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This study introduces a new electrochemical sensor for bisphenol A (BPA) and metal ions utilizing a microsphere dual‐ligand Ni‐based MOFs modified carbon paste. The MOFs (Ni‐bipy‐btc) synthesized from dual‐ligands were prepared via a hydrothermal method and characterized using X‐ray diffraction (XRD), scanning electron microscope (SEM), FT‐IR spectrometer, X‐ray photoelectron spectrum (XPS), and specific surface area test (BET) analysis. The resulting MOFs exhibited promising performance as electrode materials for electrochemical sensors targeting the detection of BPA and heavy metal ions (Pb2+ and Cu2+). The linear range of the MOFs (Ni‐bipy‐btc)/CPE electrode for BPA detection ranged from 0.2 to 150 μM, with a detection limit of 0.045 μM, demonstrating robust immunity and stability. Additionally, the limit of detection for the MOFs (Ni‐bipy‐btc)/CPE electrode was found to be 4.3 and 9.5 nM for Pb2+ and Cu2+ ions, respectively, showcasing excellent stability and reproducibility. This study presents a straightforward approach for the highly sensitive electrochemical detection of BPA and heavy metal ions using a simple hydrothermal reaction method. [ABSTRACT FROM AUTHOR]

The crystal structures of mixed-ligand sulfato-, selenato-, phosphato-, arsenato-, and chromato-fluoride complexes of uranyl and of mixed-ligand carboxylato-fluoride and mixed-ligand fluoride complexes with neutral donor ligands studied by the single-crystal X-ray diffraction method were systematized and discussed. The crystal chemical features of the structures of the mixed-ligand fluoride complexes of uranyl were determined: the coordination polyhedron of the hexavalent uranium atom in the structures of the mixed-ligand fluoride complexes of uranyl (except for three hexagonal-bipyramidal complexes) has a pentagonal-bipyramidal structure: the oxygen atoms of the uranyl group are located on the vertical axis of the pentagonal bipyramid, perpendicular to the equatorial plane in which five atoms are located. In dimeric and polymeric chains of mixed-ligand fluoride complexes of uranyl (with the exception of one compound in which the common bridge in the dimer complex is oxygen atoms), the uranyl units are linked via fluoride bridges. Inorganic and organic ligands, which contained O-donor atoms, combine dimers and polymer chains into layers and three-dimensional formation. [ABSTRACT FROM AUTHOR]

A fluoride-aided stabilization of manganese(III) was demonstrated by the preparation of unique complexes of the molecular mixed ligand fluoromanganate(III) from an aqueous medium. Complexes of mixed ligand fluoromanganate(III) were synthesized by reacting MnO(OH), 40% HF with nitrogen donor ligands that may function as neutral ligands, such as pyridine, ethylene diamine, or imidazole. The molecular complexes that were generated are stable and may be kept in polythene bags for extended periods of time without losing their properties. Consistency may be determined in a number of ways, including chemical analysis of the manganese oxidation state and periodic estimation of manganese and fluoride levels. The compounds dissolve slowly in water and partly in polar organic solvents. Element analyses, chemical oxidation state determination, FT-IR, electronic spectra, magnetic moment measurements at room temperature, thermogravimetric analysis (TGA/DTA), scanning electron microscopy (SEM), and cyclic voltammetry studies were used to characterize the complexes. The complexes produced probably have a distorted octahedral shape. [ABSTRACT FROM AUTHOR]

Crystalline organic–inorganic hybrids, which exhibit colorimetric responses to ionizing radiation, have recently been recognized as promising alternatives to conventional X‐ray dosimeters. However, X‐ray‐responsive organic–inorganic hybrids are scarce and the strategy to fine‐tune their detection sensitivity remains elusive. Herein, an unprecedented mixed‐ligand strategy is reported to modulate the X‐ray detection efficacy of organic–inorganic hybrids. Deliberately blending the stimuli‐responsive terpyridine carboxylate ligand (tpc−) and the auxiliary pba− group with different ratios gives rise to two OD thorium‐bearing clusters (Th‐102 and Th‐103) and a 1D coordination polymer (Th‐104). Notably, distinct X‐ray sensitivity is evident as a function of molar ratio of the tpc− ligand, following the trend of Th‐102 > Th‐103 > Th‐104. Moreover, Th‐102, which is exclusively built from the tpc− ligands with the highest degree of π–π interactions, exhibits the most sensitive radiochromic and fluorochromic responses toward X‐ray with the lowest detection limit of 1.5 mGy. The study anticipates that this mixed‐ligand strategy will be a versatile approach to tune the X‐ray sensing efficacy of organic–inorganic hybrids. [ABSTRACT FROM AUTHOR]

Seven novel 4-dimethylaminopyridine(dmap)-based metal complexes of [Zn(dmap)(cna)2]2 (1) (Hcna = cinnamic acid), [Zn(dmap)(dcpa)2]2 (2) (Hdcpa = 2,6-dichlorophenylacetic acid), [Zn(dmap)(mpba)2]2 (3) (Hmpba = 3-phenoxybenzoic acid), [Zn(dmap)(bdmba)2]2 (4) (Hbdmba = 4-bromo-3,5-dimethoxybenzoic acid), [Cd(damp)2(ibfa)2(H2O)2] (5) (Hibfa = ibuprofen), [Cd(dmap)2(H2O)4]·(dnba)2·H2O (6) (Hdnba = 3,5-dinitrobenzoic acid) and [Cd(dmap)2(bdmba)2(H2O)] (7) have been afforded by the introduction of the carboxylates as the auxiliary ligands and are structurally featured by distinct techniques of EA, IR spectra, TG and SCXRD analysis. The X-ray studies told that these complexes display mononuclear, binuclear to polymeric appearances with tetrahedral/square-pyramidal arrangement at the Zn2+, and octahedral/pentagonal-bipyramidal geometry for the Cd2+. The dmap in 1–7 are coordinated only in monodentate fashion with its ring N. The carboxylates coordinated to the metal ions in monodentate, chelating bidentate and bismonodentate bridging modes for 1–5 and 7. The carboxylates at 6 did not coordinated to the Cd and exhibited only as the counter ion to balance the charge. The CH3···O contacts from the N(CH3)2 of the dmap were built in all compounds, apart from 1 and 6. The π-associates originating from the aryl kernel of the anions were existed in 2–3 and 6–7. The intricate intra- and intermolecular classical H-bonds, CH···C, CH···O/CH3···O, CH···CH/CH3···CH/CH3···CH3, CH···Cl, CH3···Br, Br···Br, CH···π/CH2···π/CH3···π and π···π associations are elucidated by the X-ray crystallographic investigations, which push the discrete complexes into high-dimensional ordered supramolecular structures. In the seven prepared coordination complexes there are plenty of weak nonbonding interactions such as directional hydrogen bonds of O–H···O, intra- and interchain CH–C, CH–O/CH3–O, CH–CH/CH3–CH/CH3–CH3, CH–Cl, CH3–Br, Br–Br, CH–π/CH2–π/CH3–π and π–π interactions, on account of these collective weak interactions, these compounds displayed the 3D framework structures. [ABSTRACT FROM AUTHOR]

Abstract Crystalline organic–inorganic hybrids, which exhibit colorimetric responses to ionizing radiation, have recently been recognized as promising alternatives to conventional X‐ray dosimeters. However, X‐ray‐responsive organic–inorganic hybrids are scarce and the strategy to fine‐tune their detection sensitivity remains elusive. Herein, an unprecedented mixed‐ligand strategy is reported to modulate the X‐ray detection efficacy of organic–inorganic hybrids. Deliberately blending the stimuli‐responsive terpyridine carboxylate ligand (tpc−) and the auxiliary pba− group with different ratios gives rise to two OD thorium‐bearing clusters (Th‐102 and Th‐103) and a 1D coordination polymer (Th‐104). Notably, distinct X‐ray sensitivity is evident as a function of molar ratio of the tpc− ligand, following the trend of Th‐102 > Th‐103 > Th‐104. Moreover, Th‐102, which is exclusively built from the tpc− ligands with the highest degree of π–π interactions, exhibits the most sensitive radiochromic and fluorochromic responses toward X‐ray with the lowest detection limit of 1.5 mGy. The study anticipates that this mixed‐ligand strategy will be a versatile approach to tune the X‐ray sensing efficacy of organic–inorganic hybrids.

A mixed-ligand zinc(II) complex, [Zn(Hpma)(phen)Cl] (where Hpma- = N-(2,6-dimethylphenyl)oxamate and phen = 1,10-phenanthroline), has been prepared by the reaction of zinc chloride, ethyl (2,6-dimethylphenylcarbamoyl)formate (Hdmp) and 1,10-phenanthroline under basic conditions in dimethylformamide. The structure of the complex was characterised by elemental analysis, IR, 1H-NMR, UV-Vis absorption and X-ray crystallography. The metal complex crystallises in the monoclinic system (space group P21/c) and is composed of the five-coordinate zinc ion in a distorted spherical square pyramidal geometry. Stabilisation of single crystals occurs through hydrogen bonds and p-p stacking interactions. [ABSTRACT FROM AUTHOR]

Two new Ag(I) coordination polymers, namely [Ag(bpp)]·0.5 n(1,5-NDSA)·n(H2O) (1) and [Ag2(bpp)2]n·n(2,7-NDSA)·2 n(H2O)·n(CH3CN) (2) (Na2(1,5-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, Na2(2,7-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, bpp is 1,3-bis(4-pyridyl)propane), were generated via the solution evaporation method under room temperature. Moreover, the solids of these two compounds display strong luminescence emission at RT. And the application values of the compounds against the glioblastoma treatment were determined, and the corresponding mechanism was simultaneously tested. The analysis of CCK-8 was first implemented and the glioblastoma viability was measured. The real-time RT-PCR was next performed, and the signaling pathway activation of VEGF in glioblastoma cells was tested after treating by the above compound.

A fresh Cu(II) coordination polymer, i.e., [Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1, H2mbdc = isophthalic acid, dmphen = 4,7-dimethyl-1,10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4,7-dimethyl-1,10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay.

Four mixed-ligand complexes were prepared and formulated as [Ln(H2OBA)(H2PZDC)] and [Ln(H2OBA)(H2PDC)] {Ln = La & Gd; H2OBA = 4,4-oxybisbenzoic acid; H2PDC = 2,3-pyridinedicarboxylic acid; H2PZDC = 2,3-pyrazinedicarboxylic acid}. The complexes were modified by a nickel/cobalt impregnation method to generate bimetallic complexes 1–8. Fourier transform infrared (FTIR) spectroscopy analysis of the bimetallic complexes indicated that the carboxylate coordinated to the lanthanide ion via the OH- group while the Ni2+ and Co2+ ions were preferentially bonded to the nitrogen donor ligand via the N- group. Complete catalytic reduction of 4-nitrophenol to 4-aminophenol by the Ni@ complexes gave a maximum reduction time of 37 minutes for complex 1 while complex 7 gave a reduction time of 21 minutes. The rate constants were observed to increase with an increase in temperature up to 50 °C for complexes 3, 5, and 7. [ABSTRACT FROM AUTHOR]

We report the synthesis and characterization of two types of new mixed-ligand rare earth complexes: tetracoordinate (NacNacMes)Ln(BIANdipp) (Ln = Dy (1), Er (2) and Y (3)) and pentacoordinate (NacNacMes)Ln(APdipp)(THF) (Ln = Dy (4), Er (5) and Y (6)). The first three compounds were prepared by the reaction of [(BIANDipp)LnI] with potassium β-diketiminate. The salt metathesis of β-diketiminato-supported rare earth dichlorides (NacNacMes)LnCl2(THF)2 with sodium o-amidophenolate results in compounds 4–6. The crystal structures of complexes 1–6 were determined by single-crystal analysis. The combination of bulky monoanionic N-mesityl-substituted β-diketiminates with sterically hindered redox-active ligands led to the very low coordination numbers of rare earths and strong distortion of the chelate ligands. [ABSTRACT FROM AUTHOR]

The designing of mixed linker MOFs with identical framework structures and different chemical components provides opportunities for enhancing their inborn adsorption and photo-degradation performances. Herein, we synthesized zinc, copper, manganese, and cobalt-based iso-reticular MOFs via the solvothermal method using 2,5-furan dicarboxylic acid and 1,2-bis(4-pridyl) ethylene as green ligands. The synthesized MOFs were applied for the adsorption-assisted photo-catalytic decontamination of bromophenol blue (BPB) from wastewater without using any co-catalyst under visible light irradiation. Note-worthily, Cu-MOF (BUT-206-Cu) exhibits high adsorption capacity (299 mg/g) and removal efficiency (97 %), mainly owing to the high surface area (280 m2/g), opened porous structure, additional defective sites, efficient energy transfer, and excellent stability in aqueous, and acidic environments resulting from the strong co-ordination environment of the copper cations. The impact of key factors, including initial pH and concentration of the dye solution, on the adsorption and degradation efficiency of BUT-206-Cu was investigated. Moreover, trapping experiments and EPR results revealed that OH• and h+ were the main active species in the photocatalytic degradation of BPB. Adsorption and degradation kinetics of BPB were observed to obey pseudo-second-order and pseudo-first order models, respectively. The thermodynamics study revealed that the adsorption of BPB fitted the Langmuir model, and values of the ΔG ads , ΔH ads , and ΔS ads revealed that the adsorption process is spontaneous, physical, and exothermic and leads to increased randomness in the system. BUT-206-Cu exhibited excellent reusability for up to five cycles, indicating its potential as an environmentally friendly integrated photocatalytic adsorbent for removing BPB from wastewater. [Display omitted] • Designing of a series of mixed linker iso-reticular forms via solvothermal method. • Adsorption assisted photocatalytic degradation of bromophenol blue using synthesized MOFs. • BUT-206-Cu exhibits high adsorption capacity (299 mg/g) and removal efficiency (97 %). • Strong co-ordination environment of the copper cations leads to synergistic properties of BUT-206-Cu. [ABSTRACT FROM AUTHOR]

• A new ternary Co(II) CP was synthesized and characterized. • The first dual-response fluorescence "turn-on" sensor to detect Tb3+ and PEF. • Compound 1 exhibited highly sensitive and selective for the sensing Tb3+ and PEF. • The possible mechanism of fluorescence enhancement was analyzed in detail. It is necessary to employ highly sensitive and rapid detection of antibiotics and heavy ions in the environment. A mixed-ligands ternary Co (II) coordination polymer containing new L ligands, {[Co(L)(mip)(H 2 O)]·2H 2 O} n (1), (L = 2,2′-bis-(2-pyridin-3-yl-vinyl)-3 H ,3′ H -[5,5]bibenzoimidazole, H 2 mip= 5-methylisophthalic acid) was synthesized under solvothermal condition. Compound 1 displays a sql 2D layer with the point symbol of {44.62}. Compound 1 owns excellent thermal and pH stability and can effectively sensitize the luminescence of Tb3+ ions through the "antenna effect". Compound 1 can serve as luminescent probe for detecting pefloxacin and Tb3+ with low detection limits. Especially Compound 1 is the first turn-on sensor for the detecting Tb3+ ions and pefloxacin via fluorescence enhancement. In addition, the sensing mechanism is discussed in detail. A noval ternary Co(II)-based coordination polymer was solvothermally synthesized and characterized, which can act as dual-functional luminescence turn-on sensor to detect Tb3+ and PEF in aqueous solution with high sensitivity, selectivity, and well anti-interference. The luminescence enhancement mechanism is supported by experiments and theoretical calculations. [Display omitted] [ABSTRACT FROM AUTHOR]

Thiosemicarbazone complexes possess structural diversity and variable bonding patterns and potential biological implications and ion sensing abilities. The ability of the transition metals to acquire different geometries like octahedral, square planar and tetrahedral in different coordination environments has encouraged researchers to explore the coordination chemistry of thiosemicarbazone complexes which can also vary upon changing aldehydes and ketones, substituents attached to the carbonyl moiety, metal and its oxidation state, geometries, counter ions, presence of a solvent or additional molecules in the structures and substituents on the S or N(4)-atoms. This review aims to summarize recent developments in the synthesis and medicinal importance of thiosemicarbazone ligands and particular emphasis on their metal complexes. The mixed ligand-metal complexes have an important role to play in biological systems because a number of ligands try to combine with the same metal ions in vivo. Different ligands have different biological activities producing synergetic results and enhancing the potency of the formed complex. They also have a role to play in the storage and transport of substances, therefore the review article also covers the mixed ligand complexes of thiosemicarbazones with hetero ligands like 1,10-phenanthroline, pyridine, triphenyl phosphine etc. and their mechanistic action and medicinal benefits in recent years. The binuclear complexes of thiosemicarbazones with two different and same metal ions have also been explored here. Dinuclear complexes have been shown to possess interesting structures and in most cases, such complexes containing metal–metal bond also affects the complex's magnetic properties as well. It has been well discussed in the course of this study that metal complexes show enhanced biological activity than the free ligand or metal ion. The studies cited in the review have been sourced from publications indexed in known databases. Some of the recently explored structural alterations have been discussed in the paper and future substituted thiosemicarbazones and their complexes may emerge as multi-target inhibitors. [ABSTRACT FROM AUTHOR]

A fresh Cu(II) coordination polymer, i.e., [Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1, H2mbdc = isophthalic acid, dmphen = 4,7-dimethyl-1,10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4,7-dimethyl-1,10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay. [ABSTRACT FROM AUTHOR]

Two new Ag(I) coordination polymers, namely [Ag(bpp)]·0.5 n(1,5-NDSA)·n(H2O) (1) and [Ag2(bpp)2]n·n(2,7-NDSA)·2 n(H2O)·n(CH3CN) (2) (Na2(1,5-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, Na2(2,7-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, bpp is 1,3-bis(4-pyridyl)propane), were generated via the solution evaporation method under room temperature. Moreover, the solids of these two compounds display strong luminescence emission at RT. And the application values of the compounds against the glioblastoma treatment were determined, and the corresponding mechanism was simultaneously tested. The analysis of CCK-8 was first implemented and the glioblastoma viability was measured. The real-time RT-PCR was next performed, and the signaling pathway activation of VEGF in glioblastoma cells was tested after treating by the above compound. [ABSTRACT FROM AUTHOR]

Metal-organic frameworks (MOFs) have emerged as a highly promising platform for various sensing applications due to their tunable structures and functionalities. In the present work, a Eu 3+ -doped mixed-ligand MOF, namely, the Eu 3+ @UiO-66-IPA, exhibited excellent luminescent properties and high fluorescence stability in aqueous media, displaying dual-emission peaks under 395 and 615 nm excitation that were readily visible to the naked eye. Importantly, the presence of fluoride ions (F - ) promoted the "antenna effect" between the ligand and the Eu 3+ centers, which significantly enhanced the emission intensity of the Eu 3+ characteristic peak. In addition, the addition of F - also inhibited the quenching effect of high-energy O-H bonds existing in the aqueous environment. Notably, Eu 3+ @UiO-66-IPA demonstrated exceptional selectivity for F - over a range of competing anions, with a remarkable limit of detection as low as 0.22 μM. The developed Eu 3+ -doped mixed-ligand MOF system offers a highly promising strategy for the simple and accurate sensing of F - in practical applications.

By utilizing the mixed-ligand method, two novel metal-organic frameworks (MOFs) based on Zn(II) ions as nodes with the chemical formulae of {[Zn2.5(abta)(trz)2(H2O)]·3H2O}n (1, Htrz = 1H-1,2,4-triazole) and [Zn3(abta)2(bibb)2]n (2, bibb = 1,4-bis(benzimidazol-1-yl)-2-butene) were produced via Zn(NO3)2·6H2O reacting with the 1-aminobenzene-3,4,5-tricarboxylic acid (H3abta) in the existence of distinct nitrogen-donor co-ligands. The different N-donor ligands result in their distinct framework structures, and the compound 1 with higher solvent accessible void and large window size shows highly heterogeneous catalytic activities for Knoevenagel condensation. The treatment of Staphylococcus aureus biofilms formation during spine surgery incision infection and the related mechanism was explored at the same time. First of all, the S. aureus bacterial numbers in the infectious site was measured under compound 1 or 2 treatment. In addition to this, the relative expression levels of the genes related with S. aureus biofilms was determined with real time RT-PCR.

The development of synthetic approaches towards new mixed‐ligand metal organic frameworks (MOFs) has been attracting considerable attention recently as they display fascinating properties due to the synergistic effect between the different ligands. Herein, the initial combination of pyridine‐2,6‐dimethanol (H2pdm) with benzene‐1,4‐dicarboxylic acid (H2bdc) has provided access to three new mixed‐ligand MOFs, [M3(bdc)2(Hpdm)2]n (MII=ZnII, 1; MnII, 2) and [Mn3(bdc)3(H2pdm)2]n (3). 1–3 are the first MOFs containing H2pdm in its neutral or anionic form. 1 and 2 are isostructural 2D MOFs with a square lattice (sql) framework topology, while 3 is a 3D MOF possessing a primitive cubic (pcu) topology. Dc magnetic susceptibility measurements for 3 demonstrate antiferromagnetic interactions between the MnII ions which is a combination of intra‐ and intertrimer exchange pathways. [ABSTRACT FROM AUTHOR]

Two new mixed‐ligand complexes with general formula [Cu(SB)(L')]ClO4 (1 and 2) were synthesized and characterized by different spectroscopic and analytical techniques including Fourier transform infrared (FT‐IR) and UV–Vis spectroscopy and elemental analyses. The SB ligand is an unsymmetrical tridentate NN'O type Schiff base ligand that was derived from the condensation of 1,2‐ethylenediamine and 5‐bromo‐2‐hydroxy‐3‐nitrobenzaldehyde. The L' ligand is pyridine in (1) and 2,2′‐dimethyl‐4,4′‐bithiazole (BTZ) in (2). Crystal structure of (2) was also obtained. The two complexes were used as anticancer agents against leukemia cancer cell line HL‐60 and showed considerable anticancer activity. The anticancer activity of these complexes was comparable with the standard drug 5‐fluorouracil (5‐FU). Molecular docking and pharmacophore studies were also performed on DNA (PDB:1BNA) and leukemia inhibitor factor (LIF) (PDB:1EMR) to further investigate the anticancer and anti‐COVID activity of these complexes. The molecular docking results against DNA revealed that (1) preferentially binds to the major groove of DNA receptor whereas (2) binds to the minor groove. Complex (2) performed better with 1EMR. The experimental and theoretical results showed good correlation. Molecular docking and pharmacophore studies were also applied to study the interactions between the synthesized complexes and SARS‐CoV‐2 virus receptor protein (PDB ID:6LU7). The results revealed that complex (2) had better interaction than (1), the free ligands (SB and BTZ), and the standard drug favipiravir. [ABSTRACT FROM AUTHOR]

In the present study, through employing the mixed ligands of tetrakis(4-carboxyphenyl)silane (H4TCS) and 1,4-bis(2-methylimidazol-1-yl)benzene (BMIB), we have triumphantly created two coordination polymers (CPs) [Co2(TCS)(BMIB)2](DMF)3(H2O)2 (1) and [Co2(H2TCS)2(BMIB)2] (2) with the reaction between the H4TCS ligand and BMIB ligand and Co(NO3)2·6H2O in distinct systems of solvent. Their application values on the acute myocardial infarction were assessed, and then their corresponding mechanism was investigated. Firstly, the ELISA detection assay was performed for the detection of the inflammatory cytokines levels released into plasma during acute myocardial infarction. In addition to this, the real-time RT-PCR was performed and the lncRNA-CAIF levels were determined. [ABSTRACT FROM AUTHOR]

In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are [Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda is 1,2-phenylenediacetic acid) and [Co(mpda)(mbib)]·H2O (2, H2mpda is 1,3-phenylenediacetic acid). The two compounds’ magnetic performances suggest that between the adjacent metal ions, there present the antiferromagnetic coupling. The evaluation of their treatment activity against chronic subdural hematoma was carried out and the relevant mechanism was studied simultaneously. Firstly, before the treatment of compound, the chronic subdural hematoma was generated. Furthermore, the enzyme-linked immunosorbent assay detection kit was implemented and in hematoma capsule, the anti-inflammatory cytokines level and pro-inflammatory cytokines level was detected. Additionally, the cytotoxicity of compounds 1 and 2 on the normal human cells was determined with Cell Counting Kit-8 assay. Above all, we proved compound 1 decreased the pro-inflammatory cytokines content and increased the anti-inflammatory cytokines content in the hematoma capsule, which is much stronger than that of compound 2. Both compounds 1 and 2 showed no cytotoxicity on the normal human cells.

A new mixed-ligand Cu(II) complex, [Cu(pyr)(bpy)(OH2)]ClO4 (1), was synthesized from 4-acetyl-3-methyl-1-phenyl-2-pyrazoline-5-one (H-pyr) and 2,2-bipyridine (bpy). Single-crystal X-ray diffraction, elemental analysis, and FTIR and UV–Vis spectroscopy were used to confirm its structure. The pyr ligand is the monoanionic deprotonated form of the H-pyr enol tautomer. Additionally, the complex's battery-like capabilities were investigated. The newly synthesized complex possessed a high specific capacity and provided sufficient energy density for SC devices. Electrochemical evaluations, such as cyclic voltammetry, galvanostatic charge/discharge, and electrochemical impedance spectroscopy (EIS), indicated that (1) with redox of metal-center holds satisfactory capacity and delivered energy when constructed in three- or two-electrode configuration (KOH 3 M). (1) displayed battery-like qualities (b-value ~ 0.88), as determined by the diffusion contribution at various scan rates. In an alkaline environment, the EIS measurements revealed a low interfacial charge resistance. The maximum specific capacity measured in the three-electrode system was 483 C g−1 (413.6 C g−1 at 2 mV s−1) at a current density of 1 A g−1. These pyrazolone-based compounds would be promising candidates for further energy storage. [ABSTRACT FROM AUTHOR]

In the present study, a metal–organic framework ([Zn(bim)2(bdc)]n, MOF‐ZBB) compound was prepared and applied as an adsorbent for the removal of strontium ions from aqueous solutions. The influences of several variables such as pH, contact time, and temperature were studied in batch experiments. The effect of interfering cations (Ca2+, Mg2+, Na+, and K+) on the adsorption behavior was also investigated. The Freundlich, Langmuir, and Dubinin–Radushkevich isotherm models were used for the analysis of equilibrium data. The maximum adsorption capacity by applying the Langmuir equation was 123.451 mg g−1 at 75°C with a pH of 7. The thermodynamic study revealed that the adsorption process is endothermic and spontaneous. The results showed that the pseudo‐second‐order kinetic model for adsorption strontium ions onto MOF‐ZBB better described the adsorption process. Finally, the fixed‐bed column experiments were carried out at different feed flow rates to investigate the dynamic capacity of the adsorption process. The results revealed a decrease of about 80% in the efficiency of the column by increasing the flow rate from 1 to 4 ml min−1. [ABSTRACT FROM AUTHOR]

Two novel mixed-ligand coordination polymers, {[Co(tdc)(btrp)]·0.67DMF}n (1) and {[Zn2(bimb)2(tdc)2]·2H2O}n (2) involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb), have been synthesized by the hydrothermal method and characterized via IR, elemental analysis, thermal analysis, and powder X-ray diffraction. The biological functional studies were performed; the treatment activity of the compounds on periodontitis and the specific mechanism was explored. First, the real-time RT-PCR was carried out to determine the inflammatory genes nf-κb and p53 relative expression in periodontal mucosal cells after treating with compounds 1 and 2. Then, the level of the inflammatory cytokine in the gingival crevicular fluid after treating with compounds was also determined by the ELISA detection kit.

We report the synthesis and characterization of two types of new mixed-ligand rare earth complexes: tetracoordinate (NacNacMes)Ln(BIANdipp) (Ln = Dy (1), Er (2) and Y (3)) and pentacoordinate (NacNacMes)Ln(APdipp)(THF) (Ln = Dy (4), Er (5) and Y (6)). The first three compounds were prepared by the reaction of [(BIANDipp)LnI] with potassium β-diketiminate. The salt metathesis of β-diketiminato-supported rare earth dichlorides (NacNacMes)LnCl2(THF)2 with sodium o-amidophenolate results in compounds 4–6. The crystal structures of complexes 1–6 were determined by single-crystal analysis. The combination of bulky monoanionic N-mesityl-substituted β-diketiminates with sterically hindered redox-active ligands led to the very low coordination numbers of rare earths and strong distortion of the chelate ligands.

By utilizing the mixed-ligand method, two novel metal-organic frameworks (MOFs) based on Zn(II) ions as nodes with the chemical formulae of {[Zn2.5(abta)(trz)2(H2O)]·3H2O}n (1, Htrz = 1H-1,2,4-triazole) and [Zn3(abta)2(bibb)2]n (2, bibb = 1,4-bis(benzimidazol-1-yl)-2-butene) were produced via Zn(NO3)2·6H2O reacting with the 1-aminobenzene-3,4,5-tricarboxylic acid (H3abta) in the existence of distinct nitrogen-donor co-ligands. The different N-donor ligands result in their distinct framework structures, and the compound 1 with higher solvent accessible void and large window size shows highly heterogeneous catalytic activities for Knoevenagel condensation. The treatment of Staphylococcus aureus biofilms formation during spine surgery incision infection and the related mechanism was explored at the same time. First of all, the S. aureus bacterial numbers in the infectious site was measured under compound 1 or 2 treatment. In addition to this, the relative expression levels of the genes related with S. aureus biofilms was determined with real time RT-PCR. [ABSTRACT FROM AUTHOR]

In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are [Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda is 1,2-phenylenediacetic acid) and [Co(mpda)(mbib)]·H2O (2, H2mpda is 1,3-phenylenediacetic acid). The two compounds' magnetic performances suggest that between the adjacent metal ions, there present the antiferromagnetic coupling. The evaluation of their treatment activity against chronic subdural hematoma was carried out and the relevant mechanism was studied simultaneously. Firstly, before the treatment of compound, the chronic subdural hematoma was generated. Furthermore, the enzyme-linked immunosorbent assay detection kit was implemented and in hematoma capsule, the anti-inflammatory cytokines level and pro-inflammatory cytokines level was detected. Additionally, the cytotoxicity of compounds 1 and 2 on the normal human cells was determined with Cell Counting Kit-8 assay. Above all, we proved compound 1 decreased the pro-inflammatory cytokines content and increased the anti-inflammatory cytokines content in the hematoma capsule, which is much stronger than that of compound 2. Both compounds 1 and 2 showed no cytotoxicity on the normal human cells. [ABSTRACT FROM AUTHOR]

Transition metal carboxylates with O- and N-donor ligands are interesting for their structural features. Seven novel isonicotinamide(inic)-based metal complexes of [Cd(inic)2(L1)2(H2O)2] · 2H2O (1) (L1 = 2-chloronicotinate), [Cd(inic)2(L2)2(H2O)2] (2) (L2 = 2,4-dichlorobenzoate), [Cu(inic)2(L3)2] (3) (L3 = 4-chlorophenoxyacetate), [Cu3(inic)6(L4)2(HL4)2(H2O)2] · 2H2O (4) (L4 = azelate), [Zn(inic)2(L1)2(H2O)2] · (inic) · H2O (5), [Zn(inic)(L5)(H2O)4] (6) (L5 = 3-nitrophthalate) and [Zn2(inic)2(L6)2] · 5H2O (7) (L6 = 1,4-cyclohexanedicarboxylate) have been obtained by the introduction of the carboxylates by the common solution method and are structurally featured by different techniques of EA, IR spectra, TG and SCXRD analysis. The X-ray studies told that these complexes display mononuclear to trinuclear structures with octahedral/square-pyramidal geometry around the Zn2+, trigonal bipyramidal/octahedral at the Cu2+ and octahedral for the Cd2+. The inic in 1–7 are coordinated only in monodentate fashion with its ring N, while 5 has the lattice inic. The carboxylates coordinated to the metal in monodentate, chelating bidentate and bridging bidentate fashions. The pair of complementary N-H···O H-bonds from the CONH2 of the inic were found in all compounds except 7. Except 1 and 2, all other compounds bear the CH-O contacts from the pyridine CH of the inic. The intricate intra- and intermolecular classical H-bonds, CH-N, CH-O, CH-Cl, CH2-O, O-N, O-O, Cl-O, Cl-Cl, CH-π, CH2-π, C-π, N-π, Cl-π and π-π associations are elucidated by the X-ray crystallographic studies, which push the discrete complexes into high-dimensional ordered supramolecular structures. [ABSTRACT FROM AUTHOR]

Metal‐organic gels (MOGs) with different central metals, Al‐ATA were synthesized by using 3‐[4‐(2,4‐dioxopentan‐3‐yl) phenyl]pentane‐2,4‐dione (PDA) and 2‐aminoterephthalic acid (H2ATA) as co‐ligands. Through the post‐synthetic modification (PSM) of perfluorooctanoyl chloride, Al‐ATA‐F with hydrophobic functional groups on both the pore and surface were obtained. It was characterized by NMR that the content of ATA in the modified gel was almost 33 times that of PDA, and the amidation substituent ratio was about 20 %. The Brunauer‐Emmett‐Teller (BET) specific surface area of the modified materials increases significantly, because many microporous are formed. Al‐ATA‐F is superhydrophobic despite its poor amidation yield. The hydrophobicity helps it having good adsorption effect on oil solvent. [ABSTRACT FROM AUTHOR]

Two new mixed-ligand coordination polymers of Cd(II), namely, [Cd(H2L)(ip)H2O]n (1) and [Cd(H2L)(Hbtc)]n (2) [H2L = 3-(1H-pyrazol-4-yl)-5-(pyridin-2-yl)-1,2,4-triazole, H2ip = isophthalic acid, H3btc = 1,3,5-benzenetricarboxylic acid], have been hydrothermally synthesized and characterized by elemental analysis, IR spectra, powder X-ray diffraction, and single-crystal X-ray diffraction. Compound 1 displays a one-dimensional chain structure, which upon hydrogen bonding generates 3D supramolecular framework. Compound 2 exhibits a one-dimensional double-chain structure connected by hydrogen bonds with formation of 2D supramolecular framework. Fluorescent properties of two compounds have been studied in the solid state at room temperature. [ABSTRACT FROM AUTHOR]

Under solvothermal conditions, two new Zn(II)-based coordination polymers, namely {[Zn(tptc)0.5(2,2′-bpy)]·dioxane}n (1, H4tptc = p-terphenyl-2,2″,5″,5‴-tetracarboxylate acid, 2,2′-bpy = 2,2′-bipyridine) and [Zn(tptc)0.5(bib)]n (2, bib = 1,3-bis((imidazol-1-yl) benzene), have been synthesized using the mixed-ligand approach. Furthermore, the luminescence studies show that complex 2 can test acetylacetone selectively and sensitively, and the detection limit is 1.72 ppm. In addition, we evaluated the compounds therapeutic effect against uterine leiomyomas. The uterine leiomyomas rats model was established, the compound 1 and compound 2 was used for treatment. The detection of the transforming growth factor-β (TGF-β) releasing from endometrial stromal cells into plasma was detected with an enzyme linked immunosorbent assay (ELISA) detection kit. Then, the mmp-3 and mmp-7 relative expression levels in the uterine smooth muscle cells after compound treatment were measured by the reverse transcription-polymerase chain reaction (RT-PCR). [ABSTRACT FROM AUTHOR]

By applying the mixed-ligand approach, two new Co(II)-including coordination polymers (CPs) {[Co2(Glu)2(1,4-mbix)2(H2O)2]·H2O}n, (1) and {[Co(Glu)(1,4-mbix)]·4H2O}n (2), were formed by taking glutarate (Glu2−) blended with 1,4-bis [(2-methyl-1H-imidazol-1-yl)methyl]benzene (1,4-mbix) by using different reaction temperatures. The as-prepared complexes were evaluated through IR spectroscopy, elemental analysis, powder X-ray diffraction analysis (PXRD), TG analysis and single-crystal X-ray diffraction. The structural characterization results show that complex 1 features a 3D framework structure with a four-connected neb-type topology, while complex 2 demonstrates a 2D layered structure with a four-connected sql-type topology. The magnetic studies show that compounds 1 and 2 have antiferromagnetic coupling between the adjacent metallic ions. Their biological activity on depression animal model was determined and the mechanism was detected. Firstly, the depression animal model was built and the compounds were given for indicated treatment. The nigrostriatal dopamine D2 receptor content was measured by real time reverse transcription-polymerase chain reaction (RT-PCR). The content of the 5-hydroxy trptamine (5-HT) and Norepinephrine (NE) was measured by enzyme linked immunosorbent assay (ELISA) detection kit after compounds treatment. [ABSTRACT FROM AUTHOR]

By the reaction of a rigid π-conjugated H4L linker (5,5′-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds. [ABSTRACT FROM AUTHOR]

Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)0.5·H2O}n (1) and {[Co2(2,6-NDC)2(TPB)]·MeCN·3H2O}n (2) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H2TDC = 2,5-thiophenedicarboxylic acid, 2,6-H2NDC = 2,6-naphthalic acid), have been synthesized by a semi-rigid tetrapyridine ligand and auxiliary dicarboxylic ligands. The treatment ability of the compounds on skin necrosis after fracture was assessed and the related mechanism was discussed. First of all, the enzyme-linked immune sorbent assay (ELISA) detection kit was used in this research to detect the content level of the Recombinant Human Macrophage Colony stimulating Factor (MCSF) and Tumor Necrosis Factor-α (TNF-α) after compound treatment. Next, the real time quantitative polymerase chain reaction (RT-PCR) was conducted for the MMP2 and TIMP1 relative expression levels measurement. [ABSTRACT FROM AUTHOR]

By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H2O]8}n (1, H2ip = isophthalic acid and L = 1,1'-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]imidazole)) and {[Ni(L)(tdc)·2H2O]2}n (2, H2tdc = 2,5-thiophenedicarboxylic acid) have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction analyses, powder X-ray diffraction, thermogravimetric analysis and elemental analysis. In addition, in vitro anticancer activity of compounds 1 and 2 on four human ovarian cancer cells (CoC1, A2780, 3AO and OVCAR) was further determined. The results showed that compared with their organic ligands, the two compounds displayed efficient antitumor activity. [ABSTRACT FROM AUTHOR]

Two novel sulfonic functionalized coordination polymers (CPs) {[Cd1.5(dimb)(5-sip)(H2O)3]·3H2O}n (1, dimb = 1,4-di(1H-imidazol-1-yl)butane) and [Co2(iptz)(Hiptz)(5-sip)(H2O)]·4H2O (2, Hiptz = 1-(4-(1H-imidazole-5-yl)phenyl)-1H-1,2,4-triazole) were acquired via different metal(II) salts reacting with the mixed ligands containing 1-(4-(1H-imidazole-5-yl)phenyl)-1H-1,2,4-triazole, 1,4-di(1H-imidazol-1-yl)butane and sodium 5-sulfoisophthalate (NaH2sip), respectively. Furthermore, the complex 1 based on Cd(II) could be utilized as the luminescent senor for picric acid (PA) detection in water. In bio-research, compounds 1 and 2 treatment effect on chronic periodontitis was assessed and the specific mechanism was discussed. First of all, the RT-PCR was performed to measure the HmuY and fimA genes relative expression level in P.gingivalis after treated by compounds 1 and 2. Then, the TNF-α and IL-6 content in the fluid of gingival crevicular after compounds treatment was determined with ELISA detection kit. [ABSTRACT FROM AUTHOR]

In this study, a new Cd(II)-bearing coordination polymer with the chemical formula of {[Cd4(meda)3(dpe)4(H2O)4]·(NO3)2·2(H2O)}n (1, H2meda = 3,3′-methylenedibenzoic acid, dpe = 1,2-di(pyridin-4-yl)ethane) has been successfully prepared by reaction of Cd(NO3)·4H2O with a V-shape carboxyl ligand H2meda along with the linear dipyridine ligand dpe under the hydrothermal conditions. Due to its intensive luminescence, complex 1 could be utilized as the sensor of detecting Al3+ ion, and its detection limit is 4 × 10−6 M. Firstly, the toxicity of the compound on the normal liver cells was determined with Cell Counting Kit-8 detection kit. The triglyceride in liver cells was detected by detection kit after compound treatment and the relative expression of 15-lox and 12-lox in L02 cells was also measured by RT-PCR after compound treatment. In addition, multiple functional groups that provided by the synthesized Cd(II) complex have been studied by using molecular docking simulation for the confirmation of possible binding modes that formed between ligand and receptor. [ABSTRACT FROM AUTHOR]

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Two Cu(II)-based coordination polymers with the chemical formula of [Cu(bibb)(1,4-NDC)](DMF) (1, bibb = 1,4-bis(benzimidazol-1-yl)−2-butylene, 1,4-H2NDC = 1,4-naphthalenedicarboxylic acid, DMF = N,N-dimethylformamide) and [Cu(bibb)(1,4-NDC)](DMA) (2, N,N-dimethylacetamide) have been prepared. The structural solution and refinement results based on the crystal data show that complex 1 exhibits a rarely 2-fold interpenetrating 3D (4,5)-connected xah framework, and complex 2 possesses an unusual 3D (3,4)-connected dmc topology. Furthermore, the protective activity of compounds 1 and 2 on Viral myocarditis (VMC) was detected on CVB3-induced mouse viral myocarditis model. The relative expression of the inflammatory factors nf-κb and p38 in myocardial cells after compounds 1 and 2 treatment was measured with reverse transcription-polymerase chain reaction (RT-PCR). The release level of the inflammatory cytokines IL-1 and MCP-1 by myocardial cells was determined with enzyme linked immunosorbent assay (ELISA) detection kit. [ABSTRACT FROM AUTHOR]

A new Co(II)-based coordination polymer {[Co(ttpa)(1,4-bdc)]·H2O}n (1) as well as its nanoparticles (denoted as nano 1 hereafter) have been synthesized using hydrothermal and hand grinding methods (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,4-bdc = 1,4-benzenedicarboxylate). Furthermore, the protective effect of nano 1 on acute viral myocarditis mice was evaluated. Firstly, the CVB3-induced acute viral myocarditis model was successfully constructed and then nano 1 was given for indicated treatment. The in vivo activity of nano 1 was evaluated with mice survival rate and the CVB3 titer determination. The level of the inflammatory cytokines in the mice after treatment was measured with enzyme linked immunosorbent assay (ELISA) detection kit. [ABSTRACT FROM AUTHOR]

Solvothermal reactions of Co(OAc)2·4H2O or Ni(NO3)2·3H2O with 1,4-bis(benzimidazol-1-ylmethyl)-benzene (bmib) ligand and 1,4-terephthalic acid (H2bdc) afforded two 2-dimensional coordination polymers with the chemical formulae of [Co(bmib)(bdc)(H2O)2n (1) and [Ni(bmib)(bdc)(H2O)2n (2). Complexes 1 and 2 were characterized by elemental analysis and single-crystal X-ray diffraction. Furthermore, the anticancer activity of the complexes 1 and 2 was evaluated. Firstly, the CCK-8 assay was performed and MG63 osteogenic sarcoma cell proliferation was determined after complexes 1 and 2 treatment. Next, the Hoechst staining was performed to detect the morphological changes of treated MG63 cells. Subsequently, the western blot was conducted and the apoptotic related protein levels were determined. [ABSTRACT FROM AUTHOR]

Via using a mixed-ligand method, two novel coordination polymers based on Cu(II) ions as nodes {[Cu(Py2TTz)0.5(2,6-ndc)]·(DMF)·(C2H5OH)}n (1, Py2TTz = 2,5‐Bis(4‐pyridyl)thiazolo[5,4‐d]thiazole, 2,6-H2ndc = 2,6-naphthalenedicarboxylic acid) and [Cu2(2,6-ndc)2(4-bpdb)·(H2O)3·2DMF]n (2, 4-bpdb = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene) were prepared under the solvothermal conditions. In addition, complexes 1 and 2 could be applied as a photocatalysts under ultraviolet light, the degradation property of methylene blue is relatively high. In the research of biological function, the protective activity of compound 1 and compound 2 was assessed. First of all, the accumulation of reactive oxygen species (ROS) in thyroid cancer cells was detected by ROS detection kit. Then, Annexin V-FITC/PI method was used to detect the percentage for thyroid cancer cells apoptosis after treated by compound. [ABSTRACT FROM AUTHOR]

A systematic investigation into the reactions of Cd(NO3)2·4H2O with o- and p-phenylenediacetic acid within the presence of the semi-rigid 1,4-bis(imidazol-1-ylmethyl)benzene (bimb) co-ligands under similar conditions was carried out. In this study, two novel coordination polymers containing Cd(II) ions as the metal ions {[Cd(μ-opda)(bimb)]·DMF}n (1, opda = 1,2-phenylenediacetate) and [Cd(μ-ppda)(bimb)0.5]n (2, ppda = 1,4-phenylenediacetate) have been prepared and structurally characterized. Furthermore, the inhibitory function of these two synthetic complexes on MG-63 human osteogenic sarcoma cells was evaluated with cell counting kit-8. And the Annexin V-FITC/PI apoptosis detection was performed to detect the induction ability of the complexes on the cancer cell apoptosis. Then, the western blot was performed to measure the activation level of the PTEN-AKT pathway. [ABSTRACT FROM AUTHOR]

In this study, two new mixed-ligand coordination polymers (CPs) {[Cd6(nbta)3(bimb)4(H2O)](H2O)3}n (1, bimb = 4,4′-bis((1H-imidazol-1-yl)methyl)−1,1′-biphenyl) and [Co3(bib)2(nbta)2]n (2, bib = 1,4-bis(benzimidazol-1-yl)−2-butene) have been successfully prepared by reaction of 5-nitro-1,2,3-benzenetricarboxylic acid (H3nbta) with different N-donor ligands under the solvothermal conditions. The as-prepared two CPs have been studied via the elemental analysis along with the single crystal X-ray diffraction. The inhibitory effect of synthesized new mixed-ligand coordination polymers on K562 leukemia cells was evaluated by CCK-8 assay. And the percentage of apoptotic cells after CPs 1 and 2 treatment was assessed by Annexin V-FITC/PI assay. Finally the in vivo effect of CPs on tumor was conducted by tumor volume and mice weight measurement. [ABSTRACT FROM AUTHOR]

In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H2O) (1, H2cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine) and {[Co(pdc)(bimb)](DMF)}n (2, H2pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO3)2·6H2O with the bimb ligand in the presence of different carboxylate ligands (H2cbba for 1 and H2pda for 2). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex 2 toward the degradation of methyl violet (MV) in simulated polluted water was explored. [ABSTRACT FROM AUTHOR]

Solvothermal reaction of 4,4′-bis(imidazol-1-yl)diphenyl ether (BIDPE) or 1,4-Bis(imidazole-1-ylmethyl)benzene (BiB) with 1,4-benzenedicarboxylic acid (H2bdc) or 4,4'-(thiobis(methylene))dibenzoic acid (H2tba) in the presence of Zn(NO3)2·6H2O or Co(NO3)2·6H2O in a mixed solvent of H2O/DMF yielded two new coordination polymers, namely, [Zn(bdc)(BIDPE)](DMF)2(H2O) (1) and [Co(tba)(BIB)](H2tba)(DMF)(H2O)2 (2). These complexes were characterized by elemental analysis and X-ray single-crystal diffraction, which revealed that complex 1 is a 2D layered network with hexagonal windows while complex 2 is a 1D chain-like structure containing the 0D Co2(BIB)2 loops. Furthermore, the anticancer activity of the two coordination complexes has been evaluated via the CCK-8 assay and western blot assay. [ABSTRACT FROM AUTHOR]

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)0.5(oba)·DMF]·DMF·H2O} (1, L1 = N,N′-bis(4-pyridylmethyl)-naphthalene diimide, H2oba = 4,4′-oxydibenzoic acid) and [Co(L2)0.5(OBA)]n (2, L2 = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H2oba with different flexible N-donor organic ligands in the presence of Co(NO3)2·6H2O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg. [ABSTRACT FROM AUTHOR]

Two new coordination complexes with the chemical formula [Co(bpda)(bimb)(H2O)](H2O)(CH2Cl2) (1) and {[Co(bdc)(bimb)](H2O)2(DMF)}n (2) are successfully prepared by the reaction of Co(NO3)2·6H2O and the 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine (bimb) ligand with different carboxylate ligands (4,4′-([3,4′-bipyridine]-2′,6′-diyl)dibenzoic acid (H2bpda) for 1 and terephthalic acid (H2bdc) for 2. The two as-prepared complexes are further analyzed by powder X-ray diffraction. In addition, the photocatalytic activity of complex 2 towards the degradation of methyl violet (MV) in polluted water is explored. [ABSTRACT FROM AUTHOR]