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Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Intensive care units stand as the frontline battlegrounds where medical warriors combat the most critical illnesses and injuries. Within the labyrinth of intensive care units, where every moment teeters between life and death, prognostic markers emerge as beacons of guidance amidst uncertainty. In recent years, researchers have identified several novel mortality predictors in the intensive care population. In this review, we aimed to examine the clinical and laboratory markers that have been proposed in recent years to evaluate prognosis in the intensive care unit population and to review the literature on this topic. Management of patients in intensive care units is a dynamic process and reliable risk stratification models and prognostic markers are needed for this purpose. Novel prognostic indicators could serve as reliable diagnostic and prognostic tools in critically ill patients. [ABSTRACT FROM AUTHOR]

Objective: Gastric cancer surgery, including curative and palliative procedures, is crucial for managing gastric cancer. Accurate assessment of nutritional status is essential for risk stratification and improving patient outcomes. This retrospective study aims to identify the most reliable predictors of postoperative mortality by investigating the correlation between four nutritional scores and the mortality rate following gastric cancer surgery. Material and Method: This retrospective study evaluated 50 patients diagnosed with gastric adenocarcinoma and operated on at Hitit University Department of General Surgery between April 2021 and September 2023. Nutritional scores were calculated using albumin, cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyteto-monocyte ratio, along with mortality rates. Data collected included age, gender, operation type, laparoscopy usage, albumin, cholesterol, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, mortality rates, and TNM stages. Nutritional scores were calculated, and their predictive accuracy for mortality was assessed using time-dependent Receiver Operating Characteristic curve analysis. Results: Significant differences in albumin levels, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and nutritional scores were found between deceased and surviving patients. Specifically, albumin levels were significantly lower in deceased patients (median = 3.5 mg/dL) compared to surviving patients (median = 4.1 mg/dL, p=0.001). The median neutrophil-to-lymphocyte ratio was higher in deceased patients (p=0.005), and the median lymphocyte-to-monocyte ratio was lower in deceased patients (p=0.009). Among the scores, the Naples Prognostic Score was significantly associated with mortality but was outperformed by the Prognostic Nutritional Index. The Prognostic Nutritional Index had the highest predictive accuracy with an Area Under the curve of 0.792, a sensitivity of 76%, and a specificity of 86.2%, outperforming the others. Conclusion: Among the evaluated scores, the Prognostic Nutritional Index is the most effective predictor of prognosis. Its superior predictive accuracy suggests that the PNI can be utilized to enhance risk assessment and guide nutritional interventions in gastric cancer patients undergoing surgery. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: This study aims to analyze the experience of a tertiary health center about the complications of hysterectomy within a period of five years. Materials and Methods: This is a retrospective review of 1311 hysterectomies which were performed for both benign and malignant indications between 1 January 2017 and 1 January 2023. Results: Complications occurred in 218 patients (16.6%) and the mortality rate was 0.5% (n=6). The rate of conversion into laparotomy was 2.8%. Bladder injury, colon injury, ileus and incisional hernia were significantly more frequent in women who underwent laparotomy (p=0.007, p=0.026, p=0.027 and p=0.010 respectively). Logistic regression analysis indicated hysterectomy technique as an independent prognostic factor for its complications (p=0.001). Ureter injury, bladder injury and colon injury were significantly less frequent in patients who had hysterectomy for gynecological malignancy (p=0.001, p=0.001 and p=0.015 respectively). Hospital stay was significantly longer in patients undergoing hysterectomy for laparotomy and gynecological malignancy (p=0.001 for both). Conclusion: Minimally invasive techniques such as laparoscopy or vaginal approach should be attempted whenever it is possible and feasible. Performing hysterectomy for benign pathologies should not be considered as a distraction from meticulous work during the preoperative preparation and postoperative monitorization periods. Similar attention should be also paid to patients who have chronic diseases. [ABSTRACT FROM AUTHOR]

Objective: Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality. We aimed to evaluate the appropriateness of empiric antimicrobial treatment in patients with BSI and its effect on mortality and hospital stay. Methods: 100 BSI-diagnosed patients aged 18 and older were included in the study. Sociodemographic characteristics, clinical and microbiological data, empirically initiated treatments, time to appropriate treatment, 10th-day (early period) and hospital discharge mortality rates, and lengths of hospital stay were recorded. Data were analyzed using Pearson χ², Fisher's exact test, trend χ² test, and Mann-Whitney U test. Logistic regression assessed the impact on mortality, with p <0.05 considered statistically significant. Results: 51% of cases were female, and the median age was 64 (min-max=19-94). No significant difference was found between appropriate and inappropriate antibiotic treatment groups in age, sex, clinical severity, Charlson comorbidity index (CCI) scores, and microorganism distribution. However, multidrug-resistant organisms were significantly more common in the inappropriate empiric treatment group (p=0.001). Of all BSIs, 57% were hospital-acquired, and 43% were community-onset, with primary BSIs accounting for 55%. No significant difference was found between the groups in terms of where BSI was acquired and its source. Empiric treatment appropriateness was 57%, with resistance among microorganisms being the main factor in inappropriate treatment. Early period (10th-day) mortality was 26%, and hospital discharge mortality was 41%, with no significant association found between the empiric treatment, appropriateness, time to appropriate treatment, and mortality. However, inappropriate empiric treatment was signifi- cantly associated with higher hospital discharge mortality (p=0.033) in immunocompetent patients. Hospital stay was significantly shorter in the appropriate empiric treatment group compared to the inappropriate group (p=0.035). Conclusion: We did not find significant impact of the appropriateness of antimicrobial treatment and time to appropriate treatment on mortality but appropriate treatment significantly shortened hospital stays. [ABSTRACT FROM AUTHOR]

Copyright of Hamidiye Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Status epilepticus (SE) is a neurological emergency associated with high morbidity and mortality. The Status Epilepticus Severity Score (STESS) has been proposed as a prognostic tool to predict outcomes in SE patients. This study aims to evaluate the effectiveness of STESS in predicting clinical outcomes and in-hospital mortality rates among SE patients. Materials and Methods: We conducted a retrospective analysis of patient data collected between January 2020 and February 2024 at Harran University Faculty of Medicine Hospital. The study included 29 patients diagnosed with SE, who were categorized based on etiological factors and treatment modalities. STESS was calculated for each patient, and its correlation with clinical outcomes and mortality rates was analyzed using statistical methods. Results: The mean age of the study group was 37.55±18.81 years, and the mortality rate was 13.8% (n=4). Acute symptomatic etiology played a 31% role in the overall etiology. The most common etiology was central nervous system (CNS) infections (17.2%) and the most common comorbidity was DM (17.2%). 13.8% of the patients died during follow-up. There was no significant difference between the survivors and the deceased patients in terms of mean age, duration of hospitalization and duration of status (p>0.005). The mean STESS score of the patients was 1.48±1.05. Age was significantly higher in patients with STESS scores 3-6 (p=0.004). Mortality was significantly higher in patients with higher STESS scores (p=0.005). The sensitivity of STESS in predicting mortality was 95.7%, specificity was 50% and PPV 75%, NPV 12%. Conclusion: The study demonstrates the prognostic value of STESS in predicting clinical outcomes in SE patients. Utilizing STESS in clinical practice can help identify high-risk patients and guide therapeutic strategies to improve patient outcomes. Further research is warranted to validate these findings in larger, multi-center studies. [ABSTRACT FROM AUTHOR]

Aim: To determine the clinical and laboratory parameters that affect the mid-long term mortality of patients hospitalized for acute kidney injury (AKI). Material and methods: Patients hospitalized with the diagnosis of AKI in the intensive care unit and clinic of Nephrology for four years were retrospectively screened. The files of these patients were scanned. Demographic data, comorbidities, vital signs and laboratory parameters were scanned. It was determined in terms of factors affecting mortality in these patients (living and dying) over a 4-year period. Results: The effects of the variables found significant [age, presence of hypertension and coronary artery disease (CAD), sedimentation, C-reactive protein (CRP), urea, potassium (K), magnesium (Mg), pH and CRP-albumin ratio (CAR)] on mortality was performed using multiple logistic regression analysis, which was used to identify the independent risk factors of mortality. Multiple logistic regression analysis using Stepwise selection method revealed that increasing age (IQR=1.04, 95% CI=1.01 – 1.07, p=.004), presence of CAD (IQR =2.16, 95% CI=1.16 – 4.02, p=.016), increased Mg (IQR =2.64, 95% CI=1.18 – 5.92, p=.018) and K (IQR =1.70, 95% CI=1.21 – 2.41, p=.002) were independent risk factors for mortality. The accuracy rate for the predictive performance of this prediction model in predicting mortality was 71.1%, with a sensitivity of 26.5%, a specificity of 90%, and an AUC of 0.753. Conclusion: In our predictive model, in the medium-long term, we found old age, the presence of coronary artery disease, increased K and Mg as the independent risk factors for mortality in AKI patients. [ABSTRACT FROM AUTHOR]

Copyright of Abant Medical Journal / Abant Tıp Dergisi is the property of Abant Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Anatolian Journal of General Medical Research is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aims: To identify the predictive factors and reduce the mortality of COVID-19 in the Tambacounda region. Materials and methods: An analytical cross-sectional study was conducted on confirmed COVID-19 individuals. Sampling was exhaustive with 303 cases. Data were collected by literature review, secondary data extraction and interviews. A data extraction form and an Epi Info®7.4.2.0 input mask were used. Medians, numbers, proportions were calculated and odds ratios were estimated. Statistical analysis was performed using Epi Info®7.2.4.0, SAS®9.4 and Excel®2019. Results: Of the confirmed cases, 58 (19.1%) were deceased. The median age was 59 years (43-69 years). The sex ratio (male to female) was 1.6. Factors independently associated with mortality in COVID-19 were diabetes (ORa=9.34, CI95% [2.15-40.63]); hypertension (ORa=6.51, CI95% [1.85- 22.93]); acute respiratory distress (ORa=6.22, CI95% [2.89-13.37]); male sex (ORa=6.44, CI95% [2.22- 18.65]) and age ≥ 60 years (ORa=2.62, CI95% [1.14-6.02]). Conclusion: Prevention strategies targeting diabetics, hypertensives, males, and those at least 60 years old would reduce mortality from COVID-19 in the Tambacounda region. [ABSTRACT FROM AUTHOR]

Copyright of Acibadem Saglik Bilimleri Dergisi is the property of Acibadem University Medical School and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acibadem Saglik Bilimleri Dergisi is the property of Acibadem University Medical School and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi is the property of Oguz KARABAY and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environnement, Risques & Santé is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, the demographic characteristics, causes of trauma, prognosis, and types of trauma of pediatric trauma patients followed in a single center over a period of three years were retrospectively examined. Methods: Data of pediatric patients admitted to our (single-center, 8-bed) pediatric intensive care unit due to trauma between January 2020 and January 2023 were retrospectively reviewed from computer records. Results: This study includes 122 pediatric trauma cases (37 females and 85 males) with an average age of 75±59 months admitted to intensive care with a diagnosis of trauma. The most frequently observed type of trauma was falls from a height in 68 cases (55.7%), the most affected anatomical region was the head and neck region in 75 cases (61.5%), and the most common pathology was intracranial hemorrhage in 55 cases (45.1%). Surgery was necessary for 36% of the cases, and the predominant reason for surgical intervention was observed in 22 cases (18%), primarily attributed to falls from a height. During the course of their stay in the intensive care unit, 13 cases (10.6%) experienced mortality, indicating a mortality rate of 10.6%. Conclusion: Traumas remain a significant cause of mortality and morbidity in the pediatric age group today. [ABSTRACT FROM AUTHOR]

Aim: Despite medical advancements, heart failure (HF) maintains high mortality rates. Our research delves into examining the relationship between the serum creatinine/albumin ratio and one-year mortality in patients with decompensated systolic HF. Methods: During the period from October 2014 to October 2015, we enrolled 80 patients (comprising 37 females) who had been diagnosed with acute systolic decompensated heart failure and had a left ventricular ejection fraction (LVEF) of ≤ 40%. These patients were divided into two cohorts depending on whether they experienced all-cause mortality within the span of one year. Results: Among the 80 participants, 31 (39%) experienced mortality within the first year. The average age of the deceased group was 69±14 years, with 38.7% (n=12) being female. In contrast, the surviving group had an average age of 66±12 years, with 51% (n=25) being female. The HF group with mortality exhibited significantly higher levels of serum creatinine-albumin ratio, urea, and creatinine values, along with a higher prevalence of pretibial edema (p<0.01).Furthermore, the deceased HF group exhibited significantly lower LVEF, albumin levels, lymphocyte counts, and systolic and diastolic blood pressure values. Statistical analysis revealed a significant difference in the serum creatinine/albumin ratio between the deceased group (0.68±0.27) and the surviving group (0.38±0.18), with a p-value of less than 0.01. Using a cut-off value of 0.45 for the creatinine/albumin ratio, the sensitivity and specificity for predicting one-year mortality in HF patients were 81% and 78%, respectively. Conclusion: The conjunction of heightened creatinine levels, diminished albumin levels, and an augmented creatinine/albumin ratio could potentially function as straightforward, economical prognostic indicators for forecasting one-year mortality in systolic decompensated HF patients. [ABSTRACT FROM AUTHOR]

Susceptibility to infection and increased antibiotic resistance place burn patients at risk of infection caused by multidrug-resistant organisms (MDRO). This condition can progress to sepsis, which can increase morbidity and mortality. A retrospective cohort study using medical record data of patients treated at RSUPN dr. Cipto Mangunkusumo in the period January 2020 to June 2022 was conducted. Of a total 160 subjects in the study period, 82.5% were aged <60 years, 16.88% had comorbidities, the most common cause of burns was fire (86.25%), the use of medical devices was 90.63%, with a median length of stay of 14 days. The most common Gram-negative MDRO pathogens were K. pneumoniae (29.91%), Enterobacter sp (22.32%) and Acinetobacter (20.54%): 45% of MDRO infected patients died. Bivariate analysis was conducted to find the effect of MDRO infection on burn patient mortality (RR 1,103; 95% CI 1,004-1,211, p=0.046). After adjusting for the role variables, namely: age, comorbidities, TBSA, use of medical devices, length of stay and multivariate analysis, it was found that the variables that had an effect on MDRO infection mortality were length of stay and age. MDRO infection has an effect on the mortality rate of burn patients. Mortality of burn patients due to MDRO infection is greater (45%) compared to non MDRO (21.43%). The most common Gram-negative MDRO pathogen is K. pneumoniae. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the characteristics and prognostic value of the neutrophil/lymphocyte ratio (NLR) in patients with severe burns. A retrospective study was conducted on 245 burn patients over 18 years old without comorbidity or combined injury, burn extent =20% TBSA, hospitalized within 24 hours after burn. The collected criteria included patient characteristics, NLR on admission, 3rd and 7th day after burn, and outcome. The results showed that NLR was higher than the normal value at all collected times. In addition, compared to the survivor group, NLR on admission, 3rd and 7th day after burn was significantly higher in the mortality group (p <.01). Multivariate analysis found that the NLR on the 7th day postburn was an independent factor associated with mortality (p <.05), along with the increase in age, burn extent, and presence of inhalation injury (AUC = .85; cut off: 14.13; sensitivity: 75% and specificity: 83.43%). In conclusion, NLR on the 7th day post burn may be used as a predictive factor for mortality amongst severe burn patients. [ABSTRACT FROM AUTHOR]

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Canadian Studies in Population is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Les rhumatismes inflammatoires chroniques comprennent la polyarthrite rhumatoïde, les spondyloarthrites et le rhumatisme psoriasique. Ce sont des pathologies articulaires mais pouvant avoir une atteinte systémique. Les patients atteints de RIC ont un risque accru de comorbidités, aussi bien du fait de l'activité de la maladie que de l'utilisation de certains traitements tels que les corticoïdes. Ainsi, on retrouve une mortalité plus importante chez ces patients, notamment dans la polyarthrite rhumatoïde avec un risque de mort prématurée augmentée de moitié par rapport à la population générale dans les études épidémiologiques du début des années 2000. Cependant les formes sévères, notamment au niveau radiologique, des rhumatismes inflammatoires chroniques semblent en diminution. Cette revue rapporte l'évolution de l'incidence, de la prévalence et de la mortalité des rhumatismes inflammatoires chroniques et tente de répondre à l'imputabilité des biothérapies dans la diminution de sévérité des rhumatismes inflammatoires chroniques. Chronic inflammatory rheumatism includes rheumatoid arthritis, spondyloarthritis and psoriatic arthritis. These diseases are mainly focused on joint involvement but also have systemic involvement. Patients with chronic inflammatory rheumatism have an increased risk of comorbidities, both due to disease activity and the use of certain treatments such as corticosteroids. Thus, a higher mortality rate was shown in these patients, particularly in RA, with a risk of premature death increased by half compared to the general population in epidemiological studies from the early 2000s. However, severe forms of chronic inflammatory rheumatism, particularly at the radiological level, seem to be decreasing. This review reports the evolution of the incidence, prevalence and mortality of chronic inflammatory rheumatism and attempts to answer the attributability of biotherapies in the reduction in severity of RIC. [ABSTRACT FROM AUTHOR]

Cette revue de la littérature fait le point sur la mortalité, son évolution et les causes de décès au cours des principales maladies auto-immunes (MAI) prises en charge en rhumatologie. Ainsi il existe une surmortalité globale des MAI comparativement à la population générale, en particulier au cours du lupus érythémateux systémique, de la sclérodermie (surtout pour la forme diffuse), des myopathies (dermatopolymyosite > polymyosite) et des vascularites à ANCA. Les données sont contradictoires et ne permettent pas de conclure pour la maladie de Sjögren. Il ne semble pas y avoir de surmortalité au cours des connectivites mixtes. Les données de l'OMS entre 2001 et 2014 témoignent également d'une forte hétérogénéité de la mortalité selon les pays et les continents, expliquée en partie par les différences d'accès aux soins, au diagnostic et aux thérapeutiques de ces maladies rares mais également par des caractéristiques génétiques spécifiques de certaines ethnies et des facteurs environnementaux influençant leur sévérité. Globalement la tendance est à l'amélioration de la survie grâce à de meilleures prises en charge diagnostiques et thérapeutiques des atteintes d'organes de ces MAI, des comorbidités associées et des effets secondaires des traitements qui constituent les principales causes de décès. This review of the literature takes stock of mortality, mortality trends and causes of death in the main autoimmune diseases (AIDs) treated in rheumatology. There is an overall excess mortality rate in AIDs compared with the general population, particularly in systemic lupus erythematosus, scleroderma (especially the diffuse phenotype), myopathies (dermatopolymyositis > polymyositis) and ANCA vasculitides. The data are contradictory and do not allow any conclusions to be drawn for primary Sjögren's syndrome. There does not appear to be any excess mortality in the course of mixed connectivities. WHO data between 2001 and 2014 also show a high degree of heterogeneity in mortality between countries and continents, partly explained by differences in access to care, diagnosis and treatment for these rare diseases, but also by the specific genetic characteristics of certain ethnic groups and environmental factors influencing their severity. Globally, the trend is towards improved survival thanks to better diagnostic and therapeutic management of the organ damage associated with these AIDs, the associated co-morbidities and the side-effects of treatment, which are the main causes of death. [ABSTRACT FROM AUTHOR]

Cet article décrit le poids, les facteurs de risque, la mortalité et les tendances évolutives et à venir des fractures de l'extrémité supérieure du fémur en France. Le choix s'est porté sur l'analyse des données nationales disponibles en France avec notamment un focus méthodologique sur la caractérisation de l'événement et des paramètres associés étudiés. Si cette fracture est notamment observée chez le sujet âgé (60 ans et plus) et la femme, on ne peut négliger le rôle d'autres facteurs de risque tels les comorbidités avec notamment une place pour la démence et la dialyse, les fractures ostéoporotiques antérieures et l'insuffisance de prise en charge thérapeutique. La mortalité immédiate ou dans les suites de cette facture, qu'elle soit attribuable ou non à cette dernière, n'est pas à être sous-estimée. Si la tendance montre une augmentation du nombre des hospitalisations notamment liée aux évolutions démographiques, les projections estimées soulignent une hausse préoccupante, en particulier chez la femme, nécessitant une attention immédiate et des stratégies préventives efficaces. Il persiste le besoin de prioriser l'ostéoporose en tant que préoccupation majeure de santé publique en France. This article describes the burden, risk factors, mortality, and evolutionary and future trends of upper femoral fractures of the in France. The choice was made to analyze the national data available in France, with a methodological focus on characterizing the event and the associated parameters studied. While this fracture is particularly common in the elderly (aged 60 and over), especially women, the role of other factors cannot be overlooked, such as co-morbidities (with a particular focus on dementia and dialysis), previous osteoporotic fractures and inadequate therapeutic management. Mortality, whether or no attributable to the fracture, should not be underestimated. While the trend shows an increase in the number of hospital admissions, linked to demographic trends, estimated projections point to a worrying rise, particularly among women, requiring immediate attention and effective preventive strategies. There is still a need to prioritize osteoporosis as a major public health concern in France. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Anatolian Clinic Journal of Medical Sciences is the property of Hayat Saglik ve Sosyal Hizmetler Vakfi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The coronavirus disease (COVID) pandemic is still ongoing. Computed tomography (CT) is widely used in coronavirus disease-2019 (COVID-19) patients for lung damage determination. The aim of this study was to investigate the relationship between mortality rates and measurements of intrathoracic anatomical structures using CT images. Methods: This retrospective study was conducted in a single center and included a total of 322 cases, namely, 147 deceased and 175 surviving patients. All patients were diagnosed with COVID-19 on the basis of a positive polymerase chain reaction test. Total lung volumes, diameters of major vascular structures, comorbidity status, and laboratory blood tests were measured or determined. Total lung volumes were calculated using the range of -1024 to -300 Hounsfield Unit in the Slicer application. Results: A decrease in total lung volume was associated with a higher mortality rate (p<0.001). Increases in right and left pulmonary artery diameters were associated with high mortality rate (p=0.002 and 0.001, respectively). Increase in cardiothoracic ratio and decrease in thorax diameter were associated with high mortality rate in female patients (p=0.013 and p<0.001, respectively). It was found that patients with cardiovascular disease (p=0.043), chronic lung disease (p=0.005) and renal failure (p<0.001) had a significant mortal course. Elevated values of white blood cell count (p=0.018), aspartate aminotransferase (p<0.001), lactate dehydrogenase (p<0.001) and C-reactive protein (p<0.001) were found to be associated with high mortality rates. Conclusion: Total lung volume and intrathoracic main vascular sizes can be obtained from CT images using computer applications, and these measurements can provide an idea of the mortality rate in COVID-19 patients. In addition, comorbidity status and laboratory blood parameters can be used as prognostic markers. [ABSTRACT FROM AUTHOR]

Les urgences chirurgicales néonatales regroupent un ensemble d'affections qui nécessitent une prise en charge immédiate et adéquate en raison d'une menace vitale ou fonctionnelle. Notre travail a pour but de déterminer la fréquence et les facteurs épidémiologiques ainsi que le pronostic à court et moyen termes. Nous rapportons une étude rétrospective des urgences chirurgicales néonatales colligées sur une période de 12 mois. Ont été inclus, tous les nouveau-nés admis dans le cadre d'une urgence chirurgicale, opérés ou non, durant la période néonatale. Les anomalies étaient dominées par 46,5 % par le tableau d'occlusion néonatale, 18,6 % des nouveau-nés avaient une atrésie de l'œsophage, 10,4 % une anomalie de la paroi abdominale, 9,3 % une anomalie thoracique et 5,8 % des anomalies neurologiques, 3,4 % admis pour des malformations de l'arbre urinaire et anomalies ORL et 2,3 % une cause tumorale. Sur le plan thérapeutique 79 % des nouveau-nés avaient bénéficié d'un geste chirurgical. L'évolution clinique est marquée par le décès de 32 patients, soit 37 %. Les urgences chirurgicales néonatales requièrent une prise en charge immédiate et adéquate. D'où l'intérêt du suivi des grossesses et du diagnostic anténatal et de l'examen systématique et minutieux du nouveau-né en salle de naissance afin d'améliorer la prise en charge et le pronostic. Neonatal surgical emergencies include conditions that require immediate and adequate management due to a vital or functional threat. Our paper aims to determine the frequency and epidemiological factors as well as the short- and long-term prognosis. We report a retrospective study of neonatal surgical emergencies collected over a period of 12 months. Included were all newborns admitted as part of a surgical emergency, operated on or not, during the neonatal period. The anomalies were dominated by 46.5% by the neonatal occlusion, 18.6% of the newborns had esophageal atresia, 10.4% an abdominal wall anomaly, 9.3% a thoracic anomaly and 5.8% neurological abnormalities, 3.4% admitted for malformations of the urinary tree and ENT abnormalities and 2.3% a tumor cause. Therapeutically, 79% of newborns had benefited from a surgical procedure. The clinical evolution is marked by the death of 32 patients that is 37%. Neonatal surgical emergencies require immediate and adequate management. Hence, the interest of monitoring pregnancies and antenatal diagnosis and systematic and careful examination of the newborn in the birth room in order to improve management and prognosis. [ABSTRACT FROM AUTHOR]

Objective: Severe congenital neutropenia is a rarely encountered heterogeneous group of disorders characterized by myeloid maturation arrest in the bone marrow. The present study aimed to discuss clinical and laboratory findings, genetic mutations, therapeutic approaches and outcomes in these rarely seen seven cases followed up with the diagnosis of Kostmann syndrome in a single center so as to make a contribution to the literature. Method: In this retrospective study, data of the seven cases followed up with the diagnosis of Kostmann syndrome were retrieved from the patient files. The diagnosis was established based on an absolute neutrophil count of <500/mm³ persisting for more than 3 months and presence of HAX-1 gene mutations detected by positive molecular genetic analysis. Results: All patients were born to consanguineous parents. Six of the seven cases had sibling history. All cases had homozygous HAX-1 mutation. Case 1 had motor-mental retardation and case 5 had urogenital system anomaly. Mortality or malignancy was not encountered in any of the cases despite the absence of prophylactic granulocytecolony stimulating factor (G-CSF) therapy. Conclusion: The diagnosis and differential diagnosis of congenital neutropenia must be considered in the patients presenting with neutropenia and recurrent infections. Monitoring of the cases with severe neutropenia like Kostmann syndrome carries extreme importance. Families should be educated in terms of early signs of infection and importance of regular patient monitoring for prophylactic G-CSF-free management of the disease. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Canadian Journal of Hospital Pharmacy / Journal Canadien de la Pharmacie Hospitalière is the property of Canadian Society of Hospital Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Population & Sociétés is the property of Institut National d'Etudes Demographiques and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Maternal Early Warning Criteria including; systolic - diastolic blood pressure, peripheral oxygen saturation and urine output, is a useful marker for predicting postoperative complications. Shock index and the modified shock index were used to determine the need for fluid and transfusion in hypovolemia. The aim of this study is to evaluate the effectiveness of using shock index and modified shock index as a parameter of the early warning system to predict the need for postpartum blood transfusion, complications and mortality in pregnancy-related hypertensive diseases. Methods: Following the Ethics Committee approval, between 2012-2017, 192 patients between the ages of 13-47, undergoing caesarean section due to preeclampsia, eclampsia, chronic hypertension and gestational hypertension were enrolled in this study. Results: There was a positive correlation between SI and embolism and arrhythmia at admission and between the modified shock index and Intrauterine Growth Retardation at delivery (p<0.05). There is a significant positive correlation between the shock index and modified shock index at admission and fresh frozen plasma and Platelet suspension transfusion. There is a significant positive correlation between the shock index at delivery and packed red blood cells, fresh frozen plasma, and platelet suspension transfusion. There is a significant positive correlation between the modified shock index at delivery fresh frozen plasma and packed red blood cells transfusions (p<0.05). Conclusion: It was concluded that modified shock index and shock index could important markers in predicting maternal and fetal complications in hypertensive diseases due to pregnancy as well as postpartum blood transfusion. [ABSTRACT FROM AUTHOR]

Objective: Methyl alcohol, which is quite cheap compared to ethyl alcohol, can be used to produce imitated alcohol. For this reason, cases of methyl alcohol intoxication can be observed from time to time. Although it is rare, it is an emergency that needs to be diagnosed and treated early because of its high mortality. Methods: In this study, 22 patients aged ≥18 years who were admitted to the intensive care unit (ICU) due to methyl alcohol intoxication between 2015 and 2022 were included. The patients were divided into 2 groups, survivor and non-survivor, and compared retrospectively in terms of factors predicting mortality. Results: Except for one of the 22 patients included in the study, all patients developed methyl alcohol intoxication because of the use of imitated alcohol. Only one patient had a history of using perfume for suicidal purposes. Of the patients who developed methyl alcohol intoxication, 13 (59%) were in the non-survivor group and 9 (41%) were in the survivor group. While the rate of invasive mechanical ventilation needed before the ICU was 55.6% in the survivor group, it was 100% in the non-survivor group, and there was a statistically significant difference between them (p<0.017). In the non-survivor patient group, blood HCO3 and pH levels were found to be significantly lower after ICU admission (p=0.002, p=0.008). At the same time, blood creatinine, potassium, and total bilirubin levels were significantly higher (p=0.002, p=0.007, p<0.035). Acute physiology and chronic health evaluation-II and sequential organ failure assessment scores after ICU admission were also significantly higher in the non-survivor group than in the survivor group (p=0.005, p=0.035). Conclusion: It was determined that in patients who died due to methyl alcohol intoxication, deeper metabolic acidosis and irreversible multiorgan failure developed during the period until ICU admission. The acute physiology and chronic health evaluation-II and sequential organ failure assessment scores were both effective in predicting mortality. [ABSTRACT FROM AUTHOR]

Objective: This study developed a prediction model that can predict the intensive care admission of coronavirus disease-2019 (COVID-19) pregnant and postpartum women. Materials and Methods: The study was retrospective and single-center and was conducted with pregnant and postpartum patients 18 years of age and older who had been diagnosed with COVID-19 and were admitted to the obstetrics clinic between April 2020 and December 2021. The clinical and radiological featuresand laboratory values of the patients were recorded to develop a prediction model. Two different multivariate logistic regression models and the Naive Bayes classification algorithm were used for estimation. The results of the developed prediction models were summarized with the nomogram, and the prediction successes were evaluated with the receiver operating characteristic (ROC) curve. Results: The study included 436 pregnant and postpartum patients. Twelve of 51 patients admitted to the intensive care unit died. The specificities of the three different classification models that we developed to determine the risk factors for intensive care admission were found to be over 95% and their sensitivities were 70.6%, 86.3%, and 87%, respectively. Additionally, the area under the ROC values were found to be 0.94, 0.941 and 0.978 for the models, respectively. High procalcitonin level, fever, dyspnea, and moderate-to-severe radiological involvement were determined as risk factors for admission to intensive care in pregnant and postpartum women patients. Conclusion: It is thought that the risk models we have developed will be easy to implement and will help identify pregnant women who are at risk of severe COVID-19 disease in the early period and to take measures. [ABSTRACT FROM AUTHOR]

Aim: Upper gastrointestinal bleeding (UGK) is one of the leading causes of emergency department admissions and hospitalizations. Various risk scores are used to predict the need for invasive treatment (endoscopic hemostasis, blood transfusion, surgical management), rebleeding, and mortality at the time of admission. Our study aims to compare the performance of preendoscopic Rockall (pRS), Glasgow-Blatchford bleeding (GBS), and AIMS-65 scores before endoscopy in predicting high-risk groups. Methods: Patients who were admitted to the emergency department between January 2015 and June 2016 and were diagnosed as non-variceal UGR after clinical, laboratory, and/or endoscopic evaluation were retrospectively screened. Demographic and clinical characteristics, laboratory values, scoring points, endoscopic intervention, and clinical course (blood transfusion, rebleeding, surgical management, death) were recorded. Results: 163 patients (79% male) with a median age of 57.2± 18.7 years were included in the study. To stop bleeding, endoscopic intervention was performed in 92 patients (56.4%) and surgical intervention was performed in 6 patients (3.7%). Rebleeding occurred in 9.2% of the patients (15 patients). 63.8% (104 patients) received a blood transfusion. The mortality rate was 2.5% (4 patients). AIMS-65 score was found to be superior to others in predicting mortality (AUROC= 0.892, p=0.007). GBS was found to be superior to others in predicting rebleeding, blood transfusion, and surgical management (AUROC=0.697, p=0.012; AUROC=0.778, p<0.001, and AUROC=0.851, p=0.004, respectively). pRS and AIMS-65 are similarly effective in predicting endoscopic intervention and are superior to GBS (AUROC=0.379, p=0.008 and AUROC=0.378, p=0.008, respectively). Conclusion: The AIMS-65 score was identified to be superior in predicting mortality. GBS score was identified to be superior in predicting rebleeding, blood transfusion, and the need for surgery. None of the scores were effective in predicting endoscopic intervention. The combined use of GBS and AIMS-65 can be useful in determining UGK with the high-risk group in the emergency department. [ABSTRACT FROM AUTHOR]

Objective: In this study, we aimed to contribute to the literature by determining data such as mortality rates, demographic, clinical and radiological characteristics of patients who applied to our hospital's emergency department between January 2011 and December 2020 with the diagnosis of SISH and were operated on in our clinic. Methods:53 patients who were operated on for SISH diagnosis between January 2011 and December 2020 were retrospectively examined. Patients with SISH on brain tomography (CT) were evaluated. Hematoma localization is lobar; those with frontal, parietal, temporal and occipital locations; Those in the thalamic, putaminal and basal ganglia were considered to be deeply located. Patients were divided into three groups according to the Glasgow coma score (GCS): GCS 5-8, GCS 9-12, and GCS 13-15. Results: In our cohort, the patients mean age was 62.8 years (range, 19-92). The overall mortality rate was 62.87%. Age showed no significant association with mortality. Mortality was associated with increased hematoma volume and low GCS score at the first presentation (p < 0.001). In receiver operating characteristic curve analysis, hematoma volume was an important predictor of surgical outcome; the optimal cut-off value of 59.5 cm3 was associated with 84.4% sensitivity and 90.5% specificity (p < 0.001). Similarly, the optimal GCS score cut-off value of 8.5 was associated with a 96.9% sensitivity and 71.4% specificity for predicting mortality (p < 0.001). Conclusions:Low GCS, increased hematoma volume, and especially the presence of concomitant hypertension (HT) are associated with poor prognosis in SISH patients. [ABSTRACT FROM AUTHOR]