Search

According to quality specifications required by international guidelines, the evaluation of the 99th URL value is a very difficult task that is usually beyond the capacity of a single laboratory. The aims of this article are to report and discuss the results of a multicenter study concerning the evaluation of the 99th percentile URL and reference change (RCV) of the ADVIA Centaur High-Sensitivity Troponin I (TNIH), recently distributed to the Italian clinical laboratories. The reference population evaluated with ADVIA XPT method for the calculation of cTnI reference distribution parameters consisted of 1325 healthy adults subjects (age range from 18 to 86 years), including 653 women (mean age 50.7 years, SD 14.5 years) and 672 men (mean age 50.9 years, SD 13.8 years), well matched for both age (P =.8112) and sex (F/M = 0.97). cTnI distribution values of reference population was highly skewed, while log-transformed cTnI values roughly approximated a log-normal distribution. Men have higher cTnI values than women throughout all the adult lifespan. Moreover, the subjects with age ≤ 55 years had significantly lower cTnI values than those with age > 55 years (p <.0001). Of note, 62% of women and 77% of men had equal or higher than cTnI values than the LoD value of the method (i.e., 2.2 ng/L). The results of the present study demonstrate that the ADVIA Centaur High-Sensitivity Troponin I using the XPT automated platform fits both the criteria and quality specifications required by the most recent international guidelines for high-sensitivity methods for cTnI assay. • The 99th URL value is a very difficult task that is usually beyond the capacity of a single laboratory. • The Italian Societies SIBioC and ELAS have recently promoted a multicenter study to accurately evaluate analytical performances and reference values of the most popular cTnI methods commercially available in Italy. • cTnI reference distribution parameters were evaluated in a large population including healthy adults subjects, well matched for age and sex-ratio. • The ADVIA XPT method fits both the criteria and quality specifications required by the most recent international guidelines for high-sensitivity methods for cTnI assay. [ABSTRACT FROM AUTHOR]

UHF (ultra high frequency) method has been widely used in PD (partial discharge) detection for its high sensitivity. The resonance, distortion, and attenuation appearing in the propagation process of UHF signals in GIS (gas insulated switchgear) will influence the real situation of PD detection. Therefore, it is necessary to investigate the effect of GIS components such as disconnectors or high voltage conductors on the propagation characteristics of PD-induced UHF signals in various voltage classes GIS. The factors of PD signals propagation characteristics in axial and radial directions are both analysed to avoid the effect caused by placement of sensor in this paper. First, the simulation models of GIS are built based on FDTD (finite difference time domain) method. Then the propagation characteristics of PD-induced UHF signals are studied in the GIS with different disconnector gap lengths and different high voltage conductor radii. Finally, the reliability of the simulation results is verified by compared with laboratory tests. The disconnector gap and the change of conductor radii can both result in the signals attenuation which rises highest in the direction of 180°. The lower the GIS class voltage is, the larger the attenuation of signals after passing through disconnector gap is.