1. Trends in high intensity statin use among secondary prevention patients 76 years and older
- Author
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Michele Wood, Kari L. Olson, Anne M. Denham, Sheila L. Stadler, Roseanne Hornak, Leslie K. Ruppe, and Thomas Delate
- Subjects
Comparative Effectiveness Research ,medicine.medical_specialty ,Prescription Drugs ,Statin ,Health Services for the Aged ,mesh:Health Services for the Aged ,medicine.drug_class ,Comparative effectiveness research ,lcsh:RS1-441 ,Pharmaceutical Science ,Coronary Artery Disease ,Pharmacy ,mesh:Aged ,mesh:Coronary Artery Disease ,030226 pharmacology & pharmacy ,lcsh:Pharmacy and materia medica ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,mesh:Comparative Effectiveness Research ,Integrated ,mesh:Integrated ,Internal medicine ,Delivery of Health Care Integrated ,Medicine ,mesh:Retrospective Studies ,Aged ,Retrospective Studies ,Original Research ,Secondary prevention ,business.industry ,mesh:Delivery of Health Care ,High intensity ,lcsh:RM1-950 ,Gold standard ,Retrospective cohort study ,Statin treatment ,medicine.disease ,Drug Utilization ,United States ,lcsh:Therapeutics. Pharmacology ,mesh:Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,mesh:United States ,business ,Delivery of Health Care ,mesh:Prescription Drugs ,mesh:Drug Utilization - Abstract
Background: High intensity statin therapy (HIST) is the gold standard therapy for decreasing the risk of recurrent atherosclerotic cardiovascular disease (ASCVD); however, little is known about the use of HIST in older adults with ASCVD. Objectives: The aim of this cross-sequential study was to determine trends in statin intensity in older adults over a 10-year timeframe. Methods: The study was conducted in an integrated healthcare delivery system. Patients were 76 years or older with validated coronary ASCVD. Data were collected from administrative databases. Statin intensity level was assessed in eligible patients on January 1st and July 1st from January 1, 2007 to December 31, 2016. Results: Overall, a total of 5,453 patients were included with 2,119 (38.9%) and 3,334 (61.1%) categorized as HIST and Non-HIST, respectively. Included patients had a mean age of 79.8 years and were primarily male and white and had a cardiac intervention. The rate of HIST use increased from 14.5% to 41.3% over the study period (p
- Published
- 2019
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