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This work introduces the instrument design of the medium-energy proton detector (MEPD, detection range: 30 keV–5 MeV) mounted on the Chinese Fengyun-4B (FY-4B) satellite. Compared to a similar detector on the Fengyun-3E (FY-3E) satellite, this instrument has undergone significant changes due to the different orbital radiation environment and solar lighting conditions. Based on the calculation of the radiation model AP8, the geometrical factor is reduced to 0.002 cm2sr, while that of the MEPD on the FY-3E satellite is 0.005 cm2sr. Another difference is that the sensors in some directions are exposed to direct sunlight for 80 min every day on this orbit, depending on the attitude angle of the satellite, which is much worse than that on the FY-3E satellite. According to the calculation results of transmittance of photons through different materials, a 100 nm thickness nickel film is added in front of the sensors to eliminate light pollution completely. The test using a solar simulator shows that the measure is effective and the detector has no error count when the solar irradiance coefficient is 1.0. In addition, the Geant4 software is applied to simulate the particle transportation process under complete machine condition to check the contamination of electrons in the sensors in all directions after magnetic deflection. The data obtained in orbit show that the instrument works properly, and the data are in good agreement with the AP8 model. The observations of the MEPD on board the FY-4B satellite can provide important support for the safety of spacecraft and theoretical research related to space weather. [ABSTRACT FROM AUTHOR]

This article introduces the instrument design of the medium energy proton detector (energy range: 30 keV–5 MeV) mounted on the FY-3E satellite. Through the design and optimization of the sensor signal processing circuit, the anti-electromagnetic interference ability of the medium energy particle detector is greatly enhanced. The designed aluminum plating on sensors can effectively exclude the light pollution to the medium energy protons. The designed permanent annular magnet has a deflection efficiency of more than 95% for medium energy electrons below 1.0 MeV. Additionally, by designing the logical working mode of the sensor, the contamination by other high energy particles (high energy electrons > 1.5 MeV, high energy protons > 5 MeV, and heavy ions) is excluded. Combining the above methods, the detector achieves the detection lower limit of 30 keV for medium energy protons. Its energy resolution is better than 15%@100 keV and the mixing ratio of electrons is less than 2%. [ABSTRACT FROM AUTHOR]

This work introduces the instrument design of the medium-energy proton detector (MEPD, detection range: 30 keV–5 MeV) mounted on the Chinese Fengyun-4B (FY-4B) satellite. Compared to a similar detector on the Fengyun-3E (FY-3E) satellite, this instrument has undergone significant changes due to the different orbital radiation environment and solar lighting conditions. Based on the calculation of the radiation model AP8, the geometrical factor is reduced to 0.002 cm2sr, while that of the MEPD on the FY-3E satellite is 0.005 cm2sr. Another difference is that the sensors in some directions are exposed to direct sunlight for 80 min every day on this orbit, depending on the attitude angle of the satellite, which is much worse than that on the FY-3E satellite. According to the calculation results of transmittance of photons through different materials, a 100 nm thickness nickel film is added in front of the sensors to eliminate light pollution completely. The test using a solar simulator shows that the measure is effective and the detector has no error count when the solar irradiance coefficient is 1.0. In addition, the Geant4 software is applied to simulate the particle transportation process under complete machine condition to check the contamination of electrons in the sensors in all directions after magnetic deflection. The data obtained in orbit show that the instrument works properly, and the data are in good agreement with the AP8 model. The observations of the MEPD on board the FY-4B satellite can provide important support for the safety of spacecraft and theoretical research related to space weather.

This article introduces the instrument design of the medium energy proton detector (energy range: 30 keV–5 MeV) mounted on the FY-3E satellite. Through the design and optimization of the sensor signal processing circuit, the anti-electromagnetic interference ability of the medium energy particle detector is greatly enhanced. The designed aluminum plating on sensors can effectively exclude the light pollution to the medium energy protons. The designed permanent annular magnet has a deflection efficiency of more than 95% for medium energy electrons below 1.0 MeV. Additionally, by designing the logical working mode of the sensor, the contamination by other high energy particles (high energy electrons > 1.5 MeV, high energy protons > 5 MeV, and heavy ions) is excluded. Combining the above methods, the detector achieves the detection lower limit of 30 keV for medium energy protons. Its energy resolution is better than 15%@100 keV and the mixing ratio of electrons is less than 2%.

We present Monte Carlo simulations of the deflection of a beam of 133Cs atoms in a two wire magnetic field. Our results reveal the relationship between transmission rate of the atoms and incident parameters. Incident angle and position of the beam with maximum transmission are obtained from the simulations. The effect of the deflection field on the spatial distribution (beam profile) of 133Cs is derived. The method will help with the design of magnetic deflection experiments and to extract the magnetic properties from such experiments. [ABSTRACT FROM AUTHOR]

The work of Arthur Dempster generally has been considered significant but of less importance in the growth of mass spectrometry than that of Francis Aston, and as essentially limited to the pre‐WW II era. The development of mass spectrometry, however, as distinct from nuclear science, was shaped far more by Dempster than by Aston. This influence is seen in several aspects of instrument design and practice, and it has continued into the 21st century. [ABSTRACT FROM AUTHOR]

Purpose: To report on experimental results of a high spatial resolution silicon‐based detector exposed to therapeutic quality proton beams in a 0.95 T transverse magnetic field. These experimental results are important for the development of accurate and novel dosimetry methods in future potential real‐time MRI‐guided proton therapy systems. Methods: A permanent magnet device was utilized to generate a 0.95 T magnetic field over a 4 × 20 × 15 cm3 volume. Within this volume, a high‐resolution silicon diode array detector was positioned inside a PMMA phantom of 4 × 15 × 12 cm3. This detector contains two orthogonal strips containing 505 sensitive volumes spaced at 0.2 mm apart. Proton beams collimated to a circle of 10 mm diameter with nominal energies of 90 MeV, 110 MeV, and 125 MeV were incident on the detector from an edge‐on orientation. This allows for a measurement of the Bragg peak at 0.2 mm spatial resolution in both the depth and lateral profile directions. The impact of the magnetic field on the proton beams, that is, a small deflection was also investigated. A Geant4 Monte Carlo simulation was performed of the experimental setup to aid in interpretation of the results. Results: The nominal Bragg peak for each proton energy was successfully observed with a 0.2 mm spatial resolution in the 0.95 T transverse magnetic field in both a depth and lateral profiles. The proton beam deflection (at 0.95 T) was a consistent 2 ±0.5 mm at the center of the magnetic volume for each beam energy. However, a pristine Bragg peak was not observed for each energy. This was caused by the detector packaging having small air gaps between layers of the phantom material surrounding the diode array. These air gaps act to degrade the shape of the Bragg peak, and further to this, the nonwater equivalent silicon chip acts to separate the Bragg peak into multiple peaks depending on the proton path taken. Overall, a promising performance of the silicon detector array was observed, however, with a qualitative assessment rather than a robust quantitative dosimetric evaluation at this stage of development. Conclusions: For the first time, a high‐resolution silicon‐based radiation detector has been used to measure proton beam Bragg peak deflections in a phantom due to a strong magnetic field. Future efforts are required to optimize the detector packaging to strengthen the robustness of the dosimetric quantities obtained from the detector. Such high‐resolution silicon diode arrays may be useful in future efforts in MRI‐guided proton therapy research. [ABSTRACT FROM AUTHOR]

• Joint experimental campaigns carried out in QST lab in Naka, Ibaraki, Japan. • Full compensation of magnetic criss-cross deflection of beamlets obtained. • Non-uniform extraction assumed for interpreting the experimental results. • Numerical simulations can reproduce the experimental results with good accuracy. In the framework of the collaboration between Consorzio RFX (Padova, Italy) and QST (Naka, Japan) two experimental campaigns have been organized on the Negative Ion Test Stand (NITS) in Naka, employing an ITER-like multi-beamlet configuration. These campaigns were aimed at compensating for the undesired magnetic deflection of the ion beam. The experiments have clarified the influence of operating parameters on the optical properties of the ion beam. The physical phenomena acting on the optics have been investigated, in particular the effect of an asymmetry of the ion current density at meniscus. Comparisons with simulations have been made and the modeling has been improved consequently. During the second experimental campaign, a perfect compensation of the ion deflection has been achieved. [ABSTRACT FROM AUTHOR]

Highlights • Traps for magnetic skyrmions are proposed. • The traps consisting of located modifications of the magnetic properties. • Skyrmions can be found around magnetic defects intentionally incorporated into the nanomagnet. Abstract In this work we have used micromagnetic simulations to report four ways to build traps for magnetic skyrmions. Magnetic defects have been modeled as local variations in the material parameters, such as the exchange stiffness, saturation magnetization, magnetocrystalline anisotropy and Dzyaloshinskii-Moriya constant. We observe both pinning (potential well) and scattering (potential barrier) traps when tuning either a local increase or a local reduction for each one of these magnetic properties. It is found that the skyrmion-defect aspect ratio is a crucial parameter to build traps for skyrmions. In particular, the efficiency of the trap is compromised if the defect size is smaller than the skyrmion size, because they interact weakly. On the other hand, if the defect size is larger than the skyrmion diameter, the skyrmion-defect interaction becomes evident. Thus, the strength of the skyrmion-defect interaction can be tuned by the modification of the magnetic properties within a region with suitable size. Furthermore, the basic physics behind the mechanisms for pinning and for scattering is discussed. In particular, we discover that skyrmions move towards the magnetic region which tends to maximize its diameter; it enables the magnetic system to minimize its energy. Thus, we are able to explain why skyrmions are either attracted or repelled by a region with modified magnetic properties. Results here presented are of utmost significance for the development of future spintronic devices, in which skyrmions will work as information carriers. [ABSTRACT FROM AUTHOR]

Highlights • Novel swirl tube design for enhancing the heat transfer performance of pole shields of EAST-NBI. • Optimizing for the cooling scheme and the key structural parameters. • The design scheme effectively reduces the surface temperature of pole shields of EAST-NBI. Abstract The Neutral Beam Injection (NBI) auxiliary heating system for Experimental Advanced Superconducting Tokamak (EAST) is designed with 180 ° magnetic field deflection to deflect the particles that are not neutralized during the beam transmission. For protecting the deflection magnet from the influence of the divergent beam, the pole shields are designed to be placed on both sides of its optical path, and the highest power density of the above deposit will be as high as several MW/m2. In order to ensure reliable operation of 100s and even 1000s long pulse EAST-NBI system, it is very important to enhance the heat transfer performance of these shields. A novel heat transfer enhancement design of pole shield with swirl tube for EAST-NBI system is presented in this paper. By using a verified subcooled boiling model, the performance optimization of the key structural parameters is completed according to the operation limit of the magnetic pole shield and the cooling water system, and also the final structural optimization scheme is checked. The results show that heat transfer performance of the proposed scheme can well satisfy the requirements of the long pulse design. This study provides a potential method for the heat transfer enhancement design of other high heat flux components in EAST-NBI system, which is of great theoretical and practical significance for the future operation with long pulse (over 1000 s) and high power 2˜4 MW. [ABSTRACT FROM AUTHOR]

A common problem of the multi-beamlet, negative-ion based Heating Neutral Beam (HNB) Injectors presently used in fusion research, is the undesired deflection of negative ions due the permanent magnets embedded in the Extraction Grid (EG) for the suppression of the unwanted co-extracted electrons. A new solution has been recently developed at Consorzio RFX, which makes use of an additional set of permanent magnets, also embedded in the EG, with a series of advantages in terms of performances and versatility with respect to the traditional electrostatic compensation. This solution is now the new standard for ITER. After a thorough validation of the design by different numerical models, it was decided to experimentally test this solution for the first time on the Negative Ion Test Stand (NITS) at National Institute for Quantum and Radiological science and technology (QST), in Japan, within the framework of a scientific cooperation agreement between QST and Consorzio RFX. To this purpose, an EG having an ITER-like profile and compatible with NITS accelerator was designed and constructed at Consorzio RFX. This paper describes the design solutions adopted for this grid and its related permanent magnets, the construction phase, and a brief report on the first experimental results. [ABSTRACT FROM AUTHOR]

A modular implementation of a scanning multi-source X-ray tube is designed for the increasing number of multi-source imaging applications in computed tomography (CT). An electron beam array coupled with an oscillating magnetic deflector is proposed as a means for producing an X-ray focal spot at any position along a line. The preliminary multi-source model includes three thermionic electron guns that are deflected in tandem by a slowly varying magnetic field and pulsed according to a scanning sequence that is dependent on the intended imaging application. Particle tracking simulations with particle dynamics analysis software demonstrate that three 100 keV electron beams are laterally swept a combined distance of 15 cm over a stationary target with an oscillating magnetic field of 102 G perpendicular to the beam axis. Beam modulation is accomplished using 25 μ s pulse widths to a grid electrode with a reverse gate bias of −500 V and an extraction voltage of +1000 V. Projected focal spot diameters are approximately 1 mm for 138 mA electron beams and the stationary target stays within thermal limits for the 14 kW module. This concept could be used as a research platform for investigating high-speed stationary CT scanners, for lowering dose with virtual fan beam formation, for reducing scatter radiation in cone-beam CT, or for other industrial applications. [ABSTRACT FROM AUTHOR]

With the recent clinical implementation of real-time MRI-guided x-ray beam therapy (MRXT), attention is turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI-guided proton beam therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the current treatment workflow which is warranted arguably more than for x-ray beam therapy. This argument is born out of the fact that proton therapy toxicity outcomes are similar to that of the most advanced IMRT treatments, despite being a fundamentally superior particle for cancer treatment. In this Future of Medical Physics article, we describe the various software and hardware aspects of potential MRPT systems and the corresponding treatment workflow. Significant software developments, particularly focused around adaptive MRI-based planning will be required. The magnetic interaction between the MRI and the proton beamline components will be a key area of focus. For example, the modeling and potential redesign of a magnetically compatible gantry to allow for beam delivery from multiple angles towards a patient located within the bore of an MRI scanner. Further to this, the accuracy of pencil beam scanning and beam monitoring in the presence of an MRI fringe field will require modeling, testing, and potential further development to ensure that the highly targeted radiotherapy is maintained. Looking forward we envisage a clear and accelerated path for hardware development, leveraging from lessons learnt from MRXT development. Within few years, simple prototype systems will likely exist, and in a decade, we could envisage coupled systems with integrated gantries. Such milestones will be key in the development of a more efficient, more accurate, and more successful form of proton beam therapy for many common cancer sites. [ABSTRACT FROM AUTHOR]

We describe the use of an extrinsic fluorophore (rhodamine B isothiocyanate) as a versatile probe to measure rotational motions of proteins. To illustrate the usefulness of this probe, we describe the fluorescence anisotropy values of this fluorophore covalently linked to myoglobin protein measured in aqueous solutions of increased methanol content. Methanol-induced unfolding is revealed by the transition from constrained to free rotation of the covalently attached rhodamine B fluorophore. Graphical abstract: [ABSTRACT FROM AUTHOR]

This letter presents a novel device concept of split-current magnetic sensor that is fully compatible with silicon-on-insulator(SOI) FinFET technology. The fabricated dual-gate four-terminal device brings a step change in SOI integrated sensor capabilities, and its measured current-related relative sensitivity is as high as 3400% \textT^-1 at 2 \mu \textA of total supply current. The device’s very high sensitivity is attributed to its novel current conduction phenomena and the internal magnetic deflection enhancement loop demonstrated using 3-D TCAD numerical simulations. This new magnetic sensor is a very promising candidate for the next generation of magnetic sensitive smart-power integrated circuits. [ABSTRACT FROM PUBLISHER]

We examined discrimination of a second-language (L2) vowel duration contrast in English learners of Japanese (JP) with different amounts of experience using the magnetoencephalography mismatch field (MMF) component. Twelve L2 learners were tested before and after a second semester of college-level JP; half attended a regular rate course and half an accelerated course with more hours per week. Results showed no significant change in MMF for either the regular or accelerated learning group from beginning to end of the course. We also compared these groups against nine L2 learners who had completed four semesters of college-level JP. These 4-semester learners did not significantly differ from 2-semester learners, in that only a difference in hemisphere activation (interacting with time) between the two groups approached significance. These findings suggest that targeted training of L2 phonology may be necessary to allow for changes in processing of L2 speech contrasts at an early, automatic level. [ABSTRACT FROM AUTHOR]

We report a method for acquiring Foucault images and small-angle electron diffraction patterns in external magnetic fields using a conventional transmission electron microscope without any modification. In the electron optical system that we have constructed, external magnetic fields parallel to the optical axis can be controlled using the objective lens pole piece under weak excitation conditions in the Foucault mode and the diffraction mode. We observe two ferromagnetic perovskite-type manganese oxides, La0.7Sr0.3MnO3 (LSMO) and Nd0.5Sr0.5MnO3, in order to visualize magnetic domains and their magnetic responses to external magnetic fields. In rhombohedral-structured LSMO, pinning of magnetic domain walls at crystallographic twin boundaries was found to have a strong influence on the generation of new magnetic domains in external applied magnetic fields. [ABSTRACT FROM AUTHOR]

Magnetic anisotropy can provide important information about mineral fabrics, and thus magmatic processes, particularly when it is known how multiple mineral species contribute to the anisotropy. It may also affect the direction of induced or remanent magnetization, with important consequences for paleomagnetic studies or the interpretation of magnetic anomalies. Here, we aim at describing the magnetic fabrics in the Bjerkreim Sokndal Layered Intrusion and identifying their carriers. Anisotropies of magnetic susceptibility and remanence were measured on samples covering different geographic locations and stratigraphic units within the Bjerkreim Sokndal Layered Intrusion. The intrusion is characterized by magmatic layering and has a synform structure, with strong foliation on the limbs. Detailed comparison between magnetic and mineral fabric shows that they are not necessarily coaxial, but the minimum susceptibility, and minimum anhysteretic remanence are generally normal to the foliation or the magmatic layering. The minimum susceptibility and anhysteretic remanence are associated with pyroxene (100) axes, and the maximum susceptibility and anhysteretic remanence are sub-parallel to the pyroxene [001] axes in layers MCU IVc and MCU IVe for which electron backscatter data are available. However, the paramagnetic anisotropy of pyroxene is too weak to explain the observed anisotropy. We propose that the magnetic anisotropy of magnetite-free specimens is carried by hemo-ilmenite exsolutions within pyroxene, in addition to pyroxene itself. When present, multi-domain magnetite dominates both the anisotropy of magnetic susceptibility and anhysteretic remanence, due to shape-preferred orientation and distribution anisotropy. The orientation of the magnetic fabric appears independent of carrier, due to their common deformation history, but the degree of anisotropy is stronger for magnetite-bearing specimens. The results of this study will facilitate future structural interpretations and may be used to correct for magnetization deflection. [ABSTRACT FROM AUTHOR]

Purpose: This paper investigates, via magnetic modeling and Monte Carlo simulation, the ability to deliver proton beams to the treatment zone inside a split-bore MRI-guided proton therapy system. Methods: Field maps from a split-bore 1 T MRI-Linac system are used as input to GEANT4 Monte Carlo simulations which model the trajectory of proton beams during their paths to the isocenter of the treatment area. Both inline (along the MRI bore) and perpendicular (through the split-bore gap) orientations are simulated. Monoenergetic parallel and diverging beams of energy 90, 195, and 300 MeV starting from 1.5 and 5 m above isocenter are modeled. A phase space file detailing a 2D calibration pattern is used to set the particle starting positions, and their spatial location as they cross isocenter is recorded. No beam scattering, collimation, or modulation of the proton beams is modeled. Results: In the inline orientation, the radial symmetry of the solenoidal style fringe field acts to rotate the protons around the beam's central axis. For protons starting at 1.5 m from isocenter, this rotation is 19° (90 MeV) and 9.8° (300 MeV). A minor focusing toward the beam's central axis is also seen, but only significant, i.e., 2 mm shift at 150 mm off-axis, for 90 MeV protons. For the perpendicular orientation, the main MRI field and near fringe field act as the strongest to deflect the protons in a consistent direction. When starting from 1.5 m above isocenter shifts of 135 mm (90 MeV) and 65 mm (300 MeV) were observed. Further to this, off-axis protons are slightly deflected toward or away from the central axis in the direction perpendicular to the main deflection direction. This leads to a distortion of the phase space pattern, not just a shift. This distortion increases from zero at the central axis to 10 mm (90 MeV) and 5 mm (300 MeV) for a proton 150 mm off-axis. In both orientations, there is a small but subtle difference in the deflection and distortion pattern between protons fired parallel to the beam axis and those fired from a point source. This is indicative of the 3D spatially variant nature of the MRI fringe field. Conclusions: For the first time, accurate magnetic and Monte Carlo modeling have been used to assess the transport of generic proton beams toward a 1 T split-bore MRI. Significant rotation is observed in the inline orientation, while more complex deflection and distortion are seen in the perpendicular orientation. The results of this study suggest that due to the complexity and energy-dependent nature of the magnetic deflection and distortion, the pencil beam scanning method will be the only choice for delivering a therapeutic proton beam inside a potential MRI-guided proton therapy system in either the inline or perpendicular orientation. Further to this, significant correction strategies will be required to account for the MRI fringe fields. [ABSTRACT FROM AUTHOR]

The ejection of particles with energy up to 20 MeV u-1 was reported previously from laser-induced processes in ultra-dense deuterium D(0). Studies of the kinetics of particle formation and decay, and of particle penetration through thick plates are now reported. Magnetic deflection is used to remove charged particles like electrons formed at the target. The signals at a collector in the beam at 0.9 m distance and a shadowed loop collector behind a 1.5-4.5 mm thick steel plate at 0.6 m are compared. The signal at the distant collector matches an intermediate particle B in a decay chain A → B → C with formation and decay time constants of 5-15 ns. The signal at the loop collector is delayed relative to the more distant collector, thus showing a delay of the particles penetrating through the steel plate. The signal at this collector is due to pair production with charge cancellation. Compton electrons from gamma radiation are observed at peak current densities of 1 mA cm-2 at the distant collector. [ABSTRACT FROM AUTHOR]

We present the results of a study that simulates trajectories of ultra-high energy cosmic rays from Centaurus A to Earth, for particle rigidities from E/Z=2 EV to 100 EV, i.e., covering the possibility of primary particles as heavy as Fe nuclei with energies exceeding 50 EeV. The Galactic magnetic field is modeled using the recent work of Jansson and Farrar (JF12) which fitted its parameters to match extragalactic Faraday rotation measures and WMAP7 synchrotron emission maps. We include the random component of the GMF using the JF12 3D model for Brand(r→) and explore the impact of different random realizations, coherence length and other features on cosmic ray deflections. Gross aspects of the arrival direction distribution such as mean deflection and the RMS dispersion depend mainly on rigidity and differ relatively little from one realization to another. However different realizations exhibit non-trivial substructure whose specific features vary considerably from one realization to another, especially for lower rigidities. At the lowest rigidity of 2 EV, the distribution is broad enough that it might be compatible with a scenario in which Cen A is the principle source of all UHECRs. No attempt is made here to formulate a robust test of this possibility, although some challenges to such a scenario are noted. [ABSTRACT FROM AUTHOR]

In addition to electromagnetic attraction between the arcs in Tandem Pulsed gas metal arc welding (GMAW), arc interruptions, mostly in the trailing arc at low mean current levels, may also occur, which is a phenomenon not widely discussed in the welding field. These arc interruptions must be avoided, since they also represent interruptions in metal fusion and deposition during the welding process, leading to lack of fusion/penetration and/or deposition flaws, adding cost for repairing operations. To improve the understanding on arc interruptions in Tandem Pulsed GMAW and how the current pulsing synchronism between the arcs relates to this phenomenon, this work proposes to evaluate the influence of parameters of adjacent arcs (Tandem Pulsed GMAW) and also of a single arc (GTAW--gas tungsten arc welding), but similarly subjected to magnetic deflection, on the occurrence of arc interruptions/extinctions. High-speed filming was used to help understand the interruption! extinction mechanism. In the case of Tandem Pulsed GMAW, the pulses of current of the leading and trailing arcs need to be almost-in-phase to prevent interruptions in the trailing arc. The distance of 10 mm between the adjacent arcs helped reduce the incidence of trailing arc interruptions, yet keeping a sound weld visual quality. In the case of GTAW, the higher the electrical current flowing through the arcs and the shorter their lengths, the more they resist to the extinction. The trailing arc interruptions in Tandem Pulsed GMAW seem to be determined by the deflection and heat in this arc, and their prevention can be achieved by a balance between these two factors, which is reached by synchronized pulsing currents. [ABSTRACT FROM AUTHOR]

Phospholipase D (PLD) is a critical component of intracellular signal transduction and has been implicated in many important biological processes. It has been observed that there are abnormalities in PLD expression in many human cancers, and PLD is thus recognized as a potential diagnostic biomarker as well as a target for drug discovery. We report for the first time a phospholipid-modified nanoprobe for ratiometric upconversion fluorescence (UCF) sensing and bioimaging of PLD activity. The nanoprobe can be synthesized by a facile one-step self-assembly of a phospholipid monolayer composed of polyethylene glycol) PEG)ylated phospholipid and rhodamine B-labeled phospholipid on the surface of upconversion nanopartides (UCNPs) NaYF4: 20%Yb, 2%Er. The fluorescence resonance energy transfer (FRET) process from the UCF emission at 540 nm of the UCNPs to the absorbance of the rhodamine B occurs in the nanoprobe. The PLD-mediated hydrolysis of the phosphodiester bond makes rhodamine B apart from the UCNP surface, leading to the inhibition of FRET. Using the unaffected UCF emission at 655 nm as an internal standard, the nanoprobe can be used for ratiometric UCF detection of PLD activity with high sensitivity and selectivity. The PLD activity in cell lysates is also detennined by the nanoprobe, confirming that PLD activity in a breast cancer cell is at least 7-fold higher than in normal cell. Moreover, the nanoprobe has been successfully applied to monitoring PLD activity in living cells by UCF bioimaging. The results reveal that the nanoprobe provides a simple, sensitive, and robust platform for point-of-care diagnostics and drug screening in biomedical applications. [ABSTRACT FROM AUTHOR]

Highlights: [•] The laser assisted realignment of the exchange bias field was demonstrated. [•] A spin valve layer system for magnetic field sensor applications was investigated. [•] A rapidly deflected laser was used for the local heating. [•] The Application of continuous wave and pulsed laser radiation was compared. [•] Applying pulsed laser radiation leads to a much lower required energy input. [Copyright &y& Elsevier]

SUMMARY A Stern-Gerlach magnet applies a field gradient in order to deflect particles such that their magnetic moment can be determined. The design of such magnets is based on finite-element (FE) simulations of the magnetic field and its gradient. However, inaccuracies arise when these quantities are calculated from an FE solution for the magnetic vector potential by numerical differentiation. For first-order FE shape functions, the discretisation error for the field gradient may even fail to converge. An improved post-processing approach marks a region in the magnet aperture where the field is post-processed by matching a local analytical solution with the obtained FE solution. The local solution allows to derive values for the magnetic field and its gradient without reducing the convergence order of the discretisation error. The method is validated against the analytic solution for a two-wire configuration and is applied for the design of a Rabi-type Stern-Gerlach magnet. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Resolute Bay, Canada, with an almost vertical geomagnetic field and the associated simplicity of ionospheric current system, is an optimal location to determine the relationship between the ionospheric electric field and the magnetic deflections on the ground. Considering uniform current sheets in a plane geometry, the magnetic deflection direction on the ground is expected to be (1) the same as the ionospheric electric field direction for the Hall current only or (2) lag the electric field direction 0-to-90° in the clockwise sense looking down when the Pedersen current is included. However, our analysis of Resolute incoherent scatter radar and magnetometer data shows that the magnetic deflection angle is leading in a range 30–70° depending on the magnetic local time. Additional magnetometers at Thule and Cambridge Bay observatories were used to investigate the effect of auroral zone currents, however, a simple deconvolution using these stations did not change the results significantly. Furthermore, inclusion of the neutral winds only slightly changed the offset angle. We conclude that a sunward magnetic contribution on the order of 50nT caused by magnetospheric currents is needed to explain the offset. [ABSTRACT FROM AUTHOR]

Arc interruptions have been observed in tandem pulsed gas metal arc welding (GMAW). This fact, which is likely related to magnetic interaction between the arcs, motivated previous study concerning the influence of the welding current on this phenomenon. In order to promote further understanding, this paper investigates the effects of arc length, torch angle, and high-frequency current pulsing on the arc resistance to extinction. To mimic the situation found in tandem GMAW (magnetic field induced by one arc acting on the other arc), external magnetic fields were applied to gas tungsten arc welding arcs. It was verified that short arc lengths and torch angles set to push the weld pool increase the arc resistance to extinction, whereas the utilization of high-frequency current pulsing tends to weaken the arc resistance to extinction. According to a model devised from the results, the arc extinction takes place if the heat generated inside and the heat transferred into the arc column become insufficient to counterbalance the total heat loss in this arc region. [ABSTRACT FROM PUBLISHER]

Arc interruptions and, therefore, oscillation in the amount of energy and molten wire delivered to the plate have been observed during tandem pulsed gas metal arc welding (GMAW). It appears that these instabilities are related to the magnetic interaction between the arcs. In order to clarify the possible mechanisms involved, this paper tries to mimic the tandem GMAW arc interruptions. External magnetic fields were dynamically applied to GTAW arcs in constant current mode to verify their resistance to extinction as a function of current level and direction of deflection. High-speed filming was carried out as an additional tool to understand the extinction mechanism. The influence of the welding current level on the arc resistance to extinction was established: The higher the welding current, the more the arc resists to the extinction. The arc deflection direction has minor effect, but arcs deflected backward have more resistance to extinction. [ABSTRACT FROM PUBLISHER]

In view of the realization of the negative ion beam injectors for ITER, a test facility, named SPIDER, is under construction in Padova (Italy) to study and optimize production and extraction of negative ions. The present paper is devoted to the analysis of the expected first operations of SPIDER in terms of single-beamlet and multiple-beamlet simulations of the hydrogen beam optics in various operational conditions. The effectiveness of the methods adopted to compensate for the magnetic deflection of the particles is also assessed. Indications for a sequence of the experimental activities are obtained. [ABSTRACT FROM AUTHOR]

Fabricating soft functional materials via additive manufacturing is an emerging field with a wide variety of applications due to their ability to respond to specifically engineered stimuli (e.g., mechanical, electrical, magnetic, chemical). This article describes an approach to engineering magnetically sensitive structures using three-dimensional printing of acrylonitrile butadiene styrene scaffolds. These scaffolds are encapsulated in polydimethylsiloxane (PDMS) and removed using organic solvents. The open channels that remain after removal are filled in with a ferrofluid to render the structure magnetically sensitive. A three-point flexural test shows that introducing a channel in this way only reduces the flexural modulus of the PDMS by a factor ∼8%. We perform magnetic deflection experiments on samples with three different channel diameters. Our results show a linear dependence between applied magnetic field strength and deflection. We also find that there is a minimum magnetic field strength that needs to be applied to achieve deflection. These results suggest that there is a minimum yield stress, beyond which deflection will occur. We perform experiments on a more complex channel geometry to find that there are multiple modes of deflection. A rational approach to channel design may enable us to tune the mechanical response and direct these actuators to undergo complex motion., Competing Interests: No competing financial interests exist., (Copyright 2021, Mary Ann Liebert, Inc., publishers.)

Matter-wave near-field interference can imprint a nano-scale fringe pattern onto a molecular beam, which allows observing its shifts in the presence of even very small external forces. Here we demonstrate quantum interference of the pre-vitamin 7-dehydrocholesterol and discuss the conceptual challenges of magnetic deflectometry in a near-field interferometer as a tool to explore photochemical processes within molecules whose center of mass is quantum delocalized. [ABSTRACT FROM AUTHOR]

Predicting the impact of coronal mass ejections (CMEs) and the southward component of their magnetic field is one of the key goals of space weather forecasting. We present a new model, the ForeCAT In situ Data Observer (FIDO), for predicting the in situ magnetic field of CMEs. We first simulate a CME using ForeCAT, a model for CME deflection and rotation resulting from the background solar magnetic forces. Using the CME position and orientation from ForeCAT, we then determine the passage of the CME over a simulated spacecraft. We model the CME’s magnetic field using a force-free flux rope and we determine the in situ magnetic profile at the synthetic spacecraft. We show that FIDO can reproduce the general behavior of four observed CMEs. FIDO results are very sensitive to the CME’s position and orientation, and we show that the uncertainty in a CME’s position and orientation from coronagraph images corresponds to a wide range of in situ magnitudes and even polarities. This small range of positions and orientations also includes CMEs that entirely miss the satellite. We show that two derived parameters (the normalized angular distance between the CME nose and satellite position and the angular difference between the CME tilt and the position angle of the satellite with respect to the CME nose) can be used to reliably determine whether an impact or miss occurs. We find that the same criteria separate the impacts and misses for cases representing all four observed CMEs. [ABSTRACT FROM AUTHOR]

It is largely accepted that Galactic cosmic rays, which pervade the interstellar medium, originate by means of shock waves in supernova remnants. Cosmic rays activate the rich chemistry that is observed in a molecular cloud and they also regulate its collapse timescale, determining the efficiency of star and planet formation, but they cannot penetrate up to the densest part of a molecular cloud, where the formation of stars is expected, because of energy loss processes and magnetic field deflections. Recently, observations towards young protostellar systems showed a surprisingly high value of the ionisation rate, the main indicator of the presence of cosmic rays in molecular cloud. Synchrotron emission, the typical feature of relativistic electrons, has also been detected towards the bow shock of a T Tauri star. Nevertheless, the origin of these signatures peculiar to accelerated particles is still puzzling. Here we show that particle acceleration can be driven by shock waves occurring in protostars through the first-order Fermi acceleration mechanism. We expect that shocks in protostellar jets can be efficient accelerators of protons, which can be boosted up to mildly relativistic energies. A strong acceleration can also take place at the protostellar surface, where shocks produced by infalling material during the phase of collapse are powerful enough to accelerate protons. Our model shows that thermal particles can experience an acceleration during the first phases of a system similar to the proto-Sun, and can also be used to explain recent observations. The presence of a local source of cosmic rays may have an unexpected impact over the process of the formation of stars and planets, as well as on the pre-biotic molecule formation. [ABSTRACT FROM AUTHOR]

A numerical FLUENT-based model has been developed for the three-dimensional and time-dependent simulation of a magnetically deflected transferred arc. Results are presented for a case in which an argon arc is deflected with a 150-A current flowing in a wire parallel to the axis of the arc. [ABSTRACT FROM AUTHOR]