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Lupus anticoagulant (LA) is one of three tests identified as laboratory criteria for definite antiphospholipid syndrome (APS). The other two tests are anticardiolipin antibody (aCL) and anti-β2-glycoprotein I (aβ2GPI) antibody. The presence of LA is assessed using clot-based tests, while the presence of aCL and aβ2GPI is assessed by immunological assays. Since no test can be considered 100% sensitive or specific for LA, current guidelines recommend using two different clot-based assays reflecting different principles, with the dilute Russell viper venom time (dRVVT) and activated partial thromboplastin time (aPTT) recommended. Initially, LA-sensitive reagents are used to screen for LA, and then, in "screen-positive" samples, LA-"insensitive" reagents are used to confirm LA. Because LA assays are based on clot detection, anything that can interfere with fibrin clot development may affect test results. In particular, in addition to LA, the tests are also sensitive to the presence of a wide range of clinical anticoagulants, reflecting preanalytical issues for testing. We provide updated findings for LA testing in our geographic region, using recent data from the Royal College of Pathologists of Australasia Quality Assurance Programs, an international external quality assessment program with approximately 120 participants. Data show a wide variety of assays in use, especially for aPTT testing, and variable outcomes in reported numerical values with these assays when assessing proficiency samples. dRVVT testing mostly comprised reagents from three main manufacturing suppliers, which also showed differences in numerical values for the same homogeneous tested samples. Nevertheless, despite the use of different test reagents and processes, >98% of participants correctly identified LA-negative samples as LA-negative and LA-positive samples as LA positive. We hope our findings, reflecting on the heterogeneity of test processes and test data, help improve diagnostic testing for LA in the future. [ABSTRACT FROM AUTHOR]

AbstractObjectiveDesignSetting and subjectsMain outcome measureResultsConclusionsTo evaluate the impact of a compulsory pop-up form on the ordering pattern of proBNP blood tests by general practitioners in the Capital Region of Denmark.A follow-up study comparing the average number of proBNP tests ordered before and after the implementation of an intervention.From 2016 to 2021, the average number of proBNP tests increased by over 300%. In March 2022, a compulsory pop-up form was introduced in the electronic request system (WebReq), requiring general practitioners to select one of three indications for ordering proBNP, as recommended by the Danish Society of Cardiology. The study included 528 general practitioners in the Capital Region of Denmark, with data available from January 2020 to 2023, encompassing 83,576 proBNP results from 56,645 patients.The average number of proBNP tests ordered per month and the median level of proBNP before and after the intervention.Following the intervention, the average number of proBNP tests per month decreased by 60% over a 22-month follow-up period. The highest reduction was seen among general practitioners who previously ordered the most tests (≥3 per 1000 biochemical tests). In this group, the median proBNP level increased from 12.1 pmol/L before the intervention to 13.5 pmol/L after the intervention (p < 0.0001).This study demonstrates a significant decrease in the number of proBNP requests from general practitioners in the Capital Region of Denmark after the introduction of a pop-up form in the requisition system containing the current guidelines. [ABSTRACT FROM AUTHOR]

Objective To evaluate the impact of a compulsory pop-up form on the ordering pattern of proBNP blood tests by general practitioners in the Capital Region of Denmark.Design A follow-up study comparing the average number of proBNP tests ordered before and after the implementation of an intervention.Setting and subjects From 2016 to 2021, the average number of proBNP tests increased by over 300%. In March 2022, a compulsory pop-up form was introduced in the electronic request system (WebReq), requiring general practitioners to select one of three indications for ordering proBNP, as recommended by the Danish Society of Cardiology. The study included 528 general practitioners in the Capital Region of Denmark, with data available from January 2020 to 2023, encompassing 83,576 proBNP results from 56,645 patients.Main outcome measure The average number of proBNP tests ordered per month and the median level of proBNP before and after the intervention.Results Following the intervention, the average number of proBNP tests per month decreased by 60% over a 22-month follow-up period. The highest reduction was seen among general practitioners who previously ordered the most tests (≥3 per 1000 biochemical tests). In this group, the median proBNP level increased from 12.1 pmol/L before the intervention to 13.5 pmol/L after the intervention (p

Lab testing is a high-volume activity that is often overused, leading to wasted resources and inappropriate care. Improving test ordering practices in tertiary care involves deciding where to focus scarce intervention resources, but clear guidance on how to optimize these resources is lacking. We aimed to explore context-sensitive factors and processes that inform individual decisions about laboratory stewardship interventions by speaking to key interest holders in this area.We conducted semi-structured interviews with test-ordering intervention development experts and authors of test-ordering guidance documents to explore five broad topics: 1) processes used to prioritize tests for intervention; 2) factors considered when deciding which tests to target; 3) measurement of these factors; 4) interventions selected; 5) suggestions for a framework to support these decisions. Transcripts were double coded using directed-content and thematic analysis.We interviewed 14 intervention development experts. Experts noted they frequently consider test volume, test value, and patient care when deciding on a test to target. Experts indicated that quantifying many relevant factors was challenging. Processes to support these decisions often involved examining local data, obtaining buy-in, and relying on an existing guideline. Suggestions for building a framework emphasized the importance of collaboration, consideration of context and resources, and starting with “easy wins” to gain support and experience.Our study provides insight into the factors and processes experts consider when deciding which tests to target for intervention and can inform the development of a framework to guide the selection of tests for intervention and guideline development. [ABSTRACT FROM AUTHOR]

The purpose of this study is to analyze quality control in vitamin D testing using FMEA and fishbone diagrams. The type of research is applied research with a population in the form of retest data on vitamin D testing at PT TUV NORD Indonesia during the period January – December 2023. From the results of the pareto chart there are 6 causes of retest, then the highest percentage is analyzed using a fishbone diagram. Next, it was analyzed with FMEA to determine the priority scale so that the largest RPN value was obtained, namely not carrying out routine blender maintenance with a value of 245. And a 5W+1H analysis was carried out, so a proposal for improvement was obtained at the highest RPN value, namely carrying out maintenance planning on the equipment periodically. [ABSTRACT FROM AUTHOR]

Background/Objectives: The implementation of information quality value stream maps (IQ-VSMs) in food animal production systems can increase our understanding of the opportunities and challenges when using laboratory testing for antimicrobial resistance (AMR) to support antimicrobial stewardship (AMS). Our objectives were to (1) explore the implementation of information quality value stream mapping as a continuous improvement tool to inform decisions for bovine respiratory disease (BRD) management and AMS and (2) apply the information quality dimensions to identified Kaizen opportunities for the integration of laboratory data into BRD management systems to assess the appropriateness of BRD treatment plans in western Canadian feedlot production. Methods: A 'Current State' IQ-VSM outlined the processes, available information, information processing steps, and control decisions contributing to BRD management and treatment in commercial western Canadian feedlots, recognizing that laboratory BRD pathogens and AMR data are typically not part of BRD management. Results: The 'Future State' IQ-VSM incorporated Kaizen opportunities for improvement, including (i) the strategic collection of respiratory samples from representative samples of calves for laboratory analysis, regardless of clinical BRD status, (ii) compilation of laboratory data at the pen and feedlot levels, and (iii) analysis of pen- and feedlot-level laboratory data to inform the veterinarian's assessment of the appropriateness of current BRD treatment plans. Conclusions: The IQ-VSMs provided a valuable framework to visualize the integration of BRD pathogen and AMR laboratory data to support AMS and address any potential future testing requirements. [ABSTRACT FROM AUTHOR]

The tensile strength of rock is a critical material property in rock engineering design. In many cases, anisotropic rocks make up the intact part of the rockmass that practitioners encounter during site investigation and construction of critical infrastructure including, for example, excavations for hydropower, rapid transit development, mining of critical minerals, and the safe storage of used nuclear fuel. Anisotropic rocks do not necessarily follow the behaviour that is analytically predicted to occur during a Brazilian tensile strength (BTS) test on isotropic rock; therefore, additional care is required when analysing the true tensile strength and splitting tensile strength of anisotropic rocks. This study presents the findings of an extensive BTS laboratory testing program conducted on six lithologies with varying intensities of foliation: Pointe Du Bois tonalite gneiss, Key Anacon deposit meta-basalt, Archibald Settlement Formation (Fm) rhyolite tuff, Nepisiguit Falls Fm phenocryst tuff, Nepisiguit Falls Fm crystalline tuff, and a weakly foliated granite of the North Pole Stream Fm. The angle between the anisotropic fabric orientation and loading direction was systematically changed in order to measure the influence of the foliation on the measured tensile strengths of the rock specimens. In order to quantify the influence of the anisotropic fabric, a three-component anisotropic tensile strength failure criterion based on Mohr circle mechanics was created. Furthermore, 2D digital image correlation was used to validate the proposed anisotropic tensile strength failure criterion by analyzing the full field strain maps on the face of the disc to identify where strain is accumulating and being accommodated in the foliated rock. [ABSTRACT FROM AUTHOR]

Introduction: Direct oral anticoagulants (DOACs) reflect anticoagulation agents given to treat or prevent thrombosis, having largely replaced vitamin K antagonists (VKAs) such as warfarin. DOACs are given in fixed daily doses and generally do not need monitoring. However, there may be a variety of reasons that justify measurement of plasma DOAC levels in individual patients. Methods: We report updated findings for DOAC testing in our geographic region, using recent data from the RCPAQAP, an international external quality assessment (EQA) program, currently with some 40–60 participants in each of the different DOAC (rivaroxaban, apixaban, dabigatran) modules, to assess laboratory performance in this area. Data has been assessed for the past 5 years (2019–2023 inclusive), with 20 samples each per DOAC. Results: Data shows a limited repertoire of assays in use, and mostly consistency in reported numerical values when assessing proficiency samples. Available assays mostly comprised reagents from four manufacturing suppliers. There was good consistency across what participants identified as 'DOAC detected', but some variability when participants attempted to grade DOAC levels as low vs moderate vs high. Inter‐laboratory/method coefficient of variation (CVs) were generally <15% for each DOAC, when present at >100 ng/mL. Conclusion: We hope our findings, reflecting on mostly consistent reporting of DOAC levels and interpretation provides reassurance for clinicians requesting these measurements, and helps support their implementation in regions where there is a paucity of test availability. [ABSTRACT FROM AUTHOR]

A general urine test is considered one of the basic diagnostic tests using in healthcare. This study aimed to analyze sociodemographic factors associated with the frequency of urine testing in Poland. This cross-sectional survey was conducted using computer-assisted web interviewing (CAWI) between 1 March and 4 March 2024. A representative sample of 1113 adults in Poland (aged 18–86 years, 52.5% of whom were females) took part in the study. The survey showed that 46.3% of adults in Poland had a urinalysis in the last 12 months. One-fifth (20.7%) of the participants had a urinalysis more than a year ago but not more than 2 years ago. Moreover, 26.7% had a urinalysis performed 2–3 years ago. Among all participants, female gender (OR = 1.31 [1.01–1.68]; p < 0.05), being aged 70 years and over (OR = 2.22 [1.23–4.02]; p < 0.01), having children (OR = 1.45 [1.01–2.09]; p < 0.05), and having urologic diseases (OR = 2.34 [1.79–3.02]; p < 0.001) were significantly associated with having urinalysis in the last 12 months. Among respondents without urologic diseases, female gender (OR = 1.33 [1.02–1.74]; p < 0.05), being aged 60 years and over (p < 0.05), and being married (OR = 1.45 [1.09–1.94]; p < 0.05) were significantly associated with having a urinalysis in the last 12 months. There was no significant impact of educational level, occupational status, or financial situation on the frequency of urinalysis. [ABSTRACT FROM AUTHOR]

The recalcitrant behaviour of plastic creates an acute pollution on soil and aquatic biota. The plastic polymer synthesised from petroleum takes several hundred years to degrade. During excavation activities on the lands within or at the outskirts of urban limits, single use plastic wrappers and bags that were buried long ago, can be found in large quantities. Researchers have already identified the potentiality of microorganisms to biodegrade the plastic polymers. These microorganisms utilise plastic as a sole source of carbon and mineralise them into carbon dioxide under optimum environmental conditions. This paper provides a brief review on the biodegradation studies carried out by various researchers, spectra of microorganisms identified with the potential to degrade various polymeric substances, methods of testing and evaluations in order to quantify the effectiveness of degradation, their shortfalls and risks involved in implementing bioremediation technique in the field. A review on other related aspects that are deemed to be relevant to this topic are also discussed. [ABSTRACT FROM AUTHOR]

Copyright of Zentralblatt fuer Arbeitsmedizin, Arbeitsschutz und Ergonomie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cihan University-Erbil Scientific Journal is the property of Cihan University-Erbil and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Due to increase in population the demand of plastic material is also increased if plastic material is formed then the plastic waste also generated and the construction of buildings also increased so the shortage of natural aggregate is a serious problem. To reduce both the problems of disposing of plastic waste and saving the natural aggregates we can use the generated plastic waste in construction of road by partially substituting the natural aggregate by plastic waste. Replacement at 5% was examined. Natural coarse aggregates are replaced with plastic coarse aggregates, Compressive strength of these concrete prepared with plastic coarse aggregates are tested The burgeoning problem of plastic waste and the constant demand for sustainable infrastructure have driven innovative approaches in civil engineering. This project investigates the feasibility and effectiveness of using waste plastic in road construction. The primary objective is to evaluate how integrating plastic into bituminous mixtures can enhance road performance while addressing environmental concerns. Comprehensive laboratory tests were conducted to analyze the physical and mechanical properties of plastic-infused bitumen, focusing on durability, strength, and weather resistance. The study's findings indicate that roads constructed with plastic-modified bitumen exhibit superior performance characteristics, including improved resistance to deformation and reduced maintenance costs. This project highlights a promising avenue for sustainable development, offering a dual benefit of managing plastic waste and enhancing road infrastructure. [ABSTRACT FROM AUTHOR]

The use of remote testing to collect behavioral data has been on the rise, especially after the COVID-19 pandemic. Here we present psychometric functions for a commonly used speech corpus obtained in remote testing and laboratory testing conditions on young normal hearing listeners in the presence of different types of maskers. Headphone use for the remote testing group was checked by supplementing procedures from prior literature using a Huggins pitch task. Results revealed no significant differences in the measured thresholds using the remote testing and laboratory testing conditions for all the three masker types. Also, the thresholds measured obtained in these two conditions were strongly correlated for a different group of young normal hearing listeners. Based on the results, excellent outcomes on auditory threshold measurements where the stimuli are presented both at levels lower than and above an individual’s speech-recognition threshold can be obtained by remotely testing the listeners.

The use of remote testing to collect behavioral data has been on the rise, especially after the COVID-19 pandemic. Here we present psychometric functions for a commonly used speech corpus obtained in remote testing and laboratory testing conditions on young normal hearing listeners in the presence of different types of maskers. Headphone use for the remote testing group was checked by supplementing procedures from prior literature using a Huggins pitch task. Results revealed no significant differences in the measured thresholds using the remote testing and laboratory testing conditions for all the three masker types. Also, the thresholds measured obtained in these two conditions were strongly correlated for a different group of young normal hearing listeners. Based on the results, excellent outcomes on auditory threshold measurements where the stimuli are presented both at levels lower than and above an individual's speech-recognition threshold can be obtained by remotely testing the listeners. [ABSTRACT FROM AUTHOR]

This paper reports the cyclic behaviour of chalk, which has yet to be studied comprehensively. Multiple undrained high-resolution cyclic triaxial experiments on low- to medium-density intact chalk, along with index and monotonic reference tests, define the conditions under which either thousands of cycles could be applied without any deleterious effect, or failure could be provoked under specified numbers of cycles. Intact chalk's response is shown to differ from that of most saturated soils tested under comparable conditions. While chalk can be reduced to putty by severe two-way displacement-controlled cycling, its behaviour proved stable and nearly linear visco-elastic over much of the one-way, stress-controlled loading space examined, with stiffness improving over thousands of cycles, without loss of undrained shear strength. However, in cases where cyclic failure occurred, the specimens showed little sign of cyclic damage before cracking and movements on discontinuities led to sharp pore pressure reductions, non-uniform displacements and the onset of brittle collapse. Chalk's behaviour resembles the fatigue response of metals, concretes and rocks, where micro-shearing or cracking initiates on imperfections that generate stress concentrations; the experiments identify the key features that must be captured in any representative cyclic loading model. [ABSTRACT FROM AUTHOR]

Low-to-medium-density chalk can be destructured to soft putty by high-pressure compression, dynamic impact or large-strain repetitive shearing. These process all occur during pile driving and affect subsequent static and cyclic load-carrying capacities. This paper reports undrained triaxial experiments on destructured chalk, which show distinctly time-dependent behaviour as well as highly non-linear stiffness, well-defined phase transformation and stable ultimate critical states under monotonic loading. The chalk's response to high-level undrained cyclic loading invokes both contractive and dilative phases that lead to pore pressure build-up, leftward effective stress path drift, permanent strain accumulation, cyclic stiffness losses and increasing damping ratios that resemble those of silts. These outcomes are relatively insensitive to consolidation pressures and are distinctly different to those of the parent intact chalk. The maximum number of cycles that can be sustained under given combinations of mean and cyclic stresses are expressed in an interactive stress diagram which also identifies conditions under which cycling has no deleterious effect. Empirical correlations are proposed to predict the number of cycles to failure and mean effective stress drift trends under the most critical cyclic conditions. Specimens that survive long-term cycling present higher post-cyclic stiffnesses and shear strengths than equivalent 'virgin' specimens. [ABSTRACT FROM AUTHOR]

Low- to medium-density chalk at St Nicholas at Wade, UK, is characterised by intensive testing to inform the interpretation of axial and lateral tests on driven piles. The chalk destructures when taken to large strains, especially under dynamic loading, leading to remarkably high pore pressures beneath penetrating cone penetration testing and driven pile tips, weak putty annuli around their shafts and degraded responses in full-displacement pressure-meter tests. Laboratory tests on carefully formed specimens explore the chalk's unstable structure and markedly time- and rate-dependent mechanical behaviour. A clear hierarchy is found between profiles of peak strength with depth of Brazilian tension, drained and undrained triaxial and direct simple shear tests conducted from in situ stress conditions. Highly instrumented triaxial tests reveal the chalk's unusual effective stress paths, markedly brittle failure behaviour from small strains and the effects of consolidating to higher than in situ stresses. The chalk's mainly sub-vertical jointing and micro-fissuring lead to properties depending on specimen scale, with in situ mass stiffnesses falling significantly below high-quality laboratory measurements and vertical Young's moduli exceeding horizontal stiffnesses. While compressive strength and stiffness appear relatively insensitive to effective stress levels, consolidation to higher pressures closes micro-fissures, increases stiffness and reduces anisotropy. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) elimination is an important global public health goal. However, the United States is not on track to meet the World Health Organization's 2030 targets for HCV elimination. Recently, the White House proposed an HCV elimination plan that includes point-of-care (POC) HCV RNA testing, which is currently in use in many countries but is not approved in the United States. POC HCV RNA testing is crucial for implementing community-based testing and for enabling test-and-treat programs, assessing cure, and monitoring for reinfection. Here, we review the status of POC HCV RNA testing in the United States, discuss factors that are needed for successful implementation, and issue specific public health and policy recommendations that would allow for the use of POC HCV RNA testing to support HCV elimination. [ABSTRACT FROM AUTHOR]

Rapid laboratory tests are urgently required to inform antimicrobial use in food animals. Our objective was to synthesize knowledge on the direct application of long-read metagenomic sequencing to respiratory samples to detect bacterial pathogens and antimicrobial resistance genes (ARGs) compared to PCR, loop-mediated isothermal amplification, and recombinase polymerase amplification. Our scoping review protocol followed the Joanna Briggs Institute and PRISMA Scoping Review reporting guidelines. Included studies reported on the direct application of these methods to respiratory samples from animals or humans to detect bacterial pathogens ±ARGs and included turnaround time (TAT) and analytical sensitivity. We excluded studies not reporting these or that were focused exclusively on bioinformatics. We identified 5,636 unique articles from 5 databases. Two-reviewer screening excluded 3,964, 788, and 784 articles at 3 levels, leaving 100 articles (19 animal and 81 human), of which only 7 studied long-read sequencing (only 1 in animals). Thirty-two studies investigated ARGs (only one in animals). Reported TATs ranged from minutes to 2 d; steps did not always include sample collection to results, and analytical sensitivity varied by study. Our review reveals a knowledge gap in research for the direct detection of bacterial respiratory pathogens and ARGs in animals using long-read metagenomic sequencing. There is an opportunity to harness the rapid development in this space to detect multiple pathogens and ARGs on a single sequencing run. Long-read metagenomic sequencing tools show potential to address the urgent need for research into rapid tests to support antimicrobial stewardship in food animal production. [ABSTRACT FROM AUTHOR]

Data science methodologies can be utilized to ascertain and analyze clinical genetic data that is often unstructured and rarely used outside of patient encounters. Genetic variants from all genetic testing resulting to a large pediatric healthcare system for a 5‐year period were obtained and reinterpreted utilizing the previously validated Franklin© Artificial Intelligence (AI). Using PowerBI©, the data were further matched to patients in the electronic healthcare record to associate with demographic data to generate a variant data table and mapped by ZIP codes. Three thousand and sixty‐five variants were identified and 98% were matched to patients with geographic data. Franklin© changed the interpretation for 24% of variants. One hundred and fifty‐six clinically actionable variant reinterpretations were made. A total of 739 Mendelian genetic disorders were identified with disorder prevalence estimation. Mapping of variants demonstrated hot‐spots for pathogenic genetic variation such as PEX6‐associated Zellweger Spectrum Disorder. Seven patients were identified with Bardet‐Biedl syndrome and seven patients with Rett syndrome amenable to newly FDA‐approved therapeutics. Utilizing readily available software we developed a database and Exploratory Data Analysis (EDA) methodology enabling us to systematically reinterpret variants, estimate variant prevalence, identify conditions amenable to new treatments, and localize geographies enriched for pathogenic variants. [ABSTRACT FROM AUTHOR]

Dynamic characteristics and reliability of elastomeric pads are dominant components in the design methodology to satisfy the performance parameters under dynamic operations. The fatigue life of rubber pads fitted with elastomeric pads mainly depends upon elastomers; natural rubber, chloroprene, nitrile butadiene, silicon compounds, etc., additives, accelerators, activators, fillers, anti-degradants, and manufacturing processes. The performance of the elastomeric pad is evaluated based on service operation, simulation, and laboratory testing. New and failed elastomeric (EM) pads have been examined in the Indian Rubber Manufacturer's Research Association IRMRA laboratory for detailed failure analysis of existing EM pads. Further, chemical and physical properties are also evaluated in M&C (Metallurgical and Chemical) and Testing Directorate of Research Designs and Standards Organization (RDSO), labs respectively. The fatigue life of the EM pad is estimated based on the results extracted from the Finite Element (FE) analysis of the EM pad. An attempt is made to modify the design of the EM pad by considering the results of detailed field trials, lab testing, and FE analysis. The modified design satisfies the dynamic characteristic during FE (Structural and Thermal) analysis and lab testing. [ABSTRACT FROM AUTHOR]

Copyright of Revue Française de Géotechnique is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The mechanical behaviour of clayey loess is strongly affected by the soil structure, but although anisotropy has been identified in loess by some, the anisotropy of small-strain behaviour is rarely reported. This paper presents an experimental study on the inherent and stress-induced small-strain shear stiffness anisotropy of a clayey loess from China. Both undisturbed and reconstituted specimens were tested with bender elements under isotropic compression and shearing conditions. Under an isotropic stress state, an inherent anisotropy was found for undisturbed specimens, while the reconstituted specimens prepared by moist tamping behaved isotropically. During shearing, the ratio of horizontal to vertical shear moduli of the undisturbed specimens decreased due to both an increase of stress anisotropy and the destruction of the intact structure. In contrast, the stiffness ratio of the reconstituted specimens only decreased due to stress anisotropy and it became more anisotropic at the critical state. This study reveals the influence of intact structure and inherent anisotropy on the behaviour of loess soils, which cannot be reproduced by compaction, thus highlighting the importance of characterising the undisturbed loess. [ABSTRACT FROM AUTHOR]

Wave energy, as a significant renewable and clean energy source with vast global reserves, exhibits no greenhouse gas or other pollution during real-sea operational conditions. However, throughout the entire lifecycle, wave energy convertors can produce additional CO2 emissions due to the use of raw materials and emissions during transportation. Based on laboratory test data from a wave energy convertor model, this study ensures consistency between the model and the actual sea-deployed wave energy convertors in terms of performance, materials, and geometric shapes using similarity criteria. Carbon emission factors from China, the European Union, Brazil, and Japan are selected to predict the carbon emissions of wave energy convertors in real-sea conditions. The research indicates: (1) The predicted carbon emission coefficient for unit electricity generation ( E F co 2 ) of wave energy is 0.008–0.057 kg CO2/kWh; when the traditional steel production mode is adopted, the E F co 2 in this paper is 0.014–0.059 kg CO2/kWh, similar to existing research conclusions for the emission factor of CO2 for wave energy convertor (0.012–0.050 kg CO2/kWh). The predicted data on carbon emissions in the lifecycle of wave energy convertors aligns closely with actual operational data. (2) The main source of carbon emissions in the life cycle of a wave energy converter, excluding the recycling of manufacturing metal materials, is the manufacturing stage, which accounts for 90% of the total carbon emissions. When the recycling of manufacturing metal materials is considered, the carbon emissions in the manufacturing stage are reduced, and the carbon emissions in the transport stage are increased, from about 7% to about 20%. (3) Under the most ideal conditions, the carbon payback period for a wave energy convertor ranges from 0.28 to 2.06 years, and the carbon reduction during the design lifespan (20 years) varies from 238.33 t CO2 (minimum) to 261.80 t CO2 (maximum). [ABSTRACT FROM AUTHOR]

Abstract The slag corrosion of Al2O3-MgO-C refractories for steelmaking ladles is addressed by a dynamic test by considering their characteristics, the experimental approach, and previous cup test data and thermodynamic simulation. To obtain reliable results, an alternative to the current practice of using the samples’ dimensions to estimate the corrosion wear was proposed. The brick with the higher periclase content and high open porosity was less resistant in the dynamic test. However, in the other two bricks, the smaller particles and the lower corrosion resistance of bauxite were considered the determining factors for the greater increase in wear during the dynamic test concerning the cup test.

This study aims to contribute to limited research evidence for evaluating air leakage through Canadian manufactured CLT, by initiating research to characterize and quantify air leakage paths across CLT panels and evaluate the impact of additional air barrier system components on CLT. Understanding air leakage across CLT is important to the continuous development of design and construction practices towards ensuring the performance of CLT buildings. Through experimental testing of various panel parameters, metrics including the air leakage rate, normalized equivalent leakage area, as well as the flow exponent and flow coefficient were measured. For 3-ply and 5-ply CLT panels utilized in this research, significant air leakage through panel edges compared to air leakage through the panel face was observed due to unglued edge joint gaps typical to Canadian manufactured CLT. Further, sealing panel edges with an effective air barrier material such as a self-adhered membrane to reduce air leakage from 4 to 12 L/sm2 to 0.09–1.4 L/sm2 was not enough to meet more stringent thresholds for air barrier assemblies at 0.1 L/sm2 at a 75 Pa pressure differential.

Abstract Purpose Sincethe availability of natural aggregates is very sparse, recycled industrial and construction waste provides a sustainable alternative to ground improvement using vibro replacement method. Utilizing recycled building waste caters the requirement for its disposal and offers an effective remedy for the scarcity of natural resources. The aim of this study was to give a sustainable alternative for the natural aggregates as the material for stone column. Materials and methods A good stone column material should be hard, dense, chemically inert and must comply with the size requirement. The utilization of construction debris and spent railway ballast as column material has been the subject of numerous researches. This work focuses on finding the suitability of railway ballast and concrete debris as alternatives for stone column material. A detailed laboratory testing of these materials has been carried to judge their strength requirements as the material for both Ordinary Stone Columns (OSCs) and Geosynthetic Encased Stone Columns (GESCs). The improvement in capacity of both OSCs and GESCs is evaluated by performing California Bearing Ratio (CBR) test in laboratory by creating unit cell stone column models of different recycled aggregates and comparing their load settlement behavior with natural aggregates. Results and discussion Railway ballast, natural aggregates, concrete debris and virgin soil were found to show decreasing order in CBR test results. Loading required for causing settlement in both OSCs and GESCsshowed remarkable increase as compared to that of virgin clay and the maximum load settlement improvement was observed for railway ballast in both the types of stone columns. The CBR values for GESC made from railway ballast, natural aggregates and concrete debris were 54, 49 and 38% respectively. On the other hand, CBR for OSC made from railway ballast, concrete debris and natural aggregates were found to be 25.5, 20.4 and 24% respectively and CBR of virgin clay was found to be just 11%. Conclusion The demonstrated application of sustainable sources in place of natural aggregates provides a crucial pathway for utilizing the recycled aggregates as stone column filler material. Up on encasing the OSC with geotextile the performance of stone columns has improved appreciably in terms of load capacity. Railway ballast and concrete debris can be adopted as an alternate for the natural stone column materials to improve the bearing capacity of site consisting mainly of soft clays.

Permeability tests on unsaturated frozen sand and gravel In artificial ground freezing applications, frozen saturated soil is assumed to be practically impervious. However, in the case of partial initial saturation, this is no longer the case. As part of a pilot study, permeability tests were carried out in the laboratory on cohesionless, loose, partially saturated, frozen soil samples. Mineral oil was used as the flow medium. Since no standardized apparatus exists, suitable experimental techniques and evaluation procedures had to be developed. The permeability of unfrozen, fully saturated soil was also determined for reference. Due to the loose packing and the low degree of saturation, the partially saturated soils exhibited a significant permeability, which is in the same order as the value of the corresponding water‐saturated, unfrozen soils. [ABSTRACT FROM AUTHOR]

Overuse of laboratory tests has been a growing problem in the inpatient hospital setting for years, which adds to the rising cost of care. Various factors come into play, such as clinical routines, lack of cost transparency, and the convenience of electronic health record–based ordering. The financial ramifications of the overuse are significant, as lab costs drive most medical decisions. Eliminating unnecessary testing with clinical decision support and best practices is associated with marked cost savings, improved outcomes, and decreased patient distress. The excessive use of laboratory tests highly affects patients, resulting in hospital-induced anemia, low patient satisfaction, and poor outcomes. Tackling lab overuse requires a multifaceted approach that includes education, technology, and policy changes. In the era of precision healthcare, optimizing test utilization can reduce costs, decrease waste, and improve patient care. [ABSTRACT FROM AUTHOR]

Background: Despite the general impression that digital order-picking supportive technologies can manage a series of emerging challenges, there is still a very limited amount of research concerning the implementation and evaluation of such technologies in manual picker-to-goods order-picking systems. Therefore, this paper aims to evaluate the performance of three alternative picker-to-goods technologies (i.e., Pick-by-Radio Frequency (RF) Scanner, Pick-to-light, and Pick-by-vision) in terms of completion time and perceived workload. Methods: The Design of Experiments (DoE) methodology is adopted to investigate order-picking technologies in terms of completion time. More specifically, a full factorial design has been used (23 × 3 full factorial design) for the assessment of the aforementioned order-picking technologies via laboratory testing. Furthermore, for the comparative assessment of the reviewed order-picking technologies in terms of workload, the NASA Task Load Index (NASA-TLX) is embraced by system users. Results: The results reveal that the best picker-to-goods technology in terms of order-picking completion time and perceived workload under certain laboratory setup is light picking when combined with few items per order line and many order lines per order. Conclusion: The paper successfully identified the best picker-to-goods technology, however it is important to mention that the adoption of such order-picking technology implies certain managerial implications that include training programs for employees to ensure they are proficient in using such technologies, upfront costs for purchasing and implementing the order picking system, and adjustments to existing workflows. [ABSTRACT FROM AUTHOR]

The increasing use of finite element analysis in modern infrastructure design emphasizes the importance of determining soil stiffness at small strains. This is usually represented by the normalized shear modulus degradation curve, which is crucial for accurate design. In the absence of specific measurements on the local soil, engineers often rely on empirical correlations and assume comparable behavior of soils with similar intrinsic properties. However, the application of this approach leads to uncertainties, especially for unique geological formations such as the soft cohesive soils of the Ljubljana Marsh. The main objective of this study was to determine the small strain shear modulus of Ljubljana Marsh soil with a plasticity index between 11 and 35%. Isotropic and anisotropic stress conditions were investigated as part of an extensive laboratory test program that included 45 bender element and 89 resonant column tests on 20 soil samples. By emphasizing the importance of measuring soil stiffness at small strains, this study not only provides reliable data for the development of the built environment in the Ljubljana Marsh and similar areas, but also underlines its necessity. [ABSTRACT FROM AUTHOR]

Lightning strike events pose significant challenges to the structural integrity and performance of composite materials, particularly in aerospace, wind turbine blade, and infrastructure applications. Through a meticulous examination of the state-of-the-art methodologies of laboratory testing and damage predictive modeling, this review elucidates the role of simulated lightning strike tests in providing inputs required for damage modeling and experimental data for model validations. In addition, this review provides a holistic understanding of what is there, what are current issues, and what is still missing in both lightning strike testing and modeling to enable a robust and high-fidelity predictive capability, and challenges and future recommendations are also presented. The insights gleaned from this review are poised to catalyze advancements in the safety, reliability, and durability of composite materials under lightning strike conditions, as well as to facilitate the development of innovative lightning damage mitigation strategies. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to examine the relationship between the decrease in elective procedures and the need for blood donation during the novel coronavirus disease (COVID‐19) pandemic at university hospitals. Background: The COVID‐19 pandemic has immensely impacted transfusion medicine. By cancelling elective surgery, the German government hoped to increase the available resources for patients infected with COVID‐19, especially in intensive care units, and prevent the shortage of blood products. Methods/Materials: Over 26 weeks, from the 3rd of February 2020 to the 2nd of August 2020, during the first phase of the pandemic, we assessed the number of crossmatches, blood group typing, use of donated blood, and case mix indices by retrospectively analysing data from two major university hospitals' information systems in Essen and Hamburg, Germany. Data were pooled, analysed, and compared with that of the same period in the previous year. Results: Following the cessation of elective procedures, the number of requests for crossmatches and blood group typing significantly decreased in 2020 compared to that in 2019. However, the number of blood transfusions required was reduced to a lesser extent. The number of outpatient and inpatient cases significantly decreased, whereas the cases requiring transfusion decreased only. Conclusion: During the initial phase of the pandemic, transfusion medicine, especially in large institutions, faced an almost unchanged high demand for donated blood. This should be considered regarding personnel and blood donation allocations. Therefore, we developed a monitoring system to display the availability of blood products in real‐time. The quick and easy display of in‐stock and expiring blood products can optimise the use of this valuable resource. [ABSTRACT FROM AUTHOR]

Introduction: VWD diagnosis is challenging requiring multiple VWF activity tests using many individual assays. We have developed an ELISA‐based VWF Multiplex Activity Assay (VWF‐MAA) to address this concern; however, the ability of the VWF‐MAA to discriminate between type 1 VWD, variant VWD, and normal subjects has not been evaluated. Aim: To evaluate the VWF‐MAA and its ability to differentiate between type 1 VWD, variant VWD and normal subjects in individuals undergoing an initial laboratory evaluation for bleeding. Methods: A total of 177 plasma samples from the Zimmerman Program: Comparative Effectiveness in the Diagnosis of VWD were evaluated from 11 centres across the US and Canada. The VWF‐MAA was compared to Versiti Blood Research Institute (VBRI) and Local Center (LC) assigned VWD diagnosis. Results: Overall, 129/177 (72.9%) were correctly assigned as normal (non‐VWD), type 1, or variant VWD compared to the VBRI assigned diagnosis. VWF‐MAA assigned non‐VWD accurately in 29/57 (50.9%) samples, and type 1 VWD accurately in 93/110 (84.6%) samples. Considering LC diagnosis where there was agreement with VWF‐MAA and not VBRI diagnosis, type 1 VWD was accurate in 105/110 (95.5%) samples. Bland‐Altman analysis demonstrated good correlation between laboratory methods. VWD, types 2A, 2B, 1C VWD were also assigned by the VWF‐MAA. Conclusions: We demonstrate that the VWF‐MAA has utility in differentiating type 1 VWD, variant VWD and normal subjects in individuals undergoing an initial laboratory evaluation for bleeding. [ABSTRACT FROM AUTHOR]

Aim: The blood collection for laboratory tests has been frequently performed due to evidence-based medicine. We aimed to conduct a survey on phlebotomy among phlebotomists and patients and to reduce unnecessary blood loss by using small-volume blood collection tubes. Material and Method: A survey among phlebotomists and patients was conducted to gather their opinions. Phlebotomists received training on the importance of the preanalytical process. The blood volume required for laboratory tests was reduced by 33.3%-50.0% in children and adults, and 63.0%-84.0% in newborns. Following this intervention, we investigated its effects on the blood transfusion ratio in the neonatal and adult intensive care unit (NICU and ICU) and the amount of laboratory medical waste generated. Results: A majority of phlebotomists (91.8%) reported difficulties in drawing blood from newborns, pediatric, oncology, hematology, and geriatric patients. Additionally, 68.9% of phlebotomists and 57.1% of patients expressed an opinion for reduced blood volume. Despite an increase in the number of laboratory tests (28.4%) and samples (15.7%), we observed a 17.8% reduction in the amount of laboratory medical waste. Although the number of patients in NICU increased statistically significant, the increase in transfusion rates was not significant. Although the number of patients in ICU increased, transfusion rates decreased, but neither was found to be statistically significant. Conclusion: Post-graduation, phlebotomists should be educated regularly about the preanalytical process. Based on the opinions of both phlebotomists and patients, using small-volume tubes in patients with difficult blood collection may increase their satisfaction. Generally, laboratory medical waste may be reduced. [ABSTRACT FROM AUTHOR]