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Using hand gestures is a natural method of interaction between humans and computers. We use gestures to express meaning and thoughts in our everyday conversations. Gesture-based interfaces are used in many applications in a variety of fields, such as smartphones, televisions (TVs), video gaming, and so on. With advancements in technology, hand gesture recognition is becoming an increasingly promising and attractive technique in human-computer interaction. In this paper, we propose a novel method for fingertip detection and hand gesture recognition in real-time using an RGB-D camera and a 3D convolution neural network (3DCNN). This system can accurately and robustly extract fingertip locations and recognize gestures in real-time. We demonstrate the accurateness and robustness of the interface by evaluating hand gesture recognition across a variety of gestures. In addition, we develop a tool to manipulate computer programs to show the possibility of using hand gesture recognition. The experimental results showed that our system has a high level of accuracy of hand gesture recognition. This is thus considered to be a good approach to a gesture-based interface for human-computer interaction by hand in the future. [ABSTRACT FROM AUTHOR]