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3 results on '"layer 4 neurons"'

1. Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit

Author

Chia-Fang Wang, Hsiang-Wei Hsing, Zi-Hui Zhuang, Meng-Hsuan Wen, Wei-Jen Chang, Carlos G. Briz, Marta Nieto, Bai Chuang Shyu, and Shen-Ju Chou

Subjects
Lhx2, barrel cortex, layer 4 neurons, dendritic asymmetry, Biology (General), QH301-705.5
Abstract

Cortical neurons must be specified and make the correct connections during development. Here, we examine a mechanism initiating neuronal circuit formation in the barrel cortex, a circuit comprising thalamocortical axons (TCAs) and layer 4 (L4) neurons. When Lhx2 is selectively deleted in postmitotic cortical neurons using conditional knockout (cKO) mice, L4 neurons in the barrel cortex are initially specified but fail to form cellular barrels or develop polarized dendrites. In Lhx2 cKO mice, TCAs from the thalamic ventral posterior nucleus reach the barrel cortex but fail to further arborize to form barrels. Several activity-regulated genes and genes involved in regulating barrel formation are downregulated in the Lhx2 cKO somatosensory cortex. Among them, Btbd3, an activity-regulated gene controlling dendritic development, is a direct downstream target of Lhx2. We find that Lhx2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of Btbd3.

Published
2017
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2. Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit.

Author

Wang, Chia-Fang, Hsing, Hsiang-Wei, Zhuang, Zi-Hui, Wen, Meng-Hsuan, Chang, Wei-Jen, Briz, Carlos G., Nieto, Marta, Shyu, Bai Chuang, and Chou, Shen-Ju

Abstract

Summary Cortical neurons must be specified and make the correct connections during development. Here, we examine a mechanism initiating neuronal circuit formation in the barrel cortex, a circuit comprising thalamocortical axons (TCAs) and layer 4 (L4) neurons. When Lhx2 is selectively deleted in postmitotic cortical neurons using conditional knockout (cKO) mice, L4 neurons in the barrel cortex are initially specified but fail to form cellular barrels or develop polarized dendrites. In Lhx2 cKO mice, TCAs from the thalamic ventral posterior nucleus reach the barrel cortex but fail to further arborize to form barrels. Several activity-regulated genes and genes involved in regulating barrel formation are downregulated in the Lhx2 cKO somatosensory cortex. Among them, Btbd3 , an activity-regulated gene controlling dendritic development, is a direct downstream target of Lhx2. We find that Lhx2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of Btbd3. [ABSTRACT FROM AUTHOR]

Published
2017
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3. Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit

Author

Hsiang-Wei Hsing, Bai-Chuang Shyu, Wei-Jen Chang, Carlos G. Briz, Shen-Ju Chou, Meng-Hsuan Wen, Zi-Hui Zhuang, Marta Nieto, and Chia-Fang Wang

Subjects
0301 basic medicine, Chromatin Immunoprecipitation, Patch-Clamp Techniques, LIM-Homeodomain Proteins, Barrel (horology), Gene Expression, Nerve Tissue Proteins, Biology, Somatosensory system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Thalamus, Cell Line, Tumor, Conditional gene knockout, Animals, Promoter Regions, Genetic, lcsh:QH301-705.5, Evoked Potentials, In Situ Hybridization, Adaptor Proteins, Signal Transducing, Mice, Knockout, Neurons, dendritic asymmetry, Nuclear Receptor Subfamily 1, Group F, Member 2, Lhx2, Anatomy, Cortical neurons, Somatosensory Cortex, Barrel cortex, LIM Domain Proteins, Ephrin-A5, Mice, Inbred C57BL, layer 4 neurons, 030104 developmental biology, nervous system, lcsh:Biology (General), Ventral posterior nucleus, embryonic structures, barrel cortex, Neuroscience, 030217 neurology & neurosurgery, Adenylyl Cyclases, Transcription Factors
Abstract

Cortical neurons must be specified and make the correct connections during development. Here, we examine a mechanism initiating neuronal circuit formation in the barrel cortex, a circuit comprising thalamocortical axons (TCAs) and layer 4 (L4) neurons. When Lhx2 is selectively deleted in postmitotic cortical neurons using conditional knockout (cKO) mice, L4 neurons in the barrel cortex are initially specified but fail to form cellular barrels or develop polarized dendrites. In Lhx2 cKO mice, TCAs from the thalamic ventral posterior nucleus reach the barrel cortex but fail to further arborize to form barrels. Several activity-regulated genes and genes involved in regulating barrel formation are downregulated in the Lhx2 cKO somatosensory cortex. Among them, Btbd3, an activity-regulated gene controlling dendritic development, is a direct downstream target of Lhx2. We find that Lhx2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of Btbd3.

Published
2016

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