1. Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts
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Roberto Bono, Kees de Hoogh, Meriem Benmerad, Bénédicte Jacquemin, Valérie Siroux, Emilie Burte, Jordi Sunyer, Deborah Jarvis, Mark J. Nieuwenhuijsen, Jean Bousquet, Alessandro Marcon, Anne-Elie Carsin, Rachel Nadif, Nino Künzli, Bertil Forsberg, Bénédicte Leynaert, Isabelle Pin, Frédéric Gormand, Jocelyne Just, Simona Villani, Morgane Stempfelet, Joachim Heinrich, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universitat Pompeu Fabra [Barcelona] (UPF), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Verona (UNIVR), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University of Turin, University of Basel (Unibas), Umeå University, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Ludwig-Maximilians-Universität München (LMU), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CIBER de Epidemiología y Salud Pública (CIBERESP), CHU Grenoble, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Università degli Studi di Pavia, Imperial College London, European CommissionEuropean Commission Joint Research Centre, local studies in ECRHS III, National Institute for Health Research through the Primary Care Research Network, PHRC-Paris, PHRC-Grenoble, ANRFrench National Research Agency (ANR) [05-SEST-020-02/05-9-97, ANR-06-CEBS, ANR-CES-2009], Merck Sharp DohmeMerck and Company, Region Nord Pas-de-CalaisRegion Hauts-de-France, European Study of Cohorts for Air Pollution Effects Funding, Belgium Antwerp South, Antwerp City Research Foundation Flanders (FWO) [G.0.410.08], European CommunityEuropean Community (EC) [211250], Ministere de la Sante, Programme Hospitalier de Recherche Clinique (PHRC), Paris Agence Nationale de la SanteFrench National Research Agency (ANR), Region Ile de FranceRegion Ile-de-France, Spain Fondo de Investigacion Sanitaria [PS09/02457, PS09/00716 09/01511, PS09/02185, PS09/03190], Germany Erfurt German Research Foundation - Cariverona Foundation, Education Ministry, Sociedad Espanola de Neumologia y Cirurgia Toracica [FIS PS09/00716], Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation, Galdakao Fondo de Investigacion Sanitaria [FIS 09/01511, FIS PS09/02185], Swedish Asthma and Allergy Association, Heart Disease, Swedish Research Council for health, working life and welfare (FORTE), United Kingdom Medical Research CouncilMedical Research Council UK (MRC) [92091], European Project: 211250,EC:FP7:ENV,FP7-ENV-2007-1,ESCAPE(2008), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli studi di Verona = University of Verona (UNIVR), Università degli studi di Torino = University of Turin (UNITO), Università degli Studi di Pavia = University of Pavia (UNIPV), ANR-06-CEBS-0009,CRB CHU Grenoble,Centre de ressources biologiques tumorales du CHU de Grenoble(2006), Medical Research Council (MRC), CCSD, Accord Elsevier, Collection d'Échantillons Biologiques de la Santé (CEBS) : Valorisation et Certification - Centre de ressources biologiques tumorales du CHU de Grenoble - - CRB CHU Grenoble2006 - ANR-06-CEBS-0009 - CEBS - VALID, and European Study of Cohorts for Air Pollution Effects - ESCAPE - - EC:FP7:ENV2008-06-01 - 2012-11-30 - 211250 - VALID
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Male ,Allergy ,IMPACT ,Air pollution exposure ,[SDV]Life Sciences [q-bio] ,air pollution ,severity ,010501 environmental sciences ,Logistic regression ,01 natural sciences ,Cohort Studies ,0302 clinical medicine ,USE REGRESSION-MODELS ,Epidemiology ,Immunology and Allergy ,Medicine ,POLLUTANTS ,Rinitis ,Rhinitis ,CLIMATE-CHANGE ,Aire -- Contaminació ,Respiratory disease ,Regression analysis ,Middle Aged ,respiratory disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,ALLERGIC RHINITIS ,Europe ,Quartile ,1107 Immunology ,BRONCHIAL HYPERRESPONSIVENESS ,Female ,allergic sensitization ,environment ,Life Sciences & Biomedicine ,Adult ,medicine.medical_specialty ,GENETICS ,Immunology ,ESCAPE ,complex mixtures ,03 medical and health sciences ,Humans ,0105 earth and related environmental sciences ,Asthma ,Science & Technology ,business.industry ,Odds ratio ,Environmental Exposure ,medicine.disease ,Cross-Sectional Studies ,030228 respiratory system ,13. Climate action ,ASTHMA ,Particulate Matter ,business ,Demography - Abstract
Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO2, PM10, PM2.5, and PMcoarse (calculated by subtracting PM2.5 from PM10) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used. Results: A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd quartile) score of rhinitis severity was 4 (2-6). Higher exposure to PM10 was associated with higher rhinitis severity (adjusted odds ratio [95% CI] for a 10 μg/m3 increase in PM10: for mild: 1.20 [0.88-1.64], moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM2.5. Higher exposure to NO2 was associated with an increased severity of rhinitis, with similar adjusted odds ratios whatever the level of severity. Adjusted odds ratios were higher among participants without allergic sensitization than among those with, but interaction was found only for NO2. CONCLUSIONS: People with rhinitis who live in areas with higher levels of pollution are more likely to report more severe nasal symptoms. Further work is required to elucidate the mechanisms of this association. The following bodies funded the local studies in ECRHS III in this article: Belgium: Antwerp South, Antwerp City: Research Foundation Flanders (FWO), grant code G.0.410.08.N.10 (both sites); France: Ministère de la Santé , Programme Hospitalier de Recherche Clinique (PHRC) national 2010; Germany: Erfurt: German Research Foundation ( HE 3294/10-1 ); Spain: Fondo de Investigación Sanitaria ( PS09/02457 , PS09/00716 09/01511 , PS09/02185 , and PS09/03190 ), Servicio Andaluz de Salud, Sociedad Española de Neumología y Cirurgía Torácica ( SEPAR 1001/2010 ); Barcelona: Fondo de Investigación Sanitaria ( FIS PS09/00716 ); Galdakao: Fondo de Investigación Sanitaria ( FIS 09/01511 ); Huelva: Fondo de Investigación Sanitaria ( FIS PS09/02185 ) and Servicio Andaluz de Salud ; Oviedo: Fondo de Investigación Sanitaria ( FIS PS09/03190 ); United Kingdom: Medical Research Council (grant no. 92091 ). The Epidemiological Study on the Genetics and Environment on Asthma is funded in part by PHRC-Paris, PHRC-Grenoble, ANR 05-SEST-020-02/05-9-97, ANR-06-CEBS, ANR-CES-2009, Région Nord Pas-de-Calais, and Merck Sharp & Dohme. European Study of Cohorts for Air Pollution Effects Funding: The research leading to these results has received funding from the European Community’s Seventh Framework Program ( FP7/2007-2011 ; under grant agreement no. 211250 )
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- 2020
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