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4 results on '"liver vein thrombosi"'

1. Orthotopic liver transplantation for alagille syndrome

Author

Giuliano Torre, Paola Stroppa, Domenico Pinelli, Elena Torri, Marco Spada, Michele Colledan, Alessandro Lucianetti, Daniele Alberti, M. Zambelli, M Guizzetti, A Bertani, M. Giovanelli, V. Corno, G. Maldini, B. Gridelli, Maldini, G, Torri, E, Lucianetti, A, Guizzetti, M, Pinelli, D, Bertani, A, Corno, V, Giovanelli, M, Zambelli, M, Stroppa, P, Alberti, D, Torre, G, Spada, M, Gridelli, B, and Colledan, M

Subjects
treatment planning, Cardiac Catheterization, Time Factors, hepatic artery, bile duct obstruction, graft survival, Gastroenterology, Orthotopic Liver Transplantation, Alagille Syndrome, Postoperative Complications, Actuarial Analysis, Alagille syndrome, anastomosis dehiscence, postoperative complication, surgical drainage, Child, conference paper, intestine necrosi, hemoperitoneum, Pediatric, clinical article, Incidence (epidemiology), abdominal bleeding, Whole liver, cholestasi, lymph node metastasi, artery thrombosi, pulmonary artery stenosi, aorta reconstruction, ascite, female, priority journal, survival rate, medicine.medical_specialty, organ donor, Orthotopic liver transplantation, pleura effusion, surgical infection, reoperation, blood vessel occlusion, percutaneous transluminal angioplasty, Actuarial survival, aorta coarctation, acute graft rejection, male, liver graft, Internal medicine, death, heart ventricle septum defect, liver vein thrombosi, medicine, Humans, cadaver donor, human, portal vein thrombosi, postoperative thrombosi, treatment failure, Retrospective Studies, Transplantation, business.industry, recipient, disease association, medicine.disease, infant, Survival Analysis, thorax surgery, Surgery, Liver Transplantation, Hepatic artery thrombosis, adolescent, Split liver transplantation, bile duct fistula, incidence, surgeon, stent, business, Cadaveric spasm, radiologist, liver graft rejection, Follow-Up Studies
Abstract

Alagille syndrome (AS) is a dominantly inherited, multisystem disorder involving the liver, heart, eyes, face, and skeleton. From October 1997 through July 2004, 260 pediatric orthotopic liver transplantations (OLTx) were performed in 231 patients. This report describes 21 patients of median age 1.95 years (range, 0.7-16.7) who had alagille syndrome. We present the technical features of the OLTx, incidence and type of complications, medical conditions related to the syndrome, need for retransplantation, as well as patient and graft survival rates. A split liver technique was used in 16 patients (76%) who received a left lateral segment (LLS) graft whereas 7 patients (33%) received a whole liver. Only cadaveric donors were used. The major surgical complications requiring reintervention in 11 patients (52%) included biliary problems (19%) and vascular complications (17%). One case of hepatic artery thrombosis required retransplantation. Three recipients (14%) died. All other patients are alive with an actuarial survival rate of 90% at 1 year and 80% at 5 years. The actuarial graft survival rate is 85% at 1 year and 75% at 5 years. Patients with AS, despite the associated cardiovascular anomalies, can be treated successfully by a combined approach between cardiologist, radiologist, cardiothoracic, and liver transplant surgeons. With careful planning and operative management, the results are comparable with those obtained with other more common cholestatic diseases.

Published
2005

2. Orthotopic liver transplantation for Byler's disease

Author

Marco Spada, M Guizzetti, G. Maldini, E. Doffria, Giuliano Torre, Domenico Pinelli, V. Corno, Bruno Gridelli, M. Zambelli, A Bertani, M. Giovanelli, M.L. Melzi, Michele Colledan, Daniele Alberti, Elena Torri, Alessandro Lucianetti, Torri, E, Lucianetti, A, Pinelli, D, Corno, V, Guizzetti, M, Maldini, G, Zambelli, M, Bertani, A, Melzi, M, Alberti, D, Doffria, E, Giovanelli, M, Torre, G, Spada, M, Gridelli, B, and Colledan, M

Subjects
Liver Cirrhosis, Male, surgical mortality, medicine.medical_treatment, Fistula, hepatic artery, treatment indication, bile duct obstruction, graft survival, Liver transplantation, blood culture, Gastroenterology, postoperative complication, Child, conference paper, clinical article, Liver Cirrhosis, Biliary, Incidence (epidemiology), disease course, Biliary, Progressive familial intrahepatic cholestasis, postoperative infection, Thrombosis, artery thrombosi, Treatment Outcome, priority journal, Child, Preschool, Female, survival rate, medicine.medical_specialty, Adolescent, reoperation, Anastomosis, acute graft rejection, body weight, Internal medicine, liver vein thrombosi, medicine, fistula, follow up, Humans, human, Preschool, Retrospective Studies, Transplantation, Follow-Up Studies, Infant, Liver Transplantation, business.industry, Retrospective cohort study, intrahepatic cholestasi, medicine.disease, Surgery, clinical feature, Stenosis, incidence, business
Abstract

In this study we analyzed the features of 12 patients who underwent liver transplantation for progressive familial intrahepatic cholestasis (Byler's disease [BD]) in view of the technical features of the OLTx, incidence and type of complications, need for retransplantation, as well as patient and graft survivals. BD was the indication in 12 patients of median age 1.32 years and median weight 10 kg. Median follow-up was 670 days. Major surgical complications requiring reintervention occurred in three patients. No thrombosis of the hepatic artery was observed. Infections with positive blood cultures were diagnosed in four patients. One patient had a biliary anastomotic stenosis successfully treated by percutaneous techniques. Four patients had episodes of acute rejection treated with steroids. Two patients were retransplanted, both of whom died in the early postoperative period due to hepatic vein thrombosis and venoenteric fistula. The actuarial patient and graft survival was 83% at 1 year and 83% at 5 years. Split-liver grafts represent an excellent organ supply for these patients, achieving good results with no mortality on the waiting list.

Published
2005

3. Orthotopic liver transplantation for Alagille syndrome

Author

Maldini, G, Torri, E, Lucianetti, A, Guizzetti, M, Pinelli, D, Bertani, A, Corno, V, Giovanelli, M, Zambelli, M, Stroppa, P, Alberti, D, Torre, G, Spada, M, Gridelli, B, Colledan, M, Maldini G, Torri E, Lucianetti A, Guizzetti M, Pinelli D, Bertani A, Corno V, Giovanelli M, Zambelli M, Stroppa P, Alberti D, Torre G, Spada M, Gridelli B, Colledan M, Maldini, G, Torri, E, Lucianetti, A, Guizzetti, M, Pinelli, D, Bertani, A, Corno, V, Giovanelli, M, Zambelli, M, Stroppa, P, Alberti, D, Torre, G, Spada, M, Gridelli, B, Colledan, M, Maldini G, Torri E, Lucianetti A, Guizzetti M, Pinelli D, Bertani A, Corno V, Giovanelli M, Zambelli M, Stroppa P, Alberti D, Torre G, Spada M, Gridelli B, and Colledan M

Abstract

Alagille syndrome (AS) is a dominantly inherited, multisystem disorder involving the liver, heart, eyes, face, and skeleton. From October 1997 through July 2004, 260 pediatric orthotopic liver transplantations (OLTx) were performed in 231 patients. This report describes 21 patients of median age 1.95 years (range, 0.7-16.7) who had alagille syndrome. We present the technical features of the OLTx, incidence and type of complications, medical conditions related to the syndrome, need for retransplantation, as well as patient and graft survival rates. A split liver technique was used in 16 patients (76%) who received a left lateral segment (LLS) graft whereas 7 patients (33%) received a whole liver. Only cadaveric donors were used. The major surgical complications requiring reintervention in 11 patients (52%) included biliary problems (19%) and vascular complications (17%). One case of hepatic artery thrombosis required retransplantation. Three recipients (14%) died. All other patients are alive with an actuarial survival rate of 90% at 1 year and 80% at 5 years. The actuarial graft survival rate is 85% at 1 year and 75% at 5 years. Patients with AS, despite the associated cardiovascular anomalies, can be treated successfully by a combined approach between cardiologist, radiologist, cardiothoracic, and liver transplant surgeons. With careful planning and operative management, the results are comparable with those obtained with other more common cholestatic diseases.

Published
2005

4. Orthotopic liver transplantation for Byler's disease

Author

Torri, E, Lucianetti, A, Pinelli, D, Corno, V, Guizzetti, M, Maldini, G, Zambelli, M, Bertani, A, Melzi, M, Alberti, D, Doffria, E, Giovanelli, M, Torre, G, Spada, M, Gridelli, B, Colledan, M, Torri E, Lucianetti A, Pinelli D, Corno V, Guizzetti M, Maldini G, Zambelli M, Bertani A, Melzi ML, Alberti D, Doffria E, Giovanelli M, Torre G, Spada M, Gridelli B, Colledan M, Torri, E, Lucianetti, A, Pinelli, D, Corno, V, Guizzetti, M, Maldini, G, Zambelli, M, Bertani, A, Melzi, M, Alberti, D, Doffria, E, Giovanelli, M, Torre, G, Spada, M, Gridelli, B, Colledan, M, Torri E, Lucianetti A, Pinelli D, Corno V, Guizzetti M, Maldini G, Zambelli M, Bertani A, Melzi ML, Alberti D, Doffria E, Giovanelli M, Torre G, Spada M, Gridelli B, and Colledan M

Abstract

In this study we analyzed the features of 12 patients who underwent liver transplantation for progressive familial intrahepatic cholestasis (Byler's disease [BD]) in view of the technical features of the OLTx, incidence and type of complications, need for retransplantation, as well as patient and graft survivals. BD was the indication in 12 patients of median age 1.32 years and median weight 10 kg. Median follow-up was 670 days. Major surgical complications requiring reintervention occurred in three patients. No thrombosis of the hepatic artery was observed. Infections with positive blood cultures were diagnosed in four patients. One patient had a biliary anastomotic stenosis successfully treated by percutaneous techniques. Four patients had episodes of acute rejection treated with steroids. Two patients were retransplanted, both of whom died in the early postoperative period due to hepatic vein thrombosis and venoenteric fistula. The actuarial patient and graft survival was 83% at 1 year and 83% at 5 years. Split-liver grafts represent an excellent organ supply for these patients, achieving good results with no mortality on the waiting list.

Published
2005

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