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Robots are becoming increasingly sophisticated in the execution of complex tasks. However, an area that requires development is the ability to act in dynamically changing environments. To advance this, developments have turned towards understanding the human brain and applying this to improve robotics. The present study used electroencephalogram (EEG) data recorded from 54 human participants whilst they performed a two-choice task. A build-up of motor activity starting around 400 ms before response onset, also known as the lateralized readiness potential (LRP), was observed. This indicates that actions are not simply binary processes but rather, response-preparation is gradual and occurs in a temporal window that can interact with the environment. In parallel, a robot arm executing a pick-and-place task was developed. The understanding from the EEG data and the robot arm were integrated into the final system, which included cell assemblies (CAs)—a simulated spiking neural network—to inform the robot to place the object left or right. Results showed that the neural data from the robot simulation were largely consistent with the human data. This neurorobotics study provides an example of how to integrate human brain recordings with simulated neural networks in order to drive a robot. [ABSTRACT FROM AUTHOR]

BackgroundA number of motor abnormalities have been reported in psychotic disorders, including dyskinesia and psychomotor slowing. There is also evidence for many of the same motor abnormalities in biological first-degree relatives and accruing evidence for motor abnormalities in bipolar disorder. In addition to motor dysfunction, there are also shared symptom domains amongst these populations.ObjectivesWe explored the associations of (1) current and lifetime psychosis and mood symptom domains and (2) domains of psychosis proneness with various domains of motor function in a transdiagnostic sample (n = 149).MethodIndividuals with schizophrenia, schizoaffective disorder, or bipolar disorder, biological first-degree relatives of individuals with a psychotic disorder, and controls completed measures of psychomotor speed and movement fluidity, and neural activity related to motor preparation (stimulus-locked lateralized readiness potential, S-LRP) and execution (response-locked LRP) was assessed using EEG. All participants completed the Brief Psychiatric Rating Scale; patients were additionally assessed for lifetime psychosis and mood episode symptoms, and relatives and controls completed the Chapman psychosis proneness scales.ResultsMultiple regression revealed levels of current negative symptoms and mania were significantly positively associated with psychomotor slowing even after accounting for current antipsychotic medication dosage and duration of illness. S-LRP onset latency was significantly positively associated with magical ideation.ConclusionDomains of motor function are associated with various mood and psychosis symptom domains in a transdiagnostic sample, which may provide insight into brain abnormalities relevant to the expression of symptoms across disorders.

Robots are becoming increasingly sophisticated in the execution of complex tasks. However, an area that requires development is the ability to act in dynamically changing environments. To advance this, developments have turned towards understanding the human brain and applying this to improve robotics. The present study used electroencephalogram (EEG) data recorded from 54 human participants whilst they performed a two-choice task. A build-up of motor activity starting around 400 ms before response onset, also known as the lateralized readiness potential (LRP), was observed. This indicates that actions are not simply binary processes but rather, response-preparation is gradual and occurs in a temporal window that can interact with the environment. In parallel, a robot arm executing a pick-and-place task was developed. The understanding from the EEG data and the robot arm were integrated into the final system, which included cell assemblies (CAs)—a simulated spiking neural network—to inform the robot to place the object left or right. Results showed that the neural data from the robot simulation were largely consistent with the human data. This neurorobotics study provides an example of how to integrate human brain recordings with simulated neural networks in order to drive a robot.

Decision making often requires accumulating evidence in favour of a particular option. When choices are expressed with a motor response, these actions are preceded by reductions in the power of oscillations in the alpha and beta range in motor cortices. For unimanual movements, these reductions are greater over the hemisphere contralateral to the response side. Such lateralizations are hypothesized to be an online index of the neural state of decisions as they develop over time of processing. In contrast, the lateralized readiness potential (LRP) is considered to selectively activate a response and appears shortly before the motor output. We investigated to what extent these neural signals reflect integration of decision evidence or more motor-related action preparation. Using two different experiments, we found that lateralization of alpha and beta power (APL and BPL, respectively) rapidly emerged after stimulus presentation, even when making an overt response was not yet possible. In contrast, we show that even after prolonged stimulus presentation, no LRP was present. Instead, the LRP emerged only after an imperative cue, prompting participants to indicate their choice. Furthermore, we could show that variations in sensory evidence strength modulate APL and BPL onset times, suggesting that integration of evidence is represented in these motor cortical signals. We conclude that APL and BPL reflect higher cognitive processes rather than pure action preparation, whereas LRP is more closely tied to motor performance. APL and BPL potentially encode decision information in motor areas serving the later preparation of overt decision output.

Abnormal cognitive conflict resolution has been considered as a critical element of executive dysfunctions inpatient with major depression (MD). Further clarifying whether there was a deficit at perceptual encoding stage or the early response-execution stage in conflict control function by eventrelated potential (ERP) technique in MD would be helpful in understanding the neural mechanism of MD. Participants included twenty-six depressed patients and twenty-six healthy controls (HCs). All participants measured with Hamilton Depression Scale (17-item edition, HAMD) and a Simon task. Electroencephalograms were synchronously recorded when performing the Simon task. The method of residue iteration decomposition was used to analyze the lateralized readiness potential (LRP) and P300 components, which contributed to divides ERP components into a stimulus-locked component (S-cluster), a response-locked component (R-cluster) and an intermediate component cluster (C-cluster) by using latency variability and time markers. Results showed that reactive times (RTs) for both groups were fastest in congruent trials, and slowest in incongruent trials; however, there is no difference in RTs under the three conditions between two groups. Accuracy Rate (ACC) for both groups were the highest in neutral trials, and the lowest in incongruent trials; ACC in MD group were all lower than that of HC group under three conditions. ERP data analyses showed that depressed patients had a deficit in activating the correct response, as reflected by reduced amplitudes of R-LRP, but no abnormality in LRP-S and P300-C. In conclusion, patients with MD present conflict control dysfunction (i.e., abnormal cognitive conflict resolution) at the early response-execution stage, not at perceptual encoding stage, which may be reflected by the reduced R-LRP amplitudes. The abnormal cognitive conflict resolution in activating the correct response might constitute an interesting treatment target. [ABSTRACT FROM AUTHOR]

Previous research has demonstrated pervasive deficits in response-related processing in people with schizophrenia (PSZ). The present study used behavioral measures and event-related potentials (ERPs) to test the hypothesis that schizophrenia involves specific impairment in the ability to exert control over response-related processing. Twenty-two PSZ and 22 matched control participants completed a choice response task in counterbalanced testing sessions that emphasized only accuracy (the unspeeded condition) or emphasized speed and accuracy equally (the speeded condition). Control participants successfully modulated behavioral and ERP indices of response-related processing under speed pressure, as evidenced by faster and less variable reaction times (RTs) and an earlier onset and increased amplitude lateralized readiness potential (LRP). By contrast, PSZ were unable to improve RT speed or variability or to modulate the LRP under speed pressure, despite showing a decrease in accuracy. Notably, response-related deficits in PSZ emerged only in the speeded condition; behavioral and ERP measures did not differ between groups in the unspeeded condition. Together, these results indicate that impairment in the ability to exert control over response-related processing may underlie response-related deficits in schizophrenia.

Introduction: Preparatory motor cortical responses like the lateralized readiness potential (LRP) may be useful in revealing persistent attempts to feign hearing loss. Previous studies suggest only a marginal effect of stimulus intensity on the amplitude of the LRP. However, this has not been investigated using low-intensity auditory stimuli to cue NoGo trials. We address this in an experiment where subjects were instructed not to give a manual response to low-instensity stimuli, a situation that is akin to simulating hearing loss. Methods: The LRP was recorded from normal hearing listeners (N = 10) with 500 and 4,000-Hz pure tones and trains of 4,000 Hz (2-1-2) tonebursts. Electrophysiologic data underwent processing to (i) analyze the effect of the stimulus type on the LRP, (ii) classify results according to manual response with both logistic regression and linear support vector machine (SVM) models, and (iii) derive auditory brainstem responses (ABRs) from the tonebursts. Results: The amplitude of the LRP did not differ between the 3 stimuli used to elicit the response. Single-trial electrode data from Go and NoGo trials were submitted to supervised binary classification, and the logistic regression model gave a mean accuracy of close to 0.7. The Jewett wave V latencies of the resultant ABRs from some subjects were found to increase between the high (Go) and low (NoGo) intensity tonebursts. Conclusion: This study shows that auditory stimulus type does not affect the amplitude of the LRP and that the response can be recorded with stimuli that are near the auditory threshold. It can also be recorded with transient stimuli, and this allows for the possibility of simultaneously recording other confirmatory measurements, like ABR. [ABSTRACT FROM AUTHOR]

We combined behavioral measures with electrophysiological measures of motor activation (i.e., lateralized readiness potentials, LRPs) to disentangle the relative contribution of premotor and motor processes to multitasking interference in the prioritized processing paradigm. Specifically, we presented stimuli of two tasks (primary and background task) in each trial, but participants were instructed to perform the background task only if the primary task required no response. As expected, task performance was substantially influenced by a task probability manipulation: Background task responses were faster, psychological refractory period effects were smaller, and interference from the second task (i.e., backward compatibility effects) was larger when there was a larger probability that this task required a response. Critically, stimulus‐locked and response‐locked LRP analyses indicate that these behavioral effects of parallel processing were not driven by background task motor processing (e.g., motoric response activation) taking place during primary task processing. Instead, the LRP results suggest that these effects were exclusively localized during premotor stages of processing (e.g., response selection). Thus, the present results generally provide evidence for multitasking accounts allowing parallel task processing during response selection, whereas the task‐specific motor responses are activated in a serial manner. One plausible account is that multiple task information sources can be processed in parallel, with sharing of limited cognitive resources depending on task relevance, but a primary and still active task goal prevents motor activation related to the goals of other tasks in order to avoid outcome conflict. Although it is well known that two tasks usually interfere with each other when performed concurrently, there remains debate about the causes of this interference. By monitoring movement‐related electroencephalograms, we narrowed the possible sources of multitasking interference to premotor rather than motor processes. Our findings imply that mental representations of task goals play a crucial role in coordinating multiple processing streams. [ABSTRACT FROM AUTHOR]

Background: Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive thoughts and/or behaviors. OCD symptoms are often triggered by external stimuli. Therefore, it has been suggested that difficulty inhibiting responses to stimuli associated with strong action tendencies may underlie symptoms. The present electrophysiological study examined whether stimuli evoking a strong automatic response are associated with enhanced action tendencies in OCD participants relative to healthy controls. Methods: The lateralized readiness potential (LRP) and the N2 event-related potential (ERP) components were used as measures of action tendencies and inhibition, respectively. ERPs were recorded while 38 participants diagnosed with OCD and 38 healthy controls performed a variation of the Stroop task using colored arrows. Results: The OCD group presented with larger LRP amplitudes than the control group. This effect was found specifically in the incongruent condition. Furthermore, an interaction effect was found between group and congruency such that the OCD group showed a reduced N2 in the incongruent condition compared to the congruent condition, whereas the control group demonstrated the opposite effect. Results support the hypothesis that OCD is characterized by stronger readiness-for-action and impaired inhibitory mechanisms, particularly when the suppression of a dominant response tendency is required. Our results were supported by source localization analyses for the LRP and N2 components. These findings were specific to OCD and not associated with anxiety and depression symptoms. Conclusions: The present results support the notion of stronger habitual behavior and embodiment tendencies in OCD and impaired inhibitory control under conditions of conflict. [ABSTRACT FROM AUTHOR]

Event-related brain potentials (ERPs) have been utilized to study the cognitive implications of health-related behaviors, although many questions remain regarding the neural correlates underlying the cognition and adiposity relationship in childhood. Specifically, it is unknown whether excess fat mass is associated with the neural correlates of motor preparation and activation. The present work examined interrelationships between adiposity and ERPs that index inhibition, stimulus evaluation, and motor planning. To further elucidate the neural components of inhibitory control that are sensitive to adiposity, N2, P3, and response- and stimulus-locked Lateralized Readiness Potential (LRPs) were measured while preadolescent children completed an attentional inhibition task. Whole body percent adiposity was measured via dual-energy x-ray absorptiometry (DXA). Adiposity was related to the response-locked LRP amplitudes and marginally to P3 amplitude during the incongruent trials, such that participants with less adiposity elicited larger LRP and P3 components. Furthermore, P3 was strongly related to participant reaction times, suggesting that while LRP is strongly associated with adiposity, P3 has a more direct relationship to behavioral task performance. The results suggest that while different cognitive functions may be affected by health-related characteristics, stimulus evaluation and motor activation may be particularly sensitive to excess adiposity in children. These findings extend previous work implicating adiposity in cognitive health in the pediatric population. 1. What is already known about this subject? a. Excess adiposity is inversely associated with cognitive function in children. b. Adiposity has been associated with several event-related brain potentials, such that smaller P3 components, which index stimulus evaluation, and N2 components, which index attentional inhibition, are related to greater adiposity in children. c. The neural correlates underlying the cognition-adiposity relationship are under specified, and additional ERP components should be studied; one such component is the LRP, which underlies motor planning and activation. 2. What does your study add? a. Our results show that adiposity was related to the P3 and the response-locked LRP components such that children with less adiposity showed larger P3 and LRP waveforms. b. These findings suggest that two separable, though related, processes may be affected by adiposity in childhood: One involving the evaluation of a stimulus, represented by the P3, and one involving the activation of motor control, represented by the response-locked LRP. Clinical Registry Number: NCT02630667 at https://clinicaltrials.gov. [ABSTRACT FROM AUTHOR]

Background: Willfully not responding to auditory stimuli hampers accurate behavioral measurements. An objective measure of covert manual suppression recorded during response tasks may be useful to assess the veracity of responses to stimuli. Purpose: To investigate whether the lateralized readiness potential (LRP), an electrophysiological measure of corticomotor response and suppression, may be of use in determining when participants hear but do not respond to pure tones. Research Design: Within-subject repeated measures with a Go--NoGo paradigm. Study Sample: Five males and five females (mean age 5 38.8 years, standard deviation 5 8.8) underwent electrophysiology testing. All had normal hearing, except one. Intervention: Participants were tested in a condition where they consistently responded to tonal stimuli, and in a condition where intensity cued whether they should respond or not. Scalp-recorded cortical potentials and behavioral responses were recorded, along with a question that probed the perceived effort required to suppress responses to the stimuli. Data Collection and Analysis: Electrophysiology data were processed with independent component analysis and epoch-based artifact rejection. Averaged group and individual LRPs were calculated. Results: Group averaged waveforms show that suppressed responses, cued by NoGo stimuli, diverge positively at approximately 300 msec poststimulus, when compared with performed (Go) responses. LRPs were comparable when Go responses were recorded in a separate condition in which participants responded to all stimuli, and when Go and NoGo trials were included in the same condition. The LRP was not observed in one participant. Conclusions: Subsequent to further investigation, the LRP may prove suitable in assessing the suppression of responses to audiometric stimuli, and, thereby, useful in cases where functional hearing loss is suspected. [ABSTRACT FROM AUTHOR]

Highlights • Handedness affects reaction times in a visually guided response task. • The lateralized readiness potential (LRP) reveals asymmetrical motor activation. • The LRP differs in peak amplitude between left- and right-handers. • Peak amplitude of the LRP is also modulated by sequence complexity. Abstract Handedness is the most investigated form of functional hemispheric asymmetries, but its neural correlates remain unclear. Functional imaging studies suggest differences between left- and right-handers in ipsilateral activation during unilateral hand movements, but do not allow for conclusions on the temporal dimension. In the Tapley and Bryden task, subjects have to draw as many dots as possible on a paper within 20 s using either the left or the right hand. We adapted the task for use during EEG in 36 left- and 36 right-handers. Subjects performed a visually guided response task with each trial consisting of eight motor responses. We investigated the lateralized readiness potential (LRP) at the first and last response of the sequence. Overall, increasing complexity of sequences was associated with earlier and less negative LRP peaks. For the last response, right-handers showed more negative LRP peak amplitudes than left-handers. The effect of handedness on LRP peak amplitude in the first response was modulated by task complexity with a more negative LRP peak amplitude in right-handers than left-handers in simple, but not in medium or complex trials. This effect might be due to more symmetrical processing in right-handers with increasing task complexity. These findings complement previous imaging studies and add a new perspective on the relationship between laterality and schizophrenia, associated with less pronounced LRPs and a higher prevalence of left-handedness. [ABSTRACT FROM AUTHOR]

Does memory prepare us to act? Long-term memory can facilitate signal detection, though the degree of benefit varies and can even be absent. To dissociate between learning and behavioral expression of learning, we used high-density electroencephalography (EEG) to assess memory retrieval and response processing. At learning, participants heard everyday sounds. Half of these sound clips were paired with an above-threshold lateralized tone, such that it was possible to form incidental associations between the sound clip and the location of the tone. Importantly, attention was directed to either the sound clip (Experiment 1) or the tone (Experiment 2). Participants then completed a novel detection task that separated cued retrieval from response processing. At retrieval, we observed a striking brain-behavior dissociation. Learning was observed neurally in both experiments. Behaviorally, however, signal detection was only facilitated in Experiment 2, for which there was an accompanying explicit memory for tone presence. Further, implicit neural memory for tone location correlated with the degree of response preparation , but not response execution. Together, the findings suggest 1) that attention at learning affects memory-biased action and 2) that memory prepared action via both explicit and implicit associative memory, with the latter triggering response preparation. • Memory aids signal detection, but the degree of benefit varies and can be absent. • How is it that the brain learns, yet action does not necessarily follow? • Learning was separable from detection benefits that relied on attention at encoding. • Directed attention produced both explicit and implicit memory components. • Implicit memory triggered response preparation to induce memory-biased action. [ABSTRACT FROM AUTHOR]

In this study, we attempt to validate previous findings on extraversion-related differences in speed of sensorimotor processing and to extend them into Behavioural Approach System (BAS) subtraits within the framework of the revised Reinforcement Sensitivity Theory (rRST) of personality. Here, we assessed psychological traits of extraversion (E), four BAS facets (Goal-Drive Persistence, BAS-GDP; Reward Interest, BAS-RI; Reward Reactivity, BAS-RR; Impulsivity, BAS-I), Behavioural Inhibition System (BIS), and Fight-Flight-Freeze System (FFFS) in 51 volunteers (28 women). Stimulus-locked lateralized readiness potential (S-LRP), response-locked LRP (R-LRP), stimulus-locked and response-locked forearm electromyogram (S-EMG and R-EMG), and P3 components of the event-related potentials (ERPs), were recorded during the performance of a two-choice Go/NoGo visual letter-digit discrimination task varying in task difficulty. High extraverts, relative to introverts and individuals high relative to low on BAS-RI, were more likely to exhibit shorter S-LRP latencies and stimulus- and response-locked EMG latencies. Additionally, high BAS-I had a shorter R-RLP latency than low BAS-I participants for the difficult task. High FFFS levels were associated with longer S-LRP and S-EMG latencies, while high BIS levels had larger response accuracy. Extraverts, relative to introverts, along with those high relative to low on BAS-RR and BAS-I, exhibited smaller P3 amplitudes. The faster cortical premotor initiation, found in individuals high on extraversion, BAS-RI and low on FFFS, may account for their faster peripheral motor response initiation and execution. Smaller P3 amplitudes in extraverts and individuals high on BAS-RR and BAS-I may indicate reduced perceptual processing capacity in these individuals. [ABSTRACT FROM AUTHOR]

Abstract: In everyday life, we often must coordinate information across spatial locations and different senses for action. It is well known, for example, that reactions are faster when an imperative stimulus and its required response are congruent than when they are not, even if stimulus location itself is completely irrelevant for the task (the so‐called Simon effect). However, because these effects have been frequently investigated in single‐modality scenarios, the consequences of spatial congruence when more than one sensory modality is at play are less well known. Interestingly, at a behavioral level, the visual Simon effect vanishes in mixed (visual and tactile) modality scenarios, suggesting that irrelevant spatial information ceases to exert influence on vision. To shed some light on this surprising result, here we address the expression of irrelevant spatial information in EEG markers typical of the visual Simon effect (P300, theta power modulation, LRP) in mixed‐modality contexts. Our results show no evidence for the visual‐spatial information to affect performance at behavioral and neurophysiological levels. The absence of evidence of the neural markers of visual S‐R conflict in the mixed‐modality scenario implies that some aspects of spatial representations that are strongly expressed in single‐modality scenarios might be bypassed. [ABSTRACT FROM AUTHOR]

Alternative motor responses can be prepared in parallel. Here, we used electroencephalography (EEG) to test whether the parallel preparation of alternative response options is modulated by their relative value. Participants performed a choice response task with three potential actions: isometric contraction of the left, the right, or both wrists. An imperative stimulus (IS) appeared after a warning cue, such that the initiation time of a required action was predictable, but the specific action was not. To encourage advanced preparation, the target was presented 200 ms prior to the IS, and only correct responses initiated within ±100 ms of the IS were rewarded. At baseline, all targets were equally rewarded and probable. Then, responses with one hand were made more valuable, either by increasing the probability that the left or right target would be required (Exp. 1; n  = 31) or by increasing the reward magnitude of one target (Exp. 2, n  = 36). We measured reaction times, movement vigor, and an EEG correlate of action preparation (value-based lateralized readiness potential) prior to target presentation. Participants responded earlier to more frequent and more highly rewarded targets, and movements to highly rewarded targets were more vigorous. The EEG was more negative over the hemisphere contralateral to the more repeated/rewarded hand, implying an increased neural preparation of more valuable actions. Thus, changing the value of alternative response options can lead to greater preparation of actions associated with more valuable outcomes. This preparation asymmetry likely contributes to behavioral biases that are typically observed toward repeated or rewarded targets. [ABSTRACT FROM AUTHOR]

Objective The restless legs syndrome (RLS) is characterized by sensory-motor symptoms which usually occur predominantly at rest in the evening and at night. It is assumed that this circadian rhythm is caused by low dopamine levels in the evening. Yet, it has never been investigated whether RLS patients show diurnal variations in cognitive functions modulated by dopamine and what neurophysiological and functional neuroanatomical processes underlie such modulations. Methods We used a Simon task combined with EEG and source localization to investigate whether top-down response selection and/or automatic visuo-motor priming are subject to diurnal changes in RLS patients, as compared to matched healthy controls. Results We found that RLS patients showed better task performance due to reduced visuo-motor priming in the evening, as reflected by smaller early lateralized readiness potential (e-LRP) amplitudes and decreased activation of the superior parietal cortex and premotor cortex. Top-down response selection and early attentional processing were unaffected by RLS. Conclusions Counterintuitively, RLS patients show enhanced task performance in the evening, i.e. when experiencing dopaminergic deficiency. Yet, this may be explained by deficits in visuo-motor priming that lead to reduced false response tendencies. Significance This study reveals a counterintuitive circadian variation of cognitive functions in RLS patients. [ABSTRACT FROM AUTHOR]

According to recent interpretations of repetition priming, response codes are automatically bound to a stimulus and retrieved during successive presentations of the stimulus, hence, affecting its current processing. Despite a solid corpus of behavioural evidence in line with this interpretation, electrophysiological studies have reported contrasting results regarding the nature and the timing of response code retrieval. The present experiment aims to establish at which stage of information processing decision and action codes are retrieved in repetition priming. To this end, the lateralized readiness potential (LRP) was analysed for primed faces to monitor motor cortex activity related to response preparation. Congruent and incongruent responses were obtained by having identical or reversed tasks between study and test. Primed stimuli presented LRP activations with opposite polarities for the two congruency conditions in the time-window 250-300 ms, indicating response-related motor cortex activity resulting from the retrieval of correct and incorrect decision/action codes for congruent and incongruent trials, respectively. This result indicates that decision and action codes bound to a primed stimulus are retrieved at early stages of stimulus processing and that these codes are transmitted to the motor cortex. [ABSTRACT FROM AUTHOR]

According to reinforcement learning theory, dopamine-dependent anticipatory processes play a critical role in learning from action outcomes such as feedback or reward. To better understand outcome anticipation, we examined variation in slow cortical potentials and assessed their changes over the course of motor-skill acquisition. Healthy young adults learned a series of precisely timed, key press sequences. Feedback was delivered at a delay of either 2.5 or 8 s, to encourage use of either the striatally mediated, habit learning system or the hippocampus-dependent, episodic memory system, respectively. During the 2.5-s delay, the stimulus-preceding negativity (SPN) was shown to decline in amplitude across trials, confirming previous results from a perceptual categorization task (Morís, Luque, & Rodríguez-Fornells, 2013). This falsifies the hypothesis that SPN reflects specific outcome predictions, on the assumption that the ability to make such predictions should improve as a task is mastered. An SPN was also evident during the 8-s delay, but it increased in amplitude across trials. At the conclusion of the 8-s but not the 2.5-s prefeedback interval, a reversed-polarity lateralized readiness potential (LRP) was noted. It was suggested that this might indicate maintenance of an action representation for comparison with the feedback display. If so, this would constitute the first direct psychophysiological evidence for a popular hypothetical construct in quantitative models of reinforcement learning, the so-called eligibility trace. [ABSTRACT FROM AUTHOR]

When multisensory information concurrently arrives at our receptors, visual information often receives preferential processing and eventually dominates awareness and behavior. Previous research suggested that the visual dominance effect implicated the prioritizing of visual information into the motor system. In order to further reveal the underpinning neurophysiological mechanism of how visual information is prioritized into the motor system when vision dominates audition, the present study examined the time course of a particular motor activation ERP component, the lateralized readiness potential (LRP), during multisensory competition. The onsets of both stimulus-locked LRP (S-LRP) and response-locked LRP (R-LRP) were measured. Results showed that, the R-LRP onset to the auditory target was delayed about 91 ms when it was paired with a simultaneous presented visual target, compared to that when it was presented by itself. For the visual target, however, the R-LRP onset was comparable irrespective of whether it was paired with an auditory target or not. No significant difference was obtained for the onset of S-LRP. Taken together, the time courses of LRPs indicated that visual information was preferentially processed within the motor system, which coincides with the previous finding that the dorsal visual stream prioritizes the flow of visual information into the motor system. [ABSTRACT FROM AUTHOR]

Behavioral and recent neuroimaging findings have shown reversal of interference effects due to manipulating proportion congruency (PC), which suggests that task-irrelevant stimulus-response (S-R) associations are strengthened and applied to predict responses. However, it is unclear how the strengthened S-R associations are represented and applied in the brain. We investigated with a between-subjects PC paradigm of the Hedge and Marsh task using electroencephalography (EEG). The behavioral results showed the reversal of the conflict effects, suggesting that task-irrelevant S-R associations were strengthened and used to prepare responses. The EEG results revealed the PC-related reversal of the conflict effects in the frontocentral N2 and parietal P3b amplitudes. Time-frequency analyses showed more pronounced PC-related reversal of the conflict effects in theta band (4-8 Hz) activity in frontocentral sites. These results suggest that the strengthened S-R associations due to PC manipulation modulated cognitive control. Importantly, the amplitude of lateralized readiness potential was higher in the high-PC condition than in the low-PC condition, suggesting that the strengthened short-term-memory spatial S-R associations that modulated cognitive control were applied similarly to long-term-memory spatial S-R associations. [ABSTRACT FROM AUTHOR]

Anodal transcranial direct current stimulation (tDCS) over the motor cortex is considered a potential treatment for motor rehabilitation following stroke and other neurological pathologies. However, both the context under which this stimulation is effective and the underlying mechanisms remain to be determined. In this study, we examined the mechanisms by which anodal tDCS may affect motor performance by recording eventrelated potentials (ERPs) during a cued go/nogo task after anodal tDCS over dominant primary motor cortex (M1) in young adults (Experiment 1) and both dominant and nondominant M1 in older adults (Experiment 2). In both experiments, anodal tDCS had no effect on either response time (RT) or response-related ERPs, including the cuelocked contingent negative variation (CNV) and both target-locked and response-locked lateralized readiness potentials (LRP). Bayesian model selection analyses showed that, for all measures, the null effects model was stronger than a model including anodal tDCS vs. sham. We conclude that anodal tDCS has no effect on RT or response-related ERPs during a cued go/nogo task in either young or older adults. [ABSTRACT FROM AUTHOR]

Several studies have indicated that human observers are very efficient at tracking self-generated hand movements with their gaze, yet it is not clear whether this is simply a by-product of the predictability of selfgenerated actions or if it results from a deeper coupling of the somatomotor and oculomotor systems. In a first behavioral experiment we compared pursuit performance as observers either followed their own finger or tracked a dot whose motion was externally generated but mimicked their finger motion. We found that even when the dot motion was completely predictable in terms of both onset time and kinematics, pursuit was not identical to that produced as the observers tracked their finger, as evidenced by increased rate of catch-up saccades and by the fact that in the initial phase of the movement gaze was lagging behind the dot, whereas it was ahead of the finger. In a second experiment we recorded EEG in the attempt to find a direct link between the finger motor preparation, indexed by the lateralized readiness potential (LRP) and the latency of smooth pursuit. After taking into account finger movement onset variability, we observed larger LRP amplitudes associated with earlier smooth pursuit onset across trials. The same held across subjects, where average LRP onset correlated with average eye latency. The evidence from both experiments concurs to indicate that a strong coupling exists between the motor systems leading to eye and finger movements and that simple top-down predictive signals are unlikely to support optimal coordination. [ABSTRACT FROM AUTHOR]

To date, many different approaches have been used to study the impairment of motor function in Parkinson’s disease (PD). Event-related potentials (ERPs) are averaged amplitude fluctuations of the ongoing EEG activity that are time locked to specific sensory, motor or cognitive events, and as such can be used to study different brain processes with an excellent temporal resolution. Movement-related potentials (MRPs) are ERPs associated with processes of voluntary movement preparation and execution in different paradigms. In this review we concentrate on MRPs in PD. We review studies recording the Bereitschaftspotential, the Contingent Negative Variation, and the lateralized readiness potential in PD to highlight the contributions they have made to further understanding motor deficits in PD. Possible directions for future research are also discussed. [ABSTRACT FROM AUTHOR]

Abnormalities in motor skills have been regarded as part of the symptomatology characterizing autism spectrum disorder (ASD). It has been estimated that 80 % of subjects with autism display 'motor dyspraxia' or clumsiness that are not readily identified in a routine neurological examination. In this study we used behavioral measures, event-related potentials (ERP), and lateralized readiness potential (LRP) to study cognitive and motor preparation deficits contributing to the dyspraxia of autism. A modified Posner cueing task was used to analyze motor preparation abnormalities in children with autism and in typically developing children (N = 30/per group). In this task, subjects engage in preparing motor response based on a visual cue, and then execute a motor movement based on the subsequent imperative stimulus. The experimental conditions, such as the validity of the cue and the spatial location of the target stimuli were manipulated to influence motor response selection, preparation, and execution. Reaction time and accuracy benefited from validly cued targets in both groups, while main effects of target spatial position were more obvious in the autism group. The main ERP findings were prolonged and more negative early frontal potentials in the ASD in incongruent trials in both types of spatial location. The LRP amplitude was larger in incongruent trials and had stronger effect in the children with ASD. These effects were better expressed at the earlier stages of LRP, specifically those related to response selection, and showed difficulties at the cognitive phase of stimulus processing rather that at the motor execution stage. The LRP measures at different stages reflect the chronology of cognitive aspects of movement preparation and are sensitive to manipulations of cue correctness, thus representing very useful biomarker in autism dyspraxia research. Future studies may use more advance and diverse manipulations of movement preparation demands in testing more refined specifics of dyspraxia symptoms to investigate functional connectivity abnormalities underlying motor skills deficits in autism. [ABSTRACT FROM AUTHOR]

New evidence is accumulating for a deficit in binding visual-orthographic information with the corresponding phonological code in developmental dyslexia. Here, we identify the mechanisms underpinning this deficit using event-related brain potentials (ERPs) in dyslexic and control adult readers performing a letter-matching task. In each trial, a printed letter was presented synchronously with an auditory letter name. Incongruent (mismatched), frequent trials were interleaved with congruent (matched) infrequent target pairs, which participants were asked to report by pressing a button. In critical trials, incongruent letter pairs were mismatched but confusable in terms of their visual or phonological features. Typical readers showed early detection of deviant trials, indicated by larger modulation in the range of the phonological mismatch negativity (PMN) compared with standard trials. This was followed by stronger modulation of the P3b wave for visually confusable deviants and an increased lateralized readiness potential (LRP) for phonological deviants, compared with standards. In contrast, dyslexic readers showed reduced sensitivity to deviancy in the PMN range. Responses to deviants in the P3b range indicated normal letter recognition processes, but the LRP calculation revealed a specific impairment for visual-orthographic information during response selection in dyslexia. In a follow-up experiment using an analogous non- lexical task in the same participants, we found no reading-group differences, indicating a degree of specificity to over-learnt visual-phonological binding. Our findings indicate early insensitivity to visual-phonological binding in developmental dyslexia, coupled with difficulty selecting the correct orthographic code. [ABSTRACT FROM AUTHOR]

Decision making often requires accumulating evidence in favour of a particular option. When choices are expressed with a motor response, these actions are preceded by reductions in the power of oscillations in the alpha and beta range in motor cortices. For unimanual movements, these reductions are greater over the hemisphere contralateral to the response side. Such lateralizations are hypothesized to be an online index of the neural state of decisions as they develop over time of processing. In contrast, the lateralized readiness potential (LRP) is considered to selectively activate a response and appears shortly before the motor output. We investigated to what extent these neural signals reflect integration of decision evidence or more motor-related action preparation. Using two different experiments, we found that lateralization of alpha and beta power (APL and BPL, respectively) rapidly emerged after stimulus presentation, even when making an overt response was not yet possible. In contrast, we show that even after prolonged stimulus presentation, no LRP was present. Instead, the LRP emerged only after an imperative cue, prompting participants to indicate their choice. Furthermore, we could show that variations in sensory evidence strength modulate APL and BPL onset times, suggesting that integration of evidence is represented in these motor cortical signals. We conclude that APL and BPL reflect higher cognitive processes rather than pure action preparation, whereas LRP is more closely tied to motor performance. APL and BPL potentially encode decision information in motor areas serving the later preparation of overt decision output. [ABSTRACT FROM AUTHOR]