23 results on '"iron-based nanomaterials"'
Search Results
2. Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy
- Author
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Ya Gong, Xiaoyan Hu, Ming Chen, and Jun Wang
- Subjects
Iron-based nanomaterials ,Gene delivery ,Magnetic resonance imaging ,Gene therapy ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells to achieve the purpose of treating diseases. The safe, efficient, and stable expression of exogenous genes in cells is crucial for the success of gene therapy, which is closely related to the vectors used in gene therapy. Currently, gene therapy vectors are mainly divided into two categories: viral vectors and non-viral vectors. Viral vectors are widely used due to the advantages of persistent and stable expression, high transfection efficiency, but they also have certain issues such as infectivity, high immunological rejection, randomness of insertion mutation, carcinogenicity, and limited vector capacity. Non-viral vectors have the advantages of non-infectivity, controllable chemical structure, and unlimited vector capacity, but the transfection efficiency is low. With the rapid development of nanotechnology, the unique physicochemical properties of nanomaterials have attracted increasing attention in the field of drug and gene delivery. Among many nanomaterials, iron-based nanomaterials have attracted much attention due to their superior physicochemical properties, such as Fenton reaction, magnetic resonance imaging, magnetothermal therapy, photothermal therapy, gene delivery, magnetically-assisted drug delivery, cell and tissue targeting, and so on. In this paper, the research progress of iron-based nanomaterials in gene delivery and tumor gene therapy is reviewed, and the future application direction of iron-based nanomaterials is further prospected.
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- 2024
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- View/download PDF
3. Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy.
- Author
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Gong, Ya, Hu, Xiaoyan, Chen, Ming, and Wang, Jun
- Subjects
GENE therapy ,NANOSTRUCTURED materials ,MAGNETIC resonance imaging ,GENETIC vectors ,GENE expression ,INSERTION mutation - Abstract
Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells to achieve the purpose of treating diseases. The safe, efficient, and stable expression of exogenous genes in cells is crucial for the success of gene therapy, which is closely related to the vectors used in gene therapy. Currently, gene therapy vectors are mainly divided into two categories: viral vectors and non-viral vectors. Viral vectors are widely used due to the advantages of persistent and stable expression, high transfection efficiency, but they also have certain issues such as infectivity, high immunological rejection, randomness of insertion mutation, carcinogenicity, and limited vector capacity. Non-viral vectors have the advantages of non-infectivity, controllable chemical structure, and unlimited vector capacity, but the transfection efficiency is low. With the rapid development of nanotechnology, the unique physicochemical properties of nanomaterials have attracted increasing attention in the field of drug and gene delivery. Among many nanomaterials, iron-based nanomaterials have attracted much attention due to their superior physicochemical properties, such as Fenton reaction, magnetic resonance imaging, magnetothermal therapy, photothermal therapy, gene delivery, magnetically-assisted drug delivery, cell and tissue targeting, and so on. In this paper, the research progress of iron-based nanomaterials in gene delivery and tumor gene therapy is reviewed, and the future application direction of iron-based nanomaterials is further prospected. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
4. Engineering iron-based nanomaterials for breast cancer therapy associated with ferroptosis.
- Author
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Wei, Ruixue, Fu, Gaoliang, Li, Zhe, Liu, Yang, and Xue, Mengzhou
- Abstract
Ferroptosis has received increasing attention as a novel nonapoptotic programmed death. Recently, iron-based nanomaterials have been extensively exploited for efficient tumor ferroptosis therapy, as they directly release high concentrations of iron and increase intracellular reactive oxygen species levels. Breast cancer is one of the commonest malignant tumors in women; inhibiting breast cancer cell proliferation through activating the ferroptosis pathway could be a potential new target for patient treatment. Here, we briefly introduce the background of ferroptosis and systematically review the current cancer therapeutic strategies based on iron-based ferroptosis inducers. Finally, we summarize the advantages of these various ferroptosis inducers and shed light on future perspectives. This review aims to provide better guidance for the development of iron-based nanomaterial ferroptosis inducers. Part reprinted (adapted) with permission from [1] © American Chemical Society (2019); part reprinted (adapted) with permission from [2] © Elsevier (2018); part reprinted (adapted) with permission from [3] © American Chemical Society (2018). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Iron-Based Modified Nanomaterials for the Efficacious Treatment of Cr(VI) Containing Wastewater: A Review
- Author
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Kumari, Anjali, Sinha, Alok, Singh, D. B., Agarwal, Avinash Kumar, Series Editor, Sinha, Alok, editor, Singh, Swatantra P., editor, and Gupta, A. B., editor
- Published
- 2023
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6. Iron-Based Nanomaterials for Fenton Reaction
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de Oliveira Guidolin, Thays, Cechinel, Maria Alice Prado, Arcaro, Sabrina, and Kopp Alves, Annelise, editor
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- 2022
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7. p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides
- Author
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Zhang Y, Xia M, Zhou ZZ, Hu X, Wang J, Zhang M, Li Y, Sun L, Chen F, and Yu H
- Subjects
ferroptosis ,spio ,p53 ,tf ,xct ,iron-based nanomaterials ,Medicine (General) ,R5-920 - Abstract
Yunhan Zhang,1,* Meihui Xia,2,* Zizhen Zhou,3 Xiaoqing Hu,1 Jiabin Wang,1 Meiyu Zhang,3 Yi Li,4 Liankun Sun,1 Fangfang Chen,4,5 Huimei Yu1,6 1Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of China; 2Department of Obstetrics & Gynecology, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 3Clinical Medical College, Jilin University, Changchun 130021, People’s Republic of China; 4State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, Jilin 130012, People’s Republic of China; 5Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People’s Republic of China; 6Animal Experiment Center, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huimei YuKey Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of ChinaTel +86 431 85619485Email yuhuimei@jlu.edu.cnFangfang ChenDepartment of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People’s Republic of ChinaTel +86 431 84995312Email cff@jlu.edu.cnMethods: In this study, we used MTT assays to demonstrate that a combination of SPIO-Serum and wild-type p53 overexpression can reduce ovarian cancer cell viability in vitro. Prussian blue staining and iron assays were used to determine changes in intracellular iron concentration following SPIO-Serum treatment. TEM was used to evaluate any mitochondrial damage induced by SPIO-Serum treatment, and Western blot was used to evaluate the expression of the iron transporter and lipid peroxidation regulator proteins. JC-1 was used to measure mitochondrial membrane potential, and ROS levels were estimated by flow cytometry. Finally, xCT protein expression and mitochondrial ROS levels were confirmed using fluorescence microscopy.Results: SPIO-Serum effectively induced lipid peroxidation and generated abundant toxic ROS. It also facilitated the downregulation of GPX4 and xCT, ultimately resulting in iron-dependent oxidative death. These effects could be reversed by iron chelator DFO and lipid peroxidation inhibitor Fer-1. SPIO-Serum treatment disrupted intracellular iron homeostasis by regulating iron uptake and the cells presented with missing mitochondrial cristae and ruptured outer mitochondrial membranes. Moreover, we were able to show that p53 contributed to SPIO-Serum-induced ferroptosis in ovarian cancer cells.Conclusion: SPIO-Serum induced ferroptosis and overexpressed p53 contributed to ferroptosis in ovarian cancer cells. Our data provide a theoretical basis for ferroptosis as a novel cell death phenotype induced by nanomaterials.Keywords: ferroptosis, SPIO, p53, TF, xCT, iron-based nanomaterials
- Published
- 2021
8. 叶面喷施铁基纳米材料对大豆生长的影响及机制研究.
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马扬旸, 张辰弛, 曹雪松, and 王震宇
- Subjects
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IRON fertilizers , *NUTRIENT uptake , *CROP growth , *PHOTOSYNTHETIC rates , *SOYBEAN , *FOLIAR feeding - Abstract
In order to elucidate the effect of iron-based nanomaterials(NMs)on soybean growth and its related mechanisms, different concentrations(0, 1, 10 mg·L-1, and 50 mg·L-1)of γ-Fe2O3 NMs and Fe3O4 NMs were sprayed on the leaf of soybean cultured in hydroponic conditions. During the experiments, Fe-EDTA(10 mg · L-1)was used as control to compare the performance and related mechanisms of the soybean growth promotion by nanofertilizer and conventional fertilizers. Foliar-applied, iron-based NMs enhanced the shoot and root biomass, root length, root tips numbers, and root bulk of soybean. The biomass increased initially and decreased afterwards with the increase in iron-based NM concentration. All the treatments at 10 mg·L-1 exhibited the best performance for soybean growth in the order of γ-Fe2O3 NMs>Fe3O4 NMs>Fe-EDTA. Iron-based NMs exhibited higher bioavailability than Fe-EDTA due to the slow-release feature and high surface activity. The iron content in soybean roots, stems, and leaves after exposure to 10 mg·L-1 γ-Fe2O3 NMs was 1.29-, 1.09-, and 1.24 -fold of that of an equal quantity of iron in Fe-EDTA exposure. The net photosynthetic rate of soybean exposed to 10 mg· L-1 γ-Fe2O3 NMs, Fe3O4 NMs, and Fe-EDTA was increased by 62.7%, 41.5%, and 30.7%, respectively, compared with the control. The transpiration rate, stomatal conductance, and intracellular CO2 concentration of soybean leaf exposed to iron-based NMs were all higher than in the Fe-EDTA treatment. Iron-based NMs up-regulated the sucrose transporter related genes(GmSWEET 15, GmSUT 2), increased the transport of photosynthate from leaf to root, and increased the root-shoot ratio, thereby enhancing the uptake of nutrients(S, P, Ca, Mn, and Cu). In conclusion, foliar application of iron-nanofertilizer(γ-Fe2O3 NMs)promoted the growth and nutrient uptake of soybean over conventional iron fertilizer. The results of this study provide a foundation for the application of iron-based NMs in promoting the growth of crops. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. Light-Interacting iron-based nanomaterials for localized cancer detection and treatment.
- Author
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Alphandéry, Edouard
- Subjects
NEAR-field microscopy ,FLUORESCENCE resonance energy transfer ,NANOSTRUCTURED materials ,CANCER treatment ,FLUORESCENCE anisotropy ,FLUORESCENT proteins ,QUANTUM dots ,FLUORESCENCE - Abstract
To improve the prognosis of cancer patients, methods of local cancer detection and treatment could be implemented. For that, iron-based nanomaterials (IBN) are particularly well-suited due to their biocompatibility and the various ways in which they can specifically target a tumor, i.e. through passive, active or magnetic targeting. Furthermore, when it is needed, IBN can be associated with well-known fluorescent compounds, such as dyes, clinically approved ICG, fluorescent proteins, or quantum dots. They may also be excited and detected using well-established optical methods, relying on scattering or fluorescent mechanisms, depending on whether IBN are associated with a fluorescent compound or not. Systems combining IBN with optical methods are diverse, thus enabling tumor detection in various ways. In addition, these systems provide a wealth of information, which is inaccessible with more standard diagnostic tools, such as single tumor cell detection, in particular by combining IBN with near-field scanning optical microscopy, dark-field microscopy, confocal microscopy or super-resolution microscopy, or the highlighting of certain dynamic phenomena such as the diffusion of a fluorescent compound in an organism, e.g. using fluorescence lifetime imaging, fluorescence resonance energy transfer, fluorescence anisotropy, or fluorescence tomography. Furthermore, they can in some cases be complemented by a therapeutic approach to destroy tumors, e.g. when the fluorescent compound is a drug, or when a technique such as photo-thermal or photodynamic therapy is employed. This review brings forward the idea that iron-based nanomaterials may be associated with various optical techniques to form a commercially available toolbox, which can serve to locally detect or treat cancer with a better efficacy than more standard medical approaches. New tools should be developed to improve cancer treatment outcome. For that, two closely-related aspects deserve to be considered, i.e. early tumor detection and local tumor treatment. Here, I present various types of iron-based nanomaterials, which can achieve this double objective when they interact with a beam of light under specific and accurately chosen conditions. Indeed, these materials are biocompatible and can be used/combined with most standard microscopic/optical methods. Thus, these systems enable on the one hand tumor cell detection with a high sensitivity, i.e. down to single tumor cell level, and on the other hand tumor destruction through various mechanisms in a controlled and localized manner by deciding whether or not to apply a beam of light and by having these nanomaterials specifically target tumor cells. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Nanomaterials for Adsorption and Heterogeneous Reaction in Water Decontamination
- Author
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Zhao, Chun, Liu, Yuanyuan, Sun, Yongjun, Ma, Jiangya, Zhu, Yunhua, Sun, Zhihua, Wang, Zhaoyang, Ding, Lei, Yang, Guang, Li, Junfeng, Zhou, Liqiang, Wang, Jun, Zhu, Guocheng, Zhang, Peng, Wu, Huifang, Zheng, Huaili, Lofrano, Giusy, editor, Libralato, Giovanni, editor, and Brown, Jeanette, editor
- Published
- 2017
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11. A short review on the preparation and use of iron nanomaterials for the treatment of pollutants in water and soil
- Author
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Litter, Marta I.
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- 2022
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12. Insights into the oxidation of organic contaminants by iron nanoparticles encapsulated within boron and nitrogen co-doped carbon nanoshell: Catalyzed Fenton-like reaction at natural pH.
- Author
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Zhou, Hao, Wu, Shikang, Zhou, Yaoyu, Yang, Yuan, Zhang, Jiachao, Luo, Lin, Duan, Xiaoguang, Wang, Shaobin, Wang, Lei, and Tsang, Daniel C.W.
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POLLUTANTS , *FERRIC nitrate , *NITROGEN , *BORON , *NANOPARTICLES , *INORGANIC acids - Abstract
Iron nanoparticles encapsulated within boron and nitrogen co-doped carbon nanoshell (B/N-C@Fe) were synthesized through a novel and green pyrolysis process using melamine, boric acid, and ferric nitrate as the precursors. The surface morphology, structure, and composition of the B/N-C@Fe materials were thoroughly investigated. The materials were employed as novel catalysts for the activation of potassium monopersulfate triple salt (PMS) for the degradation of levofloxacin (LFX). Linear sweep voltammograms and quenching experiments were used to identify the mechanisms of PMS activation and LFX oxidation by B/N-C@Fe, where SO 4 − as well as HO were proved to be the main radicals for the reaction processes. This study also discussed how the fluvic acid and inorganic anions in the aqueous solutions affected the degradation of LFX and use this method to simulate the degradation in the real wastewater. The synthesized materials showed a high efficiency (85.5% of LFX was degraded), outstanding stability, and excellent reusability (77.7% of LFX was degraded in the 5th run) in the Fenton-like reaction of LFX. In view of these advantages, B/N-C@Fe have great potentials as novel strategic materials for environmental catalysis. Unlabelled Image • Iron nanomaterials were encapsulated in boron/nitrogen co-doped carbon nanoshell. • The B/N-C@Fe4 700 catalysts were synthesized through a green pyrolysis process. • The role of anions in advanced oxidation processes of PPCPs was emphasized. • The B/N-C@Fe4 700 catalysts exhibited an excellent stability and reusability. • The catalysts showed better reusability than N-doped graphene and carbon nanotubes. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
13. High yield of nano zero-valent iron (nZVI) from carbothermal synthesis using lignin-derived substances from municipal biowaste.
- Author
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Nisticò, Roberto and Carlos, Luciano
- Subjects
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LIGNINS , *MAGNETITE , *IRON , *X-ray powder diffraction , *MOSSBAUER spectroscopy , *MAGNETIZATION measurement , *SCANNING electron microscopy - Abstract
• Lignin-derived bio-based substances (BBS) isolated from composted urban biowastes were used as carbon source. • Nano zero-valent iron (nZVI) was obtained from carbothermal reduction at 800 °C of BBS-coated magnetite NPs. • Nanomaterials with a 77% of α-Fe over the total iron and saturation magnetization of 170 emu g−1 were obtained. Nano zero-valent iron (nZVI) has been used as an effective catalyst in different reduction reactions. In this work, a synthesis procedure to obtain a carbon based materials with high nZVI content is reported. This synthesis method consists in a carbothermal reduction at 800 °C of Fe 3 O 4 nanoparticles coated with lignin-derived bio-based substances (BBS) as carbon source, which have been previously prepared from the co-precipitation method. The obtained materials were characterized by powder X-ray diffraction (XRD), Mössbauer spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and magnetization measurements. The concentration of carbon used in the synthesis process was a critical parameter for obtaining high nZVI yield. Nanomaterials with a 77% of α-Fe over the total iron and saturation magnetization (Ms) of 170 emu g−1 were obtained for the best condition. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
14. Mechanistic study on the effect of foliar-applied, iron-based nanomaterials on the growth of soybean
- Author
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MA Yangyang, ZHANG Chenchi, CAO Xuesong, and WANG Zhenyu
- Subjects
Environmental sciences ,fe-edta ,photosynthesis ,Agriculture (General) ,nutrient uptake ,food and beverages ,GE1-350 ,soybean ,iron-based nanomaterials ,sucrose transport ,S1-972 - Abstract
In order to elucidate the effect of iron-based nanomaterials(NMs)on soybean growth and its related mechanisms, different concentrations(0, 1, 10 mg·L-1, and 50 mg·L-1)of γ - Fe2O3 NMs and Fe3O4 NMs were sprayed on the leaf of soybean cultured in hydroponic conditions. During the experiments, Fe-EDTA(10 mg·L-1)was used as control to compare the performance and related mechanisms of the soybean growth promotion by nanofertilizer and conventional fertilizers. Foliar-applied, iron-based NMs enhanced the shoot and root biomass, root length, root tips numbers, and root bulk of soybean. The biomass increased initially and decreased afterwards with the increase in iron-based NM concentration. All the treatments at 10 mg·L-1 exhibited the best performance for soybean growth in the order of γ-Fe2O3 NMs>Fe3O4 NMs>Fe-EDTA. Iron-based NMs exhibited higher bioavailability than Fe-EDTA due to the slow-release feature and high surface activity. The iron content in soybean roots, stems, and leaves after exposure to 10 mg·L-1 γ-Fe2O3 NMs was 1.29-, 1.09-, and 1.24 -fold of that of an equal quantity of iron in Fe-EDTA exposure. The net photosynthetic rate of soybean exposed to 10 mg·L-1 γ-Fe2O3 NMs, Fe3O4 NMs, and Fe-EDTA was increased by 62.7%, 41.5%, and 30.7%, respectively, compared with the control. The transpiration rate, stomatal conductance, and intracellular CO2 concentration of soybean leaf exposed to iron-based NMs were all higher than in the Fe-EDTA treatment. Iron-based NMs up-regulated the sucrose transporter related genes(GmSWEET 15, GmSUT 2), increased the transport of photosynthate from leaf to root, and increased the root-shoot ratio, thereby enhancing the uptake of nutrients(S, P, Ca, Mn, and Cu). In conclusion, foliar application of iron-nanofertilizer(γ-Fe2O3 NMs)promoted the growth and nutrient uptake of soybean over conventional iron fertilizer. The results of this study provide a foundation for the application of iron-based NMs in promoting the growth of crops.
- Published
- 2022
15. Fabrication and characterization of hydrophilic corn stalk biochar-supported nanoscale zero-valent iron composites for efficient metal removal.
- Author
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Yang, Fan, Zhang, Shuaishuai, Sun, Yuqing, Cheng, Kui, Li, Jiangshan, and Tsang, Daniel C.W.
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IRON , *BIOCHAR , *CORNSTALKS , *FUNCTIONAL groups , *NANOPARTICLES , *NANOSTRUCTURED materials - Abstract
Pyrolyzing low-cost agro-waste into biochar is a promising means for waste biomass utilization. This study engineers corn stalk-derived biochar with abundant hydrophilic functional groups as a support material for iron nanoparticles impregnation (nZVI-HCS). Surface chemistry and morphology of nZVI-HCS composites is characterized by SEM, TEM, TG, XRD, FTIR, XPS, and BET techniques, which helps to elucidate the mechanisms of Pb 2+ , Cu 2+ and Zn 2+ removal from single and mixed-metal solutions in batch experiments. Equilibrium adsorption capacities can reach 195.1, 161.9 and 109.7 mg·g −1 for Pb 2+ , Cu 2+ and Zn 2+ at neutral medium after 6-h process, respectively. The engineered biochar with hierarchical pores can impregnate iron nanoparticles, serve as an adsorbent, and enhance metal reduction/precipitation. Rapid removal and high performance can be maintained after five regeneration/reuse cycles. Multiple interaction mechanisms including adsorption, precipitation, reduction and complexation are responsible for metal removal by nZVI-HCS composites, which can be a novel biowaste-derived material for wastewater treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
16. nZVI decreases N2O emission from pesticide-contaminated paddy soil.
- Author
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Su, Gangping, Chen, Bingning, Wu, Xinyue, Xu, Jiang, Yang, Kun, and Lin, Daohui
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- 2023
- Full Text
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17. p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides
- Author
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Liankun Sun, Meihui Xia, Huimei Yu, Jiabin Wang, Yunhan Zhang, Meiyu Zhang, Zizhen Zhou, Yi Li, Xiaoqing Hu, and Fangfang Chen
- Subjects
p53 ,Serum ,Mitochondrial ROS ,Programmed cell death ,Cell Survival ,Biophysics ,Pharmaceutical Science ,Bioengineering ,02 engineering and technology ,Oxidative phosphorylation ,010402 general chemistry ,GPX4 ,iron-based nanomaterials ,Models, Biological ,01 natural sciences ,Biomaterials ,Lipid peroxidation ,chemistry.chemical_compound ,Western blot ,International Journal of Nanomedicine ,Cell Line, Tumor ,Receptors, Transferrin ,Drug Discovery ,medicine ,Humans ,Viability assay ,Original Research ,Cell Proliferation ,Ovarian Neoplasms ,medicine.diagnostic_test ,Chemistry ,xCT ,Organic Chemistry ,Transferrin ,General Medicine ,021001 nanoscience & nanotechnology ,ferroptosis ,Mitochondria ,0104 chemical sciences ,Cell biology ,SPIO ,Female ,Magnetic Iron Oxide Nanoparticles ,Tumor Suppressor Protein p53 ,Reactive Oxygen Species ,0210 nano-technology ,Oxidation-Reduction ,TF ,Intracellular - Abstract
Yunhan Zhang,1,* Meihui Xia,2,* Zizhen Zhou,3 Xiaoqing Hu,1 Jiabin Wang,1 Meiyu Zhang,3 Yi Li,4 Liankun Sun,1 Fangfang Chen,4,5 Huimei Yu1,6 1Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of China; 2Department of Obstetrics & Gynecology, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 3Clinical Medical College, Jilin University, Changchun 130021, People’s Republic of China; 4State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, Jilin 130012, People’s Republic of China; 5Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People’s Republic of China; 6Animal Experiment Center, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huimei YuKey Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, People’s Republic of ChinaTel +86 431 85619485Email yuhuimei@jlu.edu.cnFangfang ChenDepartment of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People’s Republic of ChinaTel +86 431 84995312Email cff@jlu.edu.cnMethods: In this study, we used MTT assays to demonstrate that a combination of SPIO-Serum and wild-type p53 overexpression can reduce ovarian cancer cell viability in vitro. Prussian blue staining and iron assays were used to determine changes in intracellular iron concentration following SPIO-Serum treatment. TEM was used to evaluate any mitochondrial damage induced by SPIO-Serum treatment, and Western blot was used to evaluate the expression of the iron transporter and lipid peroxidation regulator proteins. JC-1 was used to measure mitochondrial membrane potential, and ROS levels were estimated by flow cytometry. Finally, xCT protein expression and mitochondrial ROS levels were confirmed using fluorescence microscopy.Results: SPIO-Serum effectively induced lipid peroxidation and generated abundant toxic ROS. It also facilitated the downregulation of GPX4 and xCT, ultimately resulting in iron-dependent oxidative death. These effects could be reversed by iron chelator DFO and lipid peroxidation inhibitor Fer-1. SPIO-Serum treatment disrupted intracellular iron homeostasis by regulating iron uptake and the cells presented with missing mitochondrial cristae and ruptured outer mitochondrial membranes. Moreover, we were able to show that p53 contributed to SPIO-Serum-induced ferroptosis in ovarian cancer cells.Conclusion: SPIO-Serum induced ferroptosis and overexpressed p53 contributed to ferroptosis in ovarian cancer cells. Our data provide a theoretical basis for ferroptosis as a novel cell death phenotype induced by nanomaterials.Keywords: ferroptosis, SPIO, p53, TF, xCT, iron-based nanomaterials
- Published
- 2021
- Full Text
- View/download PDF
18. Light-Interacting iron-based nanomaterials for localized cancer detection and treatment
- Author
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Edouard Alphandéry, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Nanobactérie SARL, Universität Zürich [Zürich] = University of Zurich (UZH), University of Zurich, and Alphandéry, Edouard
- Subjects
Fluorescence-lifetime imaging microscopy ,10017 Institute of Anatomy ,Iron ,[SDV]Life Sciences [q-bio] ,0206 medical engineering ,Biomedical Engineering ,Nanotechnology ,610 Medicine & health ,02 engineering and technology ,Fluorescent nanoparticles ,Biochemistry ,Fluorescence ,Nanomaterials ,law.invention ,Biomaterials ,Confocal microscopy ,law ,Neoplasms ,Microscopy ,Quantum Dots ,Humans ,Molecular Biology ,Cancer ,Optical Imaging ,Optical methods ,General Medicine ,Nano ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,3. Good health ,Nanostructures ,Förster resonance energy transfer ,Nanomedicine ,Oncology ,570 Life sciences ,biology ,0210 nano-technology ,Fluorescence anisotropy ,Biotechnology ,Iron-based nanomaterials - Abstract
International audience; To improve the prognosis of cancer patients, methods of local cancer detection and treatment could be implemented. For that, iron-based nanomaterials (IBN) are particularly well-suited due to their biocompatibility and the various ways in which they can specifically target a tumor, i.e. through passive, active or magnetic targeting. Furthermore, when it is needed, IBN can be associated with well-known fluorescent compounds, such as dyes, clinically approved ICG, fluorescent proteins, or quantum dots. They may also be excited and detected using well-established optical methods, relying on scattering or fluorescent mechanisms, depending on whether IBN are associated with a fluorescent compound or not. Systems combining IBN with optical methods are diverse, thus enabling tumor detection in various ways. In addition, these systems provide a wealth of information, which is inaccessible with more standard diagnostic tools, such as single tumor cell detection, in particular by combining IBN with near-field scanning optical microscopy, dark-field microscopy, confocal microscopy or super-resolution microscopy, or the highlighting of certain dynamic phenomena such as the diffusion of a fluorescent compound in an organism, e.g. using fluorescence lifetime imaging, fluorescence resonance energy transfer, fluorescence anisotropy, or fluorescence tomography. Furthermore, they can in some cases be complemented by a therapeutic approach to destroy tumors, e.g. when the fluorescent compound is a drug, or when a technique such as photo-thermal or photodynamic therapy is employed. This review brings forward the idea that iron-based nanomaterials may be associated with various optical techniques to form a commercially available toolbox, which can serve to locally detect or treat cancer with a better efficacy than more standard medical approaches. STATEMENT OF SIGNIFICANCE: New tools should be developed to improve cancer treatment outcome. For that, two closely-related aspects deserve to be considered, i.e. early tumor detection and local tumor treatment. Here, I present various types of iron-based nanomaterials, which can achieve this double objective when they interact with a beam of light under specific and accurately chosen conditions. Indeed, these materials are biocompatible and can be used/combined with most standard microscopic/optical methods. Thus, these systems enable on the one hand tumor cell detection with a high sensitivity, i.e. down to single tumor cell level, and on the other hand tumor destruction through various mechanisms in a controlled and localized manner by deciding whether or not to apply a beam of light and by having these nanomaterials specifically target tumor cells.
- Published
- 2021
- Full Text
- View/download PDF
19. Bioinspired synthesis of iron-based nanomaterials for application in biofuels production: A new in-sight.
- Author
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Srivastava, Manish, Srivastava, Neha, Saeed, Mohd, Mishra, P.K., Saeed, Amir, Gupta, Vijai Kumar, and Malhotra, Bansi D.
- Subjects
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BIOMASS conversion , *BIOMASS energy , *NANOSTRUCTURED materials , *RENEWABLE energy costs , *PLANT biomass , *MANUFACTURING processes , *BIOMASS gasification , *HYDROGEN as fuel - Abstract
Nanomaterials have been predicted to play a key role as catalysts in the renewable biofuels production process by altering the reaction mechanism. In biomass to the biofuels production process, iron performs major activity as the cofactor of sugar and biofuels producing enzymes which support microbial growth. The use of iron-based nanomaterials improves the biomass to biofuels production process and perhaps reduces the production cost due to its use in very low amount as the catalyst. Additionally, iron-based nanomaterials prepared via green route are known to support low cost of the biomass to renewable energy production through thermochemical and biochemical routes wherein the major cost is perhaps due to the catalyst synthesis. Though the green synthesis route of nanomaterial is non-toxic and sustainable, the lack of detailed information about the green synthesis and its mechanism continues to be an important issue. In this review different existing routes to synthesis of iron-based nanomaterials like using microorganism, green plants and biomass have been discussed in details along with their possible mechanisms involved therein. Additionally, impacts of various parameters employed in the green synthesis route have been discussed to explore the exact picture on the physicochemical properties of the synthesized nanomaterials. Finally, applications of iron-based nanomaterials as catalysts in thermochemical and biochemical energy production (e.g. liquid hydrocarbon, hydrogen) are presented and discussed. This comprehensive review provides a new insight on the bioinspired synthesis of iron-based nanomaterials and their applications to advance the existing biofuels production processes towards its sustainable commercialization through waste to value added technology. [Display omitted] • Comprehensive review of bioinspired synthesis of iron-based nanomaterials. • Biological routes e.g. microorganism, green plants and biomass mediated synthesis. • Mechanisms involved in bio-induced synthesis of iron-based nanomaterials. • Application as catalyst in thermochemical and biochemical energy production. • Implement to advanced the existing biofuels production technology. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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20. High yield of nano zero-valent iron (nZVI) from carbothermal synthesis using lignin-derived substances from municipal biowaste
- Author
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Roberto Nisticò, Luciano Carlos, Nisticò, R, and Carlos, L
- Subjects
Thermogravimetric analysis ,CHIM/03 - CHIMICA GENERALE ED INORGANICA ,Materials science ,020209 energy ,Iron-based nanomaterial ,chemistry.chemical_element ,02 engineering and technology ,Carbothermal synthesi ,7. Clean energy ,Lignin ,Magnetization ,Analytical Chemistry ,Catalysis ,Nanomaterials ,020401 chemical engineering ,Carbothermic reaction ,0202 electrical engineering, electronic engineering, information engineering ,0204 chemical engineering ,Zerovalent iron ,Pyrolysi ,Carbothermal synthesis ,Fuel Technology ,Chemical engineering ,chemistry ,Yield (chemistry) ,Iron-based nanomaterials ,Pyrolysis ,Carbon - Abstract
Nano zero-valent iron (nZVI) has been used as an effective catalyst in different reduction reactions. In this work, a synthesis procedure to obtain a carbon based materials with high nZVI content is reported. This synthesis method consists in a carbothermal reduction at 800 °C of Fe3O4 nanoparticles coated with lignin-derived bio-based substances (BBS) as carbon source, which have been previously prepared from the co-precipitation method. The obtained materials were characterized by powder X-ray diffraction (XRD), Mossbauer spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and magnetization measurements. The concentration of carbon used in the synthesis process was a critical parameter for obtaining high nZVI yield. Nanomaterials with a 77% of α-Fe over the total iron and saturation magnetization (Ms) of 170 emu g−1 were obtained for the best condition.
- Published
- 2019
21. The potential application of nanomaterials for ferroptosis-based cancer therapy.
- Author
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Li Y, Wei X, Tao F, Deng C, Lv C, Chen C, and Cheng Y
- Subjects
- Animals, Humans, Lipid Peroxidation, Magnetite Nanoparticles, Reactive Oxygen Species metabolism, Antineoplastic Agents, Ferroptosis drug effects, Nanomedicine methods, Nanostructures, Neoplasms drug therapy
- Abstract
Ferroptosis is a new type of programmed cell death, which is expected to become an important strategy of cancer treatment. Traditional strategies for inducing iron death are small molecule inducers based on biological agents. However, because of their poor water solubility, low cell targeting ability and fast metabolism in vivo , it is difficult for molecular drugs to play the long-acting role of ferroptosis induction. With the further study of ferroptosis and development of nanotechnology, nanomaterials have been proved to be more efficient drugs for inducing ferroptosis than those biological drugs. Therein, iron-based nanomaterials can directly release high concentrations of irons and increase reactive oxygen species levels in cells, which produce a better induction effect for ferroptosis. Whereas, it is challenging to differentiate nanoparticle-induced ferroptosis and traditional inducing strategies, elucidate the detailed mechanisms and further classify the synthetical methods of nanomaterials. For better guidance on the development of anticancer strategies, comprehensive summary of the latest developments of ferroptosis related nanomaterials, especially iron-based nanomaterials are in urgent need. In the paper, we summarized the main mechanisms of ferroptosis, highlighted the latest developments of nanomaterials for ferroptosis, and emphasized the advantages of iron-based nanomaterials for ferroptosis. The future prospect in this field was also discussed, paving the way for the related nanomaterials in the clinical cancer therapy., (© 2021 IOP Publishing Ltd.)
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- 2021
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22. Emerging Strategies of Cancer Therapy Based on Ferroptosis.
- Author
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Shen Z, Song J, Yung BC, Zhou Z, Wu A, and Chen X
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- Cell Death, Humans, Iron, Reactive Oxygen Species, Neoplasms therapy
- Abstract
Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy. However, the published ferroptosis-related reviews have mainly focused on the mechanisms and pathways of ferroptosis, which motivated this contribution to bridge the gap between biological significance and material design. Therefore, it is timely to summarize the previous efforts on the emerging strategies for inducing ferroptosis and shed light on future directions for using such a tool to fight against cancer. Here, the current strategies of cancer therapy based on ferroptosis will be elaborated, the design considerations and the advantages and limitations are highlighted, and finally a future perspective on this emerging field is given., (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2018
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23. Carbon-, Gold- and Iron-based Nanomaterials – Synthesis, Characterization and Potential Applications
- Author
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Hadidi, Lida
- Subjects
- Gold-based nanomaterials, Carbon-based nanomaterials, Iron-based nanomaterials
- Abstract
Abstract: Nanomaterials are important building blocks of nanotechnology. Their size dependent unique properties (optical, magnetic, electrical, etc.) have the potential to revolutionize applications ranging from medicine to electronics. Of the various nanomaterials, carbon-based systems including porous carbon, graphene, graphite nanofibers, and carbon nanotubes (CNTs) have received considerable attention due to their high surface area, limited toxicity, biocompatibility, electronic conductivity, chemical stability, and low density. Despite the development of different synthetic approaches for preparing various carbons, there is still vast interest in developing cost-effective scalable methods for the synthesis of carbon-based materials, in particular mesoporous carbons. Owing to their high surface area, carbon based materials have been extensively studied for catalytic applications. However, important challenges related to material synthesis remain. The research described in this dissertation attempts to address challenges associated with synthesis of mesoporous carbons as well as their prototype catalytic applications. The investigations then shift to the synthesis and applications of iron oxide nanorods coated with N-doped mesoporous carbon core-shell nanostructures as catalyst. Finally, the extension of photothermally responsive hybrid gold/silica nanoparticles into catalytic applications is explored. The thesis starts with an introduction summarizing the broad field of nanomaterials. Focus then shifts to the materials (i.e., mesoporous carbon, iron oxide nanoparticles and gold nanoparticles) specific to the presented investigation. Chapter Two outlines on synthesis of hollow mesoporous carbon (HMC) nanostructures using dopamine as carbon precursor. The HMC was fully characterized. The resulting HMC was employed as an electrocatalyst for oxygen reduction/evolution reactions (ORR/OER) in zinc air battery (ZAB). The HMCs exhibited outstanding ORR onset potential and excellent stability comparable to that of precious metal catalyst. Chapter Three presents the synthesis of high surface area hollow carbon spheres (HCS) using crystalline nanocellulose (CNC) as carbon precursor and a detailed investigation and discussion on the formation mechanism. The synthesized HCS were implemented for catalytic conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The catalytic activity was investigated in terms reaction rate and activity parameter. The HCS exhibited remarkable catalytic activity comparable to that of their metallic nanoparticles counterparts. Chapter Four is extension of previous work where mesoporous carbon is used as a thin shell material. The synthesis of Fe3O4 nanorods coated with a nitrogen-doped mesoporous carbon shell (ND-Fe3O4@mC) via a new microwave-assisted approach is presented. The electrochemical performances of ND-Fe3O4@mC with different carbon shell thicknesses are evaluated. The results reveal enhanced ORR catalytic activity for the catalyst with thinnest carbon shell. The synthesis of different morphologies of gold nanostructures along with hybrid gold/silica nanoparticles is presented in Chapter Five. The optical properties of these structures are investigated in detail and co-related with structure. The application of silica decorated with gold nanoparticles investigated for catalytic conversion of 4-NP conversion to 4-AP. Finally, Chapter Six provides a summary of the conclusions of the work and outlines future work.
- Published
- 2016
Catalog
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