 2 (p=0.02 and p=0.03, respectively). Other parameters were similar among the groups. In multivariate logistic regression analysis, only patient age remained significantly different (p=0.011). Pearson correlation analysis revealed a negative relationship between patient age and IIEF score (r =-0.287, p=0.004). In receiver operating characteristic analysis, cut-off value of the patient age was found to be 47.50 years with a sensitivity of 0.604 and a specificity of 0.646 (p=0.006). Conclusion: The results suggest that prevalence of ED increases in parallel with age in men with severe OSAS. No hematological, hormonal, or biochemical parameters for predicting ED have yet been determined. [ABSTRACT FROM AUTHOR]

Objective: It has been shown that pain, depression, and fatigue related to Obstructive Sleep Apnea syndrome (OSAS) results in a significant socioeconomic burden. We aimed to determine the prevalence, demographic, and clinical properties of pain symptoms in OSAS patients. Materials and Methods: We evaluated 84 OSAS patients diagnosed after full-night polysomnography with the Brief Pain Inventory, Beck Depression Rating scale (BDS), Pittsburg Sleep Quality index (PSQI), Epworth Sleepiness scale (ESS), Fatigue Impact scale (FIS), and Fatigue Severity scale (FSS). Results: A total of 84 patients (62 males, 22 females) with a mean age of 54.37±11.03 years were included. Headache in 25 (43.1%), myofascial pain in 22 (37.9%), and other types of pain in 11 patients were defined. ESS, FSS, FIS total, physical, cognitive, and psychosocial scores were found to be significantly higher in patients with pain. The presence of pain did not differ according to the severity of OSAS, and no significant difference was found in any parameters between mild, moderate, and severe OSAS except for minimal O2 saturation. A positive correlation between last week pain severity and BDS scores, a negative correlation between PSQI scores and the decrease in pain rate as a result of the treatment, and a weak positive correlation between FIS-cognitive sub-score and pain intensity scores were found. Conclusion: In our study, excessive daytime sleepiness and the impact and severity of fatigue were found to be higher in patients with pain than in those without pain. The most obvious difference was seen in terms of cognitive, and psychosocial fatigue. Contrary to expectations, it was observed that OSAS severity did not affect pain according to our data. [ABSTRACT FROM AUTHOR]

Objective: Obstructive Sleep Apnea syndrome (OSAS) frequently seen in the adult population is an important public health problem. OSAS is related to increased cardiovascular morbidity and mortality. In studies, the relationship between OSAS, cardiovascular risk factors, and metabolic syndrome components is determined. This study aimed to evaluate the use of metabolic syndrome criteria to support prediagnosis of patients with sleep apnea who were admitted to sleep clinics. Materials and Methods: This study involved 247 patients (148 men, 99 women) admitted to our sleep clinic with prediagnosis of sleep apnea. The patients' demographic features and evaluated National Cholesterol Education Program Adult Treatment Panel metabolic syndrome components were recorded. Results: After analysis of the relationship between Apne-hipopne index (AHI) and NCEP criteria separately, AHI was higher and more severe in men with waist circumference >102 cm (p=0.0001, kadınlarda x²=9.03, p=0.003 in women; x²=15.01, p<0.0001 in men respectively). No statistically significant relationship was found between dyslipidemia and AHI (p>0.05). Although AHI was significantly higher in hypertensive and hyperglycemic men (p=0.004 and p=0.002, respectively), no significant relationship was found in women for both groups (p>0.05). A statistically significant association was found between metabolic syndrome and sleep apnea (x²=5.82, p=0.016 in women; x²=8.017, p=0.005 in men). Conclusion: Our study showed that OSAS and metabolic syndrome components are clustered in patients. Patients diagnosed with OSAS must be followed closely. Besides, population with risk factors can be determined with simple anthropometric measurements and blood tests in primary health care centers and can be prioritized in sleep clinics. [ABSTRACT FROM AUTHOR]

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There is a strong cause-effect relationship between Obstructive Sleep Apnoea syndrome (OSAS) and many cardiovascular diseases. A high prevalence of cardiac arrhythmia has also been reported in patients with OSAS. Nocturnal intermittent hypoxia, increased negative intrathoracic pressure and increase in sympathovagal activity are defined as the pathophysiological mechanisms by which OSAS triggers and/or increases cardiac arrhythmogenesis. Herein, in the light of a case report, we aimed to review the relationship between OSAS and cardiac arrhythmia. [ABSTRACT FROM AUTHOR]

Objective: Obstructive Sleep Apnoea syndrome (OSAS) is common in patients with epilepsy. A reduction in seizure frequency was reported following positive airway pressure (PAP) therapy. Thus, changes in seizures and related factors have been studied in patients with nocturnal epilepsy and OSAS. Materials and Methods: All patients with nocturnal epilepsy admitted to our sleep and disorders unit were evaluated consecutively for the last 5 years. Results: Of the 58 patients with nocturnal epilepsy and OSAS, 74.1% were male. The mean age was 48.6±14.3 years, and disease duration was 10.1±10.6 years. Moreover, 34 (58.7%) patients underwent successful PAP therapy. Conversely, seizures persisted or increased in 18 (31.0%) patients and decreased in 14 (24.2%), whereas 26 (44.8%) patients were seizure-free. Gender (p=0.773) and age (p=0.998) were not related to changes in seizure frequency. However, decrease in seizures was more common in patients with a shorter disease duration (p=0.032), higher number of seizures (p=0.027) and abnormality in electroencephalography (p=0.005). Sleep efficiency (p=0.468), slowwave sleep duration (p=0.264), or rapid eye movement sleep (p=0.238) was found to be unrelated. In patients without any decrease in seizures, the Apnoea-hypopnoea index was higher but not significant (p=0.160), whereas oxygen saturation level was significantly lower (p=0.037). Decrease in seizures was present in 71.9% of the patients under successful PAP therapy but in 66.7% of patients with non-compliance, although this disparity was not statistically significant (p=0.351). Conclusion: A decrease in seizures was associated with a shorter duration of epilepsy, higher number of seizures and abnormality in electroencephalography. Although the reduction in seizures was more prominent in patients with successful PAP therapy, this was not statistically significant. [ABSTRACT FROM AUTHOR]

Objective: In this study, it was aimed to evaluate the effects of diabetes and anthropometric measurements on disease severity in patients with Obstructive Sleep Apnea syndrome (OSAS). Materials and Methods: Seventy-three volunteers, 20 female and 53 male, who were 30 years old and over, diagnosed with OSAS, who applied to Marmara University Institute of Neurological Sciences Sleep Unit and İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Neurology, Sleep Disorders Center, participated in the study. The demographic characteristics of the patients were determined by the STOP-BANG test, face-to-face questionnaire, and anthropometric measurements were made. Results: In the study, it was observed that the OSAS risk determined by STOP-BANG test in men and women was correlated with the measurements of weight, waist circumference, chest circumference and neck circumference, except body mass index and hip circumference. Diabetes was detected in 17 (23.2%) of OSAS patients, but no significant relationship was found between OSAS severity and anthropometric measurements. Conclusion: In our study, it was determined that there is a significant relationship between anthropometric measurements and OSAS severity, and this is especially evident in male gender. A higher rate of diabetes was found in OSAS patients compared to the general population. However, it was observed that anthropometric measurements did not play a role among the mechanisms underlying the relationship between OSAS and diabetes. [ABSTRACT FROM AUTHOR]