1. Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
- Author
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Florence Busato, Catriona McLean, Johannes Schwarz, John C. van Swieten, Wolfgang Wurst, Sigrid C. Schwarz, Dennis W. Dickson, Jörg Tost, Axel Weber, Daniela M. Vogt Weisenhorn, Günter U. Höglinger, Pia Winter, Till Adhikary, Maud Fagny, Anita Windhorst, Ulrich Müller, Pawel Tacik, Thomas Arzberger, Dietrich Trümbach, Justus-Liebig-Universität Gießen (JLU), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), DZNE - University of Munich, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Biochemistry, Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Lehrstuhl für Entwicklungsgenetik, Mayo Clinic [Jacksonville], State Neuropathology Service, Department of Pathology, University of Melbourne, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Philipps Universität Marburg, ANR-13-EPIG-0003,EpiPD,Epigenomics of Parkinson's disease(2013), Neurology, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), and Philipps Universität Marburg = Philipps University of Marburg
- Subjects
0301 basic medicine ,Male ,[SDV]Life Sciences [q-bio] ,General Physics and Astronomy ,Epigenesis, Genetic ,metabolism [Homeodomain Proteins] ,metabolism [Transcription Factors] ,lcsh:Science ,Aged, 80 and over ,genetics [Epigenesis, Genetic] ,Multidisciplinary ,genetics [Supranuclear Palsy, Progressive] ,Methylation ,genetics [Transcription Factors] ,CpG site ,DNA methylation ,Female ,ddc:500 ,Supranuclear Palsy, Progressive ,pathology [Supranuclear Palsy, Progressive] ,Science ,Tau protein ,genetics [Homeodomain Proteins] ,MAPT protein, human ,tau Proteins ,Biology ,genetics [DNA Methylation] ,General Biochemistry, Genetics and Molecular Biology ,Article ,Progressive supranuclear palsy ,03 medical and health sciences ,Downregulation and upregulation ,medicine ,Humans ,Epigenetics ,Aged ,Homeodomain Proteins ,General Chemistry ,Epigenome ,DNA Methylation ,medicine.disease ,Molecular biology ,metabolism [tau Proteins] ,eye diseases ,Distal-less homeobox proteins ,genetics [tau Proteins] ,030104 developmental biology ,biology.protein ,lcsh:Q ,Transcription Factors - Abstract
Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant (P, Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression.
- Published
- 2018