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2 results on '"hsa_circ_0075341"'

1. Hsa_circ_0075341 is up-regulated and exerts oncogenic properties by sponging miR-149-5p in cervical cancer

Author

Shiqing Shao, Chen Wang, Shelian Wang, Hongxia Zhang, and Yongyan Zhang

Subjects
Cervical cancer, hsa_circ_0075341, miR-149-5p, AURKA, Therapeutics. Pharmacology, RM1-950
Abstract

Increasing evidence revealed that circular RNAs (circRNAs) play important roles in tumor progression. In the present study, we explored the roles and underlying mechanisms of hsa_circ_0075341 in cervical cancer development. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients. Hsa_circ_0075341 inhibition reduced cervical cancer cell proliferation and invasion in vitro. In mechanism, hsa_circ_0075341 negatively regulated miR-149-5p in cervical cancer progression. In addition, AURKA was confirmed as a direct target of miR-149-5p in cervical cancer and positively regulated by hsa_circ_0075341. Collectively, our data suggested that hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment.

Published
2020
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2. Hsa_circ_0075341 is up-regulated and exerts oncogenic properties by sponging miR-149-5p in cervical cancer

Author

Yongyan Zhang, Shelian Wang, Shiqing Shao, Chen Wang, and Hongxia Zhang

Subjects
0301 basic medicine, Uterine Cervical Neoplasms, RM1-950, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Cervical carcinoma, medicine, Humans, Neoplasm Invasiveness, hsa_circ_0075341, Cell Proliferation, Neoplasm Staging, Pharmacology, Cervical cancer, AURKA, Tumor size, business.industry, General Medicine, RNA, Circular, medicine.disease, miR-149-5p, In vitro, Up-Regulation, MicroRNAs, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Cancer research, Disease Progression, Female, Therapeutics. Pharmacology, business
Abstract

Increasing evidence revealed that circular RNAs (circRNAs) play important roles in tumor progression. In the present study, we explored the roles and underlying mechanisms of hsa_circ_0075341 in cervical cancer development. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients. Hsa_circ_0075341 inhibition reduced cervical cancer cell proliferation and invasion in vitro. In mechanism, hsa_circ_0075341 negatively regulated miR-149-5p in cervical cancer progression. In addition, AURKA was confirmed as a direct target of miR-149-5p in cervical cancer and positively regulated by hsa_circ_0075341. Collectively, our data suggested that hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment.

Published
2020

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