1. Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
- Author
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Umemura, Machiko, 1000020447460, Suda, Goki, Tsukamoto, Shihori, Ebata, Ko, Takahash, Shinjiro, Sasaki, Takashi, Nakajima, Sae, Hirata, Koji, Ozasa, Mariko, Takano, Masatoshi, Katagiri, Masaki, Sakamoto, Naoya, Umemura, Machiko, 1000020447460, Suda, Goki, Tsukamoto, Shihori, Ebata, Ko, Takahash, Shinjiro, Sasaki, Takashi, Nakajima, Sae, Hirata, Koji, Ozasa, Mariko, Takano, Masatoshi, Katagiri, Masaki, and Sakamoto, Naoya
- Abstract
Background In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies. Case presentation We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion. Conclusion On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP.
- Published
- 2021