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Aim: To determine the possible positive influence on correction of erection duration with redistributing of blood flow in pelvic arteries. Materials and Methods: Blood flow indices were determined with the methods of color Doppler ultrasound diagnostics of penis arteries in 9 middle-aged males with erectile dysfunction, in whose anamnesis there had been diabetic nephropathy. Results: We determined that the maximum blood flow velocity in the cavernous arteries of the penis was 31.5 cm/sec on average, and diastolic blood flow velocity was 13.4 cm/sec, compared to 60 cm/sec and 25 cm/sec respectively in the norm. The resistive index decreased to 0.58 compared to 0.92 in the norm. Gotten indices show the presence of erectile arterial dysfunction in middle-aged males with diabetic nephropathy. Performed experiments in animals with directing of arterial blood flow from the caudal sciatic artery to the deep and spinal arteries of the penis showed widened lumen in them to 50% in average that causes the continuous erection. Conclusions: According to the data of the Doppler ultrasound of the penis in middle-aged males, in whose anamnesis there had been diagnosed diabetic nephropathy, we found out bilateral cavernous dysfunction. According to the data of the angiography exclusion of the caudal sciatic artery directed the blood flow into the internal pubic artery and its final branches, the deep and spinal arteries of the penis with significant (to 50% in average), increasing of their internal diameter and continuous erection. [ABSTRACT FROM AUTHOR]

Nephropathy is one of the major vascular complications present in adults with diabetes mellitus type 1 (DM1) and is the most common cause of chronic kidney disease in adults. Currently, in everyday medical practice, microalbminuria is used as a marker to identify individuals at risk of nephropathy, however it only occasionally may be observed during the first 5 years from the diagnosis of DM1. Despite of intensive research in the field of diabetic nephropathy development, its pathomechanism is still not fully understood. In the presented work we describe the correlation between N-acetyl-β-D-glucosaminidase, cistatin C and the development of microalbuminuria. Also, we attempted to explain therelations between the degree of metabolic compliance (HbA1c), the level of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-β), interleukin 6, 12, 10 (IL-6, IL-12, IL-10) and the development of diabetic nephropathy in children. Among the analyzed immunologic markers, those prognostic for occurrence of microalbuminuria and for development of pathologic changes in kidneys in the course of DM1 in children were pointed out. Plausibly, identification of early markers of the developing diabetic nephropathy might contribute to better understanding of its pathogenesis and also to research of novel therapeutic options aimed at improvement of quality of life of DM1 patients by means of slowdown or even avoidance of the development of late vascular complications. [ABSTRACT FROM AUTHOR]

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