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Objective: To assess the level of interest, the attitude and hands-on experience of PowerLab among the medical students of Karachi. Study Design: Cross-sectional study. Setting: Dow International Medical College, Dow University of Health Sciences. Period: September to November 2021. Material & Methods: Among 360 medical students investigated the awareness and perceptions of the PowerLab system. The data were entered and analyzed on Microsoft Excel version 2016. Statistical summaries and data analysis were made using Likert scales, percentages, and the Chi-squared test. Results: A total of 360 medical students participated in this study. Mean age was 20 years ± 1.4 years. Majority of students (53.6%) were from first professional year. Out of 360 students, 322 (89%) have heard of the PowerLab system. A statistically strong correlation (p-value ≤ 0.001) was found between the perceived level of adeptness of the teaching staff with the students’ understanding of the PowerLab system. Conclusion: The study showed that students require more hands-on exposure when using PowerLab to develop a greater appreciation for the instrument. The results also suggested the importance of well-trained staff to ensure students receive a quality education that meets international standards.