10 results on '"lung neoplasms (MESH)"'
Search Results
2. Hipocratismo digital: conociendo sus causas. Reporte de caso.
- Author
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Andrés Uribe-Valencia, Mauricio, Mauricio Ocampo, José, and Parra-Camarillo, Maximiliano
- Subjects
SYMPTOMS ,LUNG diseases ,PLEURAL effusions ,WEIGHT loss ,HOSPITAL emergency services ,NAIL diseases - Abstract
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- Published
- 2019
- Full Text
- View/download PDF
3. Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?
- Author
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Derks, Jules L, Dingemans, Anne‐Marie C, Suylen, Robert‐Jan, Bakker, Michael A, Damhuis, Ronald A M, Broek, Esther C, Speel, Ernst‐Jan, and Thunnissen, Erik
- Subjects
- *
NEUROENDOCRINE tumors , *BIOPSY , *IMMUNOHISTOCHEMISTRY , *DIAGNOSIS , *CHROMOGRANINS - Abstract
Aims: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. Methods and results: Using the Dutch pathology registry (PALGA), surgically resected LCNEC with matching pre‐operative biopsy specimens were identified and haematoxylin and IHC slides (CD56, chromogranin‐A, synaptophysin) requested. Subsequently, three pathologists assigned (1) the presence or absence of the WHO 2015 criteria and (2) cumulative size of all (biopsy) specimens. For validation, a tissue microarray (TMA) of non‐small‐cell lung cancer (NSCLC) (n = 77) and LCNEC (n = 19) was used. LCNEC was confirmed on the resection specimens in 32 of 48 re‐reviewed cases. In 47% (n = 15 of 32) LCNEC was also confirmed in the paired biopsy specimens. Neuroendocrine morphology was absent in 53% (n = 17 of 32) of paired biopsy specimens, more often when smaller amounts of tissue were available for evaluation [29% < 5 mm (n = 14) versus 67% ≥5 mm (n = 18) P = 0.04]. Combined with current WHO criteria, positive staining for greater than or equal to two of three neuroendocrine IHC markers increased the sensitivity for LCNEC from 47% to 93% on paired biopsy specimens, and further validated using an independent TMA of LCNEC and NSCLC with sensitivity and specificity of 80% and 99%, respectively. Conclusions: LCNEC is difficult to diagnose because neuroendocrine morphology is frequently absent in biopsy specimens. In NSCLC devoid of obvious morphological squamous or adenocarcinoma features, positive staining in greater than or equal to two of three neuroendocrine IHC stains supports the diagnosis of LCNEC. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
4. Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group
- Author
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A Gómez-Caamaño, M Guirado, L Pijuan, C Teixido, Á Cilleruelo-Ramos, and A Sanchez-Hernandez
- Subjects
Cancer Research ,Lung Neoplasms ,media_common.quotation_subject ,Quality of health care (MeSH) ,Review Article ,Institutional support ,Therapeutic approach ,Quality of life (healthcare) ,Nursing ,Multidisciplinary approach ,Excellence ,Medicine ,Tumor board ,Humans ,Quality (business) ,Quality indicators (MeSH) ,Lung cancer ,media_common ,Quality Indicators, Health Care ,Patient Care Team ,Lung neoplasms (MeSH) ,business.industry ,General Medicine ,Multidisciplinary team ,medicine.disease ,Oncology ,Spain ,business - Abstract
Multidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administrative and institutional support; and recording of activity are key factors for the success of LC-MDTs. A set of excellence requirements in terms of staff, resources and organization of the LC-MDT have been proposed. At last, a list of quality indicators has been agreed to achieve and measure the performance of current LC-MDTs.
- Published
- 2021
5. Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?
- Author
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Michael A. den Bakker, Robert-Jan van Suylen, Erik Thunnissen, Ernst-Jan M. Speel, Esther C. van den Broek, Jules L. Derks, Anne-Marie C. Dingemans, Ronald A M Damhuis, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Promovendi ODB, Pulmonologie, MUMC+: MA Med Staf Spec Longziekten (9), Pathologie, RS: GROW - R2 - Basic and Translational Cancer Biology, and Pathology
- Subjects
0301 basic medicine ,Male ,Pathology ,PROGNOSIS ,neuroendocrine (MESH) ,Lung Neoplasms ,FEATURES ,Biopsy ,carcinoma ,0302 clinical medicine ,diagnosis (MESH) ,WHO classification ,Tissue microarray ,medicine.diagnostic_test ,biology ,General Medicine ,CHEMOTHERAPY ,Middle Aged ,PATHOLOGICAL DIAGNOSIS ,TUMORS ,Immunohistochemistry ,DIFFERENTIATION ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Original Article ,Female ,biopsy (MESH) ,EXPRESSION ,medicine.medical_specialty ,Histology ,SOCIETY ,CLASSIFICATION ,Pathology and Forensic Medicine ,LCNEC ,03 medical and health sciences ,lung neoplasms (MESH) ,LUNG-CANCER ,medicine ,Carcinoma ,Biomarkers, Tumor ,sensitivity and specificity (MESH) ,Humans ,Lung cancer ,Aged ,Retrospective Studies ,Staining and Labeling ,business.industry ,Original Articles ,Large cell neuroendocrine carcinoma of the lung ,medicine.disease ,Carcinoma, Neuroendocrine ,030104 developmental biology ,Synaptophysin ,biology.protein ,Carcinoma, Large Cell ,business - Abstract
Aims Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. Methods and results Using the Dutch pathology registry (PALGA), surgically resected LCNEC with matching pre-operative biopsy specimens were identified and haematoxylin and IHC slides (CD56, chromogranin-A, synaptophysin) requested. Subsequently, three pathologists assigned (1) the presence or absence of the WHO 2015 criteria and (2) cumulative size of all (biopsy) specimens. For validation, a tissue microarray (TMA) of non-small-cell lung cancer (NSCLC) (n = 77) and LCNEC (n = 19) was used. LCNEC was confirmed on the resection specimens in 32 of 48 re-reviewed cases. In 47% (n = 15 of 32) LCNEC was also confirmed in the paired biopsy specimens. Neuroendocrine morphology was absent in 53% (n = 17 of 32) of paired biopsy specimens, more often when smaller amounts of tissue were available for evaluation [29% = 5 mm (n = 18) P = 0.04]. Combined with current WHO criteria, positive staining for greater than or equal to two of three neuroendocrine IHC markers increased the sensitivity for LCNEC from 47% to 93% on paired biopsy specimens, and further validated using an independent TMA of LCNEC and NSCLC with sensitivity and specificity of 80% and 99%, respectively. Conclusions LCNEC is difficult to diagnose because neuroendocrine morphology is frequently absent in biopsy specimens. In NSCLC devoid of obvious morphological squamous or adenocarcinoma features, positive staining in greater than or equal to two of three neuroendocrine IHC stains supports the diagnosis of LCNEC.
- Published
- 2019
6. Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group
- Author
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Guirado M, Sanchez-Hernandez A, Pijuan L, Teixido C, Gomez-Caamano A, and Cilleruelo-Ramos A
- Subjects
Lung neoplasms (MeSH) ,Quality of health care (MeSH) ,Multidisciplinary team ,Quality indicators (MeSH) ,Tumor board - Abstract
Multidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administrative and institutional support; and recording of activity are key factors for the success of LC-MDTs. A set of excellence requirements in terms of staff, resources and organization of the LC-MDT have been proposed. At last, a list of quality indicators has been agreed to achieve and measure the performance of current LC-MDTs.
- Published
- 2021
7. Assessment of the Psychometric Properties of an English Version of the Cancer Dyspnea Scale in People With Advanced Lung Cancer
- Author
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Uronis, Hope E., Shelby, Rebecca A., Currow, David C., Ahmedzai, Sam H., Bosworth, Hayden B., Coan, April, and Abernethy, Amy P.
- Subjects
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PSYCHOMETRICS , *DYSPNEA , *LUNG cancer , *STATISTICAL reliability , *MEDICAL statistics , *CRONBACH'S alpha - Abstract
Abstract: Context: Dyspnea is a poorly understood subjective sensation. Existing dyspnea measures fail to adequately address its multidimensionality. A Japanese group developed and validated the Cancer Dyspnea Scale (CDS) for assessing dyspnea in patients with advanced lung cancer. Objectives: We evaluated the validity and reliability of the English version of the CDS (CDS-E) that has 12 items and takes, on average, 140 seconds for individuals to complete. Methods: Eligible patients had advanced lung cancer, consented, and were fluent in English. Participants completed a 100mm visual analogue scale (VAS), the modified Borg scale, the CDS-E, the Hospital Anxiety and Depression Scale, and the Functional Assessment of Cancer Therapy—Lung quality-of-life scale. Demographic, radiographic, and treatment information were obtained from patients'' medical records. Results: One hundred twelve participants were enrolled at three sites in the U.S., Australia, and the U.K. Mean age was 64.5 years (SD 11.5); 90% were Caucasian, 68% had Eastern Cooperative Oncology Group performance status 0–1, and 50% had non-small cell carcinoma. All completed the CDS-E independently, without difficulty. The CDS-E had reasonable internal consistency overall (Cronbach''s α=0.71) and for each of the three factors (effort, anxiety, discomfort Cronbach''s α=0.80–0.84). CDS-E scores were significantly correlated with the 100mm VAS (r =0.82; P <0.001) and the modified Borg (r =0.87; P <0.001). After factor analysis, the CDS-E was revised by removing three items (r-CDS-E). Conclusion: The CDS-E and r-CDS-E are reliable and valid measures of the sensation and the psychological components of dyspnea, with the shorter version having similar psychometric properties. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
8. Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?
- Author
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Derks, J.L. (Jules L.), Dingemans, A.M.C. (Anne-Marie), Suylen, R-J. (Robert-Jan) van, Bakker, M.A. (Michael) den, Damhuis, R.A. (Ronald), Broek, E.C. (Esther) van den, Speel, E.J. (Ernst-Jan), Thunnissen, E. (Erik), Derks, J.L. (Jules L.), Dingemans, A.M.C. (Anne-Marie), Suylen, R-J. (Robert-Jan) van, Bakker, M.A. (Michael) den, Damhuis, R.A. (Ronald), Broek, E.C. (Esther) van den, Speel, E.J. (Ernst-Jan), and Thunnissen, E. (Erik)
- Published
- 2019
- Full Text
- View/download PDF
9. Digital clubbing: knowing its causes. Case Report
- Author
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Uribe-Valencia, Mauricio Andrés, Ocampo, José Mauricio, and Parra-Camarillo, Maximiliano
- Subjects
Osteoartropatía hipertrófica secundaria ,Neoplasias pulmonares (DeCS) ,Osteoarthropathy, Secondary Hypertrophic ,Tobacco Use Disorder ,Tabaquismo ,Lung Neoplasms (MeSH) - Abstract
Resumen Introducción. El hipocratismo digital es un signo clínico que afecta principalmente los dedos de las manos y se caracteriza por deformidad en uñas con abombamiento en vidrio de reloj. Puede presentarse en pacientes con cáncer diseminado, enfermedad pulmonar preexistente y dolor óseo, por lo cual es importante considerar esta entidad para un diagnóstico y un tratamiento oportunos. Presentación del caso. Paciente masculino de 86 años con hipocratismo digital, tabaquista en abstinencia, quien ingresa a urgencias por cuadro clínico de 2 meses de evolución consistente en fiebre y pérdida de 19kg de peso. Al examen físico presentaba disminución de ruidos respiratorios en base pulmonar derecha, dedos en palillo de tambor y deformidad ungüeal en manos. La radiografía de tórax mostró opacidad a nivel parahiliar derecho bien definida de 5cm. La tomografía computarizada de tórax mostró masas de bordes irregulares a nivel parahiliar derecho y en segmento apical del lóbulo inferior del pulmón derecho, y derrame pleural ipsilateral. La biopsia guiada por tomografía documentó adenocarcinoma pulmonar bien diferenciado. Conclusiones. El hipocratismo digital plantea un desafío en medicina debido a que puede ser difícil llegar a un diagnóstico etiológico y se pueden requerir muchos estudios para su confirmación. Abstract Introduction: Digital clubbing is a clinical sign that affects mainly the fingers of the hands and is characterized by a watch-glass deformity of the nails. It may occur in patients with disseminated cancer, preexisting lung disease, and bone pain, so it is important to consider this entity for early diagnosis and timely treatment. Case presentation: This is the case of an 86-year-old male patient with digital clubbing, with tobacco abstinence, who was admitted to the emergency department due to clinical symptoms of 2 months of evolution consisting of fever and a 19kg weight loss. On physical examination, there was a decrease in respiratory noises in the right lung base, drumstick fingers, and nail deformity in the hands. A chest x-ray showed a well-defined right parahilar opacity of 5cm. a chest CT showed irregular masses at the right parahilar level and in the apical segment of the lower lobe of the right lung, and ipsilateral pleural effusion. CT-guided biopsy was performed, documenting well-differentiated pulmonary adenocarcinoma. Conclusions: Digital clubbing poses a challenge in medicine because reaching an etiological diagnosis may be difficult and many studies may be required for confirmation.
- Published
- 2019
10. Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group.
- Author
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Guirado M, Sanchez-Hernandez A, Pijuan L, Teixido C, Gómez-Caamaño A, and Cilleruelo-Ramos Á
- Subjects
- Humans, Spain, Lung Neoplasms therapy, Patient Care Team, Quality Indicators, Health Care
- Abstract
Multidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administrative and institutional support; and recording of activity are key factors for the success of LC-MDTs. A set of excellence requirements in terms of staff, resources and organization of the LC-MDT have been proposed. At last, a list of quality indicators has been agreed to achieve and measure the performance of current LC-MDTs., (© 2021. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
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