1. Carbohydrate Loading to Combat Acute Pancreatitis.
- Author
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Vervliet, Tim, Yule, David I., and Bultynck, Geert
- Subjects
- *
PANCREATITIS , *DEFICIENCY diseases , *PHYSIOLOGICAL effects of adenosine triphosphate , *PANCREATIC acinar cells , *ZYMOGENS , *GLUCOKINASE , *PREVENTION - Abstract
Acute pancreatitis is characterized by ATP deficiency and sustained Ca2+ overload in pancreatic acinar cells, leading to premature zymogen activation, auto-digestion of the pancreas, and necrosis. Recent research reveals a rational approach to ameliorate disease through galactose feeding, bypassing hexokinases to restore ATP levels and Ca2+ homeostasis, thereby reducing disease markers. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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