1. Microbubble Injection Enhances Inhibition of Low-Intensity Pulsed Ultrasound on Debris-Induced Periprosthetic Osteolysis in Rabbit Model.
- Author
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Hu, Bin, Cai, Xun-Zi, Shi, Zhong-Li, Chen, Yun-Lin, Zhao, Xiang, Zhu, Han-Xiao, and Yan, Shi-Gui
- Subjects
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MICROBUBBLE diagnosis , *ULTRASONIC imaging , *BONE resorption , *LABORATORY rabbits , *TITANIUM , *VETERINARY injections - Abstract
We determined whether the addition of microbubbles enhances the effect of low-intensity pulsed ultrasound (LIPUS) on bone–implant integration in an early-stage osteolysis model. The bone canals were injected with titanium particles before implantation to establish the periprosthetic osteolysis model. Before ultrasonic therapy, the microbubble-enhanced LIPUS group (G Ti-Us-Mb ) received an intra-articular injection of microbubbles. Biomechanical testing revealed that G Ti-Us-Mb had significantly greater fixation strength than the LIPUS group (G Ti-Us ). Distal periprosthetic bone mineral density was also higher in G Ti-Us than in the Ti group (G Ti ), but no significant increase was detected after administration of microbubbles. Histomorphometric analyses revealed that bone formation around the implant in G Ti-Us was enhanced by the addition of microbubbles in G Ti-Us-Mb . Taken together, our data indicate that microbubble injection enhances the inhibitory effect of LIPUS on debris-induced osteolysis and further strengthens the mechanical fixation of implants in an early-stage osteolysis model in vivo . [ABSTRACT FROM AUTHOR]
- Published
- 2015
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