1. Natural killer clones recognize specific soluble HLA class I molecules
- Author
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Loretta Tuosto, Giovanni Palazzolo, Giuseppe Terrazzano, Juan J. Pérez-Villar, Serafino Zappacosta, Klas Kärre, Ennio Carbone, Lars Franksson, Enza Piccolella, Marco Colonna, Silvia Fontana, Carbone, E, Terrazzano, G, Colonna, M, Tuosto, L, Piccolella, E, Franksson, L, Palazzolo, G, PEREZ-VILLAR, Jj, Fontana, S, Karre, K, Zappacosta, S., Carbone, E., Terrazzano, G., Colonna, M., Tuosto, L., Piccolella, E., Franksson, L., Palazzolo, G., PEREZ VILLAR, J. J., Fontana, S., Karre, K., and Zappacosta, Serafino
- Subjects
Cytotoxicity, Immunologic ,Immunology ,Down-Regulation ,Biology ,Major histocompatibility complex ,Antigen ,Antigens, CD ,HLA Antigens ,Tumor Cells, Cultured ,Humans ,Immunology and Allergy ,Lectins, C-Type ,soluble hla class i antigens ,Cytotoxicity ,Membrane Glycoproteins ,Lymphokine-activated killer cell ,natural killer receptors ,Effector ,natural killer cell clones ,Histocompatibility Antigens Class I ,MHC Class I Gene ,natural killer cell sensitivity ,Natural killer T cell ,Immunity, Innate ,Clone Cells ,Killer Cells, Natural ,Solubility ,biology.protein ,Leukemia, Erythroblastic, Acute ,NK Cell Lectin-Like Receptor Subfamily D - Abstract
Enhancement of major histocompatibility complex (MHC) class I expression leads to protection from natural killer (NK) cell recognition in several systems. MHC class I gene products are released from the cell surface and can be found in sera as soluble forms. To investigate the possible immunoregulatory role of soluble HLA (sHLA) in NK cell-target recognition, several sHLA antigens were studied for their ability to induce NK cell cytotoxicity modulation. NK cell-target recognition was inhibited by the addition of sHLA during the cytotoxicity assay. Our results indicate that sHLA molecules can down-regulate NK killing at the effector level. Moreover, different NK clones are able to specifically recognize different sHLA antigens. Kp43 molecules seem to be involved in the NK recognition of sHLA-B7.
- Published
- 1996