Search

Objective: The purpose of this study was to investigate the relationship between lymph node harvest and the prognosis in locally advanced rectal cancer (LARC) patients after neoadjuvant chemoradiotherapy (nCRT). Methods: Patients who were diagnosed with clinical LARC and treated with nCRT and radical surgery between June 2008 and July 2017 were included in this study. The relationship between lymph node retrieval and prognosis was analyzed. Other lymph node-related indicators were explored. Results: A total of 837 patients with a median follow-up of 61 (7-139) months were included in the study. The five-year DFS and OS rates of all patients were 74.9% and 82.3%, respectively. Multivariate survival analysis suggested that dissection of ≥ 12 lymph nodes did not improve OS or DFS. 7 was selected as the best cutoff value for the total number of lymph nodes retrieved by Cox multivariate analysis (χ2 = 10.072, HR: 0.503, P=0.002). Dissection of ≥ 5 positive lymph nodes (PLNs) was an independent prognostic factor for poorer DFS (HR: 2.104, P=0.004) and OS (HR: 3.471, p<0.001). A positive lymph node ratio (LNR) of more than 0.29 was also an independent prognostic factor for poorer DFS (HR: 1.951, P=0.002) and OS (HR: 2.434, p<0.001). Conclusion: The recommends that at least 7 harvested lymph nodes may be more appropriate for LARC patients with nCRT. PLN and LNR may be prognostic factors for LARC patients with ypN+ after nCRT. [ABSTRACT FROM AUTHOR]

ObjectiveThe purpose of this study was to investigate the relationship between lymph node harvest and the prognosis in locally advanced rectal cancer (LARC) patients after neoadjuvant chemoradiotherapy (nCRT).MethodsPatients who were diagnosed with clinical LARC and treated with nCRT and radical surgery between June 2008 and July 2017 were included in this study. The relationship between lymph node retrieval and prognosis was analyzed. Other lymph node-related indicators were explored.ResultsA total of 837 patients with a median follow-up of 61 (7-139) months were included in the study. The five-year DFS and OS rates of all patients were 74.9% and 82.3%, respectively. Multivariate survival analysis suggested that dissection of ≥ 12 lymph nodes did not improve OS or DFS. 7 was selected as the best cutoff value for the total number of lymph nodes retrieved by Cox multivariate analysis (χ2 = 10.072, HR: 0.503, P=0.002). Dissection of ≥ 5 positive lymph nodes (PLNs) was an independent prognostic factor for poorer DFS (HR: 2.104, P=0.004) and OS (HR: 3.471, p

Aim-Background: The number of the retrieved lymph nodes in colorectal cancer specimens is of major significance for accurate staging and deciding possible adjuvant therapy, while node-metastasis is one of the most important prognostic factors of colorectal cancer. The aim of this study is to determine the association of clinicopathological factors with the number of the retrieved lymph nodes in colorectal cancer specimens. Methods: During the period 2008-2010, 42 patients underwent surgery for colorectal cancer. The cases were reviewed according to age, gender, tumour location and diameter, and bowel length. Results: The number of lymph nodes retrieved was reviewed according to the possible association with the clinicopathological factors under study. There was no significant association between gender and the number of lymph nodes examined, between the tumour size and the number of lymph nodes retrieved or the bowel length. On the contrary, a variance in the number was noted when the different location of the tumour was considered, and also when different age groups were studied. Conclusions: The number of the lymph nodes retrieved in colorectal specimens can be associated with many different factors, but what should always be taken into consideration before proceeding to surgical treatment is the tumour location and the patient's age. [ABSTRACT FROM AUTHOR]