3,056 results on '"gene polymorphisms"'
Search Results
2. Association of Gene Polymorphisms and Serum Levels of ALAS1 with the Risk of Anti‐Tuberculosis Drug‐Induced Liver Injury.
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Han, Bing, He, Yiwen, Zhu, Min, Zhang, Meiling, Lu, Lihuan, Xu, Xiaoyan, He, Xiaomin, Yi, Honggang, and Tang, Shaowen
- Abstract
The accumulation of protoporphyrin IX in the liver caused by isoniazid and rifampicin through the disorder of heme biosynthesis was considered an important mechanism of anti‐tuberculosis drug‐induced liver injury (ATLI). Alanine synthase 1 (ALAS1) is a rate‐limiting enzyme in the process of heme synthesis. This study aimed to investigate the association between ALAS1 gene polymorphism, serum ALAS1 level, and the risk of ATLI. This study was a case‐control study including 58 ATLI cases and 192 controls. Four single nucleotide polymorphisms (SNPs) of the ALAS1 gene were selected for genotyping and serum ALAS1 concentrations were detected using ELISA kits. There was no significant difference in the genotype distribution of four SNPs between the ATLI cases and the controls under different genetic models. Patients carrying the GG genotype of SNP rs352163 in controls had higher baseline ALAS1 levels than those in ATLI cases (243.6 vs 290.2 ng/L,
P = .034), and patients with baseline ALAS1 < 337.85 ng/L had a higher risk of ATLI than those with ALAS1 ≥ 337.85 ng/L (HR = 2.679, 95% CI: 1.360‐5.278,P = .004). Our findings indicated that the serum ALAS1 concentrations in the ATLI cases were lower than those in the controls, and the lower baseline ALAS1 levels can be associated with higher ATLI risk. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Association between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis.
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Rongshan Tao, Shujuan Xiao, Lianping Wang, Chunjie Hu, Huiqin Suo, Ruiyu Long, Hangyu Liu, Wei Luo, Feng Hong, Jingming Zhao, and Qingjie Li
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VITAMIN D receptors ,VITAMIN D deficiency ,GENETIC polymorphisms ,VITAMIN D - Abstract
Objective: Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (VDR) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between VDR polymorphisms and TB susceptibility. Methods: We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (OR) and 95% confidence interval (CI) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses. Results: In our meta-analysis, we found that the FokI polymorphism in the VDR gene was associated with increased TB susceptibility in the allele and recessive genotype models (OR f vs. F = 1.235, 95%CI: 1.035-1.475; OR ff vs. Ff + FF = 1.317, 95%CI: 1.00-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the VDR gene. However, publication year was another source of heterogeneity for the TaqI polymorphism. Conclusion: In summary, the FokI polymorphism in the VDR gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Interleukin (IL)-1B and IL-1 receptor antagonist gene polymorphisms in children with primary immune thrombocytopenia.
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Ragab, Seham Mohamed, Abo Elfotoh, Wafaa Moustafa, El-Hawy, Mahmoud Ahmed, Badr, Eman Abdelfatah, Ali Mostafa, Saara Khairat, and Abd El-Hamid, Mai El-Sayad
- Abstract
Background: The pathophysiology and susceptibility of children to primary immune thrombocytopenia (ITP) are linked to polymorphisms of the interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonist genes. Purpose: To investigate the association between the susceptibility and severity of primary ITP in children and the IL-1B and IL-1R antagonist gene polymorphisms. Methods: This comparative case-control study was conducted at the Menoufia University Hospital Hematology and Oncology Unit, Pediatric Department, between August 2022 and September 2023. The children were divided into patients (28 boys, 22 girls) who received hospital and outpatient clinic care and controls (50 healthy age- and sex-matched children). Results: The mutant homozygous GG genotype and mutant G allele of rs16944 of the IL1B gene were considerably greater in patients than in controls (P<0.001). Furthermore, the mutant homozygous II/II genotype and heterozygous I/II genotype of the IL-1R antagonist gene were considerably greater in the case versus control group. The mutant II allele was significantly more prevalent in patients versus controls (P<0.001). Conclusion: IL-1B and IL-1R antagonists may have a major impact on the development of immune thrombocytopenia. Furthermore, we found a relationship between IL-1B and IL-1R antagonist gene polymorphisms and the etiology of and children's susceptibility to primary immune thrombocytopenia. [ABSTRACT FROM AUTHOR]
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- 2024
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5. The Impact of ARMS2 (rs10490924), VEGFA (rs3024997), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), and IL1B1 (rs1143623) Polymorphisms and Serum Levels on Age-Related Macular Degeneration Development and Therapeutic Responses.
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Cebatoriene, Dzastina, Vilkeviciute, Alvita, Gedvilaite-Vaicechauskiene, Greta, Duseikaite, Monika, Bruzaite, Akvile, Kriauciuniene, Loresa, Zaliuniene, Dalia, and Liutkeviciene, Rasa
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MACULAR degeneration , *ENDOTHELIAL growth factors , *BIOMARKERS , *GENETIC models , *GENE therapy - Abstract
Age-related macular degeneration (AMD) is a major global health problem as it is the leading cause of irreversible loss of central vision in the aging population. Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective but do not respond optimally in all patients. This study investigates the genetic factors associated with susceptibility to AMD and response to treatment, focusing on key polymorphisms in the ARMS2 (rs10490924), IL1B1 (rs1143623), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), VEGFA (rs3024997), ARMS2, IL1B1, TNFRSF1B, TNFRSF1A, and VEGFA serum levels in AMD development and treatment efficacy. This study examined the associations of specific genetic polymorphisms and serum protein levels with exudative and early AMD and the response to anti-VEGF treatment. The AA genotype of VEGFA (rs3024997) was significantly associated with a 20-fold reduction in the odds of exudative AMD compared to the GG + GA genotypes. Conversely, the TT genotype of ARMS2 (rs10490924) was linked to a 4.2-fold increase in the odds of exudative AMD compared to GG + GT genotypes. In females, each T allele of ARMS2 increased the odds by 2.3-fold, while in males, the TT genotype was associated with a 5-fold increase. Lower serum IL1B levels were observed in the exudative AMD group compared to the controls. Early AMD patients had higher serum TNFRSF1B levels than controls, particularly those with the GG genotype of TNFRSF1B rs1061622. Exudative AMD patients with the CC genotype of TNFRSF1A rs4149576 had lower serum TNFRSF1A levels compared to the controls. Visual acuity (VA) analysis showed that non-responders had better baseline VA than responders but experienced decreased VA after treatment, whereas responders showed improvement. Central retinal thickness (CRT) reduced significantly in responders after treatment and was lower in responders compared to non-responders after treatment. The T allele of TNFRSF1B rs1061622 was associated with a better response to anti-VEGF treatment under both dominant and additive genetic models. These findings highlight significant genetic and biochemical markers associated with AMD and treatment response. This study found that the VEGFA rs3024997 AA genotype reduces the odds of exudative AMD, while the ARMS2 rs10490924 TT genotype increases it. Lower serum IL1B levels and variations in TNFRSF1B and TNFRSF1A levels were linked to AMD. The TNFRSF1B rs1061622 T allele was associated with better anti-VEGF treatment response. These markers could potentially guide risk assessment and personalized treatment for AMD. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study.
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Fu, Yanqi, Lu, Meng, Zhang, Kun, Sun, Ying, Tan, Xiao, Wang, Ningjian, Xu, Fei, Jiang, Boren, Lu, Yingli, and Wang, Bin
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TYPE 2 diabetes ,PROPORTIONAL hazards models ,VITAMIN D receptors ,VITAMIN D ,GENETIC variation ,PREDIABETIC state - Abstract
Context Vitamin D status has been associated with risk of type 2 diabetes (T2D), but evidence is scarce regarding whether such relation differs by glycemic status. Objective To prospectively investigate the association between serum 25-hydroxyvitamin D (25(OH)D) and risk of incident T2D across the glycemic spectrum and the modification effect of genetic variants in the vitamin D receptor (VDR). Methods This prospective study included 379 699 participants without T2D at baseline from the UK Biobank. Analyses were performed according to glycemic status and HbA
1c levels. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs. Results During a median of 14.1 years of follow-up, 6315 participants with normoglycemia and 9085 patients with prediabetes developed T2D. Compared with individuals with 25(OH)D < 25 nmol/L, the multivariable-adjusted HRs (95% CIs) of incident T2D for those with 25(OH)D ≥ 75 nmol/L was 0.62 (0.56, 0.70) among the normoglycemia group and 0.64 (0.58, 0.70) among the prediabetes group. A significant interaction was observed between 25(OH)D and VDR polymorphisms among participants with prediabetes (P interaction =.017), whereby the reduced HR of T2D associated with higher 25(OH)D was more prominent in those carrying the T allele of rs1544410. Triglyceride levels mediated 26% and 34% of the association between serum 25(OH)D and incident T2D among participants with normoglycemia and prediabetes, respectively. Conclusion Higher serum 25(OH)D concentrations were associated with lower T2D risk across the glycemic spectrum below the threshold for diabetes, and the relations in prediabetes were modified by VDR polymorphisms. Improving the lipid profile, mainly triglycerides, accounted for part of the favorable associations. [ABSTRACT FROM AUTHOR]- Published
- 2024
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7. Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.
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Ciulei, George, Orășan, Olga Hilda, Cozma, Angela, Negrean, Vasile, Para, Ioana, Ciumărnean, Lorena, Leach, Nicoleta, Lucaciu, Roxana Liana, Hangan, Adriana Corina, and Procopciuc, Lucia Maria
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VITAMIN D receptors , *INSULIN receptors , *TYPE 2 diabetes , *VITAMIN D deficiency , *GENETIC polymorphisms - Abstract
Vitamin D deficiency and type 2 diabetes mellitus are risk factors for colorectal cancer, suggesting a role for vitamin D receptor (VDR) and insulin receptor (INSR) gene polymorphisms. We investigated the prevalence of the VDR-BsmI (rs1544410) and NsiI A/G-INSR (rs2059806) polymorphisms and their associations with colorectal adenoma (CRA) in a Romanian population. A case–control study was conducted with 110 participants (67 with CRA and 43 controls) who underwent colonoscopy. Polymerase chain reaction–restriction fragment length polymorphism analysis was used to determine the genotype and allele frequencies of the two polymorphisms. Regarding rs1544410 and CRA patients, genotype distribution was 35% B/B, 47% B/b, and 19% b/b. In the controls, the distribution was 21% B/B, 45% B/b, and 34% b/b. For rs2059806, 12% of CRA patients had A/A, 30% A/G, and 58% G/G, while 8% of the controls had A/A, 40% A/G, and 52% G/G. The recessive model showed an odds ratio of 2.84 (95% CI: 1.04–7.72, p = 0.033) for the b/b genotype. CRA patients with b/b or G/G genotypes were diagnosed at a younger age. The b allele of the rs1544410 was a risk factor for CRA. Patients with the b/b and G/G genotypes were diagnosed earlier. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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8. Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection.
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Zhou, Shihang, Zheng, Ziwei, Wang, Liying, Song, Wenqian, Xia, Yuexin, Shao, Linnan, and Liang, Xiaohua
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HELICOBACTER pylori infections , *GENETIC polymorphisms , *GENETIC variation , *HELICOBACTER pylori , *CHINESE people - Abstract
Background: Helicobacter pylori infection is a significant pathogen in gastrointestinal diseases. Previous studies have identified single‐nucleotide polymorphisms (SNPs) are factors associated with H. pylori infection. Notably, Leb and Sialyl‐Lex antigens, regulated by the FUT3 and FUT6 genes, play a crucial role in H. pylori infection. This study aimed to investigate the correlation between FUT3 and FUT6 gene polymorphisms and H. pylori infection in the Han population of northern China. Materials and Methods: An immunoturbidimetric assay was employed to detect H. pylori infection, categorizing subjects into infected and noninfected groups. Gene variants were identified through sequencing. Finally, FUT3 and FUT6 gene polymorphisms were analyzed to assess their association with H. pylori infection. Results: The frequency of the T allele (rs778805) and the G allele (rs61147939) in the infection group was significantly higher than that in the noninfection group (63.4% vs. 55.1%, p = 0.045; 55.2% vs. 47.0%, p = 0.042, respectively). In the infection group, the frequency of the AA genotype (rs3745635) in the recessive model, the TT genotype (rs778805) in the recessive model, and the GG genotype (rs61147939) in the recessive model were significantly higher than the noninfection group (5.8% vs. 2.3%, p = 0.042; 41.9% vs. 29.3%, p = 0.022; 34.9% vs. 20.5%, p = 0.0068, respectively). The frequency of the A13 haplotype and the A13/A13 diplotype of the FUT6 gene was significantly higher in the infection group than in the noninfection group (55.56% vs. 46.32%, p = 0.019; 34.94% vs. 20.30%, p = 0.045, respectively). The rs778805‐rs17855739‐rs28362459‐rs3745635 combination was identified as the best interaction model (p < 0.05). Conclusions: This study suggests that FUT3 and FUT6 gene polymorphisms are significantly associated with H. pylori infection in the Han Chinese from northern China. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Genetic Markers of Acute Childhood B-Lineage Lymphoblastic Leukemia in the Kazakh Population.
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Svyatova, Gulnara, Berezina, Galina, Bazarbayeva, Aigul, Omarova, Kulyan, and Kussainov, Abay
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LYMPHOBLASTIC leukemia , *GENETIC markers , *LOCUS (Genetics) , *GENETIC variation , *GENETIC polymorphisms - Abstract
AbstractIntroductionMethodsResultsDiscussionTo investigate the genetic contribution of 24 GWAS-associated polymorphic gene variants on the development of children’s B-lineage acute lymphoblastic leukemia (B-ALL) in an ethnically homogeneous population of Kazakhs.A study of 205 children with B-ALL and 204 healthy children was conducted. Genotyping of polymorphic loci was carried out using the TaqMan method.Significant associations (
p < 0.05) with the risk of childhood B-ALL were found for twelve variants, including rs6457327 of the HLA gene, rs4251961 of the IL1RN gene, and rs1800630 of the TNF gene. Carriage of the minor allele A of the protective rs1801157 polymorphism A of the CXCL12 gene reduces the risk of B-ALL in the Kazakh population by 40%.The results reveal significant associations of polymorphic genetic variants, which can serve as a basis for the development of effective methods for predicting the risk of B-ALL, early diagnosis, and timely treatment. [ABSTRACT FROM AUTHOR]- Published
- 2024
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10. NFKB1 variants were associated with the risk of Parkinson´s disease in male.
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Perez-Oliveira, Sergio, Vazquez-Coto, Daniel, Pardo, Sara, Blázquez-Estrada, Marta, Menéndez-González, Manuel, Siso, Pablo, Suárez, Esther, García-Fernández, Ciara, Fages, Beatriz de la Casa, Coto, Eliecer, and Álvarez, Victoria
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PARKINSON'S disease , *NF-kappa B , *GENDER differences (Sociology) , *PATIENTS , *LINKAGE disequilibrium - Abstract
The NF-κB pathway is involved in the pathogenesis of neurological disorders that have inflammation as a hallmark, including Parkinson's disease (PD). Our objective was to determine whether common functional variants in the NFKB1, NFKBIA and NFKBIZ genes were associated with the risk of PD. A total of 532 Spanish PD cases (61% male; 38% early-onset, ≤ 55 years) and 300 population controls (50% ≤55 years) were genotyped for the NFKB1 rs28362491 and rs7667496, NFKBIA rs696, and NFKBIZ rs1398608 polymorphisms. We compared allele and genotype frequencies between early and late-onset, male and female, and patient's vs. controls. We found that the two NFKB1 alleles were significantly associated with PD in our population (p = 0.01; total patients vs. controls), without difference between Early and Late onset patients. The frequencies of the NFKB1 variants significantly differ between male and female patients. Compared to controls, male patients showed a significantly higher frequency of rs28362491 II (p = 0.02, OR = 1.52, 95%CI = 1.10–2.08) and rs28362491 C (p = 0.003, OR = 1.62, 95%CI = 1.18–2.22). The two NFKB1 variants were in strong linkage disequilibrium and the I-C haplotype was significantly associated with the risk of PD among male (p = 0.002). In conclusion, common variants in the NF-kB genes were associated with the risk of developing PD in our population, with significant differences between male and female. These results encourage further studies to determine the involvement of the NF-kB components in the pathogenesis of Parkinson´s disease. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial
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Yukiko Owaki, Hisashi Yoshimoto, Go Saito, Shohei Dobashi, Satoshi Kushio, Akihiro Nakamura, Takahiro Goto, Yusuke Togo, Kazumasa Mori, and Hideki Hokazono
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Excessive drinking ,ALDH2 ,ADH1B ,Gene polymorphisms ,Japanese ,College students ,Medicine - Abstract
Abstract Background It is unclear whether brief interventions using the combined classification of alcohol-metabolizing enzymes aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) together with behavioral changes in alcohol use can reduce excessive alcohol consumption. This study aimed to examine the effects of a brief intervention based on the screening of ALDH2 and ADH1B gene polymorphisms on alcohol consumption in Japanese young adults. Methods In this open-label randomized controlled trial, we enrolled adults aged 20–30 years who had excessive drinking behavior (average amount of alcohol consumed: men, ≥ 4 drinks/per day and women, ≥ 2 drinks/per day; 1 drink = 10 g of pure alcohol equivalent). Participants were randomized into intervention or control group using a simple random number table. The intervention group underwent saliva-based genotyping of alcohol-metabolizing enzymes (ALDH2 and ADH1B), which were classified into five types. A 30-min in-person or online educational counseling was conducted approximately 1 month later based on genotyping test results and their own drinking records. The control group received traditional alcohol education. Average daily alcohol consumption was calculated based on the drinking diary, which was recorded at baseline and at 3 and 6 months of follow-up. The primary endpoint was average daily alcohol consumption, and the secondary endpoints were the alcohol-use disorder identification test for consumption (AUDIT-C) score and behavioral modification stages assessed using a transtheoretical model. Results Participants were allocated to the intervention (n = 100) and control (n = 96) groups using simple randomization. Overall, 28 (29.2%) participants in the control group and 21 (21.0%) in the intervention group did not complete the follow-up. Average alcohol consumption decreased significantly from baseline to 3 and 6 months in the intervention group but not in the control group. The reduction from baseline alcohol consumption values and AUDIT-C score at 3 months were greater in the intervention group than in the control group (p
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- 2024
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12. Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants
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Kaushal Kishor Agrawal, MDS, Neetu Singh, PhD, Pooran Chand, MDS, Saumyendra Vikram Singh, MDS, Neeti Solanki, MDS, Ravindra Kumar Garg, DM, and Akhilanand Chaurasia, MDS
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Dental implants ,Early crestal bone loss ,Gene polymorphisms ,Low bone density ,Osteoporosis ,Medicine (General) ,R5-920 - Abstract
المخلص: أهداف البحث: يستقصي هذا البحث تأثير تعدد أشكال الجينات لإنترلوكين ١ وإنترلوكين ٦ على كثافة المعادن في العظام وفقدان العظم الهامشي حول زراعة الأسنان. ومع ذلك، فإن تأثير كثافة المعادن بالعظام النظامية على تباين فقدان العظام الهامشي المحيط بالزرعة ليس واضحا. وبالتالي، تم إجراء هذه الدراسة للتحقق من ارتباط تعدد أشكال الجينات إنترلوكين ١ وإنترلوكين ٦ مع كثافة المعادن بالعظام الجهازية و فقدان العظام الهامشي حول زراعة الأسنان. طرق البحث: شملت الدراسة ١٩٠ مشاركا تم اختيارهم لزراعة الأسنان في المنطقة الخلفية للفك السفلي. تم تصنيف المشاركين بناء على كثافة المعادن في العظام المقاسة بالأشعة السينية ثنائية الطاقة: كثافة المعادن الطبيعية في العظام (93 مشاركا)، معدل ت ≥ -1 كثافة المعادن المنخفضة في العظام بما في ذلك هشاشة العظام وترقق العظام (97 مشاركا)، معدل ت ≤ -1 الانحراف المعياري. تم وضع زرعات الأسنان وفقا للبروتوكولات الجراحية القياسية، وتم قياس فقدان العظم الهامشي بعد ٦ أشهر باستخدام المسح الطبقي المحوري قبل جراحة المرحلة الثانية. تم إجراء تحديد النمط الجيني لكافة المشاركين للجينات آي إل-1أ-889 أ/ج، آي إل-1ب-511 ج/أ، آي إل-1ب+3954 ، و آي إل-6-572 س/ج لتحليل تعدد أشكال الجينات. النتائج: قارنت الدراسة الخصائص الديموغرافية والسريرية للمشاركين ذوي الكثافة العظمية الطبيعية والمنخفضة. وجدت الدراسة ارتباطات هامة بين تعدد أشكال الجينات إنترلوكين ١ وإنترلوكين ٦ وزيادة فقدان العظم الهامشي حول زرعات الأسنان لدى المشاركين ذوي الكثافة العظمية المنخفضة. الاستنتاجات: كان الأفراد الذين يحملون الأنماط الجينية المعينة (إنترلوكين ١ب-٥١١ ألف ألف أو إنترلوكين ٦-٥٧٢ جي جي) في خطر متزايد للإصابة بترقق العظام أو هشاشة العظام. وكانوا أيضا أكثر عرضة لفقدان العظم الهامشي حول زرعات الأسنان. Abstract: Objectives: Interleukin 1 (IL-1) and interleukin 6 (IL-6) gene polymorphisms have been suggested to be responsible for diminished bone mineral density (BMD) and high crestal bone loss (CBL) in some individuals. However, the effects of systemic BMD on variations in peri-implant CBL are unclear. Hence, this study was aimed at investigating the association of IL-1 and IL-6 gene polymorphisms with systemic BMD and CBL around dental implants. Methods: A total of 190 participants undergoing dental implantation in the mandibular posterior region were selected according to predetermined selection criteria and divided into a normal BMD group (NBD, 93 participants, T-score ≥ −1) and low BMD group (LBD, including both osteoporosis and osteopenia, 97 participants, T-score
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- 2024
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13. Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial.
- Author
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Owaki, Yukiko, Yoshimoto, Hisashi, Saito, Go, Dobashi, Shohei, Kushio, Satoshi, Nakamura, Akihiro, Goto, Takahiro, Togo, Yusuke, Mori, Kazumasa, and Hokazono, Hideki
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ALCOHOL drinking , *YOUNG adults , *BEHAVIOR modification , *RANDOMIZED controlled trials , *DRINKING behavior , *OXYGEN consumption - Abstract
Background: It is unclear whether brief interventions using the combined classification of alcohol-metabolizing enzymes aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) together with behavioral changes in alcohol use can reduce excessive alcohol consumption. This study aimed to examine the effects of a brief intervention based on the screening of ALDH2 and ADH1B gene polymorphisms on alcohol consumption in Japanese young adults. Methods: In this open-label randomized controlled trial, we enrolled adults aged 20–30 years who had excessive drinking behavior (average amount of alcohol consumed: men, ≥ 4 drinks/per day and women, ≥ 2 drinks/per day; 1 drink = 10 g of pure alcohol equivalent). Participants were randomized into intervention or control group using a simple random number table. The intervention group underwent saliva-based genotyping of alcohol-metabolizing enzymes (ALDH2 and ADH1B), which were classified into five types. A 30-min in-person or online educational counseling was conducted approximately 1 month later based on genotyping test results and their own drinking records. The control group received traditional alcohol education. Average daily alcohol consumption was calculated based on the drinking diary, which was recorded at baseline and at 3 and 6 months of follow-up. The primary endpoint was average daily alcohol consumption, and the secondary endpoints were the alcohol-use disorder identification test for consumption (AUDIT-C) score and behavioral modification stages assessed using a transtheoretical model. Results: Participants were allocated to the intervention (n = 100) and control (n = 96) groups using simple randomization. Overall, 28 (29.2%) participants in the control group and 21 (21.0%) in the intervention group did not complete the follow-up. Average alcohol consumption decreased significantly from baseline to 3 and 6 months in the intervention group but not in the control group. The reduction from baseline alcohol consumption values and AUDIT-C score at 3 months were greater in the intervention group than in the control group (p < 0.001). In addition, the behavioral modification stages were significantly changed by the intervention (p < 0.001). Conclusions: Genetic testing for alcohol-metabolizing enzymes and health guidance on type-specific excessive drinking may be useful for reducing sustained average alcohol consumption associated with behavioral modification. Trial registration: R000050379, UMIN000044148, Registered on June 1, 2021. [ABSTRACT FROM AUTHOR]
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- 2024
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14. 福州地区汉族人群 Mfn2 基因多态性 与超重/肥胖易感性的关系.
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黄惠娟, 俞烜华, 张富, 梁玲, 淼鋆, 陈孔敏, and 黄文金
- Abstract
Objective To investigate the relationships between mitofusin-2 (Mfn 2) gene polymorphism and susceptibility to overweight/obesity in Han population of Fuzhou. Methods A total of 198 healthy subjects of Han nationality in Fuzhou were selected, of whom 104 were of normal body weight and 94 were overweight/obese. Fasting venous blood was collected and the genotypes of rs2295281 locus of Mfn2 gene were detected by Sanger sequencing. The frequency of gene loci and genotype were counted. After adjusting the confounding factors, the relationships between different genotypes and susceptibility to overweight/obesity were analyzed by unconditioned Logistic regression model. Further stratification by sex was conducted to analyze the relationships between different genotypes and overweight/obesity susceptibility in male and female populations. Results There were three genotypes (namely CT, TT, and CC) in the rs2295281 site of Mfn2 gene, including 78 cases of CC genotype, 88 cases of CT genotype and 32 cases of TT genotype. The frequency of C allele was 61. 62% and the frequency of the T allele was 38. 38%. The results of the Logistic-regression analysis showed that, the T allele at the rs2295281 locus of the Mfn 2 gene had an increased risk of developing overweight/obesity in com- parison with the C allele ( P = 0, OR = 1 688, 95% CI 1.088-2.618), the TT genotype had an increased risk in com- parison with the CC genotype ( P = 0, OR = 3 3.099, 95% CI 1. 214-7.909), the TT genotype also had an increased risk in comparison with CC + CT genotype ( P = 0, OR = 2 572, 95% CI 1. 086-6.089). Stratified statistics based on gen- der found that, in males, T allele was associated with an increased risk of overweight/obesity in comparison with C allele P = 0, OR = 1 1.900, 95%CI 1. 022-3.533), CT genotype was associated with an increased risk in comparison with CC genotype ( P = 0, OR = 2.803 OR = 2.803 ), and CT + TT genotype had a higher risk than CC genotype ( P = 0.02, OR= 2.784, 95%CI 1. 178-6.584); in females, TT genotype was associated with an increased risk of overweight/obesity in comparison with CC + CT genotype (P=0.014, OR = 4 683, 95% CI 1. 366 to 16. 047). Conclusions There is an obvious correlation between the gene distribution frequency of the rs2295281 locus of Mfn 2 gene and the susceptibility to over- weight/obesity. The T allele may increase the risk, and men with CT gene and women with TT gene can have diet and exercise intervention as early as possible. [ABSTRACT FROM AUTHOR]
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- 2024
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15. The effect of single nucleotide polymorphisms on depression in combination with coronary diseases: a systematic review and meta-analysis.
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Jing Zhang, Lu Gao, Guan Lin Yang, and De Zhao Kong
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SEROTONIN ,SINGLE nucleotide polymorphisms ,CORONARY disease ,RECESSIVE genes ,GENETIC models ,GENETIC polymorphisms ,DOMINANCE (Genetics) - Abstract
Background: Depression and coronary heart disease (CHD) have common risk mechanisms. Common single nucleotide polymorphisms (SNPs) may be associated with the risk of depression combined with coronary heart disease. Methods: This study was designed according to the PRISMA-P guidelines. We will include case-control studies and cohort studies investigating the relationship between gene SNPs and depression and coronary heart disease comorbidities. The Newcastle- Ottawa Scale (NOS) will be used to assess the risk of bias. When measuring dichotomous outcomes, we will use the odds ratio (OR) and 95% confidence interval (95%CIs) in a case-control study. Five genetic models (allele model, homozygous model, co-dominant model, dominant model, and recessive model) will be evaluated for each included study. Subgroup analysis by ethnicity will be performed. If necessary, post hoc analysis will be made according to different types. Results: A total of 13 studies were included in this study, and the types of genes included are FKBP5 and SGK1 genes that act on glucocorticoid;miR-146a, IL-4-589, IL-6-174, TNF-a-308, CRP-717 genes that act on inflammatory mechanisms; eNOS genes from endothelial cells; HSP70 genes that act on the autoimmune response; ACE2 and MAS1 genes that act to mediate Ang(1-7) in the RAS system; 5-HTTLPR gene responsible for the transport of serotonin 5-HT and neurotrophic factor BDNF gene. There were three studies on 5-HTTLPR and BDNF genes, respectively, while there was only one study targeting FKBP5, SGK1, miR-146a, IL-4-589, IL-6-174, TNF-alpha-308, CRP-717, eNOS, HSP70, ACE2, and MAS1 genes. We did not perform a meta-analysis for genes reported in a single study, and meta-analysis was performed separately for studies exploring the 5-HTTLPR and BDNF genes. The results showed that for the 5-HTTLPR gene, there was a statistically significant association between 5-HTTLPR gene polymorphisms and depression in combination with coronary diseases (CHD-D) under the co-dominant model (LS vs LL:OR 1.76, 95%CI 1.20-2.59; SS vs LL: OR 2.80, 95%CI 1.45 to 5.41), the dominant model (LS+SS vs LL: OR 2.06, 95%CI 1.44 to 2.96), and the homozygousmodel (SS vs LL: OR 2.80 95%CI 1.45 to 5.5.41) were statistically significant for CHD-D, demonstrating that polymorphisms in the 5-HTTLPR gene are associated with the development of CHD-D and that the S allele in the 5-HTTLPR gene is likely to be a risk factor for CHD-D. For the BDNF gene, there were no significant differences between one of the co-dominant gene models (AA vs GG: OR 6.63, 95%CI 1.44 to 30.64), the homozygous gene model (AA vs GG: OR 6.63,95% CI 1.44 to 30.64), the dominant gene model (GA+AA vs GG: OR4.29, 95%CI 1.05 to 17.45), recessive gene model (AA vs GG+GA: OR 2.71, 95%CI 1.16 to 6.31), and allelemodel (A vs G: OR 2.59, 95%CI 1.18 to 5.67) were statistically significant for CHD-D, demonstrating that BDNFrs6265 gene polymorphisms are associated with the CHD-D development and that the A allele in the BDNFrs6265 gene is likely to be a risk factor for CHD-D. We analyzed the allele frequencies of SNPs reported in a single study and found that the SNPs in the microRNA146a gene rs2910164, the SNPs in the ACE2 gene rs2285666 and the SNPs in the SGK1 gene rs1743963 and rs1763509 were risk factors for the development of CHD-D. We performed a subgroup analysis of three studies involving the BDNFrs6265 gene. The results showed that European populations were more at risk of developing CHD-D than Asian populations in both dominant model (GA+AA vs GG: OR 10.47, 95%CI 3.53 to 31.08) and co-dominant model (GA vs GG: OR 6.40, 95%CI 1.98 to 20.73), with statistically significant differences. In contrast, the studies involving the 5-HTTLPR gene were all Asian populations, so subgroup analyses were not performed.We performed sensitivity analyses of studies exploring the 5-HTTLPR and BDNF rs6265 genes. The results showed that the results of the allele model, the dominant model, the recessive model, the homozygous model and the co-dominant model for both 5-HTTLPR and BDNF rs6265 genes were stable. Due to the limited number of studies of the 5-HTTLPR and BDNF genes, it was not possible to determine the symmetry of the funnel plot using Begg's funnel plot and Egger's test. Therefore, we did not assess publication bias. Discussion: SNPs of the microRNA146a gene at rs2910164, the ACE2 gene at the rs2285666 and the SGK1 gene at rs1743963 and rs1763509, and the SNPs at the 5-HTTLPR and BDNF gene loci are associated with the onset of comorbid depression in coronary heart disease. We recommend that future research focus on studying SNPs' impact on comorbid depression in coronary heart disease, specifically targeting the 5-HTTLPR and BDNF gene at rs6265. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology.
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Chatzidavid, Sevastianos, Flevari, Pagona, Tombrou, Ioanna, Anastasiadis, Georgios, and Dimopoulou, Maria
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- *
SICKLE cell anemia , *GENETIC polymorphisms , *PULMONARY hypertension , *SYMPTOMS , *PATHOLOGICAL physiology - Abstract
Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell disease (SCD), affecting 6–10% of adult SCD patients. Various mechanisms and theories have been evaluated to explain the pathophysiology of this disease. However, questions remain, particularly regarding the clinical heterogeneity of the disease in terms of symptoms, complications, and survival. Beyond the classical mechanisms that have been thoroughly investigated and include hemolysis, nitric oxide availability, endothelial disorders, thrombosis, and left heart failure, attention is currently focused on the potential role of genes involved in such processes. Potential candidate genes are investigated through next-generation sequencing, with the transforming growth factor-beta (TGF-β) pathway being the initial target. This field of research may also provide novel targets for pharmacologic agents in the future, as is already the case with idiopathic PH. The collection and processing of data and samples from multiple centers can yield reliable results that will allow a better understanding of SCD-related PH as a part of the disease's clinical spectrum. This review attempts to capture the most recent findings of studies on gene polymorphisms that have been associated with PH in SCD patients. [ABSTRACT FROM AUTHOR]
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- 2024
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17. 滩羊 FGF5、COQ9 基因多态性及其与生长性状的关联分析.
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马丽娜, 田进阳, 王锦, 赵正伟, and 马青
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Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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18. Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants.
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Agrawal, Kaushal Kishor, Singh, Neetu, Chand, Pooran, Singh, Saumyendra Vikram, Solanki, Neeti, Garg, Ravindra Kumar, and Chaurasia, Akhilanand
- Abstract
Copyright of Journal of Taibah University Medical Sciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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19. Do Gene Polymorphisms Play a Role in Newborn Hyperbilirubinemia?
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Hakan N, Aydin M, Ceylaner S, Dilli D, Zenciroğlu A, and Okumuş N
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neonatal hyperbilirubinemia ,gene polymorphisms ,ugt1a1 ,slco1b1/b3 ,gst ,Genetics ,QH426-470 - Abstract
Polymorphisms of the uridine-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene, hepatic solute carrier organic anion transporter 1B1/B3 (SLCO1B1/3) gene, and glutathione S-transferase (GST) gene have been associated with significant hyperbilirubinemia in some populations. This study aims to determine whether the variation of UGT1A1, SLCO1B1/3 and GST genes play an important role in neonatal hyperbilirubinemia in Turkish newborn infants.
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- 2024
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20. Clinical case of progressive pulmonary mycobacteriosis with potential genetic predisposition in a patient with mild bronchial asthma
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Natalia N. Makariantz, Maria A. Karnaushkina, Svetlana A. Salamaikina, Konstantin O. Mironov, Sergey L. Babak, and Anastasia D. Strutynskaya
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non-tuberculous mycobacteriosis ,pulmonary disease ,immunodeficiency ,gene polymorphisms ,innate immunity ,Internal medicine ,RC31-1245 - Abstract
Mycobacteriosis is an infectious disease caused by opportunistic non-tuberculous microbacteria in patients with chronic respiratory pathology and decreased immunological reactivity. The number of patients with this pathology is increasing not only in Russia, but throughout the world. Scientists' attention was drawn to the fact that the isolation of non-tuberculous mycobacteria from patient’s sputum samples does not correlate with the incidence of non-tuberculous mycobacteriosis and the need for its treatment. This may be due to the presence of gene polymorphisms that affect the structure and functional characteristics of innate immune factors. The article presents a rare clinical case of non-tuberculous mycobacteriosis caused by Mycobacterium avium in a 50-year-old woman without severe concomitant diseases and secondary immunodeficiency. The genetic study revealed polymorphic gene alleles, which may predispose this patient for the infection and severe course of this disease.
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- 2024
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21. Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women
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Jun Li, Ya Li, Siyuan Li, Yunqiu Lu, and Partab Rai
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Gene polymorphisms ,LRP5 ,Osteoporosis ,T2DM ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Objective To analyze the relationship between the polymorphism and mutation of rs7125942 and rs3736228 locus in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and bone mineral density (BMD) in postmenopausal women in Xinjiang, China, to provide a basis for prevention and treatment of the disease. Methods According to the results of dual-energy X-ray (DEXA) determination of BMD, the 136 subjects were divided into three groups: Group A: normal bone mass, Group B: osteopenia, Group C: osteoporosis. 1. Age, body, mass index (BMI), and menopause of all subjects were recorded. 2. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and clinical biochemical data were determined. 3. LRP5 locus polymorphisms were determined by time-of-flight mass spectrometry. Results 1. Compared with group A, the age, ALP, Cr, and BUN levels in group B and group C were increased, but UA levels were lower (P 0.05). 3. The ROC curves for different BMD sites such as L1, L2, L3, L4, L total, and femoral neck were 0.929, 0.955, 0.901, 0.914, 0.885, and 0.873 (P
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- 2024
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22. Correlation between vascular endothelial growth factor A gene polymorphisms and tendon and ligament injury risk: a systematic review and meta-analysis
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Xi-yong Li, Yun-lu Wang, Su Yang, Chang-sheng Liao, Song-feng Li, and Peng-fei Han
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VEGFA ,Gene polymorphisms ,Tendon injury ,Ligament injury ,Meta ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Relevant evidence suggests that angiogenic factors contribute significantly to fibril matrix reconstruction following physical injuries to tendon ligaments. Vascular endothelial growth factor A (VEGFA), with its potent angiogenic effect, has been studied extensively, and its functional polymorphisms, including rs699947, rs1570360, and rs2010963, have been the focus of numerous investigations. Some scholars have explored the association between gene polymorphisms in the VEGFA and the risk of tendon ligament injury, but the findings are not entirely consistent. Objectives The purpose of this study was to investigate the association between rs699947, rs1570360, and rs2010963 gene polymorphisms in VEGFA and the risk of tendon and ligament injuries. Methods After including articles about the association of VEGFA rs699947, rs1570360, and rs2010963 polymorphisms with tendon and ligament injuries according to the search strategy, we assessed their quality and conducted meta-analyses to examine the link between these polymorphisms and the risk of tendon and ligament injuries using odds ratios and 95% confidence intervals. Results Of 86 related articles, six were included in the meta-analysis. Some of these suggest an association between VEGFA rs2010963 and the risk of tendon and ligament injury in the population, with the specific C allele being one of the adverse factors for knee injury. Some studies suggest that VEGFA rs699947 and VEGFA rs1570360 single-nucleotide polymorphisms are associated with anterior cruciate ligament rupture. The risk of non-contact anterior cruciate ligament rupture is nearly doubled in individuals with the rs699947 CC genotype compared to the control group. Our analysis did not find any significant relationship between VEGFA gene polymorphisms (rs699947, rs1570360, and rs2010963) and the chance of tendon and ligament injury without consideration of race. However, the European population reveals that the CC genotype of VEGFA rs699947 can result in a greater risk of tendon and ligament injury, whereas the AG genotype for rs1570360 provides some protection. Additionally, rs2010963 was significantly associated with tendon and ligament injury; individuals with the C allele and the CC genotype had higher risk. False-positive report probability confirmed the high credibility of our results. Conclusion Overall, this study found no significant association between VEGFA rs699947, rs1570360, and rs2010963 polymorphisms and the risk of tendon ligament injury. However, in subgroup analysis, some genotypes of VEGFA rs699947, rs1570360, and rs2010963 were found to increase the risk of tendon ligament injury in European populations.
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- 2024
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23. Influence of Cyp3A4, Cyp3A5 and ABCB1 polymorphisms on tacrolimus concentrations and rejection risk in Indian kidney transplant recipients
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Kamal Kiran Mukkavilli, Mohammed Shoeb A Khan, Arun Kumar Donakonda, Suma Rama Gopal Gangisetty, and Dileena Poojaveli
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concentration by dose ,cyp3a5 ,gene polymorphisms ,kidney transplant ,tacrolimus ,Surgery ,RD1-811 - Abstract
Background: Tacrolimus metabolism is known to be determined by gene polymorphisms. Cyp3A5 genotype has most widely been seen to be associated with tacrolimus metabolism. Studies on other genes have produced mixed results. Objective: We studied the association of three polymorphisms CYP3A4*1B (-392 G>A), CYP3A5 (6986 A>G), and ABCB1 (3435 T>C) on tacrolimus levels and their association with either rejection or nephrotoxicity (infection or tacrolimus toxicity) in renal transplant recipients from India. Materials and Methods: In this prospective cohort study, patients who underwent kidney transplantation between July 2018 and July 2023 were studied. Inclusion criteria: Patients who underwent Kidney Transplantation and were (i) on tacrolimus-based immunosuppression and (ii) not on medications known to interact with calcineurin inhibitors, such as ketoconazole, phenytoin, and diltiazem, were studied. Tacrolimus levels, tacrolimus concentration/dose (C/D) and tacrolimus C/D per kg body weight, at monthly time points posttransplant for 6 months and biopsy-proven rejection, infection, tacrolimus toxicity, and acute tubular necrosis data were collected. Results: Three hundred and twenty-seven patients were included in the study. Two hundred and fifty-seven were male and 70 were female. A total of 1402 tacrolimus samples were collected, with an average of 3.2 ± 2.1 samples per patient. Tacrolimus levels were significantly lower in the Cyp3A5 AG and AA GG genotypes versus GG (5.27 ± 2.95 and 6.22 ± 2.79 vs. 8.05 ± 4.83, P < 0.001) as were C/D (3.45 ± 2.29 and 3.37 ± 1.91 vs. 6.47 ± 4.44, P < 0.001) and C/D/W (52.45 ± 33.98 and 52.19 ± 32.61 vs. 98.09 ± 73.80, P < 0.001). Cyp3A5 AA and AG had higher rejection rates than GG (20% vs. 13 vs. 8%, P = 0.03). The relative risk of rejection with A versus G polymorphism was 1.9 (confidence interval: 1.03–3.58), P = 0.03. Cyp3A4 and ABCB1 polymorphism studies did not show any association with the parameters studied. Conclusion: Our study showed that Cyp3A5 gene polymorphisms were significantly associated with tacrolimus metabolism, rejection episodes, and rejection risk. Cyp3A4 and ABCB1 were not significantly associated with the parameters studied.
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- 2024
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24. Association between variants in TCF7L2, CTRB1/2, and GLP-1R genes and response to therapy with glucagon-like peptide-1 receptor agonists.
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Kyriakidou, Artemis, Kyriazou, Angeliki V., Koufakis, Theocharis, Vasilopoulos, Yiannis, Avramidis, Iakovos, Baltagiannis, Stefanos, Goulis, Dimitrios G., and Kotsa, Kalliopi
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GLUCAGON-like peptide-1 receptor ,GLUCAGON-like peptide-1 agonists ,TYPE 2 diabetes ,GLYCEMIC control ,GENE therapy - Abstract
The factors determining the response to treatment with glucagon-like peptide-1 receptor agonists (GLP-1- RAs) have not been clarified. The present study investigated the association between polymorphisms in TCF7L2, CTRB1/2, and GLP-1 R genes and response to GLP-1 RAs regarding glycemic control and weight loss among Greek patients with type 2 diabetes mellitus (T2DM). Patients (n = 191) treated with GLP-1 RAs for at least 6 months were included. Participants were genotyped for TCF7L2 rs7903146 (C>T), CTRB1/2 rs7202877 (T>G) and GLP-1 R rs367543060 (C>T) polymorphisms. Clinical and laboratory parameters were measured before, 3, and 6 months after treatment initiation. The patients were classified into responders and non-responders according to specific criteria. Carriers of at least one rs7903146 'T' allele and rs7202877 'G' allele presented similar glucose control and weight loss response to GLP-1 RAs with the respective homozygous wild-type genotypes [odds ratio (OR): 1.08, 95% confidence interval (CI): 0.5, 2.31, p = 0.85 and OR: 1.35, 95% CI: 0.66, 2.76, p = 0.42; OR: 1.4, 95% CI: 0.56, 3.47, p = 0.47 and OR: 1.28, 95% CI: 0.55, 2.98, p = 0.57, respectively]. Regarding the GLP-1 R polymorphism, all participants were homozygous for the wild-type allele; thus, no comparisons were feasible. Female sex (p = 0.03) and lower baseline weight (p = 0.024) were associated with an improved glycemic and weight loss response, respectively. There is no evidence suggesting a role for the variants studied in response to GLP-1 RA therapy in people with T2DM. However, specific demographic and clinical factors may be related to a better response to treatment with these agents. [ABSTRACT FROM AUTHOR]
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- 2024
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25. H 型高血压急性缺血性脑卒中患者亚甲基四氢叶酸 还原酶 C677T 基因多态性及其与肾功能的相关性.
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徐玉洁, 高娟, 王子文, 王井辉, 任涵, 耿硕, and 刘海杰
- Abstract
Objective To observe the gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T in patients with H-type hypertension combined with acute ischaemic stroke and to analyze its correlation with renal function in these patients. Methods Totally 153 patients with H-type hypertension combined with acute ischaemic stroke were selected as the observation group, and 158 patients with non-H-type hypertension combined with acute ischaemic stroke in the same period were selected as the control group. Peripheral venous blood was collected from both groups, and MTHFR C677T genotype was detected by PCR amplification and microarray technology to measure systemic immune inflammation index (SII), and serum creatinine levels were measured using a Hitachi 7600 automatic biochemical analyzer in order to calculate the estimated glomerular filtration rate (eGFR) in both group. Multiple linear regression analysis was employed to assess the correlations of MTHFR C677T genotypes with homocysteine (Hcy) level and eGFR in patients with H-type hypertension combined with acute ischaemic stroke, and Spearman correlation analysis was employed to assess the correlations of SII with eGFR and Hcy levels in patients with H-type hypertension combined with acute ischaemic stroke. Results Compared with the control group, patients in the observation group had the highest frequency of TT genotype distribution and the highest frequency of T allele (χ2 =19. 188, 5. 138, respectively; both P<0. 05). The SII of patients in the observation and control groups were 583. 54(384. 97, 903. 73) and 425. 03(310. 26, 583. 16), respectively, with statistically significant difference between these two groups (P<0. 05). TT genotype patients with H-type hypertension combined with acute ischaemic stroke had higher serum Hcy level and lower eGFR level than patients with CC and CT geno‐ types (F=28. 544, 3. 749, respectively; both P<0. 05). The TT type of MTHFR C677T gene was positively correlated with serum Hcy level in patients with H-type hypertension combined with acute ischaemic stroke (β=4. 173, P<0. 05) and was negatively correlated with eGFR level (β=-6. 559, P<0. 05). The SII was positively correlated with serum Hcy level (r =0. 226, P<0. 05) and was negatively correlated with eGFR level (r=-0. 129, P<0. 05) in patients with H-type hyperten‐ sion combined with acute ischaemic stroke. Conclusions Patients with H-type hypertension combined with acute isch‐ aemic stroke predominantly exhibit the TT genotype of the MTHFR C677T gene. It is suggested that patients with H-type hypertension combined with acute ischaemic stroke carrying the TT genotype of MTHFR C677T may be more prone to experiencing a decline in renal function. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome.
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Segbefia, Selorm Philip, Asandem, Diana Asema, Eva Amoah, Linda, and Kusi, Kwadwo Asamoah
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GENETIC polymorphisms ,PLASMODIUM falciparum ,MALARIA vaccines ,CYTOKINES ,IMMUNE response - Abstract
Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between antiinflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Correlation between vascular endothelial growth factor A gene polymorphisms and tendon and ligament injury risk: a systematic review and meta-analysis.
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Li, Xi-yong, Wang, Yun-lu, Yang, Su, Liao, Chang-sheng, Li, Song-feng, and Han, Peng-fei
- Subjects
- *
TENDON injuries , *ONLINE information services , *MEDICAL databases , *META-analysis , *MEDICAL information storage & retrieval systems , *CONFIDENCE intervals , *LIGAMENT injuries , *GENETIC polymorphisms , *RISK assessment , *DESCRIPTIVE statistics , *CHI-squared test , *VASCULAR endothelial growth factors , *DATA analysis software , *MEDLINE , *ODDS ratio , *DISEASE risk factors - Abstract
Background: Relevant evidence suggests that angiogenic factors contribute significantly to fibril matrix reconstruction following physical injuries to tendon ligaments. Vascular endothelial growth factor A (VEGFA), with its potent angiogenic effect, has been studied extensively, and its functional polymorphisms, including rs699947, rs1570360, and rs2010963, have been the focus of numerous investigations. Some scholars have explored the association between gene polymorphisms in the VEGFA and the risk of tendon ligament injury, but the findings are not entirely consistent. Objectives: The purpose of this study was to investigate the association between rs699947, rs1570360, and rs2010963 gene polymorphisms in VEGFA and the risk of tendon and ligament injuries. Methods: After including articles about the association of VEGFA rs699947, rs1570360, and rs2010963 polymorphisms with tendon and ligament injuries according to the search strategy, we assessed their quality and conducted meta-analyses to examine the link between these polymorphisms and the risk of tendon and ligament injuries using odds ratios and 95% confidence intervals. Results: Of 86 related articles, six were included in the meta-analysis. Some of these suggest an association between VEGFA rs2010963 and the risk of tendon and ligament injury in the population, with the specific C allele being one of the adverse factors for knee injury. Some studies suggest that VEGFA rs699947 and VEGFA rs1570360 single-nucleotide polymorphisms are associated with anterior cruciate ligament rupture. The risk of non-contact anterior cruciate ligament rupture is nearly doubled in individuals with the rs699947 CC genotype compared to the control group. Our analysis did not find any significant relationship between VEGFA gene polymorphisms (rs699947, rs1570360, and rs2010963) and the chance of tendon and ligament injury without consideration of race. However, the European population reveals that the CC genotype of VEGFA rs699947 can result in a greater risk of tendon and ligament injury, whereas the AG genotype for rs1570360 provides some protection. Additionally, rs2010963 was significantly associated with tendon and ligament injury; individuals with the C allele and the CC genotype had higher risk. False-positive report probability confirmed the high credibility of our results. Conclusion: Overall, this study found no significant association between VEGFA rs699947, rs1570360, and rs2010963 polymorphisms and the risk of tendon ligament injury. However, in subgroup analysis, some genotypes of VEGFA rs699947, rs1570360, and rs2010963 were found to increase the risk of tendon ligament injury in European populations. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Individualized treatment with voriconazole in the Chinese population: Inflammation level as a novel marker for dose optimization.
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Hao, Xu, Li, Yuanyuan, Zhang, Ying, Bian, Jialu, Zhao, Jinxia, Zhao, Yinyu, Hu, Lei, Luo, Xingxian, Yang, Changqing, Feng, Yufei, and Huang, Lin
- Subjects
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CHINESE people , *VORICONAZOLE , *MULTIPLE regression analysis , *CYTOCHROME P-450 CYP2C19 , *GENETIC polymorphisms - Abstract
Aims: The aim of this study was to explore the influence and possible mechanisms of pharmacokinetics‐related gene polymorphisms, especially CYP2C19 polymorphisms, and non‐genetic factors combined with the inflammatory status on the voriconazole (VRC) metabolism of the Chinese population. Methods: Clinical studies were performed by collecting more than one VRC trough concentration and C‐reactive protein (CRP) level. A total of 265 blood samples were collected from 120 patients. Results: Results of multiple regression analyses demonstrated that CYP2C19 genotypes and albumin (Alb) level remained predictors of Cminss/D in patients with no to mild inflammation (R2 = 0.12, P <.001). In addition, in patients with moderate to severe inflammation, it resulted in a significant model containing factors of CRP and total bilirubin (T‐Bil) levels (R2 = 0.19, P <.001). In non‐clinical studies, 32 rats were divided into control and inflammatory groups, and it was found that the mean residence time (MRT(0–t)) of VRC in the inflammatory group was significantly longer than that in the control group (P <.001), which may be due to down‐regulation of mRNA and protein expression of CYP2C19 (CYP2C6 in rats) through interleukin (IL)‐6/signal transducer and activator of transcription (STAT) 3 pathway. Conclusions: Therefore, the effect of CYP2C19 polymorphisms on VRC metabolism may be masked by inflammatory status, which should be of more concern than CYP2C19 polymorphisms in patients with moderate to severe inflammation. Additionally, the impact of Alb and T‐Bil on VRC metabolism should not be disregarded. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women.
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Li, Jun, Li, Ya, Li, Siyuan, Lu, Yunqiu, and Rai, Partab
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OSTEOPOROSIS prevention , *BONE metabolism , *OSTEOPOROSIS treatment , *FASTING , *GLYCOSYLATED hemoglobin , *ALKALINE phosphatase , *GENETIC mutation , *PHOTON absorptiometry , *BLOOD urea nitrogen , *OSTEOPENIA , *PHOSPHORUS , *CHROMIUM , *GENETIC polymorphisms , *BLOOD sugar , *FEMUR neck , *REGRESSION analysis , *TYPE 2 diabetes , *POSTMENOPAUSE , *MASS spectrometry , *RESEARCH funding , *BONE density , *BODY mass index , *CALCIUM , *URIC acid , *RECEIVER operating characteristic curves , *WOMEN'S health - Abstract
Objective: To analyze the relationship between the polymorphism and mutation of rs7125942 and rs3736228 locus in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and bone mineral density (BMD) in postmenopausal women in Xinjiang, China, to provide a basis for prevention and treatment of the disease. Methods: According to the results of dual-energy X-ray (DEXA) determination of BMD, the 136 subjects were divided into three groups: Group A: normal bone mass, Group B: osteopenia, Group C: osteoporosis. 1. Age, body, mass index (BMI), and menopause of all subjects were recorded. 2. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and clinical biochemical data were determined. 3. LRP5 locus polymorphisms were determined by time-of-flight mass spectrometry. Results: 1. Compared with group A, the age, ALP, Cr, and BUN levels in group B and group C were increased, but UA levels were lower (P < 0.05), and Serum P was higher in the group C (P < 0.05). 2. There was no statistically significant difference in the prevalence of diabetes between the three groups (P > 0.05). 3. The ROC curves for different BMD sites such as L1, L2, L3, L4, L total, and femoral neck were 0.929, 0.955, 0.901, 0.914, 0.885, and 0.873 (P < 0.01). 4. At rs7125942 locus, there was statistically significant difference in the distribution of wild-type (CC) and mutant (CG) with the normal bone mass (NBM) group and the abnormal bone mass (ABM) group (P < 0.05). 5. At rs7125942 locus, compared with wild-type (CC), mutant (CG) had lower LDL and FPG in NBM group (P < 0.05), and lower serum ALP in the ABM group (P < 0.05). At rs3736228 locus, the BMD (Femoral neck) of mutant (CT/TT) was lower than that of wild-type (CC) in the NBM group (P < 0.05). 6. Age and menopausal years were negatively correlated with BMD of the femoral neck and L1-4 (P < 0.05), and BMI and TG were positively (P < 0.05), and the results of multiple linear regression analysis showed that age, BMI, and TG were both independent factors affecting BMD (P < 0.05). [ABSTRACT FROM AUTHOR]
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- 2024
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30. Allele and phenotype frequencies of CYP2D6 in the Turkish population.
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Polat, Safa Can, Batir, Muhammet Burak, and Cam, Fethi Sirri
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DRUG metabolism , *CYTOCHROMES , *GENETIC polymorphisms , *MEDICAL genetics , *POLYMERASE chain reaction - Abstract
Aim: Cytochrome P450 is a hepatic enzyme system responsible for drug metabolism that comprises different iso-enzymes. The CYP2D6 enzyme, which composes 2-4% of all cytochrome enzymes, is responsible for 25% of the metabolisms of the drugs used in clinics. The genetic polymorphisms of this enzyme can change the efficiency and toxicity of the drugs used. In this study, the retrospective evaluation of CYP2D6 gene polymorphisms that influence enzyme activity in the Turkish population is targeted. Materials and Methods: From the 192 patients sent from psychiatry, medical genetics, and neurology polyclinics to our laboratory, we determined CYP2D6 enzyme gene polymorphisms by multiplex polymerase chain reaction (PCR) and multiplex allele-specific primer extension (ASPE). Results: Of all the cases, 82.29% were determined to be extensive, 12.5% intermediate, 2.08% poor, and 3.13% ultra-rapid metabolizers. In our population, the most frequent alleles were *1 (37.63%), *2 (24.75%), *41 (15.15%), *4 (9.85%), and *10 (4.29%), respectively. Conclusion: Compared to previous studies conducted on Turkish society, the percentage of extensive metabolizers was higher in the current examined population. In contrast, the percentages of poor and ultra-rapid metabolizers were lower. In addition, the *41 allele, which has not been studied before in our population, that follows the decrease in enzyme function was detected as the most frequent allele in this study. The fact that the percentage of the cases in which changes were observed was 17.1% will help determine the CYP2D6 gene mutations in the pre-treatment cases. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Telomerase reverse transcriptase gene polymorphisms and cervical cancer susceptibility in high‐risk human papillomavirus‐infected women.
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Sun, Shuang, Wang, Yuhong, Liu, Ying, Leng, Zongxiang, Jiang, Yujuan, Liang, Yu, and Jiang, Zhe
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PAPILLOMAVIRUSES , *TELOMERASE , *GENETIC polymorphisms , *AT-risk people , *DESCRIPTIVE statistics , *GENOTYPES , *RESEARCH funding , *ODDS ratio ,CERVIX uteri tumors - Abstract
Objective: To investigate the relationship between Human telomerase reverse transcriptase (hTERT) gene polymorphisms and the susceptibility and clinicopathological parameters of cervical cancer in women infected with high‐risk human papillomavirus (HR‐HPV). Method: A total of 380 patients with HPV‐infected cervical cancer who were admitted to the Jilin province Maternal and Child Health Care Hospital (Jilin province Obstetrics Quality Control Center) from July 2019 to July 2023 were selected as case group, and 408 women with negative HPV results in the cervical cancer screening results of the physical examination in the same hospital were selected as the control group. Restriction fragment length polymorphisms polymerase chain reaction was used to detect the polymorphisms of hTERT, and its relationship with the susceptibility to high‐risk HPV infection and clinicopathological parameters in patients with cervical cancer was analysed. Results: Individuals carrying the GA and AA genotypes of rs2736122 were significantly associated with an increased risk of cervical cancer when compared with the GG genotype and the adjusted ORs were 0.53 (0.37–0.79) for the AA genotype and 0.73 (0.59–0.88) for the A allele genotype. Besides, GG genotype or G allele of rs2853677 presented a significant influence on cervical cancer, with ORs of 0.59 (0.41–0.86) and 10.77 (0.63–0.94), respectively, when compared with the AA genotype. And rs2853677 have statistically significant difference in tumour diameter and degree of differentiation subgroup(p < 0.05). Conclusion: The results of this study indicate that the hTERT gene rs2736122AA and rs2853677 GG genotypes can increase the susceptibility of high‐risk HPV infection in cervical cancer patients. And rs2853677 is related to tumours above 4 cm and highly differentiated tumours. But both have nothing to do with the patient's chemotherapy sensitivity. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients.
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Kriauciunas, Albertas, Zekonis, Gediminas, Gedvilaite, Greta, Duseikaitė, Monika, Pileckaitė, Enrika, Pacauskiene, Ingrida, and Liutkeviciene, Rasa
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AGGRESSIVE periodontitis , *PERIODONTITIS , *VASCULAR endothelial growth factors , *GENETIC polymorphisms , *HAPLOTYPES , *POLYMERASE chain reaction - Abstract
To evaluate and compare the associations of VEGFA serum levels and SNPs (rs1570360, rs699947, rs3025033, and rs2146323) with periodontitis in study participants grouped by gender. The study enrolled 261 patients with periodontitis and 441 healthy controls as a reference group. Patients underwent periodontal examination and radiographic analysis to confirm the periodontitis diagnosis. Blood samples were collected, and the DNA salting-out method was used for DNA extraction from peripheral venous blood. Genotyping of VEGFA (rs1570360, rs699947, rs3025033, and rs2146323) was performed using real-time polymerase chain reaction (RT-PCR) and serum level analysis was done for 80 individuals − 40 periodontitis-affected patients and 40 reference group subjects. The analysis of VEGFA (rs1570360, rs699947, rs3025033, and rs2146323) showed that the rs3025033 GG genotype was less frequent in the periodontitis group than in the reference group (1.6% vs. 5.7%,p = 0.008). VEGFA serum levels were not statistically significantly different between periodontitis patients and reference group subjects (554.29 (522.38) ng/ml vs. 581.32 (348.16) ng/ml, p = 0.786). Individuals carrying rs1570360, rs699947, rs3025033, and rs2146323 haplotype A-A-G-A had decreased risks of periodontitis, while rare haplotype of VEGFA (rs1570360, rs699947, rs3025033, and rs2146323) was associated with increased odds of periodontitis (OR= 0.42; 95% CI: 0.20–0.85; p < 0.017; OR= 4.08; 95% CI: 1.86–8.94; p < 0.0001, respectively). The rs3025033 GG genotype and the rs1570360, rs699947, rs3025033, and rs2146323 A-A-G-A haplotypes may play a protective role in the development of periodontitis, but a less common haplotype of the same VEGFA polymorphism may be associated with the risk of developing periodontitis. [ABSTRACT FROM AUTHOR]
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- 2024
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33. Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis.
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Hua Zhao, Xiao-Hong Jiang, Qiu-Pin Huang, Min-Li Chen, and Zheng-Fu Xie
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MATRIX metalloproteinases , *GENETIC polymorphisms , *CHRONIC obstructive pulmonary disease , *RANDOM effects model - Abstract
Introduction: Given the evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between genetic polymorphisms in MMP genes and COPD risk. However, reliable measures of these results are lacking. Material and methods: We assessed the published evidence for association of the MMP-3, MMP-9 and MMP-12 polymorphisms with COPD risk using meta-analytic techniques. The odds ratio (OR) and 95% confidence interval (CI) were calculated for each study using fixed or random effect models. Results: A total of 23 case-control studies were included in the meta-analysis. No significant association was observed between the MMP-9 rs3918242 polymorphism and COPD risk in the overall populations under the dominant (T/T + C/T vs. C/C: OR = 1.30, 95% CI: 1.00-1.69, p = 0.054) and allele contrast (T allele vs. C allele: OR = 1.22, 95% CI: 0.97-1.53, p = 0.088) models. However, in sub-group analysis the polymorphism rs3918242 was significant in Asians under the dominant model (T/T + C/T vs. C/C: OR = 1.66, 95% CI: 1.02-2.72, p = 0.043). The results for MMP-12 rs2276109 showed an association with COPD only in mixed populations (G/G + A/G vs. A/A: OR = 1.57, 95% CI: 1.10-2.24, p = 0.013; G allele vs. A allele: OR = 1.52, 95% CI: 1.09-2.14, p = 0.015). We did not find any significant association of the MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD. Conclusions: The findings of this meta-analysis suggest that there is a risk of COPD associated with the MMP-9 rs3918242 and MMP-12 rs2276109 polymorphisms in certain ethnic groups. [ABSTRACT FROM AUTHOR]
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- 2024
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34. The Relationship between Gene SLC6A3 Variable Number of Tandem Repeat (VNTR) and Attention-Deficit / Hyperactivity Disorder.
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Seymari, Abbas, Naseh, Ashkan, Rezaei, Sajjad, Salehi, Zivar, and Kousha, Maryam
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CONFIDENCE intervals , *ALLELES , *GENETIC polymorphisms , *INTERVIEWING , *ATTENTION-deficit hyperactivity disorder , *DESCRIPTIVE statistics , *CHI-squared test , *GENOTYPES , *ODDS ratio , *JUDGMENT sampling , *POLYMERASE chain reaction - Abstract
Objective: This research investigates the alleles of Variable Number of Tandem Repeats (VNTR) intron 8 of the gene SLC6A3 with attention-deficit / hyperactivity disorder (ADHD) in children and adolescents. Method: The study's target population consisted of children and adolescents referred to the specialized clinic, as well as students attending school in Rasht city during 2021-2022. A sample of 95 children between the ages of 6 and 10 with ADHD was selected as the ADHD group, and 95 healthy children were selected as the control group using purposive sampling. The subjects completed the Child Symptom Inventory-4 (CSI-4) checklist after a clinical interview, and demographic information was collected. Genetic sampling was carried out through hair follicles. The sequence of interest was proliferated using the Polymerase Chain Reaction technique (PCR); afterward, the samples were used for genotype identification on polyacrylamide gel electrophoresis. Results: The chi-square test results indicated that the 5R / 5R genotype (P = 0.026, χ² = 7.26) and the 5R allele (P = 0.002, χ² = 9.35) had a higher frequency compared to the control group. Additionally, the odds ratio test indicated that, compared to other genotypes and alleles, the 5R / 5R genotype (OR = 2.75, 95% CI = 1.29-5.82, P = 0.01) and the 5R allele (OR = 2.02, 95% CI = 1.28-3.19, P = 0.002) increase the odds of developing ADHD by 2.7 and 2 times higher, respectively. Conclusion: The present study successfully showed the association between intron 8 gene polymorphism, which is responsible for encoding the dopamine transporter as well as ADHD in children and adolescents in Iran. [ABSTRACT FROM AUTHOR]
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- 2024
35. Influence of Cyp3A4, Cyp3A5 and ABCB1 Polymorphisms on Tacrolimus Concentrations and Rejection Risk in Indian Kidney Transplant Recipients.
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Mukkavilli, Kamal Kiran, Khan, Mohammed Shoeb A., Donakonda, Arun Kumar, Gangisetty, Suma Rama Gopal, and Poojaveli, Dileena
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DNA analysis ,KIDNEY transplantation ,MEMBRANE transport proteins ,PATIENTS ,TRANSPLANTATION of organs, tissues, etc. ,NEPHROTOXICOLOGY ,HUMAN research subjects ,INFECTION ,RELATIVE medical risk ,CHI-squared test ,DESCRIPTIVE statistics ,GENETIC polymorphisms ,LONGITUDINAL method ,TACROLIMUS ,OXIDOREDUCTASES ,INFORMED consent (Medical law) ,ONE-way analysis of variance ,CONFIDENCE intervals ,DATA analysis software ,IMMUNOSUPPRESSION ,SEQUENCE analysis ,GENOTYPES - Abstract
Background: Tacrolimus metabolism is known to be determined by gene polymorphisms. Cyp3A5 genotype has most widely been seen to be associated with tacrolimus metabolism. Studies on other genes have produced mixed results. Objective: We studied the association of three polymorphisms CYP3A4*1B (-392 G>A), CYP3A5 (6986 A>G), and ABCB1 (3435 T>C) on tacrolimus levels and their association with either rejection or nephrotoxicity (infection or tacrolimus toxicity) in renal transplant recipients from India. Materials and Methods: In this prospective cohort study, patients who underwent kidney transplantation between July 2018 and July 2023 were studied. Inclusion criteria: Patients who underwent Kidney Transplantation and were (i) on tacrolimus-based immunosuppression and (ii) not on medications known to interact with calcineurin inhibitors, such as ketoconazole, phenytoin, and diltiazem, were studied. Tacrolimus levels, tacrolimus concentration/dose (C/D) and tacrolimus C/D per kg body weight, at monthly time points posttransplant for 6 months and biopsy-proven rejection, infection, tacrolimus toxicity, and acute tubular necrosis data were collected. Results: Three hundred and twenty-seven patients were included in the study. Two hundred and fifty-seven were male and 70 were female. A total of 1402 tacrolimus samples were collected, with an average of 3.2 ± 2.1 samples per patient. Tacrolimus levels were significantly lower in the Cyp3A5 AG and AA GG genotypes versus GG (5.27 ± 2.95 and 6.22 ± 2.79 vs. 8.05 ± 4.83, P < 0.001) as were C/D (3.45 ± 2.29 and 3.37 ± 1.91 vs. 6.47 ± 4.44, P < 0.001) and C/D/W (52.45 ± 33.98 and 52.19 ± 32.61 vs. 98.09 ± 73.80, P < 0.001). Cyp3A5 AA and AG had higher rejection rates than GG (20% vs. 13 vs. 8%, P = 0.03). The relative risk of rejection with A versus G polymorphism was 1.9 (confidence interval: 1.03-3.58), P = 0.03. Cyp3A4 and ABCB1 polymorphism studies did not show any association with the parameters studied. Conclusion: Our study showed that Cyp3A5 gene polymorphisms were significantly associated with tacrolimus metabolism, rejection episodes, and rejection risk. Cyp3A4 and ABCB1 were not significantly associated with the parameters studied. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Editorial: Genome-based nutrition strategies for preventing diet-related chronic diseases: where genes, diet, and food culture meet
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Arturo Panduro, Claudia Ojeda-Granados, Omar Ramos-Lopez, and Sonia Roman
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personalized nutrition ,personalized medicine ,chronic diseases ,gene polymorphisms ,gene-environmental mismatch ,ancestry ,Nutrition. Foods and food supply ,TX341-641 - Published
- 2024
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37. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review
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Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, and Qingyuan Hu
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Nicotine dependence ,Dopaminergic system ,Gene polymorphisms ,Smoking behavior ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Nicotine, the main compound in cigarettes, leads to smoking addiction. Nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding effect or satisfaction. This satisfaction is essential for continued and compulsive tobacco use, and therefore dopamine plays a crucial role in nicotine dependence. Numerous studies have identified genetic polymorphisms of dopaminergic pathways which may influence susceptibility to nicotine addiction. Dopamine levels are greatly influenced by synthesis, storage, release, degradation, and reuptake-related genes, including genes encoding tyrosine hydroxylase, dopamine decarboxylase, dopamine transporter, dopamine receptor, dopamine 3-hydroxylase, catechol-O-methyltransferase, and monoamine oxidase. In this paper, we review research progress on the effects of polymorphisms in the above genes on downstream smoking behavior and nicotine dependence, to offer a theoretical basis for the elucidation of the genetic mechanism underlying nicotine dependence and future personalized treatment for smoking cessation.
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- 2024
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38. Genetic risk factors for occupational contact dermatitis
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A.M. Amromina, D.R. Shaikhova, and I.A. Bereza
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genetic risk factors ,genetic predisposition ,allergic contact dermatitis ,irritant contact dermatitis ,occupational contact dermatitis ,gene polymorphisms ,Medicine - Abstract
Occupational contact dermatitis is an important current occupational health problem with serious economic and social consequences. Among possible risk factors for this disease, researchers pay attention to genetic predisposition. Identification of polymorphisms associated with the occupational pathology will allow specialists to establish risk groups, carry out timely preventive measures, and adjust treatment, guided by a personalized medicine approach. The purpose of this review was to summarize the results of studying genetic risk factors for occupational contact dermatitis. Three researchers did an independent search in the PubMed, Google Scholar, eLibrary, and CyberLeninka databases and further analysis of scientific literature on genetic predisposition to occupational dermatitis published in 1990 to 2023. Of 88 papers analyzed, 32 articles were included in this review. We established that genetic risk factors for occupational contact dermatitis were usually studied in metallurgical workers with a focus on potential candidate genes among skin barrier function-related genes, pro-inflammatory and anti-inflammatory genes, and xenobiotic metabolism and biotransformation genes. The most compelling evidence for the use of genetic polymorphisms as risk factors for occupational contact dermatitis has been demonstrated for the filaggrin (FLG) gene, which is involved in maintaining the skin barrier, and tumor necrosis factor alpha (TNF-α), which is involved in protecting the body and cells from inflammation and apoptosis. However, the data available are insufficient to use genetic polymorphisms as risk factors for occupational skin diseases. Further studies that take into account the mechanism of interaction of different genes during the development of occupational contact dermatitis are required.
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- 2023
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39. Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case–control study
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Yuan Wang, Xiaoya Ma, Jinping Guo, Yujie Li, and Yuyan Xiong
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ESR1, APOE ,Osteonecrosis of the femoral head ,Gene polymorphisms ,Risk ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Osteonecrosis of the femoral head (ONFH) is a disease with a high disability rate, and genetic factors are closely related to its pathogenesis. This study aimed to investigate the possible correlation between ESR1 and APOE gene polymorphisms and the risk of ONFH. Methods In this case–control study, the potential association between three genetic variants (rs2982573 C
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- 2023
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40. Association of IL-1β rs16944 and IL-1RN rs2234663 gene polymorphisms with graft function in renal transplant recipients
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Marianne Samir Makboul Issac and Maggie S. El Nahid
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Renal transplantation ,Graft function ,IL-1β (− 511C/T) ,IL-1RN (86 bp VNTR) ,Gene polymorphisms ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Abstract Background After renal transplantation, renal graft function affects both patient and graft survival. There is growing evidence of the genetic association between interleukin-1β (IL-1β) or its receptor antagonist (IL-1RN) and graft function in renal transplantation. The objective of this study is to investigate the role of the recipient IL-1β and IL-1RN gene polymorphisms and their haplotypes on renal graft outcome. Methods Using PCR, IL-1β (− 511C/T) and IL-1RN (86 bp VNTR) gene polymorphisms were determined in 31 renal allograft recipients; eight cases with stable allograft function and 23 cases with early renal dysfunction as well as 26 age- and gender-matched healthy controls. Results A statistically significant difference in IL-1 β (− 511C/T) gene polymorphisms and IL-1RN/IL-1β haplotypes was observed on comparing renal allograft recipients with stable allograft function and those with early renal allograft dysfunction. However, the difference in the frequency distribution of IL-1RN gene polymorphisms, between these two groups, did not reach statistical significance. Also, no statistically significant difference was observed in comparing these two gene polymorphisms and their haplotypes between renal allograft recipients and healthy controls. Conclusion The IL-1β − 511 CT/TT polymorphic genotypes and IL-1RN/IL-1β polymorphic haplotypes are associated with early renal allograft dysfunction. These are observational data that can be repeated in larger studies. If the results obtained are consistent, this might open doors to personalized medicine where clinicians can take necessary measures to identify the renal transplant recipients’ genotypes at risk of mounting an increased inflammatory response and hence administer the appropriate immunosuppressive protocol.
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- 2023
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41. Some genetic differences in patients with rheumatoid arthritis
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Hosam M. Ahmad, Zaki M. Zaki, Asmaa S. Mohamed, and Amr E. Ahmed
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Gene polymorphisms ,FokI ,TaqI ,Rheumatoid arthritis ,Polymerase chain reaction ,Parathyroid hormone ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective Vitamin D is important for bone and cartilage metabolism. Changes in vitamin D blood level may be related to pathological disorders such as rheumatoid arthritis (RA). The main aim of this study is to investigate the association between RA and the vitamin D receptor (VDR) genes FokI and TaqI polymorphisms. One hundred RA patients and fifty healthy matched controls were assessed for VDR FokI and TaqI genotyping. Intact parathyroid hormone (PTH) and calcium (Ca) levels were measured, categorized, and compared between the cases and control groups. Results We found that the FokI genotype frequencies for the RA cases and control groups were FF:Ff:ff = 46%:52%:2% and 50%:50%:0%, respectively (P = 0.76). The TaqI genotype frequencies for the RA cases and control groups were TT:Tt:tt = 45%:44%:11% and 42%:42%:16%, respectively (P = 0.69). A statistically significant high serum PTH level was associated with the ff genotype (p = 0.03), and a significantly low serum Ca level was associated with the TT genotype (p = 0.003). In comparison with controls, no influence of VDR FokI and TaqI genotypes on RA susceptibility or risk was demonstrated.
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- 2023
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42. Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes
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Mouhrach I, Bouguenouch L, Kamal A, Meriame A, El Khorb N, El Azami El Idrissi M, Akoudad H, and Bekkari H
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clopidogrel resistance ,coronary artery disease ,gene polymorphisms ,platelet inhibitors ,abcb1 gene ,cyp450 gene. ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Ismail Mouhrach,1,2 Laila Bouguenouch,2,3 Adil Kamal,3,4 Abbassi Meriame,2 Nada El Khorb,3,4 Mohammed El Azami El Idrissi,3 Hafid Akoudad,3,4 Hicham Bekkari1 1Laboratory of Biotechnology, Environment, Agrifood, and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco; 2Department of Medical Genetics and Oncogenetics, University Hospital Hassan II, Fez, Morocco; 3Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; 4Department of Cardiology, University Hospital Hassan II, Fez, MoroccoCorrespondence: Ismail Mouhrach, Laboratory of Biotechnology, Environment, Agrifood, and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, B.P. 1796 Fès-Atlas, Fez, 30003, Morocco, Tel +212 7 08 02 96 10, Fax +212535642500, Email ismail.mouhrach@usmba.ac.maIntroduction: Clopidogrel is an antiplatelet prodrug primarily prescribed to prevent or treat acute coronary syndrome (ACS) or acute ischemic stroke (IS), polymorphisms of genes encoding cytochrome P-450 (CYP) and P-glycoprotein transporter, could affect the efficiency of clopidogrel absorption and biotransformation, especially during the first critical hours following its administration.Methods: The present study was designed to investigate the potential association of clopidogrel responsiveness and 14 polymorphisms in the genes encoding the CYPs (CYP2C9, 2C19, 3A4, 3A5, 1A2, and 2B6), the ATP binding cassette subfamily B member 1 (ABCB1). Platelet aggregation activity was measured after 8h of 300mg clopidogrel administration for fifty-five ACS patients.Results: There was no significant association between polymorphism of the studied CYPs and clopidogrel responsiveness (P> 0.05). The frequency of the ABCB1 3435 T allele in clopidogrel non-responders was higher (78.9%) compared to responders (52.8%), but this difference was not significant (P=0.057). Demographic characteristics, comorbidities, concomitant treatments were not associated with clopidogrel response.Discussion: There was no effect of the studied genetic variations and demographic factors on the platelet activity of clopidogrel in Moroccan ACS patients.Keywords: clopidogrel resistance, coronary artery disease, gene polymorphisms, platelet inhibitors, ABCB1 gene, CYP450 gene
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- 2023
43. The Impact of ARMS2 (rs10490924), VEGFA (rs3024997), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), and IL1B1 (rs1143623) Polymorphisms and Serum Levels on Age-Related Macular Degeneration Development and Therapeutic Responses
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Dzastina Cebatoriene, Alvita Vilkeviciute, Greta Gedvilaite-Vaicechauskiene, Monika Duseikaite, Akvile Bruzaite, Loresa Kriauciuniene, Dalia Zaliuniene, and Rasa Liutkeviciene
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age-related macular degeneration ,gene polymorphisms ,ARMS2 (rs10490924) ,IL1B1 (rs1143623) ,TNFRSF1B (rs1061622) ,TNFRSF1A (rs4149576) ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Age-related macular degeneration (AMD) is a major global health problem as it is the leading cause of irreversible loss of central vision in the aging population. Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective but do not respond optimally in all patients. This study investigates the genetic factors associated with susceptibility to AMD and response to treatment, focusing on key polymorphisms in the ARMS2 (rs10490924), IL1B1 (rs1143623), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), VEGFA (rs3024997), ARMS2, IL1B1, TNFRSF1B, TNFRSF1A, and VEGFA serum levels in AMD development and treatment efficacy. This study examined the associations of specific genetic polymorphisms and serum protein levels with exudative and early AMD and the response to anti-VEGF treatment. The AA genotype of VEGFA (rs3024997) was significantly associated with a 20-fold reduction in the odds of exudative AMD compared to the GG + GA genotypes. Conversely, the TT genotype of ARMS2 (rs10490924) was linked to a 4.2-fold increase in the odds of exudative AMD compared to GG + GT genotypes. In females, each T allele of ARMS2 increased the odds by 2.3-fold, while in males, the TT genotype was associated with a 5-fold increase. Lower serum IL1B levels were observed in the exudative AMD group compared to the controls. Early AMD patients had higher serum TNFRSF1B levels than controls, particularly those with the GG genotype of TNFRSF1B rs1061622. Exudative AMD patients with the CC genotype of TNFRSF1A rs4149576 had lower serum TNFRSF1A levels compared to the controls. Visual acuity (VA) analysis showed that non-responders had better baseline VA than responders but experienced decreased VA after treatment, whereas responders showed improvement. Central retinal thickness (CRT) reduced significantly in responders after treatment and was lower in responders compared to non-responders after treatment. The T allele of TNFRSF1B rs1061622 was associated with a better response to anti-VEGF treatment under both dominant and additive genetic models. These findings highlight significant genetic and biochemical markers associated with AMD and treatment response. This study found that the VEGFA rs3024997 AA genotype reduces the odds of exudative AMD, while the ARMS2 rs10490924 TT genotype increases it. Lower serum IL1B levels and variations in TNFRSF1B and TNFRSF1A levels were linked to AMD. The TNFRSF1B rs1061622 T allele was associated with better anti-VEGF treatment response. These markers could potentially guide risk assessment and personalized treatment for AMD.
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- 2024
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44. Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility
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George Ciulei, Olga Hilda Orășan, Angela Cozma, Vasile Negrean, Ioana Para, Lorena Ciumărnean, Nicoleta Leach, Roxana Liana Lucaciu, Adriana Corina Hangan, and Lucia Maria Procopciuc
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colorectal adenoma ,vitamin D receptor ,insulin receptor ,gene polymorphisms ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Vitamin D deficiency and type 2 diabetes mellitus are risk factors for colorectal cancer, suggesting a role for vitamin D receptor (VDR) and insulin receptor (INSR) gene polymorphisms. We investigated the prevalence of the VDR-BsmI (rs1544410) and NsiI A/G-INSR (rs2059806) polymorphisms and their associations with colorectal adenoma (CRA) in a Romanian population. A case–control study was conducted with 110 participants (67 with CRA and 43 controls) who underwent colonoscopy. Polymerase chain reaction–restriction fragment length polymorphism analysis was used to determine the genotype and allele frequencies of the two polymorphisms. Regarding rs1544410 and CRA patients, genotype distribution was 35% B/B, 47% B/b, and 19% b/b. In the controls, the distribution was 21% B/B, 45% B/b, and 34% b/b. For rs2059806, 12% of CRA patients had A/A, 30% A/G, and 58% G/G, while 8% of the controls had A/A, 40% A/G, and 52% G/G. The recessive model showed an odds ratio of 2.84 (95% CI: 1.04–7.72, p = 0.033) for the b/b genotype. CRA patients with b/b or G/G genotypes were diagnosed at a younger age. The b allele of the rs1544410 was a risk factor for CRA. Patients with the b/b and G/G genotypes were diagnosed earlier.
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- 2024
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45. Rivaroxaban for Thromboembolism Prophylaxis in Patients with Nephrotic Syndrome: A Single-Arm, Prospective Study
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Meng Wei, Xue Wu, Liteng Wang, Zhichun Gu, Yuanmao Tu, Lihua Zhang, Jiong Zhang, Honglang Xie, Qing Zhou, Yanan Chu, Zhen Cheng, Guohua Zhou, and Qinxin Song
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rivaroxaban ,nephrotic syndrome ,thromboprophylaxis ,gene polymorphisms ,pharmacokinetics ,Internal medicine ,RC31-1245 - Abstract
Introduction: Thromboembolism is a recognized complication of nephrotic syndrome (NS). Evidence supporting the use of rivaroxaban to prevent NS-related thrombosis is limited and controversial. This study aimed to explore the impact of NS on rivaroxaban pharmacokinetics and to collect observational data on the efficacy and safety of rivaroxaban as primary thromboprophylaxis in patients with NS. Methods: This prospective study analyzed 141 patients with NS who received rivaroxaban (10 mg/day) for thromboprophylaxis. High-performance liquid chromatography-tandem mass spectrometry was used to measure the trough and peak plasma concentrations (Ctrough and Cmax) of rivaroxaban. The influence of clinical and genetic factors on these concentrations was examined using multivariate logistic regression. Results: The median Cmax and Ctrough were 68.5 ng/mL (interquartile range [IQR], 31.7–105.5 ng/mL) and 4.4 ng/mL (IQR, 1.2–11.9 ng/mL), respectively. The incidence of thromboembolic events (TEs) was 12.8%, while that of bleeding events was 14.2%, although all were classified as minor. Albumin level was the most significant factor affecting Cmax (ρ = 0.55; p < 0.001) and was also significantly associated with TEs (0.81; 0.71–0.91 per 1.0 g/dL increase; p = 0.001) and bleeding risks (1.11; 1.03–1.19 per 1.0 g/dL increase; p = 0.008). Single nucleotide polymorphisms in the ABCB1 gene significantly influenced Ctrough but were not associated with clinical outcomes. Conclusion: Hypoalbuminemia significantly affects the pharmacokinetics of rivaroxaban in NS patients. A dose-adjustment strategy based on rivaroxaban concentrations, accounting for variable albumin levels, may improve the safety and efficacy of thromboprophylaxis in this population.
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- 2024
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46. Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance
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- 2022
47. Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery
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Liu, Zhaohui, Luo, Fengming, Zhao, Juan, Chen, Weinan, Gao, Wei, and Zhou, Zhou
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- 2024
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48. Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case–control study.
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Wang, Yuan, Ma, Xiaoya, Guo, Jinping, Li, Yujie, and Xiong, Yuyan
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OSTEONECROSIS , *CONFIDENCE intervals , *GENETIC polymorphisms , *FEMUR head , *CASE-control method , *GENETIC variation , *RISK assessment , *APOLIPOPROTEINS , *ODDS ratio , *DISEASE risk factors - Abstract
Background: Osteonecrosis of the femoral head (ONFH) is a disease with a high disability rate, and genetic factors are closely related to its pathogenesis. This study aimed to investigate the possible correlation between ESR1 and APOE gene polymorphisms and the risk of ONFH. Methods: In this case–control study, the potential association between three genetic variants (rs2982573 C < T, rs10872678 C < T, and rs9322332 A < C) of the ESR1 gene and two genetic variants (rs7259620 A < G and rs769446 C < T) of the APOE gene with the risk of ONFH was investigated. Correlations between gene polymorphisms and ONFH risk were assessed using logistic regression analysis, with calculation of odds ratios (ORs) and 95% confidence intervals (CIs). Results: The overall analysis demonstrated that rs9322332 in the ESR1 gene exhibited a correlation with a decreased risk of ONFH under the homozygous (AA vs.CC: OR = 0.69, 95% CI [0.53–0.90], p = 0.006), dominant (CA + AA vs. CC: OR = 0.70, 95% CI [0.54–0.90], p = 0.006), and additive (OR = 0.79, 95% CI [0.66–0.95], p = 0.013) models. The stratification analysis revealed that rs9322332 was linked to a lower risk of ONFH in subgroups characterized by individuals aged over 51 years and non-smokers. Nevertheless, there were no notable correlations found between ESR1 rs2982573 and rs10872678, as well as APOE rs7259620 and rs769446, with the risk of ONFH. Conclusion: ESR1-rs9322332 is closely linked to a decreased risk of ONFH, thereby enhancing our understanding of the relationship between gene polymorphisms and ONFH. [ABSTRACT FROM AUTHOR]
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- 2023
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49. Association of the KISS1, LIN28B, VDR and ERα gene polymorphisms with early and fast puberty in Chinese girls.
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Li, Yunwei, Zhang, Huifeng, Li, Qiang, Huang, Xinwei, and Kong, Xiangyang
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CHINESE people , *GENETIC polymorphisms , *KISSPEPTINS , *GIRLS , *VITAMIN D receptors , *PUBERTY , *OVARIAN reserve - Abstract
To explore the association of KISS1, LIN28B, vitamin D receptor (VDR), and estrogen receptor α (ERα) gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone levels in EFP cases, in Chinese girls. The analysis was based on the data of 141 girls with EFP and 152 girls without EFP. Clinical features were documented, and all SNP genotyping was conducted using SNaPshot method. Statistical analysis was performed to assess the association of the SNPs with EFP risk, and with hormone levels in EFP cases. There was a significant association between rs7759938-C polymorphism in the LIN28B gene and the risk for EFP in the recessive (TT + CT vs. CC) model (p = 0.040). Remarkably, rs5780218-delA polymorphism in the KISS1 gene and rs2234693-C polymorphism in the ERα gene were significantly associated with peak LH (luteinizing hormone) levels (p = 0.008, 0.045) and peak LH/FSH (follicle-stimulating hormone) ratio (p = 0.007, 0.006). Additionally, on 7 of the 8 variant loci the alleles associated with increased levels of both peak LH levels and peak LH/FSH ratio in EFP cases were also associated with increased CPP risk. Our findings indicate that rs7759938-C polymorphism in the LIN28B gene might have a protective effect on EFP susceptibility. The most striking findings of this study is that, rs5780218-delA polymorphism in the KISS1 gene and rs2234693-C polymorphism in the ERα gene influenced levels of GnRH-stimulated peak LH and LH/FSH ratio, and in general CPP risk genes might also contributes to the abnormality of hormonal levels in EFP. [ABSTRACT FROM AUTHOR]
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- 2023
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50. Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China.
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Yongxin Liu, Chunping Xu, Yuqing Wang, Caiting Yang, Genyuan Pu, Le Zhang, Zhuang Wang, Pengyan Tao, Shenghe Hu, and Mingming Lai
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GENETIC polymorphisms , *HYPERTENSION , *GENETIC variation , *FOLIC acid , *BLOOD sugar - Abstract
Objective: Hypertension is one of the leading causes of human death and disability. MTHFR and MTRR regulate folate metabolism and are closely linked to hypertension, although the relationship is inconsistent among different ethnic groups. The present study aims to investigate the effects of MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), and MTRR A66G (rs1801394) polymorphisms on hypertension susceptibility in the Bai nationality of the Yunnan Province, China. Methods: This case-control study included 373 hypertensive patients and 240 healthy controls from the Chinese Bai population. The genotyping of MTHFR and MTRR gene polymorphisms was carried out by using the KASP method. The effects of genetic variations of MTHFR and MTRR genes on hypertension risk were evaluated with odds ratios (OR) and 95% confidence intervals (95% CI). Results: The present study revealed that the CT and TT genotypes and T allele of MTHFR C677T locus were considerably associated with an increased risk of hypertension. In addition, MTHFR A1298C locus CC genotype could significantly increase the hypertension risk. The T-A and C-C haplotypes of MTHFR C677T and MTHFR A1298C could increase the risk of hypertension. Further stratified analysis by risk rank of folate metabolism indicated that people with poor utilization of folic acid were more prone to develop hypertension. In the hypertension group, the MTHFR C677T polymorphism was significantly associated with fasting blood glucose, fructosamine, apolipoprotein A1, homocysteine, superoxide dismutase, and malondialdehyde levels. Conclusion: Our study suggested that genetic variations of MTHFR C677T and MTHFR A1298C were significantly associated with susceptibility to hypertension in the Bai population from Yunnan, China. [ABSTRACT FROM AUTHOR]
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- 2023
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