1. Easy Silica Gel Supported Desymmetrization of PEG
- Author
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Francesco Nicotra, Barbara La Ferla, Cristiano Zona, LA FERLA, B, Zona, C, and Nicotra, F
- Subjects
chemistry.chemical_classification ,010407 polymers ,010405 organic chemistry ,Silica gel ,Organic Chemistry ,Hydroxy group ,technology, industry, and agriculture ,monoprotection, desymmetrisation, PEG ,Polymer ,01 natural sciences ,Desymmetrization ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,CHIM/06 - CHIMICA ORGANICA ,PEG ratio ,Polymer chemistry ,Organic chemistry ,Ethylene glycol - Abstract
Our work shows how poly(ethylene glycol), differentially functionalized at two ends, can be easily and efficiently synthesized from commercial symmetric dihydroxy PEG 600. First, we linked the polymer onto functionalized silica gel using one of its hydroxy ends. Then, the second hydroxy group was modified, and finally, the desymmetrized PEG was cleaved from the solid support.
- Published
- 2009
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