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広島県はレモンの主要産地であることから，市場や食関連産業でのレモンの市場価値を高める活動に取り組んでいる。レモン摂取の健康への効果は，レモンに含まれるビタミンC，レモン精油，有機酸だけでなく，抗酸化力の強いフラボノイドによってももたらされる。最近ではポリフェノールが豊富なレモンを健康増進に有益な果実として注目する研究が出されている。本稿では，レモンに含まれる生物活性化合物と栄養や健康との関連について文献を通して紹介する。, Hiroshima prefecture as a leading representative of the lemon producing regions promotes to raise the commercial value of the lemon for the fresh products market and food industry.The benefi cial effects of the dietary lemon can be attributed not only to the vitamin C, essential oils and organic acids,but also to the antioxidant activity of their fl avonoids, Recently, several studies highlighted lemon as an important healthpromoting fruit rich in phenolic compounds. This review focuses on the relevance of Citrus limon for nutrition and health,bringing an overview of what is published on the bioactive compounds of this fruit., 総説

広島県はレモンの主要産地であることから，市場や食関連産業でのレモンの市場価値を高める活動に取り組んでいる。レモン摂取の健康への効果は，レモンに含まれるビタミンC，レモン精油，有機酸だけでなく，抗酸化力の強いフラボノイドによってももたらされる。最近ではポリフェノールが豊富なレモンを健康増進に有益な果実として注目する研究が出されている。本稿では，レモンに含まれる生物活性化合物と栄養や健康との関連について文献を通して紹介する。|Hiroshima prefecture as a leading representative of the lemon producing regions promotes to raise the commercial value of the lemon for the fresh products market and food industry.The benefi cial effects of the dietary lemon can be attributed not only to the vitamin C, essential oils and organic acids,but also to the antioxidant activity of their fl avonoids, Recently, several studies highlighted lemon as an important healthpromoting fruit rich in phenolic compounds. This review focuses on the relevance of Citrus limon for nutrition and health,bringing an overview of what is published on the bioactive compounds of this fruit., 総説

The aim of this study was to investigate the effect of dietary lemon polyphenols on high-fat diet-induced obesity in mice, and on the regulation of the expression of the genes involved in lipid metabolism to elucidate the mechanisms. Mice were divided into three groups and fed either a low fat diet (LF) or a high fat diet (HF) or a high fat diet supplemented with 0.5% w/w lemon polyphenols (LP) extracted from lemon peel for 12 weeks. Body weight gain, fat pad accumulation, the development of hyperlipidemia, hyperglycemia, and insulin resistance were significantly suppressed by lemon polyphenols. Supplementation with lemon polyphenols also significantly up-regulated the mRNA level of the peroxisome proliferator activated receptor-alpha (PPARalpha) compared to the LF and HF groups in the liver. Furthermore, the mRNA level of acyl-CoA oxidase (ACO) was up-regulated in the LP group compared to the LF group, but not HF group in the liver, and was also significantly increased in the epididymal white adipose tissue. Thus, feeding with lemon polyphenols suppressed body weight gain and body fat accumulation by increasing peroxisomal beta-oxidation through up-regulation of the mRNA level of ACO in the liver and white adipose tissue, which was likely mediated via up-regulation of the mRNA levels of PPARalpha.