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Computational methods such as molecular dynamics (MD) have illuminated how single‐atom ions permeate membrane channels and how selectivity among them is achieved. Much less is understood about molecular permeation through eukaryotic channels that mediate the flux of small molecules (e.g. connexins, pannexins, LRRC8s, CALHMs). Here we describe computational methods that have been profitably employed to explore the movements of molecules through wide pores, revealing mechanistic insights, guiding experiments, and suggesting testable hypotheses. This review illustrates MD techniques such as voltage‐driven flux, potential of mean force, and mean first‐passage‐time calculations, as applied to molecular permeation through wide pores. These techniques have enabled detailed and quantitative modeling of molecular interactions and movement of permeants at the atomic level. We highlight novel contributors to the transit of molecules through these wide pathways. In particular, the flexibility and anisotropic nature of permeant molecules, coupled with the dynamics of pore‐lining residues, lead to bespoke permeation dynamics. As more eukaryotic large‐pore channel structures and functional data become available, these insights and approaches will be important for understanding the physical principles underlying molecular permeation and as guides for experimental design. [ABSTRACT FROM AUTHOR]

Pillared paddle-wheel-based metal-organic framework (MOF) materials are an attractive target as they offer a reliable method for constructing well-defined, multifunctional materials. A drawback of these materials, which has limited their application, is their tendency to form catenated frameworks with little accessible volume. To eliminate this disadvantage, it is necessary to investigate strategies for constructing non-catenated pillared paddle-wheel MOFs. Hydrogen-bonding substituents on linkers have been postulated to prevent catenation in certain frameworks and, in this work, we present a new MOF to further bolster this theory. Using 2,2′-diamino-[1,1′-biphenyl]-4,4′-dicarboxylic acid, BPDC-(NH2)2, linkers and dipyridyl glycol, DPG, pillars, we assembled a MOF with pcu topology. The new material is non-catenated, exhibiting large accessible pores and low density. To the best of our knowledge, this material constitutes the pcu framework with the largest pore volume and lowest density. We attribute the lack of catenation to the presence of H-bonding substituents on both linkers.

Sub-2 μm large-pore monodispersed mesoporous silica spheres (MMSS) were synthesized by using mixed non-ionic surfactants of dodecylamine (DDA) and dodecylamine polyoxyethylene ether (AC1210) as templates through an alkali-catalyzed silica sol–gel technique combined with the template method. Methanol-H 2 O volume ratio on morphology was researched in detail. In addition, by using hydrothermal treatment, the average pore size of MMSS could be enlarged to 11 nm from 4.4 nm. The mesoporous silica particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), laser particle size analyzer, X-ray diffraction, N 2 physisorption technique. The synthesized sub-2 μm monodispersed mesoporous silica microspheres were successfully functionalized by dimethyloctadecylchlorosilane and used as a packing material in high performance liquid chromatography (HPLC). [ABSTRACT FROM AUTHOR]

[Display omitted] • Flexible ligand strategy was first proposed to prepare MOFs with simultaneous large-pore and antenna effect emission. • Flexible –CH 2 -O- group can tune the energy level of ligand. • Different diffusion dynamics was observed for MOFs with different pore sizes. • The relative specific surface area affected the linear response range. • L1-Eu MOF sensor realized the ratiometric fluorescence detection of PO 4 3- and ATP. Polycyclic aromatic ligands improve the pore size of metal–organic frameworks (MOFs), but their big π-conjugation structure forbids energy transfer for antenna effect emission. Thus, large-pore and antenna effect are a dilemma even their combination could improve the efficiency of MOFs. Herein, we construct a flexible ligand, 1,3,5-tris(5-methoxy-1,3-benzene dicarboxylic acid)benzene (L1) by attaching three isophthalic acids (L2) to a benzene ring through flexible –CH 2 -O- bonds. L1 retains the optical properties of L2 for antenna effect and expands the molecular size for MOFs with large pore. Single-crystal result of the MOFs obtained with L1 and Eu3+, Tb3+, or Gd3+ reveals the aperture of 18 Å and the density of 1.2 g/mL. L1 excites Eu3+ and Tb3+ ions for their antenna effect emission. The –CH 2 -O- group tunes the energy transfer for dual-emission at 360 and 623 nm from L1 -Eu MOF under single excitation of 290 nm. The dual-emission is used for ratiometric fluorescence detection of phosphate (PO 4 3-) and adenosine-5′-triphosphate (ATP). We reveal the effect of porous structure of MOFs on the response speed and range. The pore size affects the target entrance as L1 -Eu MOF shows faster response to PO 4 3- and ATP than L2 -Eu MOF. Moreover, fast diffusion dynamics of a target is observed in large-pore MOFs for good linear response. The relative specific surface area affects the linear range as a narrower range was observed for ATP than PO 4 3-. Thus, flexible ligand is effective to expand the aperture, improve optical properties, and study the response mechanism for the extensive applications of MOFs. [ABSTRACT FROM AUTHOR]

Abstract: CuO-loaded large-pore mesoporous SBA-15 silica was synthesized by a simple and efficient direct route in an acid media. Owing to a mesophase transformation behavior induced by inorganic salts, cubic mesostructued silica was also obtained in this system. Characterization of these mesostructured materials by the XRD, TEM, BET, FT–IR, UV–VIS, XPS, CV and ICP–AES showed that ∼37 wt.% or ∼45 wt.% copper oxide was directly introduced into hexagonal or cubic large-pore mesoporous silica, respectively. The mechanism study revealed that in-situ formation of a large amount of copper oxalate was the key step in this synthesis. The catalytic hydroxylation of benzene to phenol reveals that the direct-synthesized mesoporous CuO/silica showed the special catalytic property in comparison to the post-impregnated samples. [Copyright &y& Elsevier]

A variety of newly developed mesh products have recently become available to use inside the peritoneal cavity. This analysis reports the first clinical data evaluating the experience with the use of Proceed® mesh in laparoscopic ventral hernia repair. During a 6-month period, 114 adult patients underwent a laparoscopic ventral hernia repair using an intra-abdominal placement of a Proceed mesh. The operative procedure was stratified for all centers. Perioperatively, different parameters were evaluated considering the conversion rate to open procedure, complications such as seroma and hematoma, bowel lesions, urinary retention, acute, and chronic pain, mesh infection, and recurrences. The mean age of the patients was 45 years (range 19–84 years). There were no conversions to open repair and no mortality. Complications included 12 seromas/hematomas (four aspirated), chronic discomfort in two patients, and urinary retention in one patient. There have been four recurrences (3.5%), occurring 3, 4, 4, and 15 months after surgery, respectively. The mean follow-up period was 27 months (range 12–38 months). There have been no documented infections of the mesh. This multicentric study documents a favorable experience using large-pore mesh in laparoscopic ventral hernia repair. There were no major complications related to the mesh. Technical advantages considering mesh handling and long-term advantages considering chronic pain might be of interest with the use of this lightweight mesh for minimally invasive ventral hernia repair. [ABSTRACT FROM AUTHOR]

The first example of a large-pore framework chromium-silicate containing stoichiometric amounts of hexa-coordinated chromium(III) has been reported. Samples were characterised by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), diffuse reflectance spectroscopy ultraviolet–visible (DR UV–VIS) spectroscopy, thermogravimetry (TG), adsorption of different probe molecules and model catalytic tests; AV-15 is an active catalyst for the liquid phase epoxidation of cyclohexene to cyclohexene oxide, the oxidation of cyclohexane to cyclohexanol and cyclohexanone, and the oxidative dehydrogenation of cyclohexanol to cyclohexanone, under mild reaction conditions (using H2O2, at 50 °C). The catalyst is recyclable without significant loss of catalytic activity, but leaching tests indicate that catalysis is mainly due to some leached chromium species. In gas phase, AV-15 exhibits mainly oxydehydrogenation activity in the conversion of ethanol, 2-propanol and cyclohexanol, using air, yielding the corresponding carbonyl product. [Copyright &y& Elsevier]

Abstract: A mesoporous MCM-48 membrane with three-dimensional (3D) accessible pore structures has been prepared on a large-pore α-Al2O3 ceramic tube by adopting the pore-prefilling method. [Copyright &y& Elsevier]

Pillared paddle-wheel-based metal-organic framework (MOF) materials are an attractive target as they offer a reliable method for constructing well-defined, multifunctional materials. A drawback of these materials, which has limited their application, is their tendency to form catenated frameworks with little accessible volume. To eliminate this disadvantage, it is necessary to investigate strategies for constructing non-catenated pillared paddle-wheel MOFs. Hydrogen-bonding substituents on linkers have been postulated to prevent catenation in certain frameworks and, in this work, we present a new MOF to further bolster this theory. Using 2,2′-diamino-[1,1′-biphenyl]-4,4′-dicarboxylic acid, BPDC-(NH2)2, linkers and dipyridyl glycol, DPG, pillars, we assembled a MOF with pcu topology. The new material is non-catenated, exhibiting large accessible pores and low density. To the best of our knowledge, this material constitutes the pcu framework with the largest pore volume and lowest density. We attribute the lack of catenation to the presence of H-bonding substituents on both linkers. [ABSTRACT FROM AUTHOR]