1. Reviewing recently developed technologies to direct cell activity through the control of pore size: From the macro‐ to the nanoscale
- Author
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Chiara Tonda-Turo, Gianluca Ciardelli, and Viola Sgarminato
- Subjects
Pore size ,Scaffold ,Materials science ,Biomedical Engineering ,multiscale pore architecture ,Biocompatible Materials ,Nanotechnology ,Context (language use) ,02 engineering and technology ,010402 general chemistry ,cellular response ,01 natural sciences ,cell activity ,hierarchical structure ,scaffold pore size ,Biomaterials ,Cell activity ,Materials Testing ,Animals ,Humans ,Macro ,Nanoscopic scale ,Tissue Engineering ,Tissue Scaffolds ,Nanoporous ,Cell Differentiation ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Living systems ,0210 nano-technology ,Porosity - Abstract
Scaffold pore size plays a fundamental role in the regeneration of new tissue since it has been shown to direct cell activity in situ. It is well known that cellular response changes in relation with pores diameter. Consequently, researchers developed efficient approaches to realize scaffolds with controllable macro-, micro-, and nanoporous architecture. In this context, new strategies aiming at the manufacturing of scaffolds with multiscale pore networks have emerged, in the attempt to mimic the complex hierarchical structures found in living systems. In this review, we aim at providing an overview of the fabrication methods currently adopted to realize scaffolds with controlled, multisized pores highlighting their specific influence on cellular activity.
- Published
- 2020
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