1. Disability and Fatigue Can Be Objectively Measured in Multiple Sclerosis
- Author
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Giorgio Germani, Silvia Rossi, Diego Centonze, Stefano Rossi, Paolo Cappa, Marco Germanotta, Eduardo Palermo, Valeria Studer, and Caterina Motta
- Subjects
Male ,030506 rehabilitation ,Kinematics ,Knee Joint ,Physiology ,Cross-sectional study ,lcsh:Medicine ,Walking ,Pathology and Laboratory Medicine ,Severity of Illness Index ,Nervous System ,Material Fatigue ,Disability Evaluation ,0302 clinical medicine ,Materials Physics ,Accelerometry ,Medicine and Health Sciences ,Public and Occupational Health ,Biomechanics ,Gait disorders ,Range of Motion, Articular ,Young adult ,lcsh:Science ,Fatigue ,Observer Variation ,Muscle Weakness ,Multidisciplinary ,Physics ,Outcome measures ,Classical Mechanics ,Neurodegenerative Diseases ,Middle Aged ,Biomechanical Phenomena ,Neurology ,Muscle Fatigue ,Physical Sciences ,Metallurgy ,accelerometry ,adult ,ankle joint ,biomechanical phenomena ,cross-sectional studies ,female ,gait disorders, neurologic ,hip joint ,humans ,joints ,knee joint ,magnetics ,male ,middle aged ,multiple sclerosis ,muscle weakness ,observer variation ,quality of life ,range of motion, articular ,reproducibility of results ,sensitivity and specificity ,severity of illness index ,symptom assessment ,walking ,young adult ,disability evaluation ,musclef atigue ,agricultural and biological sciences (all) ,biochemistry, genetics and molecular biology (all) ,medicine (all) ,Female ,Hip Joint ,Settore MED/26 - Neurologia ,Symptom Assessment ,Anatomy ,medicine.symptom ,Gait Analysis ,0305 other medical science ,Research Article ,Adult ,Metal Fatigue ,medicine.medical_specialty ,Multiple Sclerosis ,Disabilities ,Immunology ,Materials Science ,Sensitivity and Specificity ,Autoimmune Diseases ,Magnetics ,Young Adult ,03 medical and health sciences ,Signs and Symptoms ,Quality of life (healthcare) ,Physical medicine and rehabilitation ,Severity of illness ,medicine ,Humans ,Gait Disorders, Neurologic ,Damage Mechanics ,Biological Locomotion ,business.industry ,Multiple sclerosis ,lcsh:R ,Reproducibility of Results ,Biology and Life Sciences ,Muscle weakness ,medicine.disease ,Demyelinating Disorders ,Motor System ,Cross-Sectional Studies ,Quality of Life ,Physical therapy ,Joints ,Clinical Immunology ,lcsh:Q ,Clinical Medicine ,business ,Ankle Joint ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Background The available clinical outcome measures of disability in multiple sclerosis are not adequately responsive or sensitive. Objective To investigate the feasibility of inertial sensor-based gait analysis in multiple sclerosis. Methods A cross-sectional study of 80 multiple sclerosis patients and 50 healthy controls was performed. Lower-limb kinematics was evaluated by using a commercially available magnetic inertial measurement unit system. Mean and standard deviation of range of motion (mROM, sROM) for each joint of lower limbs were calculated in one minute walking test. A motor performance index (E) defined as the sum of sROMs was proposed. Results We established two novel observer-independent measures of disability. Hip mROM was extremely sensitive in measuring lower limb motor impairment, being correlated with muscle strength and also altered in patients without clinically detectable disability. On the other hand, E index discriminated patients according to disability, being altered only in patients with moderate and severe disability, regardless of walking speed. It was strongly correlated with fatigue and patient-perceived health status. Conclusions Inertial sensor-based gait analysis is feasible and can detect clinical and subclinical disability in multiple sclerosis.
- Published
- 2016