188 results on '"head and neck tumours"'
Search Results
2. A Spindle Cell Tumour that Took us for a Spin!: A Case Report and Short Review of Management of Head and Neck Desmoid Fibromatosis.
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Yalla, Poojitha, Rathod, Priyank, Rojesara, Mitkumar, Pawar, Ajinkya, Devarajan, Jebin Aaron, and Pandya, Shashank J.
- Subjects
- *
FIBROMAS , *NECK , *TUMORS , *BENIGN tumors , *SURGICAL diagnosis , *DESMOID tumors - Abstract
Head and neck desmoid fibromatosis is a rare type of benign but locally aggressive tumour that has varied presentations and is difficult to manage with a high chance of causing morbidity to the patient. This report highlights the importance of proper diagnosis and surgical planning before embarking on a strenuous surgical resection. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Oral Squamous Cell Carcinoma Metastasising to Unusual Sites: A Case Series of Four Cases
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Preeti Agrawal, Swarneet Bhamra, Rambir Singh, Ashish Pandey, and Megha Shukla Pandey
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head and neck tumours ,metastasis ,oral squamous cell carcinoma ,rare sites ,Medicine - Abstract
Oral cancer ranks as the sixth most common malignancy worldwide, with Squamous Cell Carcinoma (SCC) being the predominant type observed in the head and neck region. Incidence and mortality rates of SCC have significantly increased over the past few decades. Smoking and tobacco chewing are the most common aetiological factors, predominantly affecting elderly males. Distant metastasis at the time of diagnosis is a rare occurrence, typically disseminating through blood vessels or lymphatics. The lungs are the most frequent site for distant metastasis, followed by bone, mediastinal nodes, and occasionally the liver. However, in our cases, we observed metastasis to uncommon sites, excluding the liver. Accurate diagnosis necessitates the correlation with clinical history, radiological, histopathological, and immunohistochemical findings. Despite employing various surgical and radiotherapeutic modalities, distant metastasis diminishes the chances of survival, successful treatment, and worsens the prognosis. This article presents four cases of oral SCC that exhibited metastasis to unusual sites. Two cases had a primary tumour in the left lateral border of the tongue, with distant metastasis to the breast and skin (chest wall), while the other two cases had a primary tumour in the left buccal mucosa and left mandibular region, with distant metastasis to the kidney and liver.
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- 2023
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4. Oral Squamous Cell Carcinoma Metastasising to Unusual Sites: A Case Series of Four Cases.
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AGRAWAL, PREETI, BHAMRA, SWARNEET, SINGH, RAMBIR, PANDEY, ASHISH, and PANDEY, MEGHA SHUKLA
- Abstract
Oral cancer ranks as the sixth most common malignancy worldwide, with Squamous Cell Carcinoma (SCC) being the predominant type observed in the head and neck region. Incidence and mortality rates of SCC have significantly increased over the past few decades. Smoking and tobacco chewing are the most common aetiological factors, predominantly affecting elderly males. Distant metastasis at the time of diagnosis is a rare occurrence, typically disseminating through blood vessels or lymphatics. The lungs are the most frequent site for distant metastasis, followed by bone, mediastinal nodes, and occasionally the liver. However, in our cases, we observed metastasis to uncommon sites, excluding the liver. Accurate diagnosis necessitates the correlation with clinical history, radiological, histopathological, and immunohistochemical findings. Despite employing various surgical and radiotherapeutic modalities, distant metastasis diminishes the chances of survival, successful treatment, and worsens the prognosis. This article presents four cases of oral SCC that exhibited metastasis to unusual sites. Two cases had a primary tumour in the left lateral border of the tongue, with distant metastasis to the breast and skin (chest wall), while the other two cases had a primary tumour in the left buccal mucosa and left mandibular region, with distant metastasis to the kidney and liver. [ABSTRACT FROM AUTHOR]
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- 2023
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5. 头颈部肿瘤患者术后发生谵妄危险因素的meta分析.
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向富萍, 侯黎莉, 杨玲, 王钰, and 梁家青
- Abstract
Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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6. Regulation of epigenetic modifications in the head and neck tumour microenvironment.
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Huimin Liu, Dongxu Wang, Zhijing Yang, Shuangji Li, Han Wu, Jingcheng Xiang, Shaoning Kan, Ming Hao, and Weiwei Liu
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TUMOR microenvironment ,RNA modification & restriction ,EPIGENETICS ,NECK ,NON-coding RNA - Abstract
Head and neck tumours are common malignancies that are associated with high mortality. The low rate of early diagnosis and the high rates of local recurrence and distant metastasis are the main reasons for treatment failure. Recent studies have established that the tumour microenvironment (TME) can affect the proliferation and metastasis of head and neck tumours via several mechanisms, including altered expressions of certain genes and cytokines. Increasing evidence has shown that epigenetic modifications, such as DNA methylation, histone modification, RNA modification, and non-coding RNAs, can regulate the head and neck TME and thereby influence tumour development. Epigenetic modifications can regulate the expression of different genes and subsequently alter the TME to affect the progression of head and neck tumours. In addition, the cell components in the TME are regulated by epigenetic modifications, which, in turn, affect the behaviour of head and neck tumour cells. In this review, we have discussed the functions of epigenetic modifications in the head and neck TME. We have further examined the roles of such modifications in the malignancy and metastasis of head and neck tumours. [ABSTRACT FROM AUTHOR]
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- 2022
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7. SMARCB1 (INI-1) deficient sinonasal carcinoma of the right maxillary sinus – A rare entity.
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Singh, Sourabh, Soni, Deepti, Sahoo, Anjan Kumar, and Mukhopadhyay, Sramana
- Abstract
SMARCB1 (INI-1) is a vital tumour suppressor gene on chromosome 22q11.2, preventing tumour development in the SWI/SNF complex. Mutations cause SMARCB1-deficient tumours with distinct features. Loss of INI-1 expression is seen in malignancies, including sinonasal carcinoma and atypical teratoid/rhabdoid tumours. Recently recognized as a separate entity, SMARCB1-deficient sinonasal carcinomas (SDSC) are rare, clinically aggressive, and mimic other malignancies, emphasizing their significant diagnosis due to poorer prognosis, particularly in the elderly. A 66-year-old male presented with a 4-month-old right cheek swelling, diagnosed initially as a sinonasal neoplastic mass. The biopsy revealed sinonasal mucosal fragments infiltrated by a tumour with plasmacytoid morphology. Immunohistochemistry (IHC) of the tumour cells was positive for p63 and pan-cytokeratin and showed INI-1 loss. Subsequent subtotal maxillectomy was performed, and the patient received adjuvant chemotherapy and radiotherapy. At a thirteen-month follow-up, the patient achieved his daily activities with no signs of recurrence. The loss of protein expression in sinonasal cancer is predominantly attributed to the homozygous deletion of SMARCB1. SDSC, a profoundly invasive malignant carcinoma, tends to infiltrate sinuses and extend into the intracranial regions. The IHC findings of our case were in coherence with previous studies in SMARCB1. The prognosis is particularly unfavourable in males and advanced tumours. The tumour's microscopic and immunohistochemical characteristics indicated the SDSC. Due to its aggressive nature and high mortality rates, dealing with a paranasal mass, one should be suspicious of this tumour. • Recently recognized as a separate entity, SMARCB1-deficient sinonasal tumors are rare, clinically aggressive, and mimic other malignancies, emphasizing their significant diagnosis due to poorer prognosis, particularly in the elderly. • SMARCB1 (INI-1) is a vital tumor suppressor gene on chromosome 22q11.2, preventing tumor development in the SWI/SNF complex. • Biopsy was taken and the tumor's microscopic and immunohistochemical (IHC) characteristics indicated the SMARCB1 (INI-1) deficient subtype. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Study protocol for a multicentre randomised controlled trial evaluating the efficacy of an online yoga intervention in high-grade glioma patients and their caregivers: the YINOTA-O-trial.
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Rabe A, Keßler AF, Hagemann C, Schubert J, and Jentschke E
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- Humans, Mindfulness methods, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Stress, Psychological therapy, Adult, Male, Female, Brain Neoplasms therapy, Brain Neoplasms psychology, Yoga, Glioma therapy, Glioma psychology, Quality of Life, Caregivers psychology
- Abstract
Introduction: High-grade glioma patients and their caregivers often suffer from distress and a lower quality of life. Results from studies with patients with mixed cancer entities suggest that yoga can be an effective support. However, it is unclear whether this also applies to high-grade glioma patients and their caregivers. This study aims to investigate the effects of mindfulness-based online yoga for patients and their caregivers on emotional distress, quality of life and stress-associated physiological parameters compared with a waiting control group (WCG)., Methods & Analysis: The study is designed as a multicentre randomised controlled trial. Adult glioma patients (central nervous system WHO grades 3 and 4) and their caregivers will be recruited. Examined yoga instructors deliver the intervention (1 hour per week) in a synchronous format over 8 weeks via video conferencing. The WCG will receive standard care during the 8-week waiting period. Data will be collected before and after the end of the intervention and another 3 months later using questionnaires as well as blood serum and hair samples to evaluate biochemical stress parameters. Primary outcome is self-reported generalised anxiety and secondary outcomes are self-reported fear of progression, depression and quality of life as well as brain-derived neurotrophic factor (BDNF), dehydroepiandrosterone (DHEA)/dehydroepiandrosterone sulfate (DHEAS), ferritin and hair cortisol. We hypothesise better outcomes in the intervention group compared with the WCG at all measurement points. 70 patients and 70 caregivers will be recruited consecutively. Primary endpoints are significant effect detections in the Generalised Anxiety Disorder scale-7 of patients and caregivers at the end of the intervention. Analyses of covariance will be performed to analyse the treatment effects., Ethics and Dissemination: The Ethics Committee of the University of Würzburg approved the YINOTA-O ( Y oga- I ntervention bei N euroonkologischen T umorpatienten und deren A ngehörigen - O nline) study on 26 October 2021 (No.185/18-me). Results will be presented at conferences and published in peer-reviewed journals., Trial Registration Number: German Clinical Trials Register No. DRKS00029554., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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9. Management and work-up procedures of patients with head and neck malignancies treated by radiation.
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Grégoire, V., Boisbouvier, S., Giraud, P., Maingon, P., Pointreau, Y., and Vieillevigne, L.
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HEAD & neck cancer treatment , *CANCER radiotherapy , *RADIATION doses , *MEDICAL protocols , *SURGICAL complications - Abstract
Radiotherapy alone or in association with systemic treatment plays a major role in the treatment of head and neck tumours, either as a primary treatment or as a postoperative modality. The management of these tumours is multidisciplinary, requiring particular care at every treatment step. We present the update of the recommendations of the French Society of Radiation Oncology on the radiotherapy of head and neck tumours from the imaging work-up needed for optimal selection of treatment volume, to optimization of the dose distribution and delivery. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Parapharyngeal Schwannoma Mimicking Peritonsillar Abscess in a Young Female: A Rare Case Report
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Amer Rehman, Atia Khan, Eugene Omakobia, Sanjai Sood, and Samina Kha
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flexible nasoendoscopy ,head and neck tumours ,oropharyngeal swelling ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Surgery ,RD1-811 - Abstract
Parapharyngeal Space (PPS) tumours are responsible for 0.5% of head and neck cancers. Presenting features can mimic Peritonsillar Abscess (PTA). A differential diagnosis of PPS tumour should therefore be considered in young, systemically well patients with peritonsillar masses that are refractory to antibiotic therapy. This report focuses on a rare case of parapharyngeal schwannoma in an otherwise fit 29-year-old female, who presented with a three month history of a right sided oropharyngeal swelling and a sensation of ‘something’ in her throat. Blood tests, specifically full blood count and C-Reactive Protein (CRP) were normal and attempts at aspiration under local anaesthetic yielded no pus. As the patient showed no signs of improvement despite Intravenous (i.v.) antibiotics and steroid therapy; further investigations were initiated including Flexible Nasoendoscopy (FNE) and contrast enhanced Magnetic Resonance Imaging (MRI) of the neck. The FNE revealed a right sided parapharyngeal mass which was later confirmed on MRI scanning, measuring 7 cm in craniocaudal dimension arising from the deep lobe of the parotid gland. After a fine needle aspiration yielded inconclusive histological evidence, Multidisciplinary Team (MDT) discussion advised surgical excision. The patient underwent excision of the right parapharyngeal tumour and right partial parotidectomy via a transparotid and transcervical approach utilising a modified blair incision and a facial nerve monitor. Histology confirmed a parapharyngeal schwannoma. Postoperative outcomes have been reassuring as the patient has been disease-free four years postexcision.
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- 2022
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11. Tumors of the Head and Neck
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Taguchi, Tomoaki, Matsuura, Toshiharu, Kinoshita, Yoshiaki, Losty, Paul D., editor, Flake, Alan W., editor, Rintala, Risto J., editor, Hutson, John M., editor, and lwai, Naomi, editor
- Published
- 2018
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12. Difficult airways: a 3D printing study with virtual fibreoptic endoscopy.
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Ormandy, D., Kolb, B., Jayaram, S., Burley, O., Kyzas, P., Vallance, H., and Vassiliou, L.
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THREE-dimensional printing ,AIRWAY (Anatomy) ,ENDOSCOPY ,RAPID prototyping ,HEAD & neck cancer - Abstract
Head and neck cancer patients present unique airway challenges, and oropharyngeal, laryngeal, and hypopharyngeal tumours considerably distort and narrow the anatomy of the airway. We describe the use of 3D augmented reality software combined with 3D printed models to assess the anatomy of difficult airways and to assist in the formulation of the most optimal airway management strategy in such patients. The reported patients had computed tomograms (CT) of the neck prior to their anaesthetic and surgical management. DICOM files of the respective scans were imported to 3D rendering software (OsiriX, Pixmeo). We constructed volume rendered models for initial assessment of the airway then generated serial surface rendered models to create a virtual endoscopic path of the airway to simulate the fibreoptic approach. To further facilitate the study of difficult airways we have subsequently printed 3D models of those that were most difficult using rapid prototyping. Head and neck tumours significantly distort the airway. Thorough study of the relevant anatomy prior to airway management for operating reasons enhances communication between the surgeon and anaesthetist, and aids selection of the most appropriate intubation approach. In conclusion, this paper highlights a useful and novel pre-assessment strategy that allows a virtual, visual, 3-dimensional assessment of the airway anatomy combined with 3D modelling and 3D printing. This enables the airway specialist, anaesthetist, and head and neck surgeon to anticipate any critical steps and adjust the plan accordingly. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
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Nicola Cirillo, Carmen Wu, and Stephen S. Prime
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cancer stem cells ,head and neck tumours ,CD44 ,ALDH ,CD133 ,Cytology ,QH573-671 - Abstract
The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
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- 2021
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14. Transmandibular Approach in Head and Neck Oncological Surgery.
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ALMEIDA PARRA, Fernando, BUENO DE VICENTE, Ángela, RANZ COLIO, Álvaro, DE LEYVA MORENO, Patricia, NÚÑEZ PAREDES, Jorge, PICÓN MOLINA, Manuel, and ACERO SANZ, Julio
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ONCOLOGIC surgery ,SURGICAL site infections ,TUMOR surgery ,SURGICAL margin ,FREE flaps ,NECK - Abstract
Objective: To evaluate the advantages and disadvantages of the transmandibular approach to the posterior area of the maxilla, oropharyngeal region and the hypopharynx in head and neck surgery. Methods: A series of 42 patients who underwent a lip-split mandibulotomy procedure to access malignant tumours affecting deep areas of the head and neck region between 2008 and 2018 in the Department of Oral and Maxillofacial Surgery at the Ramón y Cajal University Hospital (Madrid, Spain) were retrospectively reviewed. The diagnosis and operations data of the patients were collected and analysed. Results: Using the transmandibular approach, 42 patients were operated on to access malignant tumours located in the oropharynx (n = 23, 54.76%) including the posterior third of the tongue, tonsil and soft palate, retromolar trygone (n = 9, 21.43%), floor of the mouth (n = 3, 7.14%), skull base (n = 2, 4.76%), superior maxilla (n = 3, 7.14%) and deep lobe of the parotid gland (n = 2, 4.76%). Primary reconstruction was carried out in all cases. The most used flap reconstruction method was the forearm fasciocutaneous flap in 48.71% of cases, followed by the anterolateral thigh flap in 20.51% of cases. The remaining cases were treated with other methods. The most frequent complication was surgical wound infection. Conclusion: The transmandibular approach is a good alternative to provide access for the removal of complex tumours affecting the oropharyngeal region. This approach facilitates direct visualisation of the lesion and bleeding control, allowing tumour resection with wide margins and making primary reconstruction easier. Although further progress in the transoral robotic approach could be a good option in selected cases, given the current state of knowledge, the transmandibular approach is a good option to access tumours affecting deep areas of the oral cavity and oropharynx. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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15. A Comparison of 18F-FDG-PET/MRI and 18F-FDG-PET/CT in the Cancer Staging of Locoregional Lymph Nodes.
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SLOUKA, DAVID, KRCAL, JIRI, KOSTLIVY, TOMAS, HRABACKA, PETR, SKALOVA, ALENA, MIRKA, HYNEK, TOPOLCAN, ONDREJ, and KUCERA, RADEK
- Subjects
LYMPH node cancer ,POSITRON emission tomography ,HEAD & neck cancer ,MAGNETIC resonance imaging ,TUMOR classification ,COMPUTED tomography - Abstract
Aim: The aim of the study was to evaluate the yields of 2-deoxy-2-[
18 F]-fluoro-D-glucose positronemission tomography/magnetic resonance imaging (18 FFDG-PET/MRI) and18 F-FDG-PET/computed tomography (CT) for the detection of metastatic involvement of locoregional neck nodes in patients with head and neck malignancy. Patients and Methods: A total of 90 patients (66 men and 24 women) met the inclusion criteria. Preoperative staging was performed: 53 examinations using PET/CT and 37 using PET/MRI. Results: For PET/MRI, the study demonstrated a sensitivity of 89%, specificity of 64%, positive predictive value of 85%, and negative predictive value of 70%; PET/CT had a sensitivity of 95%, specificity 47%, positive predictive value of 82%, and negative predictive value of 78%. Conclusion: Both methods have a high yield in N-clinical staging with statistically insignificant differences. We assume PET/MRI to be the first-choice method in organ-targeted examinations, for pediatric patients and repeat examinations. In cases of MRI contraindication, PET/CT can be used with no impact on the quality of care. [ABSTRACT FROM AUTHOR]- Published
- 2020
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16. Desmoplastic ameloblastoma: a systematic review of the cases reported in the literature.
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Chrcanovic, Bruno Ramos, Gomes, Carolina Cavaliéri, and Gomez, Ricardo Santiago
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AMELOBLASTOMA ,META-analysis ,BENIGN tumors ,ELECTRONIC information resource searching ,TUMORS ,MANDIBLE - Abstract
The aim of this study was to integrate the available data published on desmoplastic ameloblastoma (DA) into a comprehensive analysis of its clinical/radiographic features. As it is not clear whether the hybrid ameloblastoma has a unique biological behaviour, the clinical/radiographic features of conventional DA were compared with those of the hybrid variant. An electronic search was undertaken in May 2019. Eligibility criteria included publications with sufficient clinical/radiographic/histological information to confirm the diagnosis. A total of 128 publications reporting 285 DAs were included (246 central non-hybrid, 33 central hybrid, 6 peripheral). There was a statistically significant difference between non-hybrid and hybrid cases concerning lesion location, radiographic limits, and size. In contrast to non-hybrid tumours, which showed a similar distribution in the mandible and maxilla, hybrid tumours showed a high predominance of mandible location. Non-hybrid lesions more often showed ill-defined radiographic margins, and were smaller tumours than hybrid DAs. Enucleation with an additional therapy (either curettage or peripheral osteotomy) or resection led to a lower recurrence risk in comparison to curettage or enucleation without additional therapy. The location of the lesion and type of treatment are related to tumour recurrence. There are important differences in location and radiographic limits between hybrid and non-hybrid DAs, which support their classification as distinct lesions. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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17. Preoperative embolisation of head and neck paragangliomas - a single-centre experience.
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Szmygin P, Szmygin M, Roman T, Kucharski A, Jargiełło T, Rola R, and Szymański M
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- Humans, Female, Middle Aged, Male, Adult, Aged, Preoperative Care, Treatment Outcome, Retrospective Studies, Embolization, Therapeutic methods, Head and Neck Neoplasms therapy, Head and Neck Neoplasms surgery, Paraganglioma surgery, Paraganglioma therapy
- Abstract
Introduction: Paragangliomas are neuroendocrine tumours commonly located in the abdomen, thorax, head and neck. The definitive treatment for these tumours is surgical resection, which in some cases can be very challenging due to the involvement of critical neurovascular structures and their high vascularity. Therefore, pre-operative embolisation may be performed to reduce the risk of complications. This study aimed to present our experience with endovascular embolisation of head and neck paragangliomas (HNP)., Material and Methods: In this single-centre study, we reviewed data from consecutive patients with HNP who underwent pre-operative embolisation from 2017 to 2023. The efficacy of embolisation, the method of embolisation, as well as the rate of complications, were noted., Results: A total of 27 patients (15 females) with an average age of 47 years underwent selective embolisation of HNP. Satisfactory embolisation, defined as occlusion of > 75% of the blood supply, was achieved in 22/27 cases (81.5%). The most commonly used embolic agents included coils and microspheres. With the exception of minor vessel dissections in two patients and embolic agent migration in two patients causing reversible occlusion of the intracranial vessels, there were no other complications associated with embolisation. No neurological deficits occurred in relation to the endovascular procedure., Conclusions: The results of our study indicate that endovascular embolisation of HNP prior to surgical resection is a safe and efficacious procedure, with a relatively low complication rate and associated morbidity.
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- 2024
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18. Ultrasound-guided wire localisation: a GPS for hidden head and neck tumours? A case series.
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Laxague F, Gualtieri T, Brahm G, Yoo J, MacNeil SD, Fung K, Mendez A, Sahovaler A, and Nichols AC
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- Humans, Neck, Preoperative Care, Ultrasonography, Interventional, Head and Neck Neoplasms surgery
- Abstract
Objectives: Ultrasound-guided wire (USGW) localisation for small non-palpable tumours before a revision head and neck surgery is an attractive pre-operative option to facilitate tumour identification and decrease potential complications. We describe five cases of pre-operative USGW localisation of non-palpable head and neck lesions to facilitate surgical localisation and resection., Methods: All patients undergoing pre-operative USGW localisation for non-palpable tumours of the head and neck region at London Health and Sciences Center, London, Ontario, Canada, were included. All the USGW localisations were performed by the same interventional radiologist, and the surgeries were performed by fellowship trained head and neck surgeons., Results: Five patients were included. All patients were undergoing revision surgery for recurrent or persistent disease. All successfully underwent a pre-operative USGW localisation of the non-palpable lesion before revision surgery. All lesions were localised intra-operatively with no peri-operative complications., Conclusions: USGW localisation is a safe and effective pre-operative technique for the identification of small non-palpable head and neck tumours., (Copyright © 2023 Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy.)
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- 2023
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19. Ein Vergleich von Photonen- und Protonentechniken bei der Bestrahlunsplanung von Tumoren im Kopf- und Halsbereich
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Sitz-Krumberger, Anika
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Risikoorganschonung ,Protonentherapie ,Head and neck tumours ,Kopf- und Halstumore ,Organs at risk sparing ,Zielvolumenabdeckung ,Photon therapy ,Photonentherapie ,Target volume coverage ,Proton therapy - Abstract
Diese Arbeit beschäftigt sich mit dem Vergleich der Bestrahlungsplanung von der Protonen- und der Photonentherapie bei Kopf- und Halstumoren in Bezug auf die Risikoorgane und das Zielvolumen. Das Ziel ist es zu untersuchen, welche Strahlenart die Risikoorgane am besten schonen kann, und ob die Protonentherapie im Vergleich zur Photonentherapie für Vorteile in der Dosisauslastung des Zielvolumen sorgt. Dafür werden dosimetrische Parameter aus Studien verglichen. Die Methodik ist eine theoretische Literaturarbeit. 13 Studien, die einen dosimetrischen Vergleich der Risikoorgane beziehungsweise des Zielvolumens im Kopf- und Halsbereich mit Zahlenwerten durchgeführt haben, wurden in dieser Bachelorarbeit inkludiert. Exkludiert wurden Studien, welche vor 2011 veröffentlicht wurden. Das Ergebnis dieser Bachelorarbeit zeigt, dass die Protonentherapie in den Risikoorganen in den meisten Fällen signifikant dosissparender ist, als die Photonentherapie. Zum Beispiel beträgt in der Studie von Holliday et al (2015) die mediane mittlere Dosis der Mundhöhle bei den IMPT Plänen 17,3 Gy und bei den IMRT Plänen 40,6 Gy. Auch die berechnete mediane mittlere Dosis des Hirnstamms mit 26,7 Gy bei der IMPT und 34,2 Gy bei der IMRT ist signifikant geringer bei der Protonentherapie. Bei dem Vergleich des Zielvolumens waren die meisten Vergleiche der beiden Strahlenarten nicht signifikant. Zum Beispiel waren bei dem Parameter D95% von den 14 durchgeführten Vergleichen nur 2 signifikant. Ergebnisse wurden anschließend grafisch dargestellt. Dies führt zu der Konklusion, dass die Protonentherapie das Zielvolumen gleich gut mit Dosis versorgen kann wie die Photonentherapie, während die Risikoorgane besser geschont werden können. Die Forschungsfragen konnten mithilfe der verwendeten Literatur beantwortet werden. Jedoch waren die Studienergebnisse sehr inhomogen, weshalb der Vergleich der Auslastung des Zielvolumens nicht immer mit denselben Parametern durchgeführt werden konnte. Auch bei den Risikoorganen gab es Unterschiede bei dem dosimetrischen Vergleich. Ein Vergleich der Protonen- und Photonentherapie, in Bezug auf die Lebensqualität während und nach der Bestrahlung, könnte weiterführend von Interesse sein. This thesis deals with the radiation planning comparison of proton therapy and photon therapy for head and neck tumors for the organs at risk and the target volume. The aim is to investigate which type of radiation can best spare the organs at risk and whether proton therapy can provide advantages in dose coverage of the target volume compared to photon therapy. For this purpose, dosimetric parameters from studies are compared. This thesis is a literature review. 13 Studies that performed a dosimetric comparison of organs at risk or the target volume in the head and neck area were included. Studies published before 2011 were excluded. The result of this thesis shows that in most cases proton therapy is significantly more dose sparing than photon therapy for the organs at risk. For example, in the study by Holliday et al (2015), the median mean dose to the oral cavity is 17.3 Gy for IMPT plans and 40.6 Gy for IMRT plans. The calculated median mean dose to the brainstem of 26.7 Gy for IMPT and 34.2 Gy for IMRT is also significantly lower for proton therapy. When comparing the target volume, most comparisons were not significant. For example, for the parameter D95%, of the 14 comparisons made, only 2 were significant. This leads to the conclusion that proton therapy can supply the target volume with dose equally as well as photon therapy, while the organs at risk can be spared better. The research questions could be answered with the help of the literature used. However, the study results were very inhomogeneous for the comparison of the of the target volume coverage. There were also differences in the comparison of the organs at risk. A comparison of proton and photon therapy in terms of quality of life during and after irradiation could be of further interest.
- Published
- 2023
20. WHO Scoping Review
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Roza, Ana, Santos-Silva, Alan, and Ruiz, Blanca
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Oral Biology and Oral Pathology ,Scoping review ,Dentistry ,FOS: Clinical medicine ,Head and Neck Tumours ,Medicine and Health Sciences ,WHO Classification - Abstract
This Scoping Review targets topics in need of review since the 4th Edition of the WHO Classification of Head and Neck Tumours
- Published
- 2022
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21. Oral Cancer.
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Wong, T. S. C., Wiesenfeld, D., and Wong, Tsc
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ORAL cancer ,EPIDEMIOLOGY ,QUALITY of life ,ONCOLOGY ,DENTAL health education - Abstract
The management of oral cancer is a multidisciplinary endeavour, as each patient presents the treating clinicians with a unique set of challenges the management of which impacts on both survival and quality of life. This article focuses on the management of oral cancer. We highlight the epidemiology and risk factors for oral cancer in Australia, the various clinical presentations that occur and the staging of oral cancer. In the vast majority of cases surgery remains the mainstay of treatment. Radiation and medical oncology is usually used in an adjuvant context. Dental professionals play a critical role in many stages of management from the initial detection, to optimising pre treatment dental health and managing the short and long term sequelae of treatment. Monitouring for recurrence and the development of second primary tumours is a key role. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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22. Controversies in patients with head and neck tumours undergoing radiotherapy: the need for adaptive radiotherapy.
- Author
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Cacicedo Fernández de Bobadilla, Jon, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., Molinillo Marín, Angélica, Cacicedo Fernández de Bobadilla, Jon, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., and Molinillo Marín, Angélica
- Abstract
[EN]The treatment of head and neck tumours is based on surgery, radiotherapy and chemotherapy. The choice of each of them or their combination depends on the stage of the tumour: in early stage tumours, radiotherapy and surgery obtain similar results and both are valid, while in advanced stages all the mentioned treatments are usually combined. As far as the use of radiotherapy is concerned, its major disadvantage is based on the possible radiation of healthy tissues, such as the parotid glands. Patients with head and neck tumours suffer from mucositis and dysphagia and are more susceptible to anatomical changes during radiotherapy treatment (which may last 6-7 weeks), due to weight loss or changes in tumour size. This causes the radiation dose received by both tumour and healthy tissues to be different from that initially planned, which increases the risk of adverse effects such as xerostomia (due to an increase in the dose received by the parotid glands). The only way to compensate for the anatomical changes is to re-plan the radiotherapy treatment, a process which is called adaptive radiotherapy. The present retrospective study included 85 consecutive patients with locally advanced head and neck tumours, who received surgery ± postoperative radiotherapy or radio- chemotherapy treatment with radical intent. The predisposing factors that cause anatomical changes during radiotherapy leading to a deviation of the dose received by healthy peritumoral tissues were analysed. According to the results, patients who lose weight during radiotherapy (especially >5%) or who receive concomitant chemotherapy are highly susceptible to require adaptive radiotherapy and therefore require close follow-up for early detection and to reduce the side effects of radiotherapy.
- Published
- 2022
23. Advanced diagnostic techniques of metastatic neck lymph nodes
- Author
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Maja Jocić, Slađana Petrović, and Dragan Stojanov
- Subjects
neck lymph nodes ,head and neck tumours ,PET ,CT perfusion ,DWI-MR ,Medicine - Abstract
The development of advanced technologies including computerized tomography devices of new generation (MSCT) and MRI devices has enabled the application of high quality techniques that are used for functional analysis of head and neck tumors. Therefore, the role of conventional CT and MR imaging techniques relating to anatomical domain has been transferred to functional level thus enabling better understanding of biological characteristics of the tumor tissue and better differentiation of benign and malignant neck lymph nodes. Positron emissin tomography (PET) is a functional technique that can detect metastatic neck lesions on the basis of increased glucose metabolism in tumor cells. However, due to poor anatomical resolution some hybrid methods (PET / CT and PET / MR) have been designed that provide morphological and functional information about the tumor tissue and thus are considered to be superior in comparison to conventional PET. Perfusion techniques have proved to be beneficial in the diagnosis of head and neck tumors, especially in the diagnosis of recurrent disease after radiotherapy and for the characterization of the lymph nodes. Diffusion weighted imaging (DWI) is very useful in the diagnosis of malignant lymph nodes smaller than 10 mm that are otherwise difficult to diagnose by means of conventional methods. The paper describes the role of high quality techniques including positron emission tomography PET in combination with CT or MRI (PET / CT and PET / MR) in the diagnostics of metastatic neck lymph nodes, possibilities of perfusion imaging techniques (MSCT / MRI) in the analysis of tumor tissues, as well as possibilities of diffusion MR imaging (DWI-MRI) and MRI with nanoparticles of iron oxide in the differentiation of benign and malignant neck lymph nodes.
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- 2013
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24. The detection of hypoxic markers in head and neck tumours
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Šťovíčková, Eliška, Šmahelová, Jana, and Rösel, Daniel
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papilomavirus ,nádory hlavy a krku ,prognosis ,hypoxia ,VEGFa ,hypoxie ,aspartát-β-hydroxyláza ,prognóza ,HIF1α ,head and neck tumours ,papillomavirus ,aspartate-β-hydroxylase - Abstract
Head and neck cancers (HNSCC) are heterogeneous group of tumours. Risk factors are mainly smoking and alcohol consumption. Some of these tumours are associated with human papillomavirus (HPV) infection, which is a significant positive prognostic factor. These tumours differ from HPV-negative tumours in clinicopathological characteristics, tumour microenvironment and response to treatment. Hypoxia is commonly found in tumors including HNSCC and is a significant prognostic and predictive factor. Elucidating the degree of hypoxia in relation to HPV infection could partly explain the differences in prognosis of these patients and allow more appropriate choice of therapy. Aspartate-β-hydroxylase is also a significant negative prognostic factor in a number of tumours, but its role in HNSCC has not yet been investigated. I focused on the detection of hypoxic markers and aspartate-β-hydroxylase expression in samples from HNSCC patients at the mRNA level by quantitative PCR and at the protein level by multispectral immunohistochemistry. The expression levels of these markers were compared in tumors stratified according to viral etiology and other characteristics such as smoking, localization or tumor stage. HPV infection had the highest impact on the expression of these markers, but the results cannot point to a...
- Published
- 2022
25. Completition of therapy in the irradiation of patients with head and neck tumours
- Author
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Morocutti, Julia
- Subjects
side effects ,psychooncology ,HNO-Tumoren ,radiology technology ,Radiologietechnologie ,Nebenwirkungen ,Psychoonkologie ,Therapieabbruch ,head and neck tumours ,therapy discontinuation ,Strahlentherapie - Abstract
Thema: Untersuchung des Therapieabschlusses bei der Bestrahlung von PatientInnen mit HNO-Tumoren. Problem: Die Strahlentherapie ist eine große Belastung für die PatientInnen. Dementsprechend kann es dazu kommen, dass sie den Abbruch der Therapie in Erwägung ziehen. Auf die genauen Ursachen dafür, wird meist nicht weiter eingegangen. Fragestellung: Die Fragestellung lautete „Welchen Einfluss haben die Nebenwirkungen auf den Therapieabschluss bei der Bestrahlung von HNO-Tumoren?“Methode: Im ersten Teil der Arbeit werden Grundlagen zur Strahlentherapie und HNO-Tumoren dargelegt. Bei der darauffolgenden Untersuchung handelt es sich um eine retrospektive Datenanalyse, die an der Universitätsklinik für Strahlentherapie-Radioonkologie Graz durchgeführt wurde. Es wurden alle PatientInnen mit HNO-Tumoren, die von 1.1.2021 bis 1.1.2022 bestrahlt wurden, auf Therapieabbrüche untersucht. Des Weiteren wurden bei PatientInnen, die die Therapie vor Erreichen der vorgeschriebenen Dosis abbrachen, die Ursachen für den Therapieabbruch ermittelt. Ergebnisse: Von 170 bestrahlten PatientInnen brachen 23 (14%) die Therapie ab. Als häufigste Ursache wurde der Allgemeinzustand der PatientInnen festgestellt. Ein weiterer Grund für einen Therapieabbruch war die psychische Verfassung und damit einhergehend die nicht durchführbare Lagerung während der Bestrahlung. Ein geringerer Teil der PatientInnen brach die Therapie aufgrund der aufgetretenen Nebenwirkungen ab. Die Entscheidung für einen Therapieabbruch ging von dem Patienten/der Patientin als auch dem behandelnden Arzt/der behandelnden Ärztin aus. Diskussion: Die PatientInnen werden im Laufe ihrer Therapie von vielen Faktoren beeinflusst. Der Allgemeinzustand der PatientInnen ist seitens des Personals nicht beeinflussbar. Die Nebenwirkungen verstärken sich mit der Dauer der Therapie, sind allerdings für die PatientInnen so aushaltbar, dass sie in der Regel die Bestrahlung erfolgreich abschließen. Hinsichtlich der psychischen Verfassung der PatientInnen spielt die Lagerung und dadurch hervorgerufene Ängste eine wesentliche Rolle, die besondere Aufmerksamkeit und Betreuung erfordert. Schlussfolgerung: Psychosoziale Unterstützung kann besonders die psychische Verfassung der PatientInnen beeinflussen und bietet die Möglichkeit Therapieabbrüche zu verhindern. Subject: Completition of therapy in the irradiation of patients with head and neck tumours. Problem: Radiotherapy is an enormous burden for the patients. That can lead the patients to consider the discontinuation of the therapy. Usually there is no further discussion about the exact reasons. Research Question: The research question was “What impact do the side effects have on the treatment completion in the irradiation of head and neck tumours?” Method: The first part of the thesis presents the basics of radiotherapy and head neck tumours. The following study is a retrospective data analysis which has taken place at the “Universitätsklinik für Strahlentherapie-Radioonkologie Graz”. It included all patients with head and neck tumours who received an irradiation between 1.1.2021 and 1.1.2022. The aim was to look for therapy discontinuations and additionally discover the causes responsible for the discontinuation before reaching the prescribed dose. Results: Out of 170 irradiated patients, 23 (14%) discontinued the therapy. The most common cause was the general condition of the patients. Another cause for the discontinuation of the therapy was the patients’ psychological condition which results in an unfeasible positioning during the irradiation. A smaller number of patients decided to discontinue the therapy due to the side effects. The decision was made by the patient as well as the attending physician. Discussion: Patients are influenced by many factors during the treatment period. The patients’ general condition cannot be controlled by the staff. The side effects increase with the duration of the therapy. Nevertheless, they seem to be so bearable for patients, that they successfully complete the irradiation. Regarding the psychological condition of the patients, especially the positioning and the resulting fear requires attention and special care. Conclusion: Psychosocial support can have an influence particularly on the psychological condition of patients and offers the possibility of preventing therapy discontinuations. Julia Morocutti Abweichender Titel laut Übersetzung der Verfasserin/des Verfassers Bachelorarbeit FH JOANNEUM 2022
- Published
- 2022
26. Controversies in patients with head and neck tumours undergoing radiotherapy: the need for adaptive radiotherapy
- Author
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Molinillo Marín, Angélica, Cacicedo Fernández de Bobadilla, Jon, F. MEDICINA Y ODONTOLOGIA, and MEDIKUNTZA ETA ODONTOLOGIA F.
- Subjects
adaptive radiotherapy ,parotid glands ,concomitant chemotherapy ,weight loss ,xerostomia ,head and neck tumours - Abstract
[EN]The treatment of head and neck tumours is based on surgery, radiotherapy and chemotherapy. The choice of each of them or their combination depends on the stage of the tumour: in early stage tumours, radiotherapy and surgery obtain similar results and both are valid, while in advanced stages all the mentioned treatments are usually combined. As far as the use of radiotherapy is concerned, its major disadvantage is based on the possible radiation of healthy tissues, such as the parotid glands. Patients with head and neck tumours suffer from mucositis and dysphagia and are more susceptible to anatomical changes during radiotherapy treatment (which may last 6-7 weeks), due to weight loss or changes in tumour size. This causes the radiation dose received by both tumour and healthy tissues to be different from that initially planned, which increases the risk of adverse effects such as xerostomia (due to an increase in the dose received by the parotid glands). The only way to compensate for the anatomical changes is to re-plan the radiotherapy treatment, a process which is called adaptive radiotherapy. The present retrospective study included 85 consecutive patients with locally advanced head and neck tumours, who received surgery ± postoperative radiotherapy or radio- chemotherapy treatment with radical intent. The predisposing factors that cause anatomical changes during radiotherapy leading to a deviation of the dose received by healthy peritumoral tissues were analysed. According to the results, patients who lose weight during radiotherapy (especially >5%) or who receive concomitant chemotherapy are highly susceptible to require adaptive radiotherapy and therefore require close follow-up for early detection and to reduce the side effects of radiotherapy.
- Published
- 2022
27. Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
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Stephen S. Prime, Nicola Cirillo, and Carmen Wu
- Subjects
cancer stem cells ,Carcinogenesis ,QH301-705.5 ,ALDH ,Antineoplastic Agents ,Review ,medicine.disease_cause ,Metastasis ,Side population ,Cancer stem cell ,medicine ,Animals ,Humans ,CD133 ,Neoplasm Metastasis ,CD44 ,Biology (General) ,biology ,business.industry ,General Medicine ,medicine.disease ,Head and neck squamous-cell carcinoma ,head and neck tumours ,Drug Resistance, Neoplasm ,Head and Neck Neoplasms ,Cancer cell ,Cancer research ,biology.protein ,Neoplastic Stem Cells ,Stem cell ,business - Abstract
The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
- Published
- 2021
28. Management of Head and Neck Tumours During Pregnancy: Case Report and Literature Review
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Velda Ling Yu Chow, Jimmy Yu Wai Chan, Raymond Wai Man Ng, and William Ignace Wei
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head and neck tumours ,pregnancy ,Surgery ,RD1-811 - Abstract
Ethical dilemmas arise in managing head and neck cancers during pregnancy. The timing of treatment is an important determinant on foetal wellbeing. Diagnostic and treatment modalities may harm the foetus, while delaying or choosing suboptimal treatment in order to preserve foetal health may worsen maternal outcome. A multidisciplinary approach should be adopted to enable parents and clinicians to make the best clinical decision. We report on two cases. Case 1 is a 34-year-old female who presented with squamous cell carcinoma of the tongue at 29 weeks' gestation. Partial glossectomy, selective neck dissection and posterior tibial flap reconstruction was performed at 31 weeks. She underwent induction and early delivery at 38 weeks prior to receiving radiotherapy. Case 2 is a 36-year-old female who presented with carcinoma of the cervical oesophagus complicated by tracheal invasion, thyroid and cervical lymph node metastasis at 13 weeks' gestation. Pregnancy was terminated at 16 weeks. She received a course of neoadjuvant chemoirradiation.
- Published
- 2008
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29. Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients' prognosis.
- Author
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Vojtechova, Zuzana, Sabol, Ivan, Salakova, Martina, Turek, Lubomir, Grega, Marek, Smahelova, Jana, Vencalek, Ondrej, Lukesova, Eva, Klozar, Jan, and Tachezy, Ruth
- Abstract
Integration, which leads to the disruption of the circular HPV genome, is considered as a critical, albeit not obligatory, step in carcinogenic progression. Although cervical carcinomas with extrachromosomal HPV plasmid genomes have been described, the virus is integrated in 70% of HPV16-positive cervical tumours. Limited information is available about HPV integration in head and neck tumours (HNC). In this study, we have characterised the physical status of HPV in a set of tonsillar tumour samples using different methods--the mapping of E2 integration breakpoint at the mRNA level, the 3' RACE based Amplification of Papillomavirus Oncogene Transcripts (APOT) assay and Southern blot. Furthermore, the impact of HPV integration on patients' prognosis has been evaluated in a larger set of 186 patients with head and neck cancer. Based on the analysis of E2 mRNA, HPV was integrated in the host genome in 43% of the HPV-positive samples. Extrachromosomal or mixed form was present in 57%. In fresh frozen samples, the APOT and E2 mapping results were in agreement. The results were confirmed using Southern blotting. Furthermore, the type and exact site of integration were determined. The survival analysis of 186 patients revealed HPV positivity, tumour size and lymph node positivity as factors that influence disease specific survival. However, no statistically significant difference was found in disease specific survival between patients with HPV-positive integrated vs. extrachromosomal/mixed forms of the virus. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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30. The role of the cytopathologist's interpretation in achieving diagnostic adequacy of head and neck fine needle aspirates.
- Author
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Chng, C. L., Beale, T., Adjei‐Gyamfi, Y., Gupta, Y., and Kocjan, G.
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- *
NEEDLE biopsy , *CELLULAR pathology , *HEAD tumors , *THYROID gland , *LYMPH nodes - Abstract
Objective We aimed to assess the potential role of interpretation by cytopathologists on the level of diagnostic adequacy of head and neck fine needle aspirations ( FNAs). Methods An audit ('first audit') was performed between 1 May 2007 and 30 April 2008 using data from three different hospitals (A, B and C). The specimens were interpreted by two cytopathologists with specific experience in head and neck pathology in hospitals A and B, and by any of the eight cytopathologists (only two of whom were experienced in head and neck cytopathology) in hospital C. Following the analysis of the initial findings, there was a change in practice in hospital C, after which specimens were also read only by two experienced cytopathologists. A new audit ('second audit') was then performed between 20 January 2011 and 20 December 2012 in the same three hospitals. Results During the first audit, the diagnostic adequacy of FNAs from hospital C was 84.2% compared with 96.6% in hospital A and 97.7% in hospital B ( P = 0.000). No significant difference in the diagnostic adequacy rate of the FNAs performed in hospitals A and B was found when comparing the first and second audits. The FNA diagnostic adequacy for hospital C increased significantly in the second relative to the first audit (95.5% versus 84.2%, P = 0.000). Conclusions Our study confirms that expert cytology interpretation is important in achieving optimal diagnostic adequacy of head and neck FNAs. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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31. Assessment and topographic characterization of locoregional recurrences in head and neck tumours.
- Author
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Ferreira, Brigida Costa, Marques, Rui Vale, Khouri, Leila, Santos, Tânia, Sá-Couto, Pedro, and do Carmo Lopes, Maria
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- *
HEAD tumors , *NECK tumors , *RADIOTHERAPY , *MEDICAL radiology , *TISSUES - Abstract
Purpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: method CTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); method TV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and method COM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses. [ABSTRACT FROM AUTHOR]
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- 2015
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32. PRIMERJAVA INTENZITETNE MODULIRANE IN TRIDIMENZIONALNE KONFORMNE TEHNIKE OBSEVANJA TUMORJEV GLAVE IN VRATU.
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Babič, Petra, Strojan, Primož, and Plavc, Gaber
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HEAD tumors ,NECK tumors ,RADIOTHERAPY ,T-test (Statistics) ,TREATMENT effectiveness - Abstract
Copyright of Bulletin: Newsletter of the Society of Radiographers of Slovenia & the Chamber of Radiographers of Slovenia is the property of Slovenian Society of Radiographers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
33. Oral and maxillofacial pathologic lesion: retrospective studies on prevalence and sociodemographic features.
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Rahman, Nurhayu Ab
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ORAL diseases ,DISEASE prevalence ,MAXILLARY diseases - Abstract
The aim was to study the prevalence and sociodemographic features of odontogenic, non-odontogenic and salivary glands lesions among patients seen in Hospital Universiti Sains Malaysia. This information is essential to assist clinician in formulating reliable differential diagnosis of such lesion. Data on patient demographics, lesion location, tissue of origin and microscopic diagnosis were extracted from the Laboratory and Diagnosis record registries for biopsy specimen accessioned from year 2000 to 2012. This data was subsequently analyzed based on World Health Organization Classification of Head and Neck Tumours (2005). A total of 748 cases were included in the study. Out of the total number of cases, 367 cases were males and 377 cases were females. Ninety seven cases (13%) were of odontogenic origin, while 90 cases (12%) and 197 cases (26%) were of non-odontogenic and salivary gland origin respectively. Forty five percent of cases involved oral mucosal lesions. The most prevalent odontogenic lesion reported within the twelve years period was radicular cyst and ameloblastoma. Non-odontogenic bone lesion was rarely encountered with it making up less than two percent of total cases reported. Pleomorphic adenoma was the most prevalent benign salivary glands neoplasm reported within similar time period. [ABSTRACT FROM AUTHOR]
- Published
- 2014
34. Hypoxia in head and neck tumours: characteristics and development during therapy
- Author
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Martin-Immanuel eBittner and Anca-Ligia eGrosu
- Subjects
PET imaging ,tumour hypoxia ,head and neck tumours ,primary chemoradiotherapy ,biological imaging ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Cancers of the head and neck are a malignancy causing a considerable health burden. In head and neck cancer patients, tumour hypoxia has been shown to be an important predictor of response to therapy and outcome. Several imaging modalities can be used to determine the amount and localization of tumour hypoxia. Especially PET has been used in a number of studies analyzing this phenomenon. However, only few studies have reported the characteristics and development during (chemoradio-) therapy. Yet, the characterization of tumour hypoxia in the course of treatment is of great clinical importance. Successful delineation of hypoxic subvolumes could make an inclusion radiation treatment planning feasible, where dose painting is hypothesized to improve the tumour control probability. So far, hypoxic subvolumes have been shown to undergo changes during therapy; in most cases, a reduction in tumour hypoxia can be observed, but there are also differing observations. In addition, the hypoxic subvolumes have mostly been described as geographically rather stable. However, studies specifically addressing these issues are needed to provide more data regarding these initial findings and the hypotheses connected with them.
- Published
- 2013
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35. Jugular paragangliomas—Resection techniques.
- Author
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Gleeson, Michael
- Abstract
The prerequisites for surgical resection of tumors arising in the jugular foramen are adequate access, control of the major vessels, and the ability to move the facial nerve safely of the operative field if necessary. Without it the surgeon risks catastrophic hemorrhage, cranial nerve palsies that might have been avoided, and insufficient access to remove the whole tumor. The aim of this article is to help the surgeon select the best approach for their patient and summarize the key steps in each. Consideration of a staged approach is prudent for paragangliomas that have significant intracranial extension, Fisch Di tumors. Paragangliomas confined to the temporal bone and intimately related to the internal carotid artery (ICA), Fisch C 2-4 , are better resected through a type A infratemporal fossa approach. Small jugular paragangliomas, Fisch C 1 , can be removed using a Fallopian bridge technique though limited rerouting of the facial nerve may sometimes be required. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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36. Primary parapharyngeal tumours: a review of 21 cases.
- Author
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Caldarelli, Claudio, Bucolo, S., Spisni, R., and Destito, D.
- Subjects
TUMORS ,COMPUTED tomography ,MAGNETIC resonance imaging ,NEEDLE biopsy ,ANGIOGRAPHY ,SURGICAL complications ,MORTALITY - Abstract
Background: The diagnostic and therapeutic procedures performed in a series of patients with primary parapharyngeal space (PPS) tumours treated at the ENT Departments of San Giovanni Bosco Hospital, Turin, and of the Pugliese-Ciaccio Hospital, Catanzaro, Italy, in the period 2001-2010 are evaluated. Materials and methods: The retrospective review included 20 patients, 11 male and 9 female, average age of 41 years operated on for 21 primary PPS tumours. The most common tumours found were neurogenic neoplasms, while those of salivary origin were the next most common. Results: There were 14 paragangliomas (7 originating from carotid glomus, 5 from vagal and 2 from tympanicum), 1 sympathetic chain schwannoma and 6 pleomorphic adenomas. All the tumours were benign in nature and gave rise to few signs or symptoms. Patients underwent preoperative computed tomography (CT) scan or magnetic resonance imaging (MRI) or both. Most contrast-enhanced masses were submitted to some type of angiography. Most of the surgeries were planned through imaging alone, as preoperative fine needle aspiration (FNA) biopsy was performed only in six cases. Four different approaches were adopted for tumour removal: transcervical, transcervical/transparotid, cervical-transparotid-transmandibular and infratemporal fossa approach. There was no operative mortality, though neurologic morbidity was significant. Follow-up, extended to a maximum of 11 years, did not reveal any recurrences. In conclusion, neurogenic tumours may be the most common of PPS masses. Surgery is the mainstay treatment and external approaches offer the potential for satisfactory tumour resection. Of such external approaches, transcervical and cervical/transparotid are the most often used in benign forms. Conclusion: The number of perioperative complications encountered in this series confirms the difficulty of performing surgery in this complex area, even in benign cases. The chances of avoiding vascular damage and saving the trunks or most of the nerve fibres involved depend not only on the skill and experience of the surgeon but also on the anatomy of the lesion, the type of connection between the tumour and the nerve from which it originates and the distribution of neural fibres in or around the tumour mass. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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37. Role of irradiation in combined treatment of head and neck paragangliomas at the Centre of Oncology in Krakow between 1970-2005.
- Author
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Pęcak, Magdalena, Pluta, Elżbieta, Hetnał, Marcin, Wróbel-Radecka, Renata, Szadurska, Agnieszka, Brandys, Piotr, Kukiełka, Andrzej, Dąbrowski, Tomasz, Walasek, Tomasz, and Skołyszewski, Jan
- Subjects
- *
PARAGANGLIOMA , *CANCER radiotherapy research , *RADIOTHERAPY , *HEAD tumors , *NECK tumors , *NEUROENDOCRINE tumors , *PROGNOSIS , *THERAPEUTICS - Abstract
Aim of the study is to evaluate the results of postoperative radiotherapy of paragangliomas, prognostic factors and causes of treatment failure. Material and methods: Forty-four patients (39 females and 5 males) aged 20 to 74 years were treated for paraganglioma between 1970 and 2010 at the Centre of Oncology in Kraków. Patient survival probability was estimated with the Kaplan-Meier method. Log-rank tests and Cox proportional hazard model were used in univariate and multivariate analysis, respectively. Results: The most common locations of paragangliomas were the following: the ear, carotid body and internal jugular vein bulb. Forty (91%) out of them were benign and 4 - malignant. All patients underwent surgery followed by adjuvant radiotherapy. The delivered dose ranged from 50 to 72 Gy, the mean dose was 60 Gy. Five-year overall survival was 84%. Five-year relapse-free survival was 84%, either. The multivariate analysis has shown that the dose in an independent prognostic factor for the overall survival. The univariate analysis has shown significantly higher 5-year overall survival in patients who received a dose of 60 Gy or higher - 92% vs. 70% in patients who received a dose lower than 60 Gy. Conclusions: Postoperative radiotherapy with doses higher than 60 Gy in patients with paragangliomas is associated with longer overall survival. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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38. Detection and quantification of focal uptake in head and neck tumours: F-FDG PET/MR versus PET/CT.
- Author
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Varoquaux, Arthur, Rager, Olivier, Poncet, Antoine, Delattre, Bénédicte, Ratib, Osman, Becker, Christoph, Dulguerov, Pavel, Dulguerov, Nicolas, Zaidi, Habib, and Becker, Minerva
- Subjects
- *
POSITRON emission tomography , *HEAD diseases , *NECK diseases , *TUMORS , *STATISTICS , *PATIENTS - Abstract
Purpose: Our objectives were to assess the quality of PET images and coregistered anatomic images obtained with PET/MR, to evaluate the detection of focal uptake and SUV, and to compare these findings with those of PET/CT in patients with head and neck tumours. Methods: The study group comprised 32 consecutive patients with malignant head and neck tumours who underwent whole-body F-FDG PET/MR and PET/CT. PET images were reconstructed using the attenuation correction sequence for PET/MR and CT for PET/CT. Two experienced observers evaluated the anonymized data. They evaluated image and fusion quality, lesion conspicuity, anatomic location, number and size of categorized (benign versus assumed malignant) lesions with focal uptake. Region of interest (ROI) analysis was performed to determine SUVs of lesions and organs for both modalities. Statistical analysis considered data clustering due to multiple lesions per patient. Results: PET/MR coregistration and image fusion was feasible in all patients. The analysis included 66 malignant lesions (tumours, metastatic lymph nodes and distant metastases), 136 benign lesions and 470 organ ROIs. There was no statistically significant difference between PET/MR and PET/CT regarding rating scores for image quality, fusion quality, lesion conspicuity or anatomic location, number of detected lesions and number of patients with and without malignant lesions. A high correlation was observed for SUV and SUV measured on PET/MR and PET/CT for malignant lesions, benign lesions and organs ( ρ = 0.787 to 0.877, p < 0.001). SUV and SUV measured on PET/MR were significantly lower than on PET/CT for malignant tumours, metastatic neck nodes, benign lesions, bone marrow, and liver ( p < 0.05). The main factor affecting the difference between SUVs in malignant lesions was tumour size ( p < 0.01). Conclusion: In patients with head and neck tumours, PET/MR showed equivalent performance to PET/CT in terms of qualitative results. Comparison of SUVs revealed an excellent correlation for measurements on both modalities, but underestimation of SUVs measured on PET/MR as compared to PET/CT. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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39. Head and neck tumours: combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types.
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Sumi, Misa and Nakamura, Takashi
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NECK tumors , *HEAD tumors , *SQUAMOUS cell carcinoma , *TUMORS , *LYMPHOMAS , *ADENOMA - Abstract
Objectives: We evaluated the combined use of intravoxel incoherent motion (IVIM) and time-signal intensity curve (TIC) analyses to diagnose head and neck tumours. Methods: We compared perfusion-related parameters ( PP) and molecular diffusion values ( D) determined from IVIM theory and TIC profiles among 92 tumours with different histologies. Results: IVIM parameters ( f and D values) and TIC profiles in combination were distinct among the different types of head and neck tumours, including squamous cell carcinomas (SCCs), lymphomas, malignant salivary gland tumours, Warthin's tumours, pleomorphic adenomas and schwannomas. A multiparametric approach using both IVIM parameters and TIC profiles differentiated between benign and malignant tumours with 97 % accuracy and diagnosed different tumour types with 89 % accuracy. Conclusions: Combined use of IVIM parameters and TIC profiles has high efficacy in diagnosing head and neck tumours. Key points: • Head and neck tumours have wide MR perfusion/diffusion properties. • Dynamic contrast-enhanced (DCE) MR imaging can characterise tumour perfusion (TIC analysis). • Intravoxel incoherent motion (IVIM) imaging can provide diffusion and perfusion properties. • However, IVIM or DCE imaging alone is insufficient for diagnosing head/neck tumours. • Multiparametric approach using both IVIM and TIC profiles can facilitate the diagnosis. [ABSTRACT FROM AUTHOR]
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- 2014
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40. Factors associated with diagnosis delay in head and neck cancer
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Matarredona-Quiles S, Martínez Ruíz de Apodaca P, Serrano Badía E, Ortega Beltrá N, and Dalmau-Galofre J
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Delayed Diagnosis ,Gestión sanitaria ,Professional delay ,Smoking ,Estadio diagnóstico ,General Medicine ,Demora diagnóstica ,Diagnostic delay ,Tumores de cabeza y cuello ,Head and neck tumours ,Diagnostic stage ,Demora médica ,Healthcare management ,Head and Neck Neoplasms ,Humans ,Demora del paciente ,Referral and Consultation ,Patient delay ,Retrospective Studies - Abstract
Introduction and objectives: Tumour stage is an important prognostic factor in head and neck tumours. Many tumours are diagnosed in advanced stages despite almost universal healthcare and their being symptomatic. This paper seeks to determine the diagnostic delay in head and neck tumours in our health department, to analyse factors associated with delay and if it is associated with diagnosis in advanced stages. Methods: Retrospective study of 137 patients with head and neck cancer diagnosed from 2016-2018. Patient delay, delay in primary health care, delay in secondary health care, diagnostic delay and possible associated factors (smoking, location, stage, ...) were evaluated. Results: Many patients (44.5%) were diagnosed in advanced stages. The median patient delay was 30 days. The median referral to otorhinolaryngology was 3.5 days. If the referral was made by another specialist (p = .008), the patients were under previous treatment (P = .000) and the tumours were in initial stages (P = .038) this delay was greater. The median from the first visit to otorhinolaryngology was 15 days, higher in regular referrals (43%) (P=.000). The median diagnostic delay was 12 days, higher in surgical biopsies (P=.000). The median professional delay was 58.5 days and total delay was 118.5 days. Conclusions: Many head and neck tumours are diagnosed in advanced stages. A relationship was not found between diagnosis in advanced stages and diagnostic delay. However, steps must be taken to reduce these excessive delays. (C) 2020 Sociedad Espanola de Otorrinolaringologia y Cirugia de Cabeza y Cuello. Published by Elsevier Espana, S.L.U. All rights reserved.
- Published
- 2020
41. ADVANCED DIAGNOSTIC TECHNIQUES OF METASTATIC NECK LYMPH NODES.
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Jociæ, Maja, Petroviæ, Slaðana, and Stojanov, Dragan
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- *
HEAD & neck cancer diagnosis , *LYMPH node cancer , *COMPUTED tomography , *GLUCOSE metabolism , *MAGNETIC resonance imaging , *POSITRON emission tomography - Abstract
The development of advanced technologies including computerized tomography devices of new generation (MSCT) and MRI devices has enabled the application of high quality techniques that are used for functional analysis of head and neck tumors. Therefore, the role of conventional CT and MR imaging techniques relating to anatomical domain has been transferred to functional level thus enabling better understanding of biological characteristics of the tumor tissue and better differentiation of benign and malignant neck lymph nodes. Positron emissin tomography (PET) is a functional technique that can detect metastatic neck lesions on the basis of increased glucose metabolism in tumor cells. However, due to poor anatomical resolution some hybrid methods (PET / CT and PET / MR) have been designed that provide morphological and functional information about the tumor tissue and thus are considered to be superior in comparison to conventional PET. Perfusion techniques have proved to be beneficial in the diagnosis of head and neck tumors, especially in the diagnosis of recurrent disease after radiotherapy and for the characterization of the lymph nodes. Diffusion weighted imaging (DWI) is very useful in the diagnosis of malignant lymph nodes smaller than 10 mm that are otherwise difficult to diagnose by means of conventional methods. The paper describes the role of high quality techniques including positron emission tomography PET in combination with CT or MRI (PET / CT and PET / MR) in the diagnostics of metastatic neck lymph nodes, possibilities of perfusion imaging techniques (MSCT / MRI) in the analysis of tumor tissues, as well as possibilities of diffusion MR imaging (DWI-MRI) and MRI with nanoparticles of iron oxide in the differentiation of benign and malignant neck lymph nodes. Acta Medica Medianae 2013;52(4):53-57. [ABSTRACT FROM AUTHOR]
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- 2013
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42. Regulation of epigenetic modifications in the head and neck tumour microenvironment.
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Liu H, Wang D, Yang Z, Li S, Wu H, Xiang J, Kan S, Hao M, and Liu W
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- Humans, Epigenesis, Genetic, DNA Methylation, Protein Processing, Post-Translational, Tumor Microenvironment genetics, Head and Neck Neoplasms genetics
- Abstract
Head and neck tumours are common malignancies that are associated with high mortality. The low rate of early diagnosis and the high rates of local recurrence and distant metastasis are the main reasons for treatment failure. Recent studies have established that the tumour microenvironment (TME) can affect the proliferation and metastasis of head and neck tumours via several mechanisms, including altered expressions of certain genes and cytokines. Increasing evidence has shown that epigenetic modifications, such as DNA methylation, histone modification, RNA modification, and non-coding RNAs, can regulate the head and neck TME and thereby influence tumour development. Epigenetic modifications can regulate the expression of different genes and subsequently alter the TME to affect the progression of head and neck tumours. In addition, the cell components in the TME are regulated by epigenetic modifications, which, in turn, affect the behaviour of head and neck tumour cells. In this review, we have discussed the functions of epigenetic modifications in the head and neck TME. We have further examined the roles of such modifications in the malignancy and metastasis of head and neck tumours., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Liu, Wang, Yang, Li, Wu, Xiang, Kan, Hao and Liu.)
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- 2022
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43. STUDY OF DISTRIBUTION OF TUMOURS IN HEAD AND NECK REGION
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O. P. Bhargava, Pranati, J. Sandhya Rani, and K. L. Azad
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Distribution (number theory) ,business.industry ,lcsh:R5-130.5 ,Cytology and Histopathology of Tumours ,Medicine ,Fine needle aspiration cytology (FNAC) ,Head and Neck tumours ,Anatomy ,Head and neck ,business ,lcsh:General works - Abstract
BACKGROUND “Head and neck tumours” form highly specific group, mainly arising in the peripheral nerves, salivary glands, paranasal sinuses, connective tissue, epithelium and skin. Fine needle aspiration cytology (FNAC) is well accepted as a useful diagnostic technique in the management of adult patients with head and neck lumps. Objective was to study the incidence of various” Head and Neck Tumours” in patients attending medical college Hospital Jabalpur and also to correlate histo-cyto pathological findings with clinical findings. MATERIALS AND METHODS The present study comprises of 379 patients who attended the outpatient department or were admitted in the wards of associated hospital of N.S.C.B. Medical College, Jabalpur during the period from July 2003 to July 2005 with the presenting complaint of Tumour. The study was carried out for two years. Permission from Institutional Ethics Committee was obtained. From each and every patient included in the study, initially informed individual consent was taken. RESULTS Benign tumours constitute 107 (28.2 percent) and malignant tumours constitute 272 (71.80 percent) benign and malignant tumour were more common in males constitutes (56.1 percent) and (66.2 percent) respectively. Male to Female ratio for all head and neck tumours was (1. 72:1) for malignant tumours were (2:1) and for benign tumours was (1.27: 1). Cytology was also done in 51 cases out of which 26 were lymph node showing metastatic squamous cell carcinoma 13 FNA were from primary lesions shows squamous cell carcinoma. In four cases, FNA was negative for malignancy but positive histopathologically. 2 benign tumours were incorrectly diagnosed remaining 6 tumours were diagnosed correctly, which were benign. CONCLUSION Incidence, patterns and trends of head and neck tumours were analysed in all age group patients. Incidence of head and neck tumours in relation to all tumours was 23.56 percent. Total 379 cases were studied, out which 272 (71.8 percent), were malignant while 107 (28.2 percent) were benign. 213 tumours were found in oral cavity out of them 187(87.8 percent) were malignant and 26 (13.2 percent) were benign.
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- 2018
44. Pattern of Head and Neck Malignant Tumours in a Tuzla ENT Clinic – A Five Year Experience
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Hasan Altumbabić, Almir Salkić, Almedina Ramaš, Musfaha Burgić, Merima Kasumović, and Fuad Brkić
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head and neck tumours ,epidemiology ,sex ,stage ,distribution ,Biology (General) ,QH301-705.5 - Abstract
Head and neck neoplasia can affect certain fundamental functions, including eating, drinking, speaking and respiration. One overriding factor in deciding on treatment policy is the tendency for head and neck malignancy to be limited to the primary site and regional lymph nodes with surgery and chemotherapy and radiotherapy. The aim of the study was to analyze the occurrence of Head and Neck tumours operated at ENT clinic Tuzla, University Clinical Center Tuzla, Bosnia and Herzegovina. Medical records of patients with histopathologically confirmed head and neck malignancies over a 5 year period (2003-2007) were analyzed. Eight hundred and eight one (881) cases, made up of 519 (58,8%) males and 362 (41,1%) females were found. The most common sites for head and neck malignancies were found to be in the larynx (26,1%), oral cavity (21,7%), the thyroid gland (14,64 %) and the neck (8,51%). A total of 230 patients were diagnosed with laryngeal carcinoma (M:173; E57), showing the increasing number of female patients. The histopathological tumour types found in this work were mostly squamous cell carcinoma (72,09%), papillary carcinoma (12,2%), while many other minor histopathological variants accounted for 13%. The most patients were presented with stage I and stage III of disease (27% and 28,3%), and 19,9% with stage IV. About 40% of patients did not have data about smoking habit and alcohol drinking. The incidence of head and neck tumours seems to be relatively high, but without significant increase during investigated period. More investigation concerning risk factors, diagnostic procedures, and management strategies should be done in future.
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- 2008
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45. Transoral robotic surgery in the management of head and neck tumours.
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Rinaldi, Vittorio, Pagani, Davide, Torretta, Sara, and Pignataro, Lorenzo
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ROBOTICS , *NECK tumors , *HYPOPHARYNX , *OROPHARYNX , *ONCOLOGY - Abstract
The article reviews the use of robotic technology for head and neck tumours. The authors discuss the development of transoral robotic surgery (TORS), the current status of the technology, and the set-up in the operating room. The article provides a review of the literature, highlighting the applications, advantages, functional outcomes, and disadvantages of TORS for each anatomic subsite (oropharynx, hypopharynx, larynx, parapharyngeal space, and skull base). New challenges related to reconstruction are also presented. Overall early functional and oncologic outcome data are promising; further long-term prospective trials are still needed to confirm the oncological safety of TORS [ABSTRACT FROM AUTHOR]
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- 2013
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46. Exploratory geographical analysis of hypoxic subvolumes using 18F-MISO-PET imaging in patients with head and neck cancer in the course of primary chemoradiotherapy.
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Bittner, Martin-Immanuel, Wiedenmann, Nicole, Bucher, Sabine, Hentschel, Michael, Mix, Michael, Weber, Wolfgang A., and Grosu, Anca-Ligia
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- *
CANCER radiotherapy , *CANCER chemotherapy , *HEAD & neck cancer treatment , *HEALTH outcome assessment , *CANCER prognosis - Abstract
Abstract: Background and purpose: Hypoxia in head and neck tumours is associated with poor prognosis and outcome, and can be visualized using 18F-MISO-PET imaging; however, it is not clear whether the size and location of hypoxic subvolumes remain stable during therapy. In a pilot project, we conducted an exploratory analysis of persistent tumour hypoxia during treatment. Materials and methods: Sixteen patients with locally advanced head and neck tumours underwent consecutive 18F-MISO-PET scans before and during primary chemoradiotherapy. The size, location and overlap of the hypoxic subvolumes were analysed using a semi-automatic algorithm based on a tumour to normal tissue ratio of 1.5. Results: Quantitative evaluation showed tumour hypoxia in week 0 in 16 out of 16 and in week 2 in 5 out of 14 patients. For the five patients with persistent hypoxia, both increased and decreased hypoxic subvolumes could be observed. Mean hypoxic subvolume overlap was 55% of the hypoxic volume of the first scan and 72% of the hypoxic volume of the second scan. A stationary (in four out of five patients) and dynamic component (in three out of five patients) could be differentiated. Conclusion: In patients with persistent hypoxia after 2weeks of treatment, the hypoxic subvolumes showed mostly a geographically relatively stable conformation. [Copyright &y& Elsevier]
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- 2013
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47. Rzadki przypadek mięśniaka poprzecznieprążkowanego (rhabdomyoma) okolicy podżuchwowej, podbródkowej i dna jamy ustnej.
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MARKOWSKI, JAROSŁAW, ŚWIDEREK-KLISZEWSKA, MONIKA, GIEREK, TATIANA, LIKUS, WIRGINIA, PAJĄK, JACEK, LEPICH, TOMASZ, and WITKOWSKA, MAŁGORZATA
- Abstract
Introduction. Rhabdomyoma in adults is a rare benign tumor originating from striated muscle cells. It was first described by Zenker in 1864. The term rhabdomyoma is now used for two types of tumours: cardiac rhabdomyoma and the far rarer extracardiac form. Ninety per cent of the tumours occur in the head and neck region. Material and methods. We present a case of rhabdomyoma localized in the submandibular and mental area in a 46-year-old man. The patient had been originally treated twice by surgery at the Department of Maxillofacial Surgery. The procedure had proved to be non-radical, the tumour recurred, and the patient was sent to the ENT Department of the Silesian Medical University. The patient was operated from external approach under general anaesthesia. Central tracheotomy was performed and the tumour was removed from the floor of oral cavity and submandibular region, including the submandibular gland. Results. Eighteen-month follow-up did not reveal symptoms of tumour recurrence. Conclusions. Rhabdomyoma should always be considered in case of neck tumours, particularly those that are slow-growing, non-painful and oligosymptomatic. The patients should be followed- up even several tens of years after the surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2012
48. Odległa analiza kliniczna chorych operowanych z powodu przyzwojaków niechromochłonnych.
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Markowski, Jarosław, Dziubdziela, Włodzimierz, Gierek, Tatiana, Budziński, Grzegorz, Pająk, Jacek, Klimczak-Gołąb, Lucyna, Pasternak, Katarzyna, Witkowska, Małgorzata, Mazurek, Klaudia, and Wardas, Piotr
- Abstract
Introduction. Nonchromaffin paragangliomas (chemodectomas) are rare tumors of the nervous system. They are formed from receptive cells of the parasympathetic autonomic system that create groups of nonchromaffin paragangliomatic bodies. The term 'chemodectoma' is related to the chemoreceptive abilities of the neoplastic cells. In the head and neck region they are usually situated in glomus caroticum, glomus tympanicum, glomus vagale and glomus jugulare. Aim. The aim of study was a long-term clinical analysis of three paragangliomatic patients treated by surgery. Materials and methods. The authors present a retrospective study of three glomus tumours: two situated in glomus caroticum and one in glomus tympanicum. Results. Imaging techniques, such as computed tomography, magnetic resonance and arteriography were found to be vital for successful preoperative diagnostics. In both patients with glomus caroticum tumour, a paralysis of the vocal folds was observed on the operated side after 13 and 6 years since the surgical treatment. There were no differences in hearing ability in the patient with glomus tympanicum tumor after 10 years since the surgery. Conclusions. The prognosis for benign glomus tumours is good, while considerable experience is required in their surgical treatment due to the risk of profuse intraoperative heamorrhage. The paralysis of the vocal fold after glomus caroticum surgery is irreversible. [ABSTRACT FROM AUTHOR]
- Published
- 2012
49. Acute toxicity in 14 patients with locally advanced head and neck squamous cell carcinoma treated with concurrent cetuximab and radiotherapy.
- Author
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Valeriani, M., Muni, R., Osti, M., Sanctis, V., Minniti, G., Ardito, F., and Maurizi Enrici, R.
- Abstract
Copyright of La Radiologia Medica is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
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50. Neuerungen der TNM-Klassifikation der Kopf-Hals-Tumoren.
- Author
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Weber, A., Schmid, K.W., Tannapfel, A., and Wittekind, C.
- Abstract
Copyright of Der Pathologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
- Full Text
- View/download PDF
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