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BACKGROUND: Urinary dysfunction is linked to spinal cord injury (SCI). The quality of life (QoL) declines in both neurogenic bladder impairment and non-disordered patients. OBJECTIVE: To ascertain the effectiveness of pulsed magnetic therapy on urinary impairment and QoL in individuals with traumatic incomplete SCI. METHODS: This study included forty male paraplegic subjects with neurogenic detrusor overactivity (NDO) for more than one year following incomplete SCI between T6-T12. Their ages ranged from 20 to 35 and they engaged in therapy for three months. The subjects were divided into two groups of equal size. Individuals in Group I were managed via pulsed magnetic therapy once per week plus pelvic floor training three times a week. Individuals in Group II were managed with only three times a week for pelvic floor training. All patients were examined for bladder cystometric investigations, pelvic-floor electromyography (EMG), and SF-Qualiveen questionnaire. RESULTS: There was a noteworthy increment in individuals in Group I in volume of bladder at first desire to void and maximum cystometric capacity, detrusor pressure at Qmax, and maximum flow rate. There was a momentous increment in Group I in measures of evaluation of EMG biofeedback. There was a notable rise in Group I in SF-Qualiveen questionnaire. CONCLUSION: Magnetic stimulation should be favored as beneficial adjunct to traditional therapy in the management of bladder impairment and enhancing QoL in individuals with SCI. [ABSTRACT FROM AUTHOR]

Traditional drug solutions or suspensions, have been shown to treat pain in complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain in rats, with or without combination with magnetic therapy. In this study, we aimed to prepare, characterize, and evaluate the therapeutic effects of microparticles containing dexamethasone for local administration and treatment of chronic inflammatory pain. The results showed the following; a) Preparation and characterization: two ratios of poly(lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) were used. The prepared batches were similar in size and magnetic responsiveness. The microparticle size distribution assessed via electron microscopy suggested a homogeneous distribution and absence of aggregates. Dexamethasone release profiles (microparticles synthesized with a feed ratio of 1:4) showed a sustained release in vitro and good biocompatibility with tissues. b) Therapeutic effect: the treatment effect of dexamethasone-PLGA magnetic microspheres + magnetic therapy was substantially better than that observed for other groups on day 4, as monitored by appearance, mechanical pain threshold, and histological analysis. This type of carrier could be a suitable magnetically retainable local drug delivery system for treating chronic pain.

Absract. Having analyzed the data of scientific and methodological literature, information was presented on the status and topical trends in the development of physiotherapy. The principle of action, the effect on the human body, the main indications and contraindications of various methods of physiotherapy are considered. Nowadays, interest in methods of exposure to physical factors is growing significantly. This is due to the safety and availability of non-drug treatments. Of course, the importance of drug therapy cannot be denied. However, there are many contraindications to the use of drugs, including allergies and drug intolerances. In such cases physiotherapy as a method becomes one of the most important. The article presents data on the principle of magnetic stimulation, in particular transcranial magnetic stimulation, magnetic therapy and functional magnetic stimulation. Transcranial magnetic stimulation allows non-invasive action on the cerebral cortex with short-term magnetic impulses. The method of magnetic therapy is based on the effect of a magnetic field (constant or variable) on the human body. Using this technique it is possible to achieve analgesic, anti-inflammatory and anti-edematous effect. Functional magnetic stimulation is a unique method of nerve myostimulation that allows to affect the deepest muscles, inaccessible to other forms of action in the patient's body. Also TEСAR-therapy is considered: an approach that stimulates the regeneration and recovery of muscles with high-frequency electric stream that penetrates the tissues with electromagnetic waves and generates heat. The principle of action on the human body of the most common electrophysical device, therapeutic ultrasound, was analyzed. Ultrasound therapy can affect almost all body systems and has physicochemical, mechanical and thermal effects. Vibrotraction therapy (traction, spinal traction), which has an instant analgesic and long-term therapeutic effect on areas of spinal lesions, also has been analysed. In addition, the article concludes on the viability of physiotherapy techniques and the need for their improvement.

Traditional drug solutions or suspensions, have been shown to treat pain in complete Freund's adjuvant (CFA)-induced chronic inflammatory pain in rats, with or without combination with magnetic therapy. In this study, we aimed to prepare, characterize, and evaluate the therapeutic effects of microparticles containing dexamethasone for local administration and treatment of chronic inflammatory pain. The results showed the following; a) Preparation and characterization: two ratios of poly(lactic-co-glycolic acid) (PLGA)/poly(lactic acid) (PLA) were used. The prepared batches were similar in size and magnetic responsiveness. The microparticle size distribution assessed via electron microscopy suggested a homogeneous distribution and absence of aggregates. Dexamethasone release profiles (microparticles synthesized with a feed ratio of 1:4) showed a sustained release in vitro and good biocompatibility with tissues. b) Therapeutic effect: the treatment effect of dexamethasone-PLGA magnetic microspheres + magnetic therapy was substantially better than that observed for other groups on day 4, as monitored by appearance, mechanical pain threshold, and histological analysis. This type of carrier could be a suitable magnetically retainable local drug delivery system for treating chronic pain. [ABSTRACT FROM AUTHOR]

To date, a new coronavirus disease caused by the SARS-CoV-2 virus (also known as COVID-19) has become a serious public health problem worldwide. Unfortunately, there are no specific drugs for the treatment of this infection until now. It is known that COVID-19 is caused by the SARS-CoV-2 betacoronavirus, which mainly affects the cells of the respiratory and digestive systems. There are scientific data on the effectiveness of a number of physiotherapy methods for a new coronavirus infection, which justifies their inclusion in the complex rehabilitation within the in-patient stage. Aim. This work aimed at the scientific justification of the physical factors use in the rehabilitation programs of patients after pneumonia associated with COVID-19. Material and methods. 60 patients (40 women and 20 men) who had suffered from COVID-19 pneumonia were examined. The time from the onset of the disease was on average 2 months. The study involved patients with mild and moderate pneumonia. The patients were randomly divided into 2 groups. The first group (30 patients) received low-intensity magnetic therapy for the chest area, infrared laser therapy for the lung roots, chest massage, therapeutic gymnastics and a course of hyperbaric oxygenation. The second group (30 patients) received high-intensity magnetic stimulation of the respiratory muscles, infrared laser therapy on the lung roots, chest massage, therapeutic gymnastics and a course of hyperbaric oxygenation. Results. As a result of the conducted rehabilitation programs, there was an improvement in the well-being of patients in both groups.There was a decrease in shortness of breath, an increase in physical activity, a decrease and disappearance of pain in the chest area. This was confirmed by a significant reliable dynamics of the 6-minute walk test and the laser Doppler flowmetry parameters and spirometry. Positive dynamics in the C — reactive protein parameter and a tendency to improve the D –dimer parameter were revealed. The changes in the studied parameters were more significant in patients of the second group. Conclusion. Thus, analyzing the results obtained, it can be argued that the developed comprehensive treatment programs for patients who have suffered pneumonia associated with COVID-19 lead to clinical improvement in this category of patients. However, more significant changes in the studied parameters were noted in the group of patients that received a comprehensive program that included a high-intensity electromagnetic field.

Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite the great advances in conventional treatment approaches, including surgery and chemotherapy. Spatio-temporally controllable approaches to glioma are now being actively investigated due to the preponderance, including spatio-temporal adjustability, minimally invasive, repetitive properties, etc. External stimuli can be readily controlled by adjusting the site and density of stimuli to exert the cytotoxic on glioma tissue and avoid undesired injury to normal tissues. It is worth noting that the removability of external stimuli allows for on-demand treatment, which effectively reduces the occurrence of side effects. In this review, we highlight recent advancements in drug delivery systems for spatio-temporally controllable treatments of glioma, focusing on the mechanisms and design principles of sensitizers utilized in these controllable therapies. Moreover, the potential challenges regarding spatio-temporally controllable therapy for glioma are also described, aiming to provide insights into future advancements in this field and their potential clinical applications., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V.)

This bibliometric study investigates the research landscape of magnetotherapy, also known as magnetic field therapy, which utilizes magnetic fields to promote healing, reduce pain, and improve overall health and well-being. The study uses bibliographic data from Scopus and employs Biblioshiny and CiteSpace for analysis. Key aspects examined include annual scientific production, most relevant authors, co-citation of cited authors, most relevant sources, countries' scientific production, and collaborations. Additional analyses feature a historiograph, trend topics, thematic maps, and keywords with the strongest citation bursts. Findings highlight significant trends in research activity, identify influential contributors, and map out collaborative networks in the field. The study reveals a noticeable absence of long-term studies and standardized treatment protocols in magnetotherapy research. Identified research gaps indicate the need for interdisciplinary studies and a deeper mechanistic understanding of magnetotherapy. Practical implications emphasize the potential for enhanced clinical applications, healthcare policy integration, and medical device innovations. The study underscores the importance of educational and training programs for healthcare professionals. Addressing these gaps and leveraging practical implications can significantly advance the field of magnetotherapy., Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, M N et al.)

Magnetic therapy (MT) is a non-drug method that improves the effectiveness of treatment of musculoskeletal pain, including:acute non-specific back pain (NBP). Objective of our study was to evaluate the results of complex treatment of patients with acute/subacute NBP at home using MT. The study group consisted of 339 patients with severe acute/subacute NBP. All patients received nonsteroidal anti-inflammatory drugs (NSAIDs). 166 patients (Group 1) received a course of MT (ALMAG+ device), 173 patients or a control group (Group 2) who did not receive MT. The dynamics of pain was significantly higher in group 1 than in group 2. So, the intensity of pain during movement (NRS) decreased from 7 [5;8] and 7 [5;8] to 0 [0;13] and 2 [1;3] after 1 month. (p<0.001). Significant differences between Groups 1 and 2 were observed in the dynamics of pain at rest and at night, overall health assessment (OHA), and sleep function and disorders. The average duration of NSAIDs use in Group 1 was 8.8±3.9, Group 2 - 11.8±5.7 days (p<0.001). The use of MT increases the effectiveness of treatment of acute/subacute NBP and reduces the need for NSAIDs use. [ABSTRACT FROM AUTHOR]

Aim: To assess the effectiveness of the physiopharmacological treatment of GERD in persons who successfully completed a full course of CHC therapy with direct antiviral drugs no more than 6 months ago. Materials and Methods: 67 people with GERD who completed a course of CHC therapy with direct antiviral drugs no more than 6 months ago were under observation. The patients were divided into: 1 group (n=20) – received rabeprazole 20 mg in the morning 40 minutes before meals, 2 group (n=23) – rabeprazole 20 mg in combination with taking mineral water “Polyana Kvasova” according to the proposed scheme, group 3 (n=24 patients) – took rabeprazole 20 mg in combination with MV«Polyana Kvasova» for 24 days, and with a course of magnetic therapy procedures. Results: Under the influence of treatment, on the 24 th day of observation, all 100% of patients in the 3rd group had positive dynamics: the elimination of heartburn (p<0.001), pain in the epigastrium (p<0.001), and manifestations of dysphagia (p<0.001), which were confirmed by fibrogastroscopy - disappearance of esophagitis (p<0.001) and gastroesophageal reflux (p<0.001). In 80% of the patients of the second group, positive dynamics of the clinical and endoscopic picture was also observed (p<0.005), and in the rest of the patients, the improvement was unreliable (p>0.05). After the treatment, a decrease in manifestations of asthenovegetative and dyspeptic syndromes, cholestatic syndrome was recorded in all groups of patients, with a predominance in group 3. Conclusions: The use of complex physiopharmacological treatment has a reliable advantage over standard pharmacological treatment, as it has a positive effect not only on GERD manifestations, but also on clinical and laboratory manifestations of CHC and improves the quality of life [ABSTRACT FROM AUTHOR]

Magnetic therapy (MT) is a non-drug method that improves the effectiveness of treatment of musculoskeletal pain, including:acute non-specific back pain (NBP). Objective of our study was to evaluate the results of complex treatment of patients with acute/subacute NBP at home using MT. The study group consisted of 339 patients with severe acute/subacute NBP. All patients received nonsteroidal anti-inflammatory drugs (NSAIDs). 166 patients (Group 1) received a course of MT (ALMAG+ device), 173 patients or a control group (Group 2) who did not receive MT. The dynamics of pain was significantly higher in group 1 than in group 2. So, the intensity of pain during movement (NRS) decreased from 7 [5;8] and 7 [5;8] to 0 [0;13] and 2 [1;3] after 1 month. (p

Abstract Background Osteoporosis is a common metabolic bone disease without effective treatment. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into multiple cell types. Increased adipogenic differentiation or reduced osteogenic differentiation of BMSCs might lead to osteoporosis. Whether static magnetic fields (SMFs) might influence the adipo-osteogenic differentiation balance of BMSCs remains unknown. Methods The effects of SMFs on lineage differentiation of BMSCs and development of osteoporosis were determined by various biochemical (RT-PCR and Western blot), morphological (staining and optical microscopy), and micro-CT assays. Bioinformatics analysis was also used to explore the signaling pathways. Results In this study, we found that SMFs (0.2–0.6 T) inhibited the adipogenic differentiation of BMSCs but promoted their osteoblastic differentiation in an intensity-dependent manner. Whole genomic RNA-seq and bioinformatics analysis revealed that SMF (0.6 T) decreased the PPARγ-mediated gene expression but increased the RUNX2-mediated gene transcription in BMSCs. Moreover, SMFs markedly alleviated bone mass loss induced by either dexamethasone or all-trans retinoic acid in mice. Conclusions Taken together, our results suggested that SMF-based magnetotherapy might serve as an adjunctive therapeutic option for patients with osteoporosis.

Teresa Paolucci,1 Letizia Pezzi,1 Antonello Marco Centra,1 Niki Giannandrea,1 Rosa Grazia Bellomo,2 Raoul Saggini1 1Department of Medical Oral Sciences and Biotechnology (DiSmob), Physical Medicine and Rehabilitation Unit, G. D’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Department of Biomolecular Sciences, University of Study of Urbino Carlo Bo, Urbino, ItalyCorrespondence: Teresa PaolucciG. D’Annunzio University of Chieti-Pescara, Chieti, ItalyEmail teresapaolucci@hotmail.comAbstract: Electromagnetic fields (EMFs) provide a non-invasive, safe, and easy method to treat pain with respect to musculoskeletal diseases. The purpose of this systematic review was to describe the use of electromagnetic therapy in the rehabilitation field by investigating the efficacy in acute and chronic pain in the musculoskeletal disorders. A database search was conducted using the following resources: PubMed, Cochrane, PEDro, SCOPUS, and WoS. The following MESH terms were used: [Electromagnetic field AND/OR Rehabilitation], [Electromagnetic field AND/OR Pain], [Pulsed Magnetic field AND/OR Rehabilitation] and [Pulsed Magnetic field AND/OR Pain], [Pulsed Electromagnetic field AND/OR Rehabilitation] and [Pulsed Electromagnetic field AND/OR Pain], per the guidelines of the PRISMA statement. Articles published between January 1, 2009 and December 31, 2018 were included as assessment of musculoskeletal pain conditions, randomized clinical trial including crossover and prospective design studies, full English text available, population age > 18 years; instead were excluded neurological randomized clinical trials, transcranial magnetic stimulation application, neuropathic pain, animal/in vitro studies, and articles without English abstract or English full text. Three independent investigators (AMC, NG, and LP) retrieved all the information. Twenty-one RTC (N=21) were considered for the inclusion and exclusion criteria. The results showed as pulsed magnetic fields at low intensity and frequency (from 1 Hz up to 100 Hz) are commonly used with efficacy in resolving musculoskeletal pain. EMFs therapy is a well tolerated, effective with no negative side effects, which can be integrated with rehabilitation for the treatment of chronic and acute pain in musculoskeletal diseases, but further studies are needed to examine the use of more standardized protocols.Keywords: pulsed electromagnetic fields, rehabilitation, physical medicine, magnetic therapy, pain

Background. The choice of physiotherapeutic method in the treatment of joint diseases remains an urgent problem in physiotherapy. The aim: а comparative study of the effciency of a low-frequency pulsed magnetic feld (LPMF) and its combination with infrared light (photomagnetic therapy) in experimental arthritis. Material and methods. Studies were performed on 50 male rats. A zymosan model of arthritis was used. The animals were divided into 4 groups, the 1st group – intact animals, the 2nd – animals with arthritis without treatment, in the 3rd group they underwent course exposure to LPMF, in the 4th group LPMF in combination with infrared light. Clinical, laboratory, morphological and histochemical studies were performed. Results. It was revealed that photomagnetic therapy to a greater extent than a LPMF reduces the activity of the inflammatory process, and also leads to a partial normalization of the structure of cartilage tissue. Conclusions. The data obtained can be used to develop differentiated methods of physiotherapy in rheumatology.

Background. Carpal tunnel syndrome is the most common tunnel neuropathy in which the median nerve is compressed at the level of the wrist in the carpal canal. Treatment of carpal tunnel syndrome can be conservative and surgical. Surgical treatment is indicated in case of ineffective conservative treatment. However, the strategy of managing patients with carpal tunnel syndrome in the postoperative period has not yet been determined; there is no clear understanding of the effectiveness and necessity of rehabilitation in the early and long-term postoperative periods.Aim. Follow-up the patients after decompression of the median nerve in the late (up to 3 weeks after surgery) and long-term (3 weeks after surgery) postoperative periods to assess the effectiveness of different methods of rehabilitation.Materials and methods. A randomized controlled study included 108 cases of idiopathic carpal tunnel syndrome (unilateral and bilateral). After surgery, the patients were divided into three groups: the restorative treatment group using magnetic therapy, the kinesiotherapy group, and the control group. Clinical, neurophysiological and ultrasound monitoring was carried out for six months.Results. Patients of all the groups showed similar improvement in the most of the analyzed parameters, without any significant difference.Conclusion. Thus, according to the results of a comprehensive study, it is evident that early diagnosis of carpal tunnel syndrome and a high-quality surgical decompression of the median nerve with a complete dissection of the flexor retinaculum of the hand guarantee improvement within six months or later after surgical treatment without additional rehabilitation measures.

Frequency of vascular complications, including strokes, in patients suffered from COVID-19 infection is known to be increased up to 8 times, especially compared with influenza. The purpose: to investigate the fundamental mechanisms of brain ischemia in the patients with mnestic dysfunctions who previously underwent COVID-19 through pharmacocorrection via Phenibut (g-amino-b-phenylbutyric acid hydrochloride) and magnetic therapy in the early recovery period of ischemic stroke. The authors describe the possibilities of cognitive rehabilitation for people who have had ischemic stroke in the post-COVID period. Considering that the presence of mnestic dysfunctions has a negative impact on the process of rehabilitation of cerebral accidents, the fundamental mechanisms of brain ischemia in patients with mnestic dysfunctions in the early recovery period in patients who have undergone COVID-19 have been studied through pharmacocorrection via Phenibut (g-amino-b-phenylbutyric acid hydrochloride) and magnetic therapy. 46 patients aged 40 to 60 years were examined. A comparative study of three randomized clinical groups of patients with separate and complex use of Phenibut and magnetic stimulation. The effectiveness of the proposed therapy in restoring executive functions was established on the basis of indicators of the MMSE scale, the test for the study of frontal dysfunction – FAB, regression of depressive symptoms and is characterized by a decrease in the score on the GDS scale. The authors conclude that mnestic disorders are a functional "target" in cerebral ischemia in the post-COVID period, which requires close attention in relation to pharmacocorrection methods and comprehensive rehabilitation and further research, including the elucidate the pathogenetic mechanisms of cerebral ischemia.

The article discusses a multifactorial approach to the restoration of muscle volume and rehabilitation of football players after sports injuries, which includes the implementation of electric myostimulation in a magnetic field in combination with the effect of electromagnetic radiation of the visible or infrared spectrum on muscles and the area of injury. Comparative studies were carried out in two groups of footballers in rehabilitation after ankle injury rehabilitation. The medical rehabilitation of the players of the 1st group was carried out according to the protocol approved in the center: the MIT-FM apparatus, the protocol for the implementation of rehabilitation provides for the implementation of drug treatment and physiotherapeutic procedures based on the combined use of therapy with electromagnetic waves of the red, blue and infrared spectral range with a power of 50 mW in a pulsed magnetic field of intensity 30 mT and a pulse repetition rate of 9.4 Hz. In group 2, the rehabilitation of footballers after injuries of the lower extremities was carried out according to the protocol developed by the authors: sequential connection of the rehabilitation protocol of the first group and combined magneto-photo electric myostimulation of muscles with myotonic impulses, with a pulse repetition rate of 9.4 Hz. The repetition period of the packs of impulses is 8 seconds with the duty cycle of repetition of the packs of impulses 2. The current strength was set individually for each patient - until the appearance of visible muscle contractions. Muscle photostimulation was performed with electromagnetic radiation of red (wavelength 0.63 μm, power 30 mW), blue (wavelength 0.45 μm, power 30 mW) and infrared (wavelength 0.75 μm, power 50 mW) spectral ranges in constant magnetic field (intensity 30 mT). The first electrode is placed on the muscle's innervation zone. The second electrode provides a combined effect of electrical impulses and optical flux in a constant magnetic field on the abdomen of the muscle according to the labile technique. The time of one procedure was 40 minutes. The number of procedures for a course of treatment is 15. As a result, the analysis of the data obtained (assessment of the quality of life according to the extended table SF-36) revealed a positive dynamics of clinical manifestations in both groups. The main result of the research is the development of a protocol for the rehabilitation of football players after injuries of the lower extremities based on the use of drug treatment, physiotherapy procedures based on the combined use of therapy with electromagnetic waves of the blue and infrared spectrum in a constant magnetic field in combination with muscle electrostimulation, which has a higher level rehabilitation potential versus applicable footballerІ rehabilitation protocols.

Background: Elaeocarpus ganitrus Seeds (Rudraksha) claimed by the various traditional system of medicine for their astonishing therapeutic healing property. When it contacts the human body for a prolonged period it cures various diseases. It appealed to cures slowly various diseases like blood pressure, Insomnia, Tension, Anxiety, Impotency, etc. Rudraksha's medicinal effect can correlate to an ancient medicinal healing technique like Acupressure and magnetic therapy which healing technique comparable to the healing Technique of Rudraksha. Objective: Scientifically congregate Rudraksha healing effect concerning Acupressure and Magnetic Healing. Method: The inclusive and comprehensive literature on Rudraksha therapy carried out with its similarity with Acupressure and Magnetic Healing using different online resources, such as Google Scholar, PubMed, Science Direct, and other reliable online database. Important applicable evidence from the articles analyzed and included. Result: Rudraksha has regulated piezoelectric impact on the human body, which suggests that it can generate an electric charge because of applied mechanical pressure. Rudraksha therapy application is similar to the effect of Acupressure and magnetic cure technique. Conclusion: Insomnia, stress, anxiety, lack of concentration are some common mental diseases in modern times, which can be safely cured by a traditional technique like Rudraksha therapy in combination with Acupressure and Magnetic Healing techniques. [ABSTRACT FROM AUTHOR]

The primary purpose of the recent experiment was to scrutinize the dissimilarity between single and multiple exposures by electrotherapeutic modalities to determine the development of Gram-positive and Gram negative bacteria spectrum. Bacterial strains employed in this study were Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonae and Gram-positive bacteria such as Staphylococcus aureus, Staphylococcus saprophyticus and Streptococcus pyogenes. Fluence for Low level laser therapy (LLLT) (810 nm) was 40 J/cm2 for 80 s, for microwave (MWD) a dosage of 100-Watt with duration of 5 min and for magnetic field therapy (MT) duration of 30 min with 100% intensity was used. Repeated Measures of analysis of variances (RANOVA) for within-subject effects was used to detect a global significant change within the means at dissimilar time points. The experiments of within-subjects revealed a significant difference within groups, df of (3, 40), F value of 39.38 and a p value less than 0.001, representing a significant variation between the three groups between pre and post exposures. There was a significant variation between single exposure and multiple exposures in the experimental sample's pre-post between the four groups with df (1, 40) f value of 2943.69 and p value less than 0.001. Scanning and Transmission electron microscopy images were also taken into account to determine the extent of damage caused to the bacterial cells surface topography in Gram negative and Gram positive spectrums. The study demonstrated that single high exposure with the LLLT appears to have the most emphatic effect followed by exposure by MWD and MT. [ABSTRACT FROM AUTHOR]

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used for the treatment of a great variety of neurological disorders. The technique involves applying a magnetic field in certain areas of the cerebral cortex in order to modify neuronal excitability outside the skull. However, the exact brain mechanisms underlying rTMS effects are not completely elucidated. For that purpose, and in order to generate a pulsed magnetic field, a half-bridge converter controlled by a microcontroller has been designed to apply rTMS in small animals. Moreover, the small size of the rodent head makes it necessary to design a magnetic transducer, with the aim of focusing the magnetic field on selected brain areas using a specific and a small magnetic head. Using such devices, our purpose was to compare the effects of five different rTMS dosages on rat brain metabolic activity. The experimental results showed that one day of stimulation leads to an enhancement of brain metabolic activity in cortical areas, meanwhile with three days of stimulation it is possible to also modify subcortical zones, results that were not found when extending the number of rTMS applications up to seven days. In consequence, the number of pulses delivered might be an important parameter in rTMS protocols, highlighting its importance in rTMS impact. [ABSTRACT FROM AUTHOR]

Purpose: To study the effect of magnetic therapy on the formation of distraction regenerate of the lower jaw in patients with lower micrognathia., Materials and Methods: The study comprised 159 patients with inferior micrognathia of congenital and acquired etiology. The patients were divided into 2 groups. The main group consisted of 112 patients who received magnetic therapy: 55 patients with congenital micrognathia and 57 patients with acquired micrognathia. The control group included 47 patients who did not undergo magnetic therapy: 20 patients with congenital micrognathia and 27 patients with acquired micrognathia. Magnetic therapy was performed daily starting from day 1 or 2 after surgery. Ultrasound monitoring began on the 7th day of distraction and was carried out every 3-4 days, which made it possible to assess the dynamics of the formation of the distraction regenerate., Results: Ultrasound examination on the 7th day of distraction revealed that in the main group the number of distraction regenerates of the normotrophic type was 36.5%, hypotrophic type 18%, hypertrophic type 54.5%. In the control group, the corresponding rates were 53%, 31% and 22%., Conclusion: Magnetic therapy induces osteogenesis and accelerates the maturation of the distraction regenerate. This makes it possible to accelerate the pace of distraction without reducing the quality of the regenerate.

An innovative nanomechanical strategy for in vivo biomedical applications is reviewed. The strategy is based on the use of complexes of special functionalized magnetic nanoparticles controlled by an external low-frequency nonheating magnetic field as deformation machines. The advantages of the strategy are the possibility of easily achieved nanoscale locality and molecular selectivity of action (at the level of individual macromolecules and macromolecular structures such as liposomes, living cells, cell organelles), multimodality, safety, and a high potential of therapeutic application, in particular, for noninvasive oncotherapy without drugs. [ABSTRACT FROM AUTHOR]

Background: Therapeutic action of physical therapy aims at the recovery of conductibility of optic tracts, improvement of microcirculation and hemodynamics, stimulation of regulatory brain structures and improvement of psycho-neurological status of patients. Aim: To assess efficacy of transcranial magnetic therapy, contemporary transcranial magnetic therapy/electrostimulation and magnetic sympathocorrection in the treatment of primary open-angle glaucoma. Materials and methods: 397 patients (634 eyes), aged 58–76 years, with verified diagnosis of stage I, II or III primary open-angle glaucoma, received transcranial magnetic therapy (group 1, 182 eyes), contemporary transcranial magnetic herapy/electrostimulation (group 2, 258 eyes) and magnetic sympathocorrection (group 3, 194 eyes). All patients underwent routine ophthalmological examination, visual evoked potential recording and assessment of ocular circulation. Results: In patients with initial stage of glaucoma, most prominent changes of electrophysiological parameters was demonstrated in the group 2: visual evoked potential amplitude increased from 8.4 ± 0.4 to 11.3 ± 0.2 mcV, latency decreased from 77.6 ± 1.3 to 70.4 ± 2.1 ms. Maximal improvement of ocular circulation (decrease of resistance index of posterior short ciliary arteries from 0.69 ± 0.02 to 0.51 ± 0.03) was registered in the group 3. In patients with evolved glaucoma (stage II), significant increase of P100 amplitude of visual evoked potentials (from 7.5 ± 0.2 to 9.8 ± 0.3 mcV) was found in the group 2; latency period decreased from 84.6 ± 1.5 to 74.8 ± 2.1 ms. In stage II glaucoma patients, prominent increase of systolic blood velocity was demonstrated in groups 3 and 2: from 11.26 ± 0.8 to 13.64 ± 0.63 cm/s and from 10.5 ± 0.2 to 13.9 ± 0.7 cm/s, respectively. Resistance index decreased from 0.76 ± 0.05 to 0.52 ± 0.02 and from 0.75 ± 0.02 to 0.65 ± 0.02 in groups 3 and 2, respectively. In advanced glaucoma (stage III), most prominent increase of P100 amplitude of visual evoked potentials was demonstrated in group 2: amplitude of visual evoked potentials increased from 6.5 ± 0.2 to 8.1 ± 0.2 mcV, latency decreased from 87.5 ± 2.3 to 80.1 ± 2.1 ms. Maximal improvement of ocular circulation (increase of systolic blood velocity from 9.2 ± 0.72 to 11.2 ± 0.6 cm/s) and decrease of resistance index (from 0.84 ± 0.04 to 0.66 ± 0.03) was found in patients with stage III glaucoma in the group 3. Conclusion: Use of different methods of magnetic therapy especially in combination with electrostimulation activates ocular hemodynamics and stimulates bioelectric activity of visual cortex and may prevent visual functions impairment in glaucoma.

In this paper, the convection dynamics of super paramagnetic iron oxide nanoparticles (MNPs) in blood fluid is studied. The system under consideration consists of a fluid which contains the layer of blood with MNPs having iron oxide core (Fe3O4) nanoparticle which is moving through the cavity of the blood vessel which has depositions of cholesterol on the inner lining. In its passing through the blood vessel it is subjected to external magnetic field and heat. The nonlinear three dimensional governing equations for the system under study are derived from the partial differential equations of conservation of momentum and energy. The effect of magnetic field for Hartman number on the chaotic convection of the MNPs in blood fluid is studied using phase portrait, time series and stability analysis. It is assumed that a minimum magnetic field is necessary to stabilise the convection of the MNPs to regulate its flow in specific directions so that the drug can be delivered to specific locations by magnetic dragging. Rectangular cavity structure is considered for the study based on non-uniform cholesterol deposition. It is observed that with magnetisation by external applied magnetic field the convection of MNPs are stabilised in a particular direction. This indicates towards the growing utilization as contrast agents in non-invasive imaging technique of magnetic resonance imaging (MRI) and magnetic drug delivery (MDD). [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteoporosis usually develops gradually and progresses without significant signs and symptoms. It is one of the most common musculoskeletal conditions associated with aging. OBJECTIVES: To evaluate the effects of whole body vibration (WBV) or magnetic therapy in addition to standard pharmacological treatment on bone mineral density (BMD) in elderly individuals being treated for osteoporosis. METHODS: Eighty-five participants, 60-75 years of age, were randomly divided into three groups. All three groups received the same standard pharmacological treatment comprised of vitamin D, calcium, and alendronate sodium. In Group I, thirty participants were also exposed to WBV for 25 minutes in each session with two sessions per week for 4 months. In Group II, thirty participants were exposed to magnetic therapy for 50 minutes in each session with two sessions per week for 4 months. In Group III, twenty-five participants received only pharmacological treatment. Dual-energy X-ray absorptiometry was used to measure BMD of the lumbar spine and femoral heads before and after interventions. Venus blood sample was drawn for analysis of calcium and vitamin D. RESULTS: An ANOVA test detected significant (p < 0.05) differences in BMD after treatment among the three groups with no significant difference was detected between patients receiving WBV and magnetic therapy. Statistical t-tests detected significant (p < 0.05) increases in BMD after application of WBV or magnetic therapy in combination with pharmacological treatment, but no significant increase after pharmacological treatment alone. CONCLUSIONS: Addition of either WBV or magnetic therapy to standard pharmacological treatment for osteoporosis significantly increased BMD in elderly subjects. No significant difference in effectiveness was detected between these two alternative therapy modalities. Consequently, either WBV or magnetic therapy could be effectively applied in conjunction with pharmacological treatment to increase BMD in elderly osteoporotic patients. [ABSTRACT FROM AUTHOR]

Nanotechnology is addressing major urgent needs for cancer treatment. We conducted a study to compare the frequency of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) adducts, biomarkers of oxidative stress and/or lipid peroxidation, on human hepatocarcinoma HepG2 cells exposed to increasing levels of Fe3O4-nanoparticles (NPs) versus untreated cells at different lengths of incubations, and in the presence of increasing exposures to an alternating magnetic field (AMF) of 186 kHz using 32P-postlabeling. The levels of oxidative damage tended to increase significantly after ≥24 h of incubations compared to controls. The oxidative DNA damage tended to reach a steady-state after treatment with 60 μg/mL of Fe3O4-NPs. Significant dose–response relationships were observed. A greater adduct production was observed after magnetic hyperthermia, with the highest amounts of oxidative lesions after 40 min exposure to AMF. The effects of magnetic hyperthermia were significantly increased with exposure and incubation times. Most important, the levels of oxidative lesions in AMF exposed NP treated cells were up to 20-fold greater relative to those observed in nonexposed NP treated cells. Generation of oxidative lesions may be a mechanism by which magnetic hyperthermia induces cancer cell death. [ABSTRACT FROM AUTHOR]

Purpose: To study the effectiveness of the rotating magnetic field by means of complex magnetotherapeutic «Alma» in the spa treatment of patients with combined cardial and endorine pathology. Material and methods: 60 patients with coronary artery disease in combination with type 2 diabetes are studied Results: The advantage of the comprehensive use of rotating magnetic field and natural healing factors of Essentuki resort is showed. Improvements in the daily monitoring of electrocardiogram ECG, lypid, carbohydrate metabolism, in the functional state of homeostasis in second group patients is 18-20% higher than in the first group (p1-2

Nanotechnology is addressing major urgent needs for cancer treatment. We conducted a study to compare the frequency of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) adducts, biomarkers of oxidative stress and/or lipid peroxidation, on human hepatocarcinoma HepG2 cells exposed to increasing levels of Fe3O4-nanoparticles (NPs) versus untreated cells at different lengths of incubations, and in the presence of increasing exposures to an alternating magnetic field (AMF) of 186 kHz using 32P-postlabeling. The levels of oxidative damage tended to increase significantly after ≥24 h of incubations compared to controls. The oxidative DNA damage tended to reach a steady-state after treatment with 60 μg/mL of Fe3O4-NPs. Significant dose–response relationships were observed. A greater adduct production was observed after magnetic hyperthermia, with the highest amounts of oxidative lesions after 40 min exposure to AMF. The effects of magnetic hyperthermia were significantly increased with exposure and incubation times. Most important, the levels of oxidative lesions in AMF exposed NP treated cells were up to 20-fold greater relative to those observed in nonexposed NP treated cells. Generation of oxidative lesions may be a mechanism by which magnetic hyperthermia induces cancer cell death.

(1) Background: The aim of the study is to evaluate the analgesic effectiveness of a physical therapy regimen that combines the use of an electromagnetic field with light radiation emitted by LEDs, along with the use of Traumeel S ointment, in patients with gonarthrosis. (2) Methods: The study included 90 patients with knee osteoarthritis (grade 2 Kellgren and Lawrence osteoarthritis). They were divided into three groups: Group I, 30 patients treated with magnetic stimulation plus LED therapy; Group II, 30 patients treated with Traumeel S ointment; and Group III, 30 patients treated with magnetic stimulation plus LED therapy with Traumeel S ointment. Pain intensity was assessed using the VAS and Laitinen scales before and after a series of treatments. (3) Results: Significant results in terms of pain reduction before and after treatment were obtained in each of the study groups, as there were significant differences in the VAS pain intensity scores before and after the procedures between the groups. In group I, with electromagnetic field and LED light treatment, the difference was 35.5; in group II, which received Traumeel S ® ointment, the difference was 18.5; and in group III, with electromagnetic field and LED light treatment as well as Traumeel S ointment, the difference was 26.5. In the Laitinen scale, the differences were insignificant, although the size distribution was similar. (4) Conclusions: The therapy used in this study showed that magnetic stimulation plus LED therapy and the use of Traumeel S ointment gave positive results in terms of pain reduction in each of the study groups. The strongest analgesic factor seems to be magnetic and LED therapies used separately. Traumeel S in magnetoledophoresis does not work synergistically with the magnetic field of LED light, and even worsens the effect of the therapy used.

Background and Aims Cellular and animal models investigating extremely low frequency magnetic fields (ELF-MF) have reported promotion of leukocyte-endothelial interactions, angiogenesis, myofibroblast and keratinocyte proliferation, improvement of peripheral neuropathy and diabetic wound healing. In humans, it has also been reported that systemic exposure to ELF-MF stimulates peripheral blood mononuclear cells, promoting angiogenesis and healing of chronic leg ulcers. The aim of the study was to investigate the effect of exposing different blood volumes to specific ELF-MFs (120 Hz sinusoidal waves of 0.4–0.9 mT RMS) to induce healing of diabetic foot ulcers (DFUs). Methods Twenty six diabetic patients with non-responsive DFUs were divided into two exposure groups to receive treatment and record healing time. The forearm group, exposed to ELF-MF 2 h/day, twice weekly (3.6 l of blood/session); and the thorax group, exposed 25 min/day, 2 times/week (162.5 l of blood/session). Treatment period was 100 days or upon complete healing. Ulcer recurrences and adverse effects were investigated during short-term (<1 year) and long-term (3.4–7.8 years) follow-up. Results Mean healing time was 61.48 ± 33.08 days in the forearm group and 62.56 ± 29.33 days for the thorax group. No adverse effects or ulcer recurrences in the original ulcer site were reported during treatment, the short-term follow-up period or the long-term follow-up period in both groups. Conclusions Healing time was independent of the amount of blood exposed to ELF-MF used in this trial. ELF-MFs are effective and safe and could be applied to non-healing DFUs in conjunction with other preventive interventions to reduce DFUs complications. [ABSTRACT FROM AUTHOR]