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Your search keyword '"junceellolide"' showing total 3 results
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3 results on '"junceellolide"'

1. Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea.

Author

Zhou, Wei, Li, Jiao, E, Heng-Chao, Liu, Bao-Shu, Tang, Hua, Gerwick, William H, Hua, Hui-Ming, and Zhang, Wen

Subjects
Cell Line, Tumor, Animals, Humans, Anthozoa, Neoplasms, Diterpenes, Antineoplastic Agents, Spectrum Analysis, Drug Screening Assays, Antitumor, China, Oceans and Seas, Junceella gemmacea, briarane, diterpenoid, junceellolide, Cell Line, Tumor, Drug Screening Assays, Antitumor, Physical Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Physical Chemistry (incl. Structural)
Abstract

Four new briarane diterpenoids, junceellolides M-P (1-4), were isolated together with seven known analogs (5-11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1-3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.

Published
2014

2. Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea

Author

Wei Zhou, Jiao Li, Heng-Chao E, Bao-Shu Liu, Hua Tang, William H. Gerwick, Hui-Ming Hua, and Wen Zhang

Subjects
Junceella gemmacea, briarane, diterpenoid, junceellolide, Biology (General), QH301-705.5
Abstract

Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.

Published
2014
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3. Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea

Author

William H. Gerwick, Hua Tang, Hui-ming Hua, Jiao Li, Baoshu Liu, Wen Zhang, Wei Zhou, and Heng-Chao E

Subjects
China, South china, Oceans and Seas, Medicinal & Biomolecular Chemistry, Coral, diterpenoid, Pharmaceutical Science, Antineoplastic Agents, Junceella gemmacea, junceellolide, Growth inhibitory, Drug Screening Assays, Physical Chemistry, Article, Cell Line, Cell Line, Tumor, Neoplasms, Anthozoa, Drug Discovery, Botany, Animals, Humans, Bioassay, lcsh:QH301-705.5, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Tumor, biology, Spectrum Analysis, Absolute configuration, Antitumor, Pharmacology and Pharmaceutical Sciences, biology.organism_classification, Terpenoid, Gorgonian, lcsh:Biology (General), briarane, Drug Screening Assays, Antitumor, Diterpenes, Physical Chemistry (incl. Structural)
Abstract

Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.

Published
2014

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