1. LESM: a laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples
- Author
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L. Labate, Gian Luigi Russo, G. C. Bussolino, Lorenzo Fulgentini, Y Oishi, Antonio Giulietti, Andrea Borghini, L. A. Gizzi, Ranieri Bizzarri, Antonella Sgarbossa, Silvia Pulignani, Debora Lamia, F. Baffigi, Maria Grazia Andreassi, Francesco Ghetti, T. Levato, and P. Köster
- Subjects
Materials science ,Acoustics and Ultrasonics ,Physics::Medical Physics ,Analytical chemistry ,Electron ,01 natural sciences ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Optics ,law ,ultrahigh dose rate ,0103 physical sciences ,Relative biological effectiveness ,010306 general physics ,Range (particle radiation) ,business.industry ,Condensed Matter Physics ,Laser ,sub-MeV electron sources ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Characterization (materials science) ,radiobiology ,Picosecond ,Physics::Accelerator Physics ,cell radiation damage ,laser-driven electron accelerators ,business ,Ultrashort pulse ,Energy (signal processing) - Abstract
We present a laser-driven source of electron bunches with average energy 260 keV and picosecond duration, which has been setup for radiobiological tests covering the previously untested sub-MeV energy range. Each bunch combines high charge with short duration and sub-millimeter range into a record instantaneous dose rate, as high as 10(9) Gy s(-1). The source can be operated at 10 Hz and its average dose rate is 35 mGy s(-1). Both the high instantaneous dose rate and high level of relative biological effectiveness, attached to sub-MeV electrons, make this source very attractive for studies of ultrafast radiobiology on thin cell samples. The source reliability, in terms of shot-to-shot stability of features such as mean energy, bunch charge and transverse beam profile, is discussed, along with a dosimetric characterization. Finally, a few preliminary biological tests performed with this source are presented. .
- Published
- 2016
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