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Copyright of Revista Didasc@lia: Didáctica y Educación is the property of Universitaria de Las Tunas, Centro de Estudios de Didactica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Childhood cancer is the second cause of mortality of the population between 4 and 15 years. More than 20 million new cases of cancer in the world are expected by the year 2025, and 80% of the load will be on countries of low to middle income. In the past two decades, significant changes have been observed in patterns of incidence, prevalence, survival, and childhood cancer mortality in Mexico. An extensive review of all the published studies in Mexico by various health institutions revealed a steady 18-year trend of 150 new cases/million/year. The prevalence showed that acute leukemias constitute a 50% of all childhood cancer cases, followed by lymphoma (Hodkin and non-Hodgkin), and primary malignant brain tumors. A significant survival rate was observed in 8 thousand children with acute lymphoblastic leukemia with an overall 5-year survival rate of 62%, with a range of 45 to 73%. The national mortality rate for all types of cancer was 5.2/100,000/year, which is higher than what is reported in most middle-income countries. In the face of the current results, the need arises to modify how we approach this group of diseases by integrating a socio-educational healthcare of the Mexican children who are currently treated under unfavorable conditions. The current sanitary authorities must be aware of the importance of the transmission and adjustment of the care received by children with these diseases at a national level, to be in line with international standards. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Gastroenterología del Perú is the property of Sociedad de Gastroenterologia del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Spinal bone lymphoma is a rare disease, with diffuse large B-cell lymphoma being the most common subtype. It is usually a late manifestation of a systemic disease. Its management is multidisciplinary, including surgery, chemotherapy and radiotherapy. Clinical case: A 40-year-old woman, with human immunodeficiency virus infection, miliary tuberculosis monoresistant isoniazid, with disease period of 7 month with progressive motor and sensory deficit in addition to sphincter dysfunction. The contrasted MRI shows a left vertebral and paravertebral tumor that invades spinal canal through left T2/T3 foramina with spinal cord compression. Laminectomy T2 and T3 plus total resection of tumor plus spinal fixation is performed. The patient progressively recovered the motor deficit and began chemotherapy with a good response. Conclusion: The spinal bone lymphoma is an infrequent etiology of bone tumor of the spine, which requires multidisciplinary management. [ABSTRACT FROM AUTHOR]

The clinical case of a 30-year-old female patient with supraclavicular and ipsilateral axillary lymphadenopathy who underwent excisional biopsy with subsequent study is presented. Histopathological analysis of the resected tissue sample revealed a series of distinctive features associated with hyalinevascular variant Castleman disease. The presentation of this case not only provides detailed information about the clinical evolution of the patient, but also serves as a basis to illustrate Key aspects of histopathological diagnosis and immunohistochemical implications in Castleman disease. In addition to making a review of the topic regarding this rare pathology in which case reports are essential to increase the understanding of its clinical variability and its diagnostic approach, illustrating the challenges in differential diagnosis and how they should be addressed. [ABSTRACT FROM AUTHOR]

Introdução/Justificativa: O PET-CT com FDG-18F é amplamente empregado no estadiamento inicial e avaliação de resposta terapêutica nas doenças linfoproliferativas, bem como na suspeita de recidiva. No entanto, seus achados não são específicos, já que a glicose radiomarcada identifica sítios com aumento da atividade metabólica, observados em diversas neoplasias malignas, bem como em processos inflamatórios ou infecciosos. Relato: Feminino, 73 anos, tratada em 2021 para linfoma linfoplasmacítico indolente, com boa resposta. Evoluiu com sintomas respiratórios recorrentes, atribuídos a processos infecciosos de repetição, apesar da terapêutica antimicrobiana prolongada. Desenvolveu manifestações orotraqueais importantes, cursando com insuficiência respiratória, resultando em traqueostomia. Propedêutica evidenciou amiloidose, sendo instituído tratamento específico, com resposta clínica favorável. Na reavaliação com médico assistente, a paciente apresentava tosse e dispneia, sendo submetida a TC de tórax que evidenciou adenomegalias mediastinais. Diante da suspeita clínica de recidiva do linfoma, solicitou-se PET-CT com FDG-18F para elucidação e definição de conduta, que mostrou aumento volumétrico e hipermetabólico das glândulas salivares maiores, consolidações pulmonares paracardíacas bilaterais acentuadamente hipermetabólicas associadas a redução volumétrica dos lobos médio e inferior esquerdo, além de linfonodos cervicais, axilares e mediastinais discretamente hipermetabólicos. Os achados do PET-CT levaram a suspeita da coexistência de: amiloidose em atividade, sobretudo no parênquima pulmonar e possivelmente nas glândulas salivares; e recidiva do linfoma nas cadeias linfonodais alteradas. Sugeriu-se, então, estudo anatomopatológico das áreas hipermetabólicas que mostrou: 1. deposição amiloide no interstício e paredes dos vasos pulmonares, fibrose estromal e infiltrado linfocítico intersticial e algo nodular de linfócitos pequenos e heterogêneos; ausência de evidências de doença linfoproliferativa; 2. doença linfoproliferativa B de pequenas células, associada a presença de acúmulos de material amiloide no interstício e paredes dos vasos na glândula submandibular esquerda e nos linfonodos cervicais ipsilaterais, consistente com linfoma da zona marginal, com acúmulo secundário amiloide. Conclusão: O PET-FDG tem papel bem estabelecido nas doenças linfoproliferativas, desde o diagnóstico inicial e avaliação de resposta, bem como na recidiva, podendo definir, em exame único, a extensão da doença, características metabólicas, além de sugerir sítio de biópsia. Na amiloidose este método tem sua importância, demonstrando atividade e extensão da doença. Diante da coexistência das entidades, o PET-FDG pode então definir a conduta terapêutica inicial. Comentários Finais: O caso apresentado demonstra a contribuição do PET-FDG na coexistência de doenças sistêmicas, ao indicar sítios de biópsia, demonstrar a atividade e extensão de cada uma e, assim, guiar a terapêutica inicial, decisão crítica em doenças complexas e potencialmente graves.

La presencia de linfadenopatías generalizadas se ha asociado de forma usual con lupus eritematoso sistémico (LES), sin embargo, no es usual encontrar este hallazgo como manifestación inicial de la enfermedad. Existen múltiples diagnósticos diferenciales que incluyen la linfadenitis necrotizante histiocítica de Kikuchi, la enfermedad de Castleman, infecciones y el linfoma cuando se presenta este hallazgo como síntoma inicial de LES. Presentamos el caso de un hombre de 56 años que se presentó con 2 meses de linfadenopatía generalizada sin datos al examen o antecedentes que sugirieran diagnóstico de LES; se sospechó inicialmente linfoma o enfermedad infecciosa y se realizó un estudio exhaustivo incluido biopsia de ganglio cervical. La investigación de laboratorio finalmente reveló leucopenia, proteinuria significativa, ANA y anti-dsDNA positivos e hipocomplementemia, lo que confirma el diagnóstico de enfermedad autoinmune tipo LES. Este caso ilustra la importancia de reconocer esta forma de presentación inusual, dado que se trata de una enfermedad potencialmente fatal.

El linfoma cerebral primario es una variedad de linfoma no Hodgkin agresivo que se origina en el sistema nervioso central y se diagnostica cuando no hay evidencia de linfoma en ninguna otra parte del cuerpo. Aunque los linfomas sistémicos son más conocidos y estudiados, el linfoma cerebral primario ha sido menos comprendido debido a su baja frecuencia hasta hace algunas décadas. El tratamiento de esta enfermedad sigue siendo objeto de debate. En esta oportunidad se reporta el inusual caso de linfoma B de células grandes NOS asociada a hidrocefalia y su manejo.

Introducción: los linfomas son enfermedades malignas que se originan en las células del sistema inmune y se manifiestan predominantemente por linfoadenopatías o tumores sólidos. El tratamiento se basa en el empleo de inmunoquimioterapia. La incorporación del anticuerpo monoclonal a la terapéutica tiene como objetivo mejorar los resultados de tratamiento de inducción en términos de remisión, aumentar los índices de sobrevida global y libre de enfermedad así como disminuir la resistencia primaria a la quimioterapia. Objetivo: Describir la importancia del uso de los anticuerpos monoclonales en el tratamiento de los linfomas. Método: se realizó una revisión de artículos publicados en las bases de datos PubMed, MEDLINE, SciELO, Scopus, Lilacs y BVS, acerca del uso de anticuerpos monoclonales en el tratamiento de los linfomas. Se excluyeron las cartas al editor, artículos breves, casos clínicos, y todo artículo queno mostrara el texto completo. Se revisaron un total de 125 artículos de los cuales se incluyeron 27. Desarrollo: la introducción de los anticuerpos monoclonales en el tratamiento de neoplasias oncológicas y hematológicas ha cambiado la historia natural de algunas enfermedades mejorando la calidad de vida y de supervivencia. El rituximab, el primer anticuerpo aprobado para su administración en Hematología, ha servido como modelo para el desarrollo de nuevos tratamientos biológicos. Conclusión: las mejoras biotecnológicas de los anticuerpos monoclonales han arrojado moléculas de mayor calidad biológica antitumoral. Se mantiene y se fomenta así el desafío de lograr nuevos tratamientos que apunten a obtener mayores curas terapéuticas.

Resumo O objetivo deste relato é mostrar a evolução da cardiotoxicidade (CTX) por quimioterápicos em paciente com linfoma por exames de imagens, destacando a importância da captação miocárdica de flúor-18 fluordeoxiglicose (18F-FDG) pela tomografia por emissão de pósitrons, acoplada à tomografia computadorizada (PET/CT). Feminino, 43 anos, com linfoma uterino, submetida a histerectomia, três esquemas de quimioterapia (QT), sucessivamente, e radioterapia. Apresentou episódios de insuficiência cardíaca aguda dois anos após QT. Ecocardiograma mostrou redução da fração de ejeção do ventrículo esquerdo (FEVE). Análise retrospectiva do 18F-FDG PET/CT observou elevação da captação miocárdica em todos os exames durante o seguimento oncológico. Apesar da remissão oncológica, a paciente desenvolveu IC com FEVE reduzida. Durante a QT, ocorreu aumento difuso e significativo da captação miocárdica de 18F-FDG, que precedeu a queda do desempenho cardíaco, e pareceu refletir alterações metabólicas nos cardiomiócitos relacionadas à CTX. A análise da captação miocárdica de 18F-FDG modificaria o desfecho cardiológico da paciente? Esse questionamento é relevante, visto que outros pacientes podem se beneficiar desse método como marcador precoce de CTX. Os exames de imagem são imprescindíveis no acompanhamento de pacientes com risco de CTX. O ecocardiograma permanece como principal auxílio diagnóstico, porém o 18F-FDG PET/CT pode estar surgindo como uma poderosa ferramenta para um diagnóstico mais precoce dessa condição clínica.

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Arquivos de Ciências da Saúde da UNIPAR is the property of Associacao Paranaense de Ensino e Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: orbital tumors, in spite of not being so frequent, represent a challenge for the Ophthalmology Specialist in their diagnosis and management. Malignant lesions are more frequent, as well as primary lesions of the orbit, in which non-Hodgkin's lymphoma represents the highest number of cases. Objective: to deepen the current knowledge on the diagnostic and therapeutic approach to this disease. Methods: theoretical and empirical methods were used to analyze the updated knowledge on this disease, a bibliographic review was carried out in different databases, both in English and Spanish, and a series of principles on clinical presentation, diagnosis of certainty and adequate treatment were presented. Conclusions: orbital lymphoma is very rare, but should be considered in a patient with proptosis or ocular symptoms and an orbital mass, especially unilateral. Imaging studies and biopsy should be performed for diagnosis and staging. Treatment should be administered as soon as possible and usually consists of radiotherapy. The prognosis is usually favorable. [ABSTRACT FROM AUTHOR]

Copyright of Acta Médica Peruana is the property of Colegio Medico del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of the Argentine Society of Rheumatology/Revista de la Sociedad Argentina de Reumatología is the property of Editorial Biotecnologica S.R.L and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diversas etiologías pueden desencadenar a las vasculitis ANCA (anticuerpos anticitoplasma de neutrófilo). Entre ellas se encuentran las neoplasias hematológicas, como los linfomas no Hodgkin, que pueden asociarse con diferentes autoanticuerpos y manifestaciones reumatológicas. Es esencial sospechar estas causas secundarias si la enfermedad tiene un curso crónico con respuesta tórpida al tratamiento. En el presente artículo se reporta un caso inusual de asociación entre granulomatosis eosinofílica con poliangeitis y linfoma no Hodgkin de bajo grado de agresividad.

Background: Non-Hodgkin's lymphoma (NHL) is a group of malignant tumors of the nodal and extranodal lymphoid tissues, and it is associated with autoimmune diseases, mainly rheumatoid arthritis (RA). Extra nodal presentation is observed in 40%, mainly affecting the gastrointestinal tract in 3% of cases, with bleeding in the digestive tract being a rare cause of clinical presentation that requires a detailed diagnostic approach. Clinical case: 55-year-old female with a history of RA, admitted to an internal medicine service due to bleeding in the digestive tract; patient presented clinical data of deep vein thrombosis in the left pelvic limb and consumptive syndrome under study. During her approach she was identified with splenic and liver infarctions, as well as multiple lymph node conglomerates, due to which it was performed an axillary lymph node biopsy reporting neoplastic proliferation of lymphoid cells, and bone marrow aspirate with presence of lymphoplasmacytic infiltration, with which a diagnosis of stage IV non-Hodgkin lymphoma was made. Patient was sent to a third-level hospital to start treatment. Conclusions: This case shows us what has already been described in literature, which is why it is of fundamental importance to carry out a comprehensive approach of clinical findings in patients with previously identified risk factors, with the aim of achieving an etiological diagnosis that allows early therapy to improve their survival. [ABSTRACT FROM AUTHOR]

Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is characterized by atypical T-cells expressing the α/β T-cell receptor in the subcutaneous fat. Although it is usually indolent, some cases can show an aggressive course. It is usually a disease of the middle-aged, but can rarely affect children. Case report: We describe the case of a 12-year-old male, previously healthy, who presented a dermatosis disseminated to the four segments consisting of vesicles, blisters, erythematous and hematonecrotic plaques, atrophic scars, associated with edema. The biopsy confirmed limited cutaneous panniculitic T-cell lymphoma with extensive epidermal necrosis. Conclusions: We report the case of a SPTCL in a child. Although rare in this age group, the diagnosis should be considered in children who present similar conditions and who do not respond to treatment. Diagnosis is made on clinical suspicion and confirmed by histology. We discuss the challenges in its management and how timely diagnosis influences patient survival. [ABSTRACT FROM AUTHOR]

BACKGROUND: Primary cutaneous lymphomas can be of the B or T cell type. Primary B lymphomas represent 25-29% of lymphomas of the skin, within these, follicular center B-cell cutaneous lymphoma is of slow, indolent history and generally presents as a solitary, small lesion, located mainly on the head and trunk, only 5% occur on the legs. CLINICAL CASE: A 76-year-old female patient consulted for painful skin lesions on the left leg of 2 months’ history. Multiple confluents, smooth, pinkish neoformations were observed. At dermoscopy, punctate vessels, shiny-white structures on a salmoncolored base were observed. Histopathology showed thinned epidermis with a dense population of atypical, monomorphic lymphocytes in the dermis, with little cytoplasm, vesicular nucleus and central nucleolus, and apoptotic cells. Tomography and bone marrow biopsy did not show systemic involvement, thus diagnosing follicular center B-cell cutaneous lymphoma. She received treatment with local radiotherapy and 6 cycles of chemotherapy and monoclonal antibody. Two months later, she became disoriented, computed tomography and magnetic resonance image of the brain showed a mass in the left temporal region; it was considered secondary to skin lesions by the neurosurgery service, and she died. CONCLUSIONS: This case of follicular center B-cell cutaneous lymphoma is reported due to its unusual location and its aggressive and deadly behavior. It is important to consider it in the differential diagnosis for prompt diagnosis and correct management. [ABSTRACT FROM AUTHOR]

We describe the case of a 73-year-old female patient with priors of a mantle cell lymphoma (MCL), diagnosed 9 months ago, treated with chemotherapy, and currently with maintenance rituximab therapy, and a total knee replacement on the left leg 1 year ago. The patient presented to the Dermatology Department with patches on the left leg, with 3 months of evolution. On examination, the patient presented infiltrated, confluent erythematous-violaceous patches and plaques, on the anterior surface of the left knee and leg, along the arthroplasty scar. No complaints associated. Blood work showed anaemia, neutropenia and an elevation of lactate dehydrogenase (LDH). A skin biopsy revealed occupation of the skin by a diffuse lymphoid proliferation, with intermediate-sized cells, with scarce cytoplasm, hyperchromatic nuclei and irregular borders. At immunohistochemistry, the cells were a cluster of differentiation (CD) 20+, CD5+, B-cell lymphoma 2 (Bcl-2) +, cyclin D1+ and CD3-. These findings are compatible with cutaneous involvement by MCL. The patient underwent radiotherapy on the left leg with regression of the lesions and is currently under chemotherapy. Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL). Cutaneous involvement is rare, secondary and means lymphoma dissemination. This case is also interesting for the site of skin involvement on a scar of knee replacement surgery. [ABSTRACT FROM AUTHOR]

Copyright of Alerta (San Salvador) - Revista Cientifica del Instituto Nacional de Salud is the property of Instituto Nacional de Salud and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Children with childhood cancer are at high risk of a wide range of cognitive difficulties. Therefore, interventions directed to these difficulties are necessary. Anticancer treatments such as chemotherapy and/or radiotherapy are at high risk of late effects of neurocognitive deficits. The present study presents the case of an 8-year-old female child, attending elementary school, diagnosed with acute lymphoblastic leukemia -ALL at 8 years of age, undergoing chemotherapy during the COVID-19 pandemic. Pragmatic language, verbal and visual episodic memory, executive functions, concentrated attention, writing ability, and behavior were evaluated. The results of the neuropsychological evaluation suggested deficits in the tasks of executive functions of lexical access (free fluency, phonemic and semantic), with significant impairments also in cognitive flexibility, working memory, and concentrated attention. The deficits presented are well linked to the existing literature on the neuropsychological outcome of children with ALL during childhood. However, these findings may also be linked to the pandemic's consequences on children's cognition.This study sought to contribute to the Brazilian and international knowledge that is still lacking in reports of neuropsychological outcomes of children with ALL undergoing treatment, and after the pandemic, who receive pedagogical assistance at hospitals provided by the public education and health network in a hospital environment by the public school and health network. In order to elucidate the national importance of this clinically delicate Clinical group having access to neuropsychological examination, in order to trace possible deficits and potentialities. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Cirugía Oral y Maxilofacial is the property of Sociedad Espanola de Cirugia Oral y Maxilofacial (SECOM) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Trabalho apresentado no VI Congresso Internacional de Câncer – São Paulo, Brasil.

O esquema quimioterápico ideal para o tratamento dos línfornas primários do SNC é ainda objeto de investigações. O presente trabalho descreve um caso tratado com vincristina e doses elevadas de dexametasona, metotrexate e citosina arabinosfdeo (Ara-C), além de quimioterapia intratecal, que resultou na remissão completa do tumor. Uma revisão da literatura também é feita.

O linfoma mediastinal é uma neoplasia que ocorre pela proliferação desordenada de linfócitos malignos e pode acometer animais de diferentes faixas etárias. Este estudo teve como objetivo relatar o caso de um felino, Sem Raça Definida, de quatro anos de idade, atendido em emergência, apresentando dificuldade respiratória e anorexia. Após realização de exame radiográfico, verificou-se efusão pleural, no qual foi realizado toracocentese em ambos os lados. Foi possível realizar o hemograma, no qual não apresentou alterações dignas de nota. O animal apresentou piora do quadro e veio a óbito. Sendo assim, realizou-se a necropsia, revelando uma enorme massa em região de mediastino. Na sequência, foi confirmado o linfoma no mediastino por meio do exame histopatológico.

Os tumores de células redondas consistem na semelhança morfológica entre as células que compõem esses tumores, que são classificados quanto a origem embriológica em neoplasias mesenquimais. Entre os diferentes tipos neoplásicos provenientes das células redondas este trabalho dará ênfase para o mieloma múltiplo e o linfoma. O mieloma múltiplo é uma neoplasia rara, que tem origem da proliferação neoplásica de plasmócitos a partir da medula óssea. O linfoma é uma neoplasia com origem nos tecidos hematopoiéticos sólidos e a etiologia em cães ainda é desconhecida. Desta forma, o objetivo deste trabalho foi relatar um animal com diagnostico de linfoma cutâneo não epteliotrópico de imunofenótipo T apresentando aspectos clínicos evidentes de mieloma múltiplo.

Background and objective. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare and partially understood disease that has aroused great interest due to the social and economic impact it generates. Little is known about the possible occurrence of the disease associated with the use of implants in other body locations. The objective of this article is to characterize and present the cases of anaplastic large cell lymphoma associated with implants located outside the breast described in the literature. Methods. A review of the literature was performed in PubMed, Cochrane, ScienceDirect and SciELO databases looking for reports of implant-associated anaplastic large cell lymphoma (IA-ALCL) in sites other than the breast. Results. Two case reports of IA-ALCL in the buttocks were found in patients with previous augmentation gluteoplasty with implants performed for aesthetic purposes. Additionally, the finding of a greater number of other types of lymphomas associated with the placement of different devices for medical use and the application of gluteal biopolymers in an additional case. Conclusions. The existence of a new disease associated with silicone implants in other body sites is possible. The literature is scant and does not allow us to confirm its existence. There must be a high index of suspicion in any case suggestive of the entity for its study, proper classification and timely management. We propose a diagnostic algorithm that can be very useful in patients with gluteal implants who present some associated symptoms. [ABSTRACT FROM AUTHOR]

BACKGROUND: Cutaneous T-cell lymphomas comprise approximately 2% of all lymphomas and are the result of malignant transformation of resident T cells that target the skin; they comprise a heterogeneous collection of non-Hodgkin lymphomas arising from T lymphocytes of tropic memory of the skin. Among them, mycosis fungoides and Sezary syndrome are the most common neoplasms. CLINICAL CASE: A 39-year-old female patient who started about a year ago with disseminated dermatosis to head, upper extremities, lower extremities, and trunk with an eczematous appearance, reporting mycosis fungoides by histopathology. By immunostaining analysis, atypical lymphocytes infiltrating the epidermis were reported and those found in the papillary and superficial reticular dermis expressed CD3, as well as CD4:CD8 of 4:1; the patient was multi-treated with various therapeutic regimens. CONCLUSIONS: The case commented on highlights the refractory nature that this disease can sometimes present, since mycosis fungoides has a chronic and relapsing course, and patients frequently undergo multiple consecutive therapies; hence, the importance of sharing cases like this in the area of dermatology in addition to keeping in mind this diagnostic option in early stages that can become a real clinical and therapeutic challenge. [ABSTRACT FROM AUTHOR]

Introducción. El consorcio europeo BIOMED-2 se creó para determinar si una población linfoide de difícil clasificación patológica es clonal. En Colombia, la implementación de estas pruebas comenzó en el 2015 en el Instituto Nacional de Cancerología E.S.E. (Bogotá). Objetivos. Determinar el comportamiento de las pruebas de reordenamiento clonal o clonalidad linfoide. y determinar las dificultades de su uso en nuestro medio verificando su adaptación local y los resultados en una serie retrospectiva de casos y consecutiva de proliferaciones linfoides sometidas a los protocolos BIOMED-2. Materiales y métodos. A partir de las historias clínicas, se recolectaron los datos clínicos e histológicos y los resultados de los análisis de los reordenamientos en todos los casos de proliferaciones linfoides sometidas a los protocolos BIOMED-2, entre febrero de 2015 y mayo de 2019. Resultados. Se hallaron 132 casos, de los cuales 47 se clasificaron mediante los protocolos de Biomed-2 como hiperplasias linfoides reactivas, 62 como linfomas T, 19 como linfomas B y 3 como neoplasias linfoides de linaje no establecido. Solo en un caso falló la extracción de ADN. Según estos resultados, la mayor dificultad diagnóstica para el patólogo fue el análisis de los infiltrados linfoides T, la mayoría (44) de los cuales correspondía a lesiones cutáneas. Conclusiones. Las pruebas de clonalidad pueden usarse en tejidos de diversa calidad en nuestro medio como ayuda en el diagnóstico de proliferaciones linfoides de difícil clasificación. Es importante hacerlas e interpretarlas de manera multidisciplinaria y considerar cada caso por separado.

High dose methotrexate (HD-MTX) based chemoimmunotherapy is a central part of the standard approach to treatment of primary central nervous system lymphoma (PCNSL). Renal dysfunction leads to delayed MTX complete elimination and critical MTX concentration. Despite the recommendations, hemodialysis status should not exclude HD-MTX.We report the case of a 64 years old woman on chronic hemodialysis with PCNSL successfully treated with HD-MTX-based chemoimmunotherapy with an adjusted dose of 100 mg/m2, instead of the usual dose of 3500 mg/m2, and daily hemodialysis started 24 h later. The patient had no significant toxicity and was in complete remission at 1 year after the end of the treatment.We argue that ESRD is not an absolute pitfall to the use of HD-MTX for hematological malignancies. Experts should consider the use of adjusted dose at 100 mg/m2 as a viable therapeutic modality in ESRD patients. Resumen: La quimioinmunoterapia basada en una dosis elevada de metotrexato (HD-MTX) es una parte central del enfoque terapéutico estándar del linfoma primario del sistema nervioso central (PCNSL). La insuficiencia renal causa la demora de la eliminación completa de MTX, así como la concentración crítica del mismo. A pesar de las recomendaciones, el estatus de hemodiálisis no debería excluir la HD-MTX.Reportamos el caso de una mujer de 64 años con PCNSL y tratamiento de hemodiálisis crónica que fue exitosamente tratada con quimioinmunoterapia basada en HD-MTX con una dosis ajustada de 100 mg/m2, en lugar de la dosis habitual de 3.500 mg/m2, iniciándose la hemodiálisis diaria al cabo de 24 h. La paciente no reflejó toxicidad significativa y experimentó remisión completa al cabo de un año desde la finalización del tratamiento.Nosotros argumentamos que la enfermedad renal en etapa terminal (ESRD) no constituye un escollo en absoluto para utilizar la HD-MTX para neoplasias hematológicas. Los expertos deberían considerar el uso de una dosis ajustada a 100 mg/m2 como modalidad terapéutica viable en los pacientes de ESRD.

A Leucemia viral felina (FELV) tem fatores que afetam diretamente o tecido hematopoiético levando a predisposição ao linfoma que é a neoplasia mais comum em felinos, o diagnóstico é obtido através dos exames físico e clínico do paciente e exames complementares como: exames de imagem, hematimétricos e histopatológico. Foi atendido um felino SRD, macho, castrado de aproximadamente 8 anos de idade, positivo para FELV, apresentando êmese, prostração, anorexia e perda de peso progressiva. No exame físico, o paciente apresentava desidratação moderada e foi notado nódulo palpável em região abdominal além de renomegalia em rim direito. Os exames complementares de imagem, hematológicos e de urina revelaram suspeita de linfoma e alterações na função renal. O paciente foi estagiado como doente renal crônico em estágio III e subestadiado como normotenso. O tutor optou por não dar continuidade ao tratamento, foi realizado eutanásia e autorizado a realização de necrópsia, onde foi confirmado a suspeita de linfoma em região mesentérica englobando linfonodo com infiltração em duodeno e em ambos os rins. O objetivo do presente trabalho visa relatar o caso de um felino, diagnosticado com linfoma e descrever a sua associação com a lesão renal causada após sinais de infiltração metastática.

Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During lymphoma's natural history of disease, 5-10% of cases may develop Central Nervous affectation. We present the case of a 57-years-old man with less than 24 h of onset symptoms of paraparesis, lower limb hypoesthesia and sphincter dysfunction who was operated due to dorsal tumor with epidural component which caused severe cord compression. Pathological analysis concluded atypical T-cell lymphoblastic lymphoma, a rare subtype of lymphoma which accounts 1%-2% of all Non-Hodgkin Lymphomas. Our case was particularly aggressive and atypical due to its origin in paraspinal soft tissue. Despite specific treatment, the patient presented an early epidural relapse, frequent in this lymphoma subtype., Competing Interests: Declaration of competing interest Not applicable., (Copyright © 2024 Sociedad Española de Neurocirugía. Published by Elsevier España, S.L.U. All rights reserved.)

Objective: Evaluating the impact of solid organ neoplasms (SON) and hematological neoplasms (HN) on mortality among RA patients in a nationwide study., Methods: A retrospective, observational comparison of SON and HN-related deaths in RA patients and the general Spanish population was conducted (Spanish Hospital Discharge Database). Binary logistic regression analyzed the impact of RA on mortality risk from each neoplasm., Results: From 2016 to 2019, 139,531 neoplasm-related deaths were recorded, including 813 (0.6%) from RA patients. Patients with RA presented a lower mortality rate from SON (85.1% vs 91.2%, OR 0.99), mainly due to colorectal carcinoma (8% vs 10.6%, OR 0.67) and hepatocarcinoma (1% vs 2.7%, OR 0.44), but higher lung neoplasms risk (20.2% vs 18.6%, OR 1.31). HN-related deaths were also more prevalent in RA patients (14.9% vs 8.8%, OR 1.73), especially B and T/NK non-Hodgkin's lymphoma (6% vs 2.8%, OR 2.12) and myeloid leukemia (4.4% vs 2.3%, OR 1.92)., Conclusion: RA patients might have a higher mortality risk from lung and hematologic neoplasms. Reducing immunosuppressive burden and developing early-detection programs should be primary goals in this population., (Copyright © 2024 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Diffuse Large B-Cell Lymphoma associated with Epstein Barr virus Not otherwise specified is a frequent entity in South America, which affects patients of all ages but more frequently senile patients. Diagnosis is through the identification of the Epstein Barr virus within the tumor cell using the EBER test. The prognosis is unfavorable despite having improved with the introduction of rituximab. There are new prognostic scores for the identification of risk subgroups. The treatment continues to be the same as for cases of Epstein Barr virus-negative diffuse Large B-Cell Lymphoma. New novel therapeutic strategies against this entity are expected. [ABSTRACT FROM AUTHOR]

BACKGROUND: Nasal T-cell/natural killer cell lymphomas are rare, aggressive neoplasms, predominantly in males, presenting between 40 and 80 years of age. Mexico and Peru are the countries with the highest incidence in Latin America. These lymphomas have an almost exclusively extranodal presentation, the classic presentation involves palatal perforation. The most affected sites in order of frequency are the gastrointestinal tract, skin, and testicles. In the skin, the nasal cavity, nasopharynx and palate are affected. CLINICAL CASE: A 24-year-old female patient began her condition with nasal obstruction, anosmia and epistaxis, later she presented an increase in volume in the region of the right nostril, local pain, as well as fever spikes quantified up to 39°C. The tumor extended to the oral cavity and included the floor of the maxillary sinus, anterior nasal spine and the palate with an ulceration of 1 cm in its anterior portion. The histopathological study of the biopsy reported a nasal-type extranodal T/NK cell lymphoma with extensive necrosis, so it was decided to send her to the Hematology service, where chemotherapy and radiotherapy were given. CONCLUSIONS: Extranodal T/NK lymphomas are a diagnostic challenge that require a high index of clinical suspicion; the differential diagnosis includes other neoplasms, citotósuch as nasopharyngeal squamous cell carcinoma, as well as infectious processes such as fungal. In this patient, mucormycosis was suspected at first, so antifungal treatment was started without response. [ABSTRACT FROM AUTHOR]

Objectives: to describe the clinical profile and treatment outcomes of cases of lymphoma associated with Human Immunodeficiency Virus infection. Methods: retrospective study of cases of lymphoma associated with Human Immunodeficiency Virus infection treated at the Hematology Department of the Materno Infantil Hospital, La Paz, Bolivia during the period 2010-2021. Results: Eight cases were studied, of which 6 (75%) were male. The mean age was 40.75 years. 7 (87.5%) were Non-Hodgkin's Lymphoma and one case was Hodgkin's Lymphoma. In seven patients, the diagnosis of lymphoma was made after the detection of Human Immunodeficiency Virus infection, with a mean time of 4.6 years. 75% of the cases presented with advanced stage. Of the seven cases of Non-Hodgkin's Lymphoma, five corresponded to Large B-Cell Lymphoma. Chemotherapy was started in all cases but only three completed the scheduled cycles, the remainder stopped treatment mainly due to infectious complications. Four (50%) deaths were recorded, three of which occurred within the first four months after the diagnosis of lymphoma. Conclusions: In this study, Non-Hodgkin's Lymphoma was the most frequent, represented mainly by Large B-Cell Lymphoma. A common characteristic was the presentation at advanced stages. Chemotherapy could not be completed in the majority of cases due to complications related to immunodepression, and half of the cases died during the study period. [ABSTRACT FROM AUTHOR]

A incidência de lesões oncológicas tem aumentado nos últimos anos, sendo o linfoma a neoplasia mais comum em gatos na rotina clínica, acomete cerca de 50% de todos os tumores hemolinfáticos nos gatos. Este aumento ocorre de forma multifatorial, sendo um dos principais a maior longevidade dos animais de companhia. Não se conhece a etiologia precisa do linfoma felino em muitos casos, entretanto, causas virais de linfoma felino são bem definidas, havendo infecções tanto pelo vírus da leucemia felina quanto pelo vírus da imunodeficiência felina. O linfoma consiste em uma neoplasia maligna de origem linfocitária, caracterizado pela proliferação clonal de linfócitos malignos, originando-se principalmente de órgãos linfoides, como a medula óssea, baço e linfonodos. Os linfócitos fazem parte do nosso sistema imune e distribuem-se por todo o corpo. O linfoma pode ser classificado como multicêntrico que possuem origem nos gânglios linfáticos, tímico, hepático, esplénico, gastrointestinal e os linfomas extra nodais linfoma cutâneo, nasal, renal e em sistema nervoso. Os sintomas mais comuns são a perda de peso e apetite e os sinais gastrointestinais: vómitos e diarreia.

Se describen hallazgos en las imágenes definiendo el diagnostico: linfoma óseo primario.

Paciente canino (Canis lupus familiaris) hembra esterilizada, de raza mestiza, de 8 años de edad, que fue atendido en el centro integral veterinario de la ciudad de Guayaquil, Ecuador, el primero de noviembre del año 2021 refiere cuadro clínico caracterizado por astenia, anorexia, temperatura evaluada en 39,5°C y disnea a medianos esfuerzos. Al examen físico se apreció mal estado general, decaída, piel pálida y seca, ruidos cardíacos hipofonéticos, abdomen distendido con signo de baloneo positivo. En la consulta se realizó un A-Fast (Focussed assessment with sonography in trauma) en el que se observó líquido libre en los 4 cuadrantes, al realizar una exploración ecográfica T-Fast (Thoraic Focussed assessment with sonography in trauma), se evidenció efusión pericárdica. En una consulta posterior, durante la pericardiocentesis a cargo del cardiólogo, quien extrajo 40 mililitros (mL) cuyo contenido fue analizado mediante citología, mostrando células monomórficas linfoblásticas con mitosis aberrantes que sugerían el diagnóstico de linfoma. En la ecocardiografía se halló una masa a nivel de la base del corazón (pared pericárdica visceral en contacto directo con el miocardio), la cual fue removida mediante cirugía y se envió muestra al laboratorio de patología, cuyo informe diagnóstico fue compatible con linfoma difuso de células intermedias grado II.

Introducción. El retroperitoneo es una estructura que se extiende desde el diafragma hasta la pelvis, está delimitado adelante por el peritoneo parietal, atrás y a los lados por la fascia transversalis y se divide en 9 compartimientos. Se pueden encontrar lesiones primarias o secundarias, cuya evolución clínica varía desde un curso indolente hasta rápidamente progresivo, tanto local como a distancia. Su enfoque, desde el hallazgo hasta el tratamiento, es fundamental para el desenlace oncológico. Objetivo. Analizar la evaluación, el diagnóstico y el tratamiento de las masas retroperitoneales halladas incidentalmente y brindar un algoritmo de manejo. Métodos. Se hizo búsqueda en bases de datos como PubMed y MedicalKey de literatura referentes a tumores retroperitoneales, su diagnóstico y enfoque terapéutico, con el fin de presentar una revisión sobre el abordaje de las masas retroperitoneales y dar nuestras opiniones. Resultados. Se revisaron 43 referencias bibliográficas internacionales y nacionales, y se seleccionaron 20 de ellas, de donde se obtuvieron datos actualizados, recomendaciones de guías internacionales y experiencias nacionales, con lo cual se estructuró este manuscrito. Conclusiones. Las masas retroperitoneales abarcan un espectro de patologías que establecen un reto diagnóstico por su origen embriológico, localización y baja frecuencia. El diagnostico histológico es de vital importancia desde el inicio, para conocer la evolución natural de la enfermedad, y el manejo multidisciplinario en centros de referencia es fundamental para impactar en los desenlaces oncológicos. Existen variadas modalidades terapéuticas, como quimioterapia, radioterapia y resección quirúrgica con estándares oncológicos.

Introducción: El linfoma primario de la tiroides es una enfermedad infrecuente. El diagnóstico oportuno implica una evaluación clínica precisa, la realización de estudios de imágenes, citológicos e inmunológicos. Entre las modalidades del tratamiento están la quimioterapia, la cirugía y la radioterapia.] Objetivo: Reportar el caso clínico de una paciente con linfoma primario de la tiroides como forma de presentación neoplásica en el curso de un bocio multinodular, que requirió tratamiento quirúrgico. Caso clínico: Paciente de 56 años de edad, que presentó tumor gigante del cuello, acompañado de disnea, disfagia, disfonía, signos de compresión vascular y adenopatías. La citología por aspiración con aguja fina informó bocio multinodular. Por la sospecha de malignidad, se decidió el tratamiento quirúrgico que consistió en una tiroidectomía total con linfadenectomía. El resultado histológico informó un linfoma primario de la tiroides. Evolucionó favorablemente y continúo seguimiento por oncología. Conclusiones: En este caso se presenta un paciente con una rara enfermedad, sin embargo, el conocimiento profundo de los aspectos esenciales del diagnóstico oportuno y del tratamiento oportuno, elevan la tasa de supervivencia de estos pacientes.

O linfoma ou linfossarcoma é uma neoplasia hematopoiética de elevada prevalência em caninos que apresenta diferentes características e classificações, com predisposição racial e genética, sendo o linfoma multicêntrico o mais acometido. Objetivou-se com esse trabalho relatar um caso de neoplasia linfóide ocorrida, onde o paciente ainda se encontra livre de doença superando as estatísticas. A suspeita diagnóstica de neoplasia foi confirmada pela citologia e no tratamento foram utilizadas medicações como Vincristina, Ciclofosfamida, Doxorrubicina e Prednisona.

Introdução: A Doença Linfoproliferativa Pós-Transplante (PTLD) corresponde a neoplasia maligna secundária mais comum após transplante de órgãos sólidos (excluindo câncer de pele não melanoma e neoplasia uterina in situ). Em contrapartida, corresponde a minoria das neoplasias secundárias após transplante de medula óssea. No pós-transplante renal, a incidência cumulativa corresponde a 1-3%. Apresentação do caso: Paciente masculino, 43 anos, doença renal crônica sem etiologia definida, transplantado renal há 9 anos e em uso de imunossupressão com Micofenolato, Tacrolimus e Prednisona. Apresentou colite por Citomegalovírus há 1 ano e Paracoccidioidomicose há 2 anos, ambas tratadas. Em março de 2023, apresentou lesões ulceradas em membros e tronco, com biópsia de pele compatível com PTLD polimórfica. Reduzida imunossupressão com retirada de Tacrolimus e estabilização do quadro. Em março de 2024, apresentou episódio de crise convulsiva tônico-clônica e RM de crânio evidenciando múltiplos focos com captação periférica pelo meio de contraste. Realizou biópsia de lesão frontoparietal esquerda com imunohistoquímica sugerindo Linfoma Difuso de Grandes Células B com positividade para vírus Epstein-Barr (EBV), compatível com PTLD monomórfica (m). Paciente interna-se no Hospital Universitário Pedro Ernesto em 04/06/24 para início de tratamento, porém evolui com hipertensão intracraniana, herniação de uncus e morte encefálica 5 dias após a admissão. Discussão: A PTLD caracteriza-se por um espectro heterogêneo de desordens linfoproliferativas, em sua maioria derivadas de células B e em 52 a 80% dos casos associadas a infecção latente pelo vírus EBV. Divide-se em subtipos histológicos destacando-se a PTLD monomórfica e polimórfica. O linfoma primário de Sistema Nervoso Central PTLD pode se apresentar como PTLDm ou PTLDp e ocorre comumente após transplante renal. A principal estratégia terapêutica inclui redução da imunossupressão, com cerca de 25% dos pacientes atingindo resposta completa sem necessitar de quimioterapia adicional. No caso de acometimento do SNC, a terapêutica pode incluir: rituximabe, radioterapia e/ou uso de altas doses de metotrexato, que em alguns casos não é exequível devido à função renal do paciente. O aumento da sobrevida dos pacientes pós transplantes de órgão sólido provocou o aumento da incidência da PTLD fazendo-se necessário o surgimento de novas estratégias terapêuticas que possam atender essa rara e desafiadora entidade clínica. [ABSTRACT FROM AUTHOR]