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Abstract It is important to directly characterize the modulus of objects through wearable systems, which can further develop electronic skin and human‐computer interaction. In this work, a modulus sensing system based on a pressure sensor and vibration module is developed. This resistive pressure sensor exhibits good linearity and sensitivity. Combined with the vibration module to adjust the applied stress and strain, the modulus value of the objects can be directly calculated. The modulus sensing system demonstrates excellent modulus monitoring capabilities in the range of 60‒3000 kPa modulus and high linearity. In addition, it is used to detect modulus values for different parts of the human body and integrate a concept eye mask to prevent and monitor migraine. The system shows the potential to be further applied to wearable devices for human health monitoring and disease prevention.