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As technology progresses, mobile devices such as laptops, tablets, cell phones, and two-way radios have become smaller in size. Consequently antennas become electrically small to fit inside aggressive packaging requirements with rapidly changing real and imaginary impedances. As such, these antennas are very narrow in bandwidth with high-Q and input impedance which is very sensitive to environmental effects. The radiation efficiency of the device is drastically decreased as the antenna is detuned and signal quality is degraded. As the number of mobile devices we use increases, adaptive impedance tuners have and will become a bigger necessity, especially as more radios are integrated into a single device. This dissertation presents novel improvements to closed loop tuning topologies from a system level perspective addressing impedance tuners, sensing techniques, and how they apply to different antennas. The biggest design hindrance to impedance tuners are losses due to small signal resistance, and loss due to circuit resonances and radiation. A detailed explanation of these loss mechanisms is developed, providing designers with the knowledge to minimize the impact of said losses and improve system efficiency. By exploiting loss mechanisms, a novel small and low cost VHF impedance synthesizer is presented to characterize impedance tuners in load pull measurements.With full consideration of circuit loss mechanisms, a new directional coupler based tuning topology is presented. Traditional tuning topologies aim to minimize |S11| of the matching network. As demonstrated in this work, such a method has the potential to maximize losses in the circuit, especially in multi-stage tuners. Alternative directional coupler based topologies are presented which maximize the system transducer gain. Furthermore, a novel method of sensing a tuned state through the use of a near field probe that detects far field radiated power is introduced. A design guide is detailed with several examples for use with different types of antennas. Concepts developed in this dissertation are demonstrated in an adaptive tuning system where mechanical means of tuning is applied as a low loss tuner. An electrically small monopole is tuned using the power sensor to provide feedback over a 2.2:1 bandwidth (180 to 400MHz) where at the lowest tunable frequency the antenna is 1/11.3 wavelengths in size.