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1. Planning benchmark study for SBRT of early stage NSCLC: Results of the DEGRO Working Group Stereotactic Radiotherapy

Author

Moustakis, Christos, Blanck, Oliver, Ebrahimi Tazehmahalleh, Fatemeh, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, Altenstein, Georg, Beckers, Eric, Jurianz, Katrin, Sterzing, Florian, Kretschmer, Matthias, Seegenschmiedt, Heinrich, Maass, Torsten, Droege, Stefan, Wolf, Ulrich, Schoeffler, Juergen, Haverkamp, Uwe, Eich, Hans Theodor, and Guckenberger, Matthias

Published
2017
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2. Time for standardization of SBRT planning through large scale clinical data and guideline-based approaches

Author

Moustakis, Christos, Blanck, Oliver, Ebrahimi, Fatemeh, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, Altenstein, Georg, Beckers, Eric, Jurianz, Katrin, Sterzing, Florian, Kretschmer, Matthias, Seegenschmiedt, Heinrich, Maass, Torsten, Droege, Stefan, Wolf, Ulrich, Schoeffler, Juergen, Haverkamp, Uwe, Eich, Hans, and Guckenberger, Matthias

Published
2017
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3. Planning benchmark study for SBRT of early stage NSCLC

Author

Moustakis, Christos, Blanck, Oliver, Tazehmahalleh, Fatemeh Ebrahimi, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, Altenstein, Georg, Beckers, Eric, Jurianz, Katrin, Sterzing, Florian, Kretschmer, Matthias, Seegenschmiedt, Heinrich, Maass, Torsten, Droege, Stefan, Wolf, Ulrich, Schoeffler, Juergen, Haverkamp, Uwe, Eich, Hans Theodor, Guckenberger, Matthias, Moustakis, Christos, Blanck, Oliver, Tazehmahalleh, Fatemeh Ebrahimi, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, Altenstein, Georg, Beckers, Eric, Jurianz, Katrin, Sterzing, Florian, Kretschmer, Matthias, Seegenschmiedt, Heinrich, Maass, Torsten, Droege, Stefan, Wolf, Ulrich, Schoeffler, Juergen, Haverkamp, Uwe, Eich, Hans Theodor, and Guckenberger, Matthias

Abstract

Purpose The aim was to evaluate stereotactic body radiation therapy (SBRT) treatment planning variability for early stage nonsmall cell lung cancer (NSCLC) with respect to the published guidelines of the Stereotactic Radiotherapy Working Group of the German Society for Radiation Oncology (DEGRO). Materials and methods Planning computed tomography (CT) scan and the structure sets (planning target volume, PTV; organs at risk, OARs) of 3 patients with early stage NSCLC were sent to 22 radiotherapy departments with SBRT experience: each department was asked to prepare a treatment plan according to the DEGRO guidelines. The prescription dose was 3 fractions of 15 Gy to the 65% isodose. Results In all, 87 plans were generated: 36 used intensity-modulated arc therapy (IMAT), 21 used three-dimensional conformal radiation therapy (3DCRT), 6 used static field intensity-modulated radiation therapy (SF-IMRT), 9 used helical radiotherapy and 15 used robotic radiosurgery. PTV dose coverage and simultaneously kept OARs doses were within the clinical limits published in the DEGRO guidelines. However, mean PTV dose (mean 58.0 Gy, range 52.8-66.4 Gy) and dose conformity indices (mean 0.75, range 0.60-1.00) varied between institutions and techniques (p <= 0.02). OARs doses varied substantially between institutions, but appeared to be technique independent (p = 0.21). Conclusion All studied treatment techniques are well suited for SBRT of early stage NSCLC according to the DEGRO guidelines. Homogenization of SBRT practice in Germany is possible through the guidelines; however, detailed treatment plan characteristics varied between techniques and institutions and further homogenization is warranted in future studies and recommendations. Optimized treatment planning should always follow the ALARA (as low as reasonably achievable) principle.

Published
2017

4. Planvergleichsstudie bei der SBRT des NSCLC im Frühstadium : Ergebnisse der DEGRO AG Stereotaxie.

Author

Moustakis, Christos, Blanck, Oliver, Ebrahimi Tazehmahalleh, Fatemeh, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, and Altenstein, Georg

Subjects
BENCHMARKING (Management), COMPARATIVE studies, LUNG cancer, LUNG tumors, RESEARCH methodology, MEDICAL cooperation, MEDICAL protocols, COMPUTERS in medicine, RADIATION doses, RADIOSURGERY, RADIOTHERAPY, RESEARCH, RESEARCH evaluation, TUMOR classification, EVALUATION research, TREATMENT effectiveness, DISEASE prevalence, STANDARDS
Abstract

Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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5. Zeit für eine Standardisierung der SBRT-Planung mithilfe großer klinischer Datenmengen und leitlinienbasierter Ansätze.

Author

Moustakis, Christos, Blanck, Oliver, Ebrahimi, Fatemeh, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, and Altenstein, Georg

Published
2017
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