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Background: The dopamine active transporter (DAT) gene has been implicated in various psychiatric disorders such as attention-deficit hyperactivity disorder and externalizing behaviors. Studies on the methylation loci of DAT and Internet addiction (IA) are sparse. The study aimed to look at the association between various methylation loci of the DAT gene and IA, impulsivity, and other related variables. Methodology: Thirty-two youths with 10/10 genotype of DAT gene were administered the IA Test, Barratt's Impulsivity Scale (BIS), and Adult Self-Report Scale and using buccal swab methylation loci 1–7 of DAT gene were assessed. The data were analyzed by a correlation between various variables and a multiple regression analysis. Results: It was noted that the met5 allele (r = 0.844, P < 0.01) and met7 allele (r = 0.517, P = 0.01) correlated with DAT MEDIA scores. The total scores on the BIS and Internet Addiction Scale (IAS) also showed a positive correlation (r = 0.641, P = 0.01). Positive correlations were also noted between the scores on IAS and rule-breaking behavior as well as withdrawn behavior. Similar positive correlations were found between total scores on the BIS and rule-breaking behavior, withdrawn behavior, and intrusive behavior. Conclusions: Further studies in larger samples are needed to draw conclusions on the relationship between DAT gene methylation loci and IA or impulsivity.

Background: The dopamine active transporter (DAT) gene has been implicated in various psychiatric disorders such as attention-deficit hyperactivity disorder and externalizing behaviors. Studies on the methylation loci of DAT and Internet addiction (IA) are sparse. The study aimed to look at the association between various methylation loci of the DAT gene and IA, impulsivity, and other related variables. Methodology: Thirty-two youths with 10/10 genotype of DAT gene were administered the IA Test, Barratt's Impulsivity Scale (BIS), and Adult Self-Report Scale and using buccal swab methylation loci 1-7 of DAT gene were assessed. The data were analyzed by a correlation between various variables and a multiple regression analysis. Results: It was noted that the met5 allele (r = 0.844, P < 0.01) and met7 allele (r = 0.517, P = 0.01) correlated with DAT MEDIA scores. The total scores on the BIS and Internet Addiction Scale (IAS) also showed a positive correlation (r = 0.641, P = 0.01). Positive correlations were also noted between the scores on IAS and rule-breaking behavior as well as withdrawn behavior. Similar positive correlations were found between total scores on the BIS and rule-breaking behavior, withdrawn behavior, and intrusive behavior. Conclusions: Further studies in larger samples are needed to draw conclusions on the relationship between DAT gene methylation loci and IA or impulsivity. [ABSTRACT FROM AUTHOR]